Citra Tarannita
Program Studi Pendidikan Dokter Fakultas Kedokteran Unibraw Malang

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EFEK HAMBATAN EKSTRAK DAUN CEPLUKAN (PHYSALIS MINIMA L)TERHADAP KONTRAKTILITAS OTOT POLOS USUS HALUS TERPISAH MARMUT DENGAN STIMULASI METAKOLIN EKSOGEN Tarannita, Citra; Permatasari, Nur; Sudiarto, Sudiarto
Jurnal Kedokteran Brawijaya Vol 22, No 1 (2006)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (115.951 KB) | DOI: 10.21776/ub.jkb.2006.022.01.4

Abstract

Physalis sp. has lots of merits as a kind of traditional medicine and one of them is its function as an alternatif treatment for diarrhea. Physalis minima leaf contains alkoloid atropine which is assumed can inhibit the contractionof guinea pig?s isolated ileum smooth muscle. This research was to know the effect of Physalis minima leaf extract toward the contraction of small intestine smooth muscle. This research was  an experimental study using ?The Post Control GroupDesign?, and guinea pig?s isolated ileum as samples. The samples  consisted of five guinea pigs, each sample was given four kinds of treatment. The control was given metacholine at the  dose of 10 -5 without Physalis minima leaf extract. Before givingmetacholine at the dose of 10 -5 , the samples were given the first dosage of Physalis minima leaf extract (0.15%), the second dose (0.30%) and the third dose (0.45%) so getting four graphs for each sample. The level of contraction was recorded by using kymograph. The result showed that  the ileum contraction of the third group was inhibited (One Way ANOVA, p=0.041), and there was a relation between the increasing dosage of Physalis minima leaf extract and the decreasing ileum contraction (simple linear regression, with R=-0.608 p=0.04 and regression equation y=52.150 ? 7.660x).
POOR ADHERENCE TO SECONDARY PROPHYLAXIS IS ASSOCIATED WITH MORE SEVERE RHEUMATIC VALVE IN PEDIATRIC PATIENTS: A CROSS-SECTIONAL STUDY Makhmud, Taufieq Ridlo; Rohman, Mohammad Saifur; Suwarniaty, Renny; Sargowo, Djanggan; Nugroho, Faris Wahyu; Hasanah, Annisa; Kusbandono, Bambang; Tarannita, Citra; Wardani, Ratih Kusuma; Widito, Sasmojo; Martini, Heny
Heart Science Journal Vol 1, No 1 (2020): The Importance of Adherence to The Guidelines
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.409 KB) | DOI: 10.21776/ub.hsj.2020.001.01.4

Abstract

Background : Rheumatic heart disease (RHD) contributed to a large number of proportion amoung cardiovascular problems in developing county, especially Indonesia. Secondary prophylaxis method using intramuscular injection of Benzathin Penicillin-G (BPG) has been known as the most effective strategy in the prevention of RHD. However, whether this prevention method also resulting in prevention of disease severity in Indonesian patients remained to be examined.Objectives : This study aimed to assess the difference of rheumatic valve severity in Indonesian pediatric patients between adequate and poor adherence to secondary prophylaxis by using intramuscular BPG injection.Methods : This cross-sectional study was conducted at Pediatric Cardiology Department of Saiful Anwar General Hospital from November 2018 to June 2019. Patients with documented history of RHD were included. Frequency of intramuscular BPG injection during the last one year was recorded. Adherence was measured using the proportion of days covered (PDC) and adequate adherence was defined as PDC ?0.90. The severity of RHD was assessed based on the severity of the mitral and / or aortic valve using echocardiography. Bivariate analysis and multivariate logistic regression analysis was used to identify characteristics associated with rheumatic valve severity.Results : A significant difference of rheumatic mitral and/or aortic valve severity was observed between adequate adherence compared to poor adherence group (p = 0.016). Rheumatic mitral and/or aortic valve were found to be more severe in patients who has one or more episode of ARF recurrence (p = 0.003). Multivariate logistic regression analysis demonstrated that adherence to secondary prophylaxis within the last 1 year has the strongest influence on the severity of rheumatic mitral and/or aortic valve (p = 0.049; OR 7.20).Conclusion : The adherence to secondary prophylaxis has the strongest related the rheumatic valve severity compared to other factors.