Aris Widayati
Faculty of Medicine, Universitas Brawijaya

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Edukasi Manfaat Tanaman Obat dan Pengolahannya dengan Metode CBIA di Desa Bulusulur, Kabupaten Wonogiri, Jawa Tengah Widayati, Aris; Wulandari, Erna Tri
ABDIMAS ALTRUIS: Jurnal Pengabdian Kepada Masyarakat Vol 1, No 1 (2018)
Publisher : ABDIMAS ALTRUIS: Jurnal Pengabdian Kepada Masyarakat

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The community service program reported in this paper aims to educate people about benefits of herbs and how to process herb raw materials for medication. This community service program was conducted in December 2016. The program involved 25 leaders of housewife communities (Kader PKK) in Bulusulur Village, Wonogiri, Central Java. The education was conducted using the CBIA (Cara Belajar Ibu Aktif) method. The CBIA supports the participants to be active during the education process. Results of the active learning through the CBIA method showed participants’ knowledge as folows: (1) participants were able to mention that herbal medicines are safe, have no side effects, can be easily obtained around their house; (2) they commonly used herbal for medication more than 4 times per month, obtained from their garden or local market; (3) they were able to mention the benefits of herbs commonly used; for example, “temu lawak” for stomachache, “kunyit” for pre-menstrual pain. However, they were not able to differentiate categories of herbal medicines which were produced by herbal manufacturers, such as “Jamu”, “Obat Herbal Terstandar”, and “Fitofarmaka”. Their knowledge about benefits of herbs was limited to those which were available in their garden. They also appreciated the demonstration of producing “Bir Jawa” and “Sambiloto cookies”.
Peran Apoteker dalam Pengelolaan Penyakit Degeneratif di Dusun Mergan Sendangmulyo, Sleman, D.I. Yogyakarya Virginia, Dita Maria; Widayati, Aris
ABDIMAS ALTRUIS: Jurnal Pengabdian Kepada Masyarakat Vol 1, No 1 (2018)
Publisher : ABDIMAS ALTRUIS: Jurnal Pengabdian Kepada Masyarakat

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Findings of the preliminary survey showed a high proportion of geriatric people in Dusun Mergan, Sendangmulyo, Sleman, which leads to high risk of cardiovascular and other degenerative diseases. This community service program aimed to identify the health status of Mergan’s people through health screening and to help them to maintain their health. This program was conducted in collaboration  between the Faculty members and students of Pharmacy Faculty of Universitas Sanata Dharma Yogyakarta (USD). There were two consecutive periods; the first was in 7th of May and the second was in 22nd of October 2018. Health education, health screening, and health examination were conducted in each period. There were 93 people involved in the first period and 64 people in the second; however, only 32 persons who completely attended the two meeting periods. The program resulted data of 60.7% Mergan’s people with a risk of dyslipidemia, and 59.0% with hyperglycemic. There was no significant difference between the first and the second periods of examination of glucose level, cholesterol, and uric acid. Therefore, it is urgent to educate people in Mergan Village to promote and maintain a healthy lifestyle in order to decrease morbidity of degenerative disease in the community.
Evaluation of antibiotic usage in patient with fever in a private hospital in Yogyakarta (period January – June 2002) Widayati, Aris; Budiarti, L. Endang; Donatus, Imono Argo
INDONESIAN JOURNAL OF PHARMACY Vol 15 No 3, 2004
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (271.798 KB) | DOI: 10.14499/indonesianjpharm0iss0pp144-150

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Fever as a symptom may indicate to any other diseases. According to the standard therapy by IDI (1998) fever should be treated without antibiotic, but the fact showed that 70 % antibiotics were used for treatment. This study aimed at describing about fever and evaluating antibiotic usage in patients with fever as a final diagnose by appropriateness, effectiveness, and safety as a criteria of evaluation.The present study was done with retrospective data collection and descriptive-evaluative design. Data was collected from medical records within a period from 2002 January to June. A number of 157 patients were used for the assesment.The highest percentage of patient’s fever was a group of 17 – 60 years old (63. 28%). The final diagnose was fever (29.58%) and others (70.42%) such as viral infection (17.16%), DHF (8.28%), DF (7.01%) and acute respiratory traction infection (5.92%). There were 29 kinds of antibiotics (79.62%) that given to the patients as an empirical therapy and the highest was pefloxacin (13.14%). The percentage of antibiotic usage in patients with fever as a final diagnose (50 patients) was 86.00% (21 kinds of antibiotics) and the highest was pefloxacin (17.19%). Both of fever less than 5 days ormore than 5 days were treated with antibiotic, which was inappropriate usage because fever less than 5 days related to viral infection. There was only 4.65% had a culture and sensitivity test, which was appropriate antibiotics usage. There were 46.51% no growth of culture and 48.84% without culture, which was inappropriate antibiotics usage. Treatment with and without antibiotics could normalize vital signs each was 90.70% and 85.71% with no significant difference (with non parametric exact probability Fisher analysis, CI 0.05) and RR value (95%, 0.69-1.30). Patient’s recoveries were 88.37% and 85.71% with and without antibiotic therapy with no significant difference (CI 95% and 0.96 RR value with CI 95%; 0.66 – 1.41). There were two cases (4.00%) of contraindication and 12.00% of potential drug interactions. According to the standard therapy and supporting data of this study, so that fever should not always be treated with antibiotic.Key words: antibiotic, fever, evaluation.
THE INFECTION EFFECT OF STRAIN H37Rv MYCOBACTERIUM TUBERCULOSIS ON APOPTOSIS OF MICE’S NEURON CELL BRAIN (MUS MUSCULUS) Kaspia, Rima Nor; Hidayati, Dwi Yuni Nur; Widayati, Aris
Malang Neurology Journal Vol 2, No 2 (2016): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (615.744 KB) | DOI: 10.21776/ub.mnj.2016.002.02.2

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Background. Ischemia on the cells and the lack of supply of glucose, will trigger a Ca2 + influx into the cell and increased expression of glutamate. Result in mitochondrial Ca2 + Influx be "overloaded". Glucose metabolism then switched to the anaerobic process that makes ATP increasingly depleted and there acidosis. This situation makes the neuron cell apoptosis triggered to occur. Apoptosis is programmed cell death. Neuron cell apoptosis is thought to have a strong connection to the tuberculosis infection in the brain.Objective. To determine the number of cells undergoing apoptosis neurons in brain tissue of mice.Methods. This study is a semiquantitative by comparing the number of cells undergoing apoptosis neurons in the three groups of samples. Observations apoptosis of neuronal cells in the brain tissue of mice was conducted using TUNEL staining technique (terminal deoxynucleotidyl transferase dUTP nick end labeling) are seen in a microscope with a magnification of 1000x.Results. The results showed that neuronal cells undergo apoptosis in brain tissue infected with M.tb for 8 and 16 weeks were marked with brown color in the cell nucleus. Neuron cell apoptosis were observed at M.tb-infected brain tissue for 16 weeks.Conclusion. The longer the M.tb infection can affect the increase in the number of neuronal cell apoptosis.
HEALTH SEEKING BEHAVIOR DI KALANGAN MASYARAKAT URBAN DI KOTA YOGYAKARTA Widayati, Aris
Journal of Pharmaceutical Sciences and Community Vol 9, No 2 (2012)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (506.958 KB) | DOI: 10.24071/jpsc.9271

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Abstract : Research presented in this article investigated health seeking behavior among people in an urban area of Yogyakarta City Indonesia. The research was a cross-sectional survey involved adults in Yogyakarta City who were selected using a cluster random sampling technique. Sample size was 640 respondents. Data were collected using a pre-tested questionnaire during March to May 2010. Data were analyzed using descriptive statistics, Chisquare tests, and Logistic regression. A total of 559 questionnaires were completed, resulted in 90% of response rate. Mostly respondents stated that they had one to three medical complaints within a month (51% of 559). The most popular health seeking behavioris a combination between self-care and consultation to health care providers (41%). Other options are self-care (36%), consultation to public health care centre (16%), and consultation to private health care (5%). Among the socio-demographic and economic characteristics, marital status is the only factor that significantly correlated with health seeking behavior. Based on the results it can be recommended that programs for improving health behavior should consider self-care, including no medication and self medication with modern and herbal/traditional medicines. The role of family members (e.g. spouse) should also be considered as an important factor of health related behavior.Keywords : Health seeking behavior
PENGETAHUAN MENGENAI ANTIBIOTIKA DI KALANGAN MAHASISWA ILMU – ILMU KESEHATAN UNIVERSITAS GADJAH MADA YOGYAKARTA Pratiwi, Rizky Indah; Rustamadji, Rustamadji; Widayati, Aris
Journal of Pharmaceutical Sciences and Community Vol 10, No 2 (2013)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (820.639 KB) | DOI: 10.24071/jpsc.10291

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Abstract: Inappropriate use of antibiotics, both prescribed and non-prescribed, is a global public health problem. In Indonesia, there is an increase of self-medication with antibiotics in the community in the last decade. Health practitioners are the main source of information and advice on self-medication with antibiotics in the community. Therefore, it is important to investigate knowledge of antibiotics among students of health sciences because they are candidates for future health practitioners. This study is an observational cross-sectional survey using a validated questionnaire. Respondents were 150 students of health sciences faculties at Gadjah Mada University Yogyakarta who were selected using a non-random convenience sampling technique. Of the 150 respondents, 79%(119) were familiar with antibiotics. Only these data (n =119) were subsequently analysed. Overall, they had appropriate knowledge about efficacy of antibiotics for bacterial infections and risks of antibiotic use, i.e. allergic reactions and antibiotic resistance. However, their knowledge about efficacy of antibiotics for viral infections and the use of antibiotics immediately for fever were not appropriate. In general, 34% of respondents had high level of knowledge about antibiotics, 54% in the moderate level and 12% in the low level.Keywords: knowledge of antibiotics, health sciences students
EVALUASI DRUG RELATED PROBLEMS PADA PASIEN GERIATRI DENGAN HIPERTENSI DISERTAI VERTIGO DI RS PANTI RINI YOGYAKARTA AGUSTUS 2013 Yosriani, Kresensiana; Donowati, Maria Wisnu; Widayati, Aris
Journal of Pharmaceutical Sciences and Community Vol 11, No 2 (2014)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.428 KB) | DOI: 10.24071/jpsc.112106

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Abstract : This study aimed to evaluate Drug Related Problems (DRPs) among hypertensive geriatric patients with vertigo co morbid at Panti Rini Hospital Yogyakarta. This is a non-experimental research descriptive evaluative design using a retrospective medical record data. Collected data including patients identity; initial, final, and complication diagnosis; cardiovascular system drugs and antivertigo, laboratory data. The inclusion criteria were ≥ 60 years with an initial diagnosis of hypertension with vertigo co morbid, used a diuretic drug, and had creatinine test result. Data were analyzed case by case using selected literatur. There were 20 cases found. Result of the study showed that 100% of patients used antihypertensive as the cardiovascular system drugs and 80% patients used antivertigo as nervous system drugs. There were 18 cases of DRPs found related to the use of antihypertensive and antivertigo. 1 case of dosage too low, 8 cases of adverse drug reaction, and 9 cases of dosege too high.Keywords : hypertension with vertigo co morbid, geriatrics, Drug Related Problems
Pengaruh Pemberian Aromaterapi Lavender secara Inhalasi terhadap Penurunan Intensitas Nyeri Persalinan Fisiologis pada Primipara Inpartu Kala Satu Fase Aktif di BPM “Fetty Fathiyah” Kota Mataram Karlina, Sisca Dewi; Reksohusodo, Subandi; Widayati, Aris
Majalah Kesehatan FKUB Vol 2, No 2 (2015)
Publisher : Faculty of Medicine Universitas Brawijaya

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Nyeri merupakan perasaan sensorik dan emosional yang tidak menyenangkan. Pada persalinan nyeri  disebabkan kontraksi miometrium, regangan segmen bawah rahim dan serviks, serta iskemia otot rahim sebagai proses fisiologis yang menimbulkan rasa takut dan khawatir yang dapat berdampak pada ibu dan janin. Aromaterapi adalah salah satu metode nonfarmakologis untuk menangani nyeri dengan memproduksi   enkefalin. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pemberian aromaterapi lavender secara inhalasi terhadap penurunan intesitas nyeri persalinan fisiologis pada primipara inpartu kala I fase aktif. Desain penelitian ini adalah experimental dengan rancangan one group pretest-posttes without control. Jumlah sampel 20 orang yang ditentukan dengan metode purposive sampling. Variabel bebas adalah pemberian aromaterapi dan variabel terikatnya adalah nyeri persalinan. Uji statistik menggunakan paired t-test diperoleh nilaii p value = 0,000 (p value < 0,05) artinya pemberian aromaterapi lavender terbukti signifikan dapat menurunkan intensitas nyeri persalinan fisiologis kala satu fase aktif. Dapat disimpulkan bahwa terdapat pemberian aromaterapi lavender secara inhalasi mampu menurunkan intensitas nyeri persalinan fisiologis pada primipara inpartu kala satu fase aktif. Kata kunci: Aromaterapi Lavender, Nyeri persalinan, Primipara.
Swamedikasi di Kalangan Masyarakat Perkotaan di Kota Yogyakarta Widayati, Aris
Indonesian Journal of Clinical Pharmacy Vol 2, No 4 (2013)
Publisher : Indonesian Journal of Clinical Pharmacy

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Penelitian observasional potong lintang ini bertujuan mengeksplorasi prevalensi dan pola swamedikasi di Kota Yogyakarta. Sejumlah 640 sampel di Kota Yogyakarta dipilih secara klaster acak pada periode Maret–Mei 2010. Data yang diperoleh kemudian dianalisis secara statistik deskriptif. Sebanyak 50% dari responden tersebut berswamedikasi satu kali, 33% dua kali dan 17% lebih dari dua kali. Responden yang membeli obat modern sebanyak 86% dan obat tradisional sebanyak 14%. Obat swamedikasi diperoleh dari apotek (42%), toko/warung kelontong (35%), toko obat (7%), dan kombinasi ketiganya (16%). Sebanyak 99% responden sembuh atau setidaknya berkurang keluhannya setelah berswamedikasi. Jika tidak sembuh setelah berswamedikasi, 45% responden menyatakan akan pergi ke dokter, sementara 20% lainnya ke puskesmas, 5% ke rumah sakit dan 5% kembali melakukan swamedikasi. Sumber informasi tentang obat mereka peroleh dari iklan (32%), dokter (17%), teman (17%), dan dari apotek (5%). Alasan mereka berswamedikasi antara lain pengalaman sembuh menggunakan obat tersebut sebelumnya (24%), berpersepsi bahwa penyakitnya ringan (22%), cepat dan praktis (17%) dan murah (13%). Temuan diatas mengindikasikan peluang dari aspek bisnis apotek sekaligus tantangan peningkatan peran profesi apoteker terutama di apotek dalam membantu masyarakat berswamedikasi secara tepat.Kata kunci: Swamedikasi, masyarakat perkotaanSelf-Medication among Urban Population in YogyakartaThis observational cross-sectional study is aimed at exploring prevalence and patterns of SM in Yogyakarta. A cluster random sampling technique was applied to select 640 adults in Yogyakarta between March and May 2010. From a total of 559 completed questionnaires, 247 (44%) respondents who had self-medicated during two previous weeks were included in subsequent analysis. Among these respondents, 50%had self-me-dicated once, 33% twice and 17% more than two times. Eighty-six percent of respondents had consumedmodern medicines while the rest 14% had used traditional ones. The drug for SM was obtained from pharmacies (42%), groceries (35%), drug stores (7%) and combination of those three sources (16%). Most of the respondents (99%) were recovered from their illnesses or at least experienced a symptom relieve after SMs. Forty-five percent respondents stated that they will visit a physician when they see no improvement after SM, while the rest said they will visit primary healthcenters (20%) and hospitals (5%) orrepeat their SM (5%). Information about the medicines areobtained from advertisements (32%), physicians (17%), friends (17%) and pharmacists (5%). The motivation for SM are previous experience of being relieved (24%), perception that they haveminor illnesses (22%), quick and easy (17%) and cheap (13%). Above findings indicate a business opportunityof pharmacies and a challenge to improve the role of pharmacists in assisting people regarding the selection of medicines for SM.Key words: Self-medication, urban people
Korelasi Antropometri terhadap Profil Lipid pada Masyarakat Pedesaan Cangkringan, Kabupaten Sleman, Daerah Istimewa Yogyakarta Hendra, Phebe; Virginia, Dita Maria; Fenty, Fenty; Widayati, Aris
Indonesian Journal of Clinical Pharmacy Vol 6, No 2 (2017)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (612.501 KB) | DOI: 10.15416/ijcp.2017.6.2.107

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Prevalensi abnormalitas profil lipid cukup besar pada masyarakat pedesaan. Pengukuran profil lipid (kolesterol total (KT), low density lipoprotein (LDL), high density lipoprotein (HDL), dan trigliserida (TG)) di laboratorium membutuhkan implementasi teknologi kesehatan sedangkan di daerah pedesaan kurang tenaga medis dan permasalahan ekonomi. Pengukuran antropometri yang mudah, tidak invasif, ekonomis, dan dapat dilakukan oleh tiap individu diharapkan dapat memprediksi abnormalitas profil lipid bagi masyarakat pedesaan. Penelitian ini bertujuan untuk mengobservasi korelasi pengukuran antropometri dengan abnormalitas profil lipid di daerah pedesaan. Penelitian ini merupakan penelitian observasional dengan desain potong lintang. Pengukuran antropometri meliputi Body Mass Index (BMI), lingkar pinggang (LP), dan rasio lingkar pinggang panggul (RLPP). Kriteria inklusi adalah penduduk Kecamatan Cangkringan, Sleman, DI Yogyakarta berumur 40–60 tahun, tidak ada riwayat penyakit kardiometabolik, tidak edema, dan konsumsi obat-obatan terkait kardiometabolik. Lokasi penelitian dipilih menggunakan klaster random sampling. Sampel penelitian dipilih secara purposive sampling dan diperoleh besar sampel 100 responden. Analisis data menggunakan Kolmogorov-Smirnov, Mann-Whitney, dan Spearman. Hasil penelitian ini menunjukkan korelasi antara BMI (r= –0,286; p=0,044), LP (r= –0,410; p=0,003), dan RLPP (r= –0,365; p=0,009) terhadap HDL pada kelompok wanita. Terdapat juga korelasi antara BMI (r=0,325; p=0,021), LP (r=0,394; p=0,005), dan RLPP (r=0,368; p=0,009) terhadap trigliserida pada kelompok wanita. Terdapat korelasi antara BMI terhadap KT (r=0,285;p=0,045), LDL (r=0,344;p=0,014), dan TG (r=0,446; p=0,001). Parameter LP pria memiliki korelasi terhadap HDL (r= –0,355; p=0,011) dan TG (r=0,488; p=0,000). Parameter RLPP pria memiliki korelasi terhadap seluruh profil lipid; terhadap KT (r=0,287; p=0,043), LDL (r=0,338; p=0,016), HDL (r=0,316; p=0,025), dan TG (r=0,359; p=0,011). Kesimpulan, pada kelompok wanita pengukuran anthropometri memiliki korelasi terhadap HDL dan TG, sedangkan parameter RLPP lebih sensitif pada kelompok pria.