Mokhamad Fakhrul Ulum
Faculty of Veterinary Medicine, Bogor Agricultural University

Published : 16 Documents
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Journal : Jurnal Veteriner

PEMBIUSAN BABI MODEL LAPAROSKOPI UNTUK MANUSIA DENGAN ZOLETYL, KETAMIN DAN XYLAZIN -, Gunanti; Siswandi, Riki; Soehartono, Raden Harry; Ulum, Mokhamad Fakhrul; Sudisma, I Gusti Ngurah
Jurnal Veteriner Vol 12 No 4 (2011)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

In the last decade the use of pig as animal model for trining in laparoscopic surgery showed onincreased in Indonesia. The training for laparoscopy surgery involved cholecystectomy, ovariohysterctomy,hysterectomy, nefrectomy, spleenectomy, and cardiosurgery. The success of such training depends on themethod and the process as such as the proper used to handle the animal. The study was a retrospectivestudy over 2009-2010 laparoscopic training on 62 pigs. The objective of this study was to elucidate theprocedure of pig laparoscopic surgery, anesthesia methods, obstacle, and the solutions. Method ofanesthesia induction was performed by using combination of tiletamine-zolazepam (8 mg/kg bw), ketamineHCl (6 mg/kg bw), and xylazine HCl (2 mg/kg bw) /ZKX without premedication. Anesthetized pigs weremaintained with combination of ketamine HCl (5 mg/kg bw)-xylazine HCl (2 mg/kg bw) without anyanalgesic agent. Onset of ZKX induction induction was 3-5 minutes. Time of surgery varied from 40 to 120minutes, depend on surgery procedures. Heart beat and respiration rate per minute were remain stableduring surgery procedure, with observed at 68.4±12.1 and 41.3±14.1 respectively. The anesthetic methodused for Indonesian local pigs appeared to be suitable for laparoscopic surgery model for human.
CHEMICAL CASTRATION USING IRON (III) CHLORIDE HEXAHYDRATE (KEBIRI KIMIAWI MENGGUNAKAN FERIKLORIDA HEKSAHIDRAT) Ulum, Mokhamad Fakhrul; Paramitha, Devi; Sariningrum, Arlita; Maharani, Anizza Dyah Kartika; Tumbelaka, Ligaya ITA; Noviana, Deni
Jurnal Veteriner Vol 18 No 3 (2017)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/jveteriner.2017.18.3.360

Abstract

Chemical castration is a method that can be applied easily without any surgical intervention in animals. This study utilized iron (III) chloride hexahydrate (FeCl3.6H2O) as a new material for chemical castration in mice. Twenty seven adult male mice were divided into five groups: FeCl3 20% (n = 6), FeCl3 10% (n = 6), FeCl3 5.0% (n = 6), FeCl3 2.5% (n = 6), and control NaCl 0.9% (n = 3). A 0.2 mL of NaCl 0.9% or FeCl3 in various concentrations was injected intra-testicularly on each testis of the mice. Post-castration survival rate with LD50 values was obtained at the concentrations between 2.5-5.0% of FeCl3 groups, and 100% mice survived in the control group. The size of testis and concentration of spermatozoa decreased, in contrast with the increased concentration of FeCl3 solution used seven days post-injection compared to the control group. ABSTRAK Kebiri/kastrasi kimiawi secara injeksi intra-testis merupakan metode pengebiriam yang dapat dilakukan dengan mudah tanpa prosedur bedah pada hewan. Penelitian ini memanfaatkan larutan besi (ferri/III) klorida (FeCl3) sebagai bahan baru untuk tindakan kebiri kimiawi pada mencit. Mencit jantan dewasa umur lima bulan sebanyak 27 ekor dibagi dalam lima kelompok yaitu FeCl3 20% (n=6), FeCl3 10% (n=6), FeCl3 5,0% (n=6), FeCl3 2,5% (n=6) dan kontrol NaCl 0,9% (n=3). Larutan FeCl3 sebanyak 0,2 mL diinjeksikan secara intra-testikel pada setiap organ testis. Daya hidup pascakebiri injeksi nilai LD 50 diperoleh pada kelompok FeCl3 konsentrasi di antara 2,5-5,0 % dan kelompok kontrol 100 % hidup. Organ testis dalam skrotum mengalami pengecilan ukuran dan konsentrasi spermatozoa mengalami penurunan seiring dengan peningkatan konsentrasi larutan FeCl3 yang digunakan setelah tujuh hari pasca injeksi dibandingkan dengan kontrol.