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Journal : Pharmaceutical Sciences and Research (PSR)

Toksisitas Ekstrak Etanol Mangifera foetida L. Sebagai Pengkelat Besi Ditinjau dari LD50 dan Komponen Sel Darah Wahyuni, Tri; Sari, Santi Purna; Estuningtyas, Ari; Freisleben, HJ
Pharmaceutical Sciences and Research (PSR) Vol 2, No 3 (2015)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (43.52 KB) | DOI: 10.7454/psr.v2i3.3345

Abstract

Ethanolic extract of bacang mango leaves (Mangifera foetida L.) was reported could decrease blood iron concentration of iron overloaded-Sprague dawley rats. The aim of this experiment was to determine acute toxicity (LD50) value of ethanolic extract of M. foetida by weil method and its effect to blood component. This study was conducted by employing a complete random design using 25 male and 25 female mice of DDY strain which was divided into 5 groups. The first until fourth group were administered by the aquadest suspension of ethanolic extract of M. foetida with dose variation, orally. The fifth group was control group that administered by aquadest only. The LD50 was determined by the total of death on all group. LD50 value of the extract showed no death in the biggest doses (13.013 g/kg). The examination was continued with measured blood count (erythrocytes, trombocytes, leukocytes, and haemoglobin concentration). It was shown that the extract at dose 1.626; 3.253; 6.506 and 13.013 g/kg unchanged the blood count measurement. It is concluded that Mangifera foetida L. leaf was not toxic, but could not change the blood count measurement.  
Co-Authors A, Ivon A, Yuli Abidin, Faris Achyanadia, Septy Adelina Hasyim Agistiana, Seruni Aishah Abdul Jalil Akhirmen Akhirmen Anastasya, Lidwina Anggraeni Anggraeni Anita Rahmawati Anjarsari, Dwi Indah Ari Estuningtyas, Ari Arif Widiyatmoko, Arif Arisanti, Tiffani Nindya Armanda, Armanda Asep Tata Gunawan, Asep Tata Ashari, . Atni Prawati Bakar, abdoel Bambang Sri Anggoro Bhakti, Wida Kuswida C, Vatim D Cahya Mulat, Trimaya Calista Siagian, Irma Dawam, Ahmad Anwarud Denah Suswati Deniswaty, . Desi Areva Desi Ulandari, Desi Dewi Kurniati Dewi, Arum Kusnila Diana Achmad Didik Prasetyoko Dina Mardiana Een Yayah Haenilah Eka Puspitasari, Eka Endang Ernawati Endarwati, Susiani Erni Erni F, Eva Fadly Azhar Fahmi Medias, Fahmi Fatchurohman, Fatchurohman Feriadi Feriadi, Feriadi H, Hotma M H, Setyo Haeriah, . Hanna, Rina Ayu Hariani, Lilik Sri Hasan, Sholeh Hasliza Bahruji Hasmin Tamsah, Hasmin Hermi Yanzi Heru Pramono HJ Freisleben, HJ Imroatul Qoniah Isa Akhlis Iskandar Abdul Samad, Iskandar Abdul K, Hana K, Hanna S Kalanjati, Woro Wulandari Kamaluddin, Muhammad Totong Kardiatun, Tutur Katrin Katrin Komara, Adi Komarudin Komarudin Kumar, Abdul Malik Kurniasari, Nova Laksmi Widajanti Lulus Irawati, Lulus M, Yunita R M, Yustinus Mamik Sarwendah Mangiliwati Winardi, Mangiliwati Melda Agarina Melda S Suebu, Melda S Mujiatun, . Mulawarman Mulawarman Munaris Munaris Munstermann, Susanne Mun’im, Abdul N, Evi I Nanik Setiyawati, Nanik Nugraha, I Ketut Destian Nugraismia, Wilda Nur Annis Hidayati, Nur Annis Nurhayati Damiri Nurliza Nurliza O, Antonius S Ochi Marshella Febriani Oxyandi, Miming P, Mardi R Parisa, Nita Perryanis, Perryanis Prastanti, Hestu Pratiwi, Chalies Diah Puji Harto Putri, Rahmah Dianti Qurotaayunina, Yasmin Rahmat Hidayat Rahmiati Rahmiati Raja Muhammad Amin Ramadhaniyati, Ramadhaniyati Ramdhani, Eka Putra Rani Mega Putri Ridwan Affandi rini hazriani Rosalina, Linda S, Faith HS S, Lidwina Santi Purna Sari Semuel Sandy Silitonga, Risma Juniarti Paulina Sinanto, Agus Siroj, Muhammad Badrus Siti Fatimah Pradigdo Siti Nurjannah Soni Kurniawan Sri Ariyanti Sri Ayem, Sri Sri Lestari Sri Wahyuni Sriyanto, . Subagyo, Tutut Suciati Sudarisman Sugeng Triwahyono Sulistiono, nFN Sumartono, Fareza Ferdyna Nanda Suprapto Suprapto Suyanto Suyanto Syswianti, Desy Tandjung, Ratna Taupik Rahman Tedi Rusman Tri Karyono Tri Noor Aziza Triyanto Pristiwaluyo W, Irawati W, Mirna Wahyu Ardianto Werdiningsih, Sri Werner R. Murhadi Widuri, Anggita Widuri, Anggita Yatim Lailun Ni’mah Yaya Sukaya Yeni Agustin Yuliana, Citra Yuliarni Yuliarni Yushardi Yushardi, Yushardi Zaenuddin, Nuryani