p-Index From 2015 - 2020
12.508
P-Index
This Author published in this journals
All Journal Journal Riset Bisnis Indonesia PROSIDING SEMINAR NASIONAL Jurnal Pendidikan Matematika Jurnal Radioisotop dan Radiofarmaka Jurnal Sains Materi Indonesia JURNAL PSIKOLOGI UDAYANA Jurnal Kreatif Tadulako Online SPEKTRUM INDUSTRI Business Accounting Review Kesmas: Jurnal Kesehatan Masyarakat Nasional Jurnal Pendidikan MIPA Jurnal Pendidikan Matematika Universitas Lampung The Journal of Pure and Applied Chemistry Research Jurnal Administrasi Negara Forum Geografi Pharmascience MUDARRISA Indonesian Journal of Islamic Education Studies Dental Journal (Majalah Kedokteran Gigi) Al-Jabar : Jurnal Pendidikan Matematika Jurnal Kedokteran Gigi Universitas Padjadjaran Paediatrica Indonesiana Psikologia : Jurnal Psikologi Tekinfo | Scientific Journal of Industrial and Information Engineering Jurnal Psikologi TALENTA Register Journal Jurnal Pena Ilmiah SYUKUR (Jurnal Inovasi Sosial dan Pengabdian Masyarakat) Jurnal Sains Farmasi & Klinis JKPD : Jurnal Kajian Pendidikan Dasar JURNAL AKUNIDA Citra Delima : Jurnal Ilmiah STIKES Citra Delima Bangka Belitung JURNAL KESEHATAN PERINTIS (Perintis´s Health Journal) Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Journal of Pragmatics Research Humaniora JURNAL ILMU KEFARMASIAN INDONESIA MUWAZAH: Jurnal Kajian Gender Jurnal Pembelajaran Biologi: Kajian Biologi dan Pembelajarannya Jurnal Riset Akuntansi Aksioma Limacon: Journal of Mathematics Education Review of Primary Care Practice and Education (Kajian Praktik dan Pendidikan Layanan Primer) DENTA Jurnal Kedokteran Gigi Integrated Lab Journal
Articles

Found 1 Documents
Search
Journal : The Journal of Pure and Applied Chemistry Research

Effect of Radioactivity of Technetium-99m on the Autosterilization Process of non-sterile Tetrofosmin Kits Widyastuti, Widyastuti; Lestari, Enny; Sangaji, Darma
The Journal of Pure and Applied Chemistry Research Vol 6, No 1 (2017): Edition of January - April 2017
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (626.482 KB) | DOI: 10.21776/ub.jpacr.2017.006.01.286

Abstract

Technetium-99m labeled radiopharmaceutical is commonly used in nuclear medicines as a diagnostic agent, by mixing the sterile kit with Tc-99m. Manufacturing of kits requires an aseptic facility which need to be well designed and maintained according to cGMP, since mostly kits can not be terminally sterilized. Radiopharmaceuticals as pharmaceuticals  containing radionuclide is assumed to have an autosterilization property, but correlation between radioactivity and capability of killing microorganisms has to be studied so far.  The aim of this study is to investigate the effect of radioactivity on the autosterilization process of radiopharmaceuticals.  The study was carried out by adding Tc-99m of various radioactivity into non-sterile tetrofosmin kits, then the samples were tested for sterility. Sterile tetrofosmin kit and non-sterile kit with no Tc-99m added will be used as a negative control and positive control respectively. The sterility was tested using standard direct inoculation method, by inoculating samples in culture media for both bacteria and fungi and observing qualitatively within 14 days. The results showed that the samples with radioactivity of 1, 3 and 5 mCi changed the clarity of the media to turbid,  conformed with the performance of positive controls but samples with radioactivity of 10 mCi and 20 mCi did not change the clarity of the media, conformed with the performance of negative control, indicating neither growth of bacteria nor fungi.  It is concluded that Tc-99m behaves as an autosterilizing agent at certain radioactivity. Therefore the preparation of Tc-99m radiopharmaceutical can be considered as terminal sterilization rather than aseptic preparation.
Co-Authors Adang Hardi Gunawan Affandi, Iqbal Arif Afif, Muhammad Nur Afif, Muhammad Nur Agung Cahyono Agung Putra Wijaya, Agung Putra AGUS FRIANTO Agus Sugiarto Agustina, Safitri Andini, Yuri Tri Anwar, Hilwa Aprilia Aprilia, Aprilia Aprilina, Ulfah Ari Subowo Arnelis Djalil Asandimitra, Nadia Asri, Peggy Nurida Bambang Sri Anggoro Bidari, Masgusti Dinda Caswita Caswita Cecep Taufik Rustendi Charyadie, Arlita Gladys Tricia Damaiyanti, Dian Widya Dewi, Brigita Ayu Kirana Dharma Himawan, Muhammad Agung Dian Mulawarmanti, Dian Diba, Shofura Farah Dwi Kurniawati, Dwi Dwi Laila Sulistiowati, Dwi Laila Elin Erlina Sasanti Eni Indriani Eni Kartika, Eni Enny Lestari Erimson Siregar Eva Meizara Puspita Dewi, Eva Meizara Fantari, Hanifah Rifnola Febby Eka Putri Fitri Rahmawati Fitri, Rizkana Fitriyani ZS, Syawalia Florensia Evindonta Bangun, Florensia Evindonta Fu'aidah, Wisda Isma Gunawan, A. H. Guslihan Dasa Tjipta, Guslihan Dasa Hamzah Afandi Hanafiah A. Haninda Bharata Hasaruddin Hafid, Hasaruddin Husen, Mariyani Indah Damayanti, Indah Iswanti, Nina Iwan Nurwantoro, Iwan Jayadinata, Asep Kurnia Jermsittiparsert, Kittisak Juhamzah, Sulfiani Karim, Nina Karina Katibi, Ahmad Yakub Kesumawati, Amelia Khairi, Husain Komarudin Komarudin Kusuma, Ariya Eka Laksmi A. Lenap, Indria Puspitasari Lucia Maria Santoso, Lucia Maria M Coesamin M. Coesamin Mahfudho, Zahidatun Marlita, Deta Maskuroch Adesty Mella Triana MONIKA TIARAWATI Mora Claramita, Mora Muhammad Ferdiansyah, Muhammad Muhammad Yusuf Mulia, Septi Dianna Bunga Mursini, Septian Dwi Mustika, Lia Nanda, Evi Tirto Nasrun Nasrun Ningrum, Nia Widya Ningsih, Santi Mulya Novianti, Elvita Lia Nur?ainingsih, Dyah Nurfadhilah, Nurfadhilah Nurhanurawati Nurhanurawati Nurlaili Nurlaili Nurul Rohmah Nurvita Nurvita Octavia, Nur Pentatito Gunowibowo Pertiwi, Intania Pratiwi, Ganjar Febriyani Pratiwi, Rafi Puji Rahayu Purnama Dewi Putri, Vevia Risa Qorri Ayuni R, Dyah Lestarining Rahmy, Aghnesia Ramadhana Komala, Ramadhana Rani, wayan Widya Regina Lichteria Panjaitan, Regina Lichteria Retna Siwi Padmawati, Retna Siwi Retno Cahyani, Retno ria septiana Ridfah, Ahmad Ridfah, Ahmad Ridfah, Ahmad Rini Asnawati Rini Rita T Marpaung Risdianti, Ernia Riyanto Riyanto Rizky, Alifia Ainun Robith Hudaya Rosa, Wanda Restia Rosalia Deviana Cahyaningrum Rusdi Setiono Sab'ati, Mila Sabati, Mila Sangaji, Darma Sapitri, Nonik Mega Saptaswari, Dianty Saputri, Suci Indah Sarlina Sarlina, Sarlina Setiyowati, Yunda Silvana, Silvana Siti Laelatul Chasanah, Siti Laelatul Slamet Suprayogi Soraya, Rahayu Sri Hastuti Noer Sri Hastuti Noer Sri Setiyowati Sri Setyowati Sri Wahyuningsih Sriyono Sriyono Sugandi, Awan Sugeng Sutiarso Sukma, Nova Permata Sukmawati, Fitriani Supriatmo Supriatmo, Supriatmo Syakir Mahid Tina Yunarti Titi Murniati Utami, Fithrina Yudha Utari Rezki Veronika Yulianti Wayan Rumite Wijayanti, Chusna Yessy Artanti Yuliana Yuliana Yulisa Yulisa Yuniarti, Tina Yunilda Yunilda YUSLI MARIADI Zuma Herdiyanti