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Journal : Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)

Efek Imunomodulator Ekstrak Etanol Spons Melophlus sarasinorum Terhadap Aktivitas Fagositosis Sel Makrofag Pada Mencit Jantan Balb/C: Immunomodulatory Effects of Ethanol Extract of Melophlus sarasinorum Sponge Against Phagocytosis Activity of Macrophage Cells on Balb/C Male Mice Wahyuni, Wahyuni; Yusuf, Muhammad Ilyas; Malik, Fadhliyah; Lubis, Adryan Fristiohady; Indalifiany, Astrid; Sahidin, I
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (221.925 KB) | DOI: 10.22487/j24428744.2019.v5.i2.13611

Abstract

Immunomodulator is an ingredient or drug that can modulate immune system functions and activities. This study was conducted to determine the effect of ethanol extract of Melophlus sarasinorum sponge on macrophage phagocytosis activity. Twenty four male mice balb/c were divided into six groups. The first group received 100 mg/kg of ethanol extract of Melophlus Sarasinorum sponge, the second group received 200 mg/kg of ethanol extract of Melophlus sarasinorum sponge, the third group received 300 mg/kg of ethanol extract of Melophlus Sarasinorum sponge and the fourth group received 400 mg/kg of ethanol extract of Melophlus Sarasinorum sponge. The positive control group received Phyllanthus niruri linn extract (Stimuno┬«) 0,13 mg/g and the negative control group received NaCMC 0,5%. The extract was orally administered from first day to seventh day. On the eighth day, each of the mice was injected Staphylococcus aureus bacteria (SA) 0.5 mL intraperitoneally. Macrophage cell activity is calculated from smears of peritoneal fluid of mice. Increased doses of ethanol extract of Melophlus sarasinorum sponge increase the amount of macrophage phagocytosis activity that are 25,25% (negative control), 61,5% (positive control), 55,75% (100 mg/kg), 60,75% (200 mg/kg), 62,25% (300 mg/kg) dan 66,25% (400 mg/kg). The results showed that the ethanol extract of Melophlus sarasinorum sponge has the potential as immunomodulator at a doses of 300 mg/kgBB and 400 mg/kg with no significantly different effectiveness with positive control in increasing macrophage cell phagocytosis activity based on the result of post-hoc statistical test of Tukey (sig.> 0,05).  
Uji Daya Hambat Formula Gel Ekstrak Etanol Daun Murbei (Morus alba L.) Sebagai Anti Acne Terhadap Bakteri Propionibacterium acne.: Inhibition Test of Ethanol Extract Gel of Mulberry (Morus alba L.) Leaves as an Anti Acne on Propionibacterium acne Bacteria Aliah, Ahmad Irsyad; Wahyuni, Wahyuni; Bachri, Nurjannah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (140.636 KB) | DOI: 10.22487/j24428744.2019.v5.i2.13663

Abstract

A research on the inhibition of formula gel test ethanol extract of leaves of mulberry (Morus alba L.) as an anti-acne against bacteria Propionibacterium acne. This study uses a gel formulation made using mulberry leaf extract (Morus alba L.), which aims to determine the inhibition of antibacterial gel mulberry leaf extract (Morus alba L.) against the bacteria Propionibacterium acne. Gel made three dosage concentrations of 2%, 4% and 6%. Testing inhibition of antibacterial gel agar diffusion method. Test Antibacterial inhibition obtained by looking at the clear zone in the medium and measured using calipers. The results showed that the inhibition of antibacterial gel formulation with a concentration of 2%, 4% and 6% showing that inhibiting bacterial activity.
Aktivitas Antioksidan Ekstrak Etanol Buah, Daun, Batang Dan Rimpang Pada Tanaman Wualae (Etlingera Elatior (Jack) R.M Smith): Antioxidant Activity of Ethanol Extract of Fruits, Leaves, Stems and Rhizome of Wualae (Etlingera elatior (Jack) R.M Smith) Jabbar, Asriullah; Wahyuni, Wahyuni; Malaka, Muh Hajrul; Apriliani, Apriliani
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (277.075 KB) | DOI: 10.22487/j24428744.2019.v5.i2.13671

Abstract

Wualae (Etlingera elatior (Jack) R.M Smith) is one of the plants in the Zingiberaceae family, widely used in medicine ranging from rhizomes, fruits, and flowers. Empirically Wualae are usually used by people for treating skin diseases, flavoring food, a natural soap, and in Southeast Sulawesi, it is used to treat typhoid fever. This study aims to examine the antioxidant activity of Wualae (Etlingera elatior) plant. The plant extracts were extracted by maceration method, antioxidant activity test was performed by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) method. The results showed that ethanol extracts of fruits, leaves, stems and rhizomes of Wualae (Etlingera elatior) has the potential antioxidant activity with the IC50 values of 72.518 mg/L, 99.890 mg/L, 52.345 mg/L and 58.638 mg/L, respectively. and Vitamin C has IC50 value of 3,787 mg/L.
Co-Authors A P, I Nyoman Nugraha Abdullah, Dahliana Abinowo, Abinowo Abu Bakar Adi Pratama, All Fraida Adrianus Adrianus, Adrianus Adryan, Fristiohady Afriani, Miskah Alam, Ilham Kudratul Alfyano, Aexsa Aliah, Ahmad Irsyad Amirullah Amirullah Amri, Siti Belinda Andayani Andayani Andi Alfian Zainuddin Andi Parenrengi Andriani, Rina Andriani, Rina Anggraini Anggraini Anika, Mutia Annawaty Annawaty, Annawaty Anwar Umar Anwar, Sakaria To Anwar, Zakariya Apriliani, Apriliani Ardianti, M. Ardyana, Della Arianto, Asnandar Arianto, Asnandar Ariastika, Dian Arief, I. I. Arief, Tita Rahayu Arizal, Ridha Armadany, Fery Indradewi Armin, La Ode Arsa Wahyu Nugrahani Arsyad, Usman ASMAN SADINO, ASMAN Asrul Sani Astuti Wijayanti, Astuti Bafadal, Mentarry Bahrun Bahrun Bambang Budi Utomo Baru Sadarun, Baru Benny Rusli, Benny Benny, Faichal Budiono, Arifin Nur Budirman Bachtiar Budiwitjaksono, Gideon Setyo Damanhuri Daud, Damanhuri Darsono Darsono Daviq Chairilsyah Desiana Trisnawati Tobigo, Desiana Trisnawati Dj, MUHAMMAD ZUHRI Dj, MUHAMMAD ZUHRI Dwi Hilda Putri Dwi Kesuma Sari Dwi Shintia, Ulan Emilia Emilia Entang, M Eva Dolorosa Fahri Fahri Farida Mayar Fauziyyah, Afifah Febriani, Suci Ramadhanti Febriansyah, Hendra Febriliasmanto, Febriliasmanto Feriadi, Eva Feriadi, Eva Fredricka, Jhoanne Fristiohady, Adryan Fristiohady, Adryan Fristiyohadi, Adryan hajrawati, Hajrawati Halik, Tian Amalia Harahap, Milna Chairunnisa Hartoyo Hartoyo Hasratuddin Hasratuddin Herfina Herfina heri aryadi, heri Herri Mahyar Hidayat Hidayat Hidayat, Alfa Manarul Hidayati, Siti Aisyah Himawan, Noni I Sahidin Idris, Nurlaily Ifada novikasari Ihwan, Muhamad Bisri Imelda Imelda Imran Imran Inayah Inayah Indalifiany, Astrid Indalifiany, Astrid Indasari, Ningsih Indrayana, Sofyan Irawati Mei Widiastuti Irmawanty, Irmawanty Irwan, Andi Ishak, Chamsiah Islamiah, Nurul Ismartoyo Ismartoyo Isnaini Herawati, Isnaini Istiqomah, Widya Izwita Dewi Jabbar, Asriullah Jamaluddin . Jayanto, Imam Jesi Alexander Alim Juliati, Juliati Kalimin, Wa OIL. Kardi, Ipa Sari Kasmawati, Henny Ketut Sofjan Firdausi, Ketut Sofjan Khaeruddin Khaeruddin Khoirotunnajihah, Khoirotunnajihah Kurniawan, Dedy Hendra Kusrini Kusrini Latief, Kamaluddin Lestari Sukarniati, Lestari Lestari, Indri Limbongan, Amelia A Lubis, Adryan Fristiohady M., Fadliah Mahidin Mahidin Mahmudah, Zakiyatul Malaka, Muh Hajrul Malaka, Muhammad Hajrul Malik, Fadhliyah Malik, Fadhliyah Mallarangeng, A. N. T. A Manuputty, Charles J. Masdul, Muhammad Rizal Mashudi Mashudi Matandung, Karla Kembongallo Mesi Leorita, Mesi Mirda, Mirda Mohammad, Habsah Muhammad Adam, Muhammad Muhammad Fadjar Perkasa, Muhammad Fadjar Muhammad Fadli Muhammad Ikhsan Muhammad Ilyas Muhammad Ilyas Yusuf Muhammad Irfan Muhammad, Tengku Sifzizul Tengku Muis, Mirna Mukarramah Mukarramah, Mukarramah Munar Munar Musa, Najiah Muwakhidah, Muwakhidah Naim, Muh. Rezky Nasution, Rina Mahyurni Ningsi, Andryani Ningsih, Andryani Nisa, Haiyun Normawati Normawati, Normawati Nur Illiyyin Akib Nurahmi, Nurahmi Nuralifah Nuralifah, Nuralifah Nurbaiti Nurbaiti Nurjaman, Jajang Nurjannah Bachri, Nurjannah Nurjunitar, Annita Vury Nurlaela Rauf Nurlina Ibrahim Nuryamin Nuryamin, Nuryamin Parawansah Parawansah, Parawansah Pariyati, Pariyati Permana, La OMJ. Pinuji, Sukmo Poko, Feny Rizkia Purba, Fika Yuliza Purnama, La Ode Muhammad Julian Rahayu, Gustin Sari Margiani Rahmanpiu, Rahmanpiu Rahmayani, Nur Rasyid, Muhammad Rusyidi Rina Sri Widayati Rini Hamsidi, Rini Rizki, Makbull Roland Alexander Barkey, Roland Alexander Rosalina, Lutfah Rosmiati Rosmiati Rustam HN, Muhammad Sabrianto Aswad, Sabrianto sadimantara, muhammad syukri Safa?at, Rachmat Sahidin Sahidin Sahidin, Idin Sahidin, Idin Saktiani, Dwi Nur Salma, Wa Ode Salsabila, Syefira Sari, Anggita Nindya Saripuddin, Saripuddin Satria Bijaksana Shorayasari, Susi silvitasari, ika Siregar, Khoirotun Najihah Sitanggang, Andri Sahata Siti Hafsah Sitti Mania, Sitti Solihin Solihin Soma, Andang Suryana Sri Mulyani Sri Wahyuni Supriati, Yulia Suriana Suriana Surjono Surjono Suryani Suryani Sutji Rochaminah Suwarjo Suwarjo Suyudi, Bambang Syafariani, R Fenny Talebong, Fredy Taufiq Taufiq Torro, Supriadi Tukiran Tukiran Umar Dani, Ali Vitarani Dwi Ananda Ningrum, Vitarani Dwi Ananda Wanialisa, Mery Wardoyo, Supriyono Eko Widasri, Mirna Widodo Widodo Wildana Wargadinata Winda Irwanti, Winda Wirawan, Reza Ashari Yuliansyah Yuliansyah Yusuf, Muhammad I. Yusuf, Muhammad I. Zubaydah, Wa Ode Siti Zubaydah, Wa Ode Sitti Zubaydah, Wa Ode Sitti