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HOMOLOGY MODELING EPITOP ISOCITRATE DEHYDROGENASE TIPE 1 (R132H) MENGGUNAKAN MODELLER, I-TASSER DAN (PS)2 UNTUK VAKSIN GLIOMA Yeni, Yeni; Tjahjono, Daryono Hadi
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 4 No. 1 (2017)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1031.61 KB) | DOI: 10.22236/farmasains.v4i1.189

Abstract

Glioma is a type of primary malignant brain tumor. The presence of gliomas can be characterized by a mutation R132H of isocitrate dehydrogenase type 1 (IDH1). IDH1 (R132H) contains specific immunogenic epitopes to the tumor. It is appropriate to be used as a gliomas vaccine. Therefore, it was necessary to do homology modeling for IDH1 (R132H) epitopes. TMHMM, MEMSAT-SVM and MEMSAT3 were used to predict transmembrane topology of IDH1 (R132H). Analysis of IDH1 (R132H) epitopes was performed using NetMHCII and IEDB®. The antigenicity of epitopes were predicted using VaxiJen to obtained 91 epitopes. Homology modeling using Modeller, I-TASSER  and (PS)2 was established for the epitopes that have probability as tumor antigen. The results of homology modeling of IDH1 (R132H) epitopes were validated by MolProbity, ProSA-web dan QMEAN. A 3D stucture model of the epitopes was selected from three models from the homology modeling based on the validation results. Refinement was established on the epitopes using GalaxyRefine and GROMACS for energy minimization.
PENERAPAN METODE KOOPERATIF DALAM PEMBELAJARAN NOTASI BALOK PADA KELAS VII-I DI MTSN TARUSAN Yeni, Yeni; Kadir, Tulus Handra; Indrayuda, Indrayuda
SENDRATASIK UNP Vol 1, No 3 (2013): Seri A
Publisher : FBS Universitas Negeri Padang

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Abstract

Abstract This article aims to explain and reveal how to raise students' motivation in learning notation in MTsN Tarusan. During this time the teacher is plagued with low student motivation, thereby disrupting the smooth teaching and learning. The research was conducted by qualitative research with descriptive methods. Data obtained by interviews, direct observation, library research, and documentation. The research instrument is the researcher himself as a key instrument. Data were analyzed with phenomenological techniques. Results of previous studies suggest that students lack motivation in learning notation, it is caused by lack of proper teaching methods by teachers in the art of music MTsN. After the change in the method by teachers in teaching the art of music notation, reveal positive results in improving student learning motovasi notation. Means cooperative method is able to change the level of student motivation towards learning in MTsN Tarusan notation. Through cooperative pembelajran methods students have the motivation to read notation, because the element of cooperation pembnelajaran important role in practice, so that students are able to help a fellow co weaknesses of the students themselves. Keywords: learning notation, and methods of cooperative learning
PARITAS DAN PERAN SERTA SUAMI DALAM PENGAMBILAN KEPUTUSAN TERHADAP PENGGUNAAN METODE KONTRASEPSI Yeni, Yeni; Mutahar, Rini; Etrawati, Fenny; Utama, Feranita
Media Kesehatan Masyarakat Indonesia Vol 13, No 4: DESEMBER 2017
Publisher : Faculty Of Public Health, Hasanuddin University, Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (242.411 KB) | DOI: 10.30597/mkmi.v13i4.3158

Abstract

Data Riskesdas tahun 2013 menunjukkan prevalensi penggunaan KB yang meningkat dari 55,8% pada tahun 2010 menjadi 59,7% pada tahun 2013. Penelitian sebelumnya menunjukkan bahwa hanya 8,4% pria menggunakan kontrasepsi atau terlibat secara langsung dalam penggunaan pelayanan keluarga berencana terutama kondom pria. Tujuan dari penelitian ini adalah mengetahui pengaruh paritas dan peran serta suami dalam pengambilan keputusan terhadap penggunaan metode kontrasepsi. Desain penelitian yang digunakan adalah desain cross sectional. Sampel penelitian ini adalah wanita menikah usia 15-45 tahun sebanyak 216 orang. Kriteria inklusi sampel adalah wanita dengan status menikah. Hasil penelitian menunjukkan sebanyak 79,2% responden menggunakan kontrasepsi, 91,7% responden memiliki suami yang mendukung kontrasepsi dan 72,7% responden memiliki jumlah anak 2 sampai 4 orang. Ada pengaruh yang signifikan antara peran serta suami (PR:4,570;95%CI:1,647-12,682) dan paritas (multipara (PR:0,218;95%CI:0,060-0,790), primipara (PR:0,518;95%CI:0,132-2,028)) terhadap penggunaan kontrasepsi. Hasil penelitian ini menunjukkan bahwa peran serta suami merupakan faktor risiko perilaku penggunaan metode kontrasepsi sedangkan paritas merupakan faktor protektif dari perilaku penggunaan metode kontrasepsi. Penelitian ini menunjukkan pentingnya mendorong para ibu rumah tangga untuk mengajak pasangan ikut serta dalam setiap pengambilan keputusan mengenai penggunaan metode kontrasepsi dengan meningkatkan cakupan partisipasi suami secara langsung dalam menggunakan metode kontrasepsi.
Studi Intervensi Klaster Kawasan Tanpa Rokok pada Tingkat Rumah Tangga Najmah, Najmah; Etrawati, Fenny; Yeni, Yeni; Utama, Feranita
Jurnal Kesehatan Masyarakat Nasional Vol. 9 No. 4 Mei 2015
Publisher : Faculty of Public Health Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (153.227 KB) | DOI: 10.21109/kesmas.v9i4.752

Abstract

AbstrakPerilaku merokok memberikan dampak negatif, baik bagi perokok aktifmaupun pasif, ditinjau dari sudut pandang kesehatan maupun ekonomi.Regulasi mengenai Kawasan Tanpa Rokok (KTR) yang telah diterbitkanbelum ada yang mengatur mengenai penerapan KTR di tingkat rumah tangga. Penelitian ini bertujuan untuk mengidentifikasi perubahan perilaku melalui intervensi terpadu KTR pada tingkat rumah tangga. Penelitian dilakukan pada bulan Juli - September 2014 menggunakan desain cluster trial pada empat desa di Kabupaten Ogan Ilir, Sumatera Selatan. Selanjutnya, 200 sampel kepala keluarga dipilih melalui metode cluster random sampling. Intervensi yang dilakukan meliputi konseling terpadu, pemberian permen pengganti rokok, dan tabungan sehat. Hasil penelitian menunjukkan bahwa proporsi responden yang merokok setiap hari dalam sebulan terakhir dan komitmen untuk tidak akan merokok di masa yang akan datang mencapai 71,6% dan 62% pada kelompok intervensi serta 91% dan 38% pada kelompok non-intervensi. Intervensi ini berpeluang 46% mengurangi perilaku merokok responden (RP = 0,46) setelah dikontrol oleh variabel pendidikan (RP = 0,152) dan sikap (RP = 0,216) dengan nilai p < 0,0001. Intervensi terpadu ini terbukti berhasil mengubah perilaku merokok pada kawasan rumah tangga sehingga diperlukan partisipasi masyarakat dan dinas kesehatan setempat untuk menindaklanjuti penerapan intervensi ini dalam jangka panjang.AbstractSmoking behavior has negative impacts, both for active and passive smokers, as reviewed from health and economic perspectives. Regulation concerning non-smoking area issued has not yet arranged implementation of non-smoking area at household level. This study aimed to identify any behavior change through integrated intervention of non-smoking area athousehold level. This study was conducted on July - September 2014 usingcluster trial design in four villages at Ogan Ilir District, South Sumatra.Then 200 household head samples were selected through cluster randomsampling method. The intervention included integrated counseling, distribution of candy as substitute for cigarette, and healthy saving. Results of study showed that proportion of respondents who smoked every day in a recent month and had a commitment not to smoke in the future reached 71.6% and 62% in the intervention group, then 91% and 38% in the non-intervention group respectively. This intervension had opportunity worth 46% reducing the smoking behavior of the respondents (RP= 0.46) after controlled by the variable of education (RP = 0.152) and attitude (RP = 0.216) with p value < 0.0001. This integrated intervention was profoundly successful changing smoking behavior at household level. So that, public participation and health agency need to follow up the implementation of this intervention in a long term.
OPTIMALISASI PELAYANAN (SERVICE) PUSKESMAS DALAM PENINGKATAN KUALITAS PELAYANAN KESEHATAN MASYARAKAT DI KABUPATEN KUBU RAYA PROVINSI KALIMANTAN BARAT Yulian, Ryani; Yeni, Yeni
JURNAL MANAJEMEN MOTIVASI Vol 13, No 2 (2017): Jurnal Manajemen Motivasi (Oktober)
Publisher : Universitas Muhammadiyah Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (386.582 KB) | DOI: 10.29406/jmm.v13i2.760

Abstract

ABSTRAKPenelitian ini merupakan kajian optimalisasi pelayanan puskesmas dalam peningkatan layanan meliputi: pengukuran kebutuhan, keinginan, harapan  dan persepsi masyarakat selaku pengguna jasa. Metode yang digunakan dalam penelitian ini yaitu metode deskriptif analisis kualitas dengan pendekatan IKM dan model SERVQUAL (Service Quality), analisis kualitatif menggunakan Diagram Kartesius serta terakhir  analisis optimalisasi dengan pendekatan medan kekuatan (Force Field Analysis). Hasil analisis menunjukkan bahwa nilai indeks sebesar 2,65 yang dikonversikan dengan nilai dasar adalah 65,10 secara keseluruhan  kinerja unit pelayanan Puskesmas adalah baik.  Dari atribut pelayanan, ada 10 atribut pelayanan termasuk kategori Baik (B), dan 3 unsur pelayanan yang termasuk kategori Kurang Baik (C). Dari 3 unsur pelayanan yang termasuk ketegori Kurang Baik (C), indeks terendah adalah atribut kecepatan pelayanan (P7). Optimalisasi pelayanan dituangkan dalam matrik dengan skala prioritas melengkapi fasilitas dan ketersediaan obat-obatan yang penting, rasio tenaga  kesehatan, pengembangan sistem pelayanan, dan supporting budget serta melibatkan unsur atau  instansi yang terkait.Kata Kunci: indeks kepuasan masyarakat, pelayanan, puskesmas, kebutuhan, keinginan, harapan, persepsi ABSTRACTThis study reviews the optimization of Community Health Care services in improving public health service that includes the measurement of needs, wants, hopes, and perception of service users. The method of research uses three stages nameky; descriptive method of quality analysis and SERVQUAL model, Cartesian Diagram, and optimization analysis with Force Field Analysis. The findings suggested that score of indexes of community satisfaction of the overall performance of Community Health Care is good with mean score 65,10. Out of the attributes of services, there were 10 attributes of services classified as good, and 3 attributes of services classified as poor. The lowest index of the attributes of services was speed of service The optimization of services is imprinted into matrix with priority scale to complete the facility, the availability of essential medicine, and the ratio of health workers, the development of service system, supporting budget and participation from relevant agencies.Keywords: indexes of community satisfaction, service, community health care, needs, wants, hopes, expectations
Kematangan Emosi Dan Tingkat Kecemasan Persalinan Pertama Usia 17-21 Tahun Di Kecamatan Candi Sidoarjo Maryam, Effy Wardati; Yeni, Yeni
Psikologia : Jurnal Psikologi Vol 1, No 1 (2011): Psikologia (Jurnal Psikologi)
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1040.247 KB) | DOI: 10.21070/psikologia.v1i1.743

Abstract

The background of this research by the researcher’s curiosity about the level of emotional maturity and anxiety experienced by mothers who gave birth for the first time at age 17-21 years. The purpose of this study is to determine whether there is a significant correlation between the level of emotional maturity level of anxiety at first birth mothers 17-21 years of age and indicators of what the most dominant influence of emotional maturity and high levels of anxiety. Based on the analysis of obtained results of product moment correlation coefficient rxy ‘correlation with p = -0.167(0.257) > 0.05. this means that relations between the two variables are not significant. Supported also by results of interviews with the related subject of research and data in the field, says that not only emotional maturity factors that influence the level of anxiety a person in the first childbirth, but also the factor of family support, especially husbands and mothers, information about pregnancy and labor that they could get from print and electronic media and the internet which can be accessed with ease, some from their participation in the exercise group became pregnant, briefing the local health clinic doctor or midwife about childbirth and the high level of religiosity. All this is another factor which also makes the low level of anxiety to face the first delivery in mothers 17-21 years of age. 
Studi Intervensi Klaster Kawasan Tanpa Rokok pada Tingkat Rumah Tangga Najmah, Najmah; Etrawati, Fenny; Yeni, Yeni; Utama, Feranita
Jurnal Kesehatan Masyarakat Nasional Vol. 9 No. 4 Mei 2015
Publisher : Faculty of Public Health Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (153.227 KB) | DOI: 10.21109/kesmas.v9i4.752

Abstract

AbstrakPerilaku merokok memberikan dampak negatif, baik bagi perokok aktif maupun pasif, ditinjau dari sudut pandang kesehatan maupun ekonomi. Regulasi mengenai Kawasan Tanpa Rokok (KTR) yang telah diterbitkan belum ada yang mengatur mengenai penerapan KTR di tingkat rumah tangga. Penelitian ini bertujuan untuk mengidentifikasi perubahan perilaku melalui intervensi terpadu KTR pada tingkat rumah tangga. Penelitian dilakukan pada bulan Juli - September 2014 menggunakan desain cluster trial pada empat desa di Kabupaten Ogan Ilir, Sumatera Selatan. Selanjutnya, 200 sampel kepala keluarga dipilih melalui metode cluster random sampling. Intervensi yang dilakukan meliputi konseling terpadu, pemberian permen pengganti rokok, dan tabungan sehat. Hasil penelitian menunjukkan bahwa proporsi responden yang merokok setiap hari dalam sebulan terakhir dan komitmen untuk tidak akan merokok di masa yang akan datang mencapai 71,6% dan 62% pada kelompok intervensi serta 91% dan 38% pada kelompok non-intervensi. Intervensi ini berpeluang 46% mengurangi perilaku merokok responden (RP = 0,46) setelah dikontrol oleh variabel pendidikan (RP = 0,152) dan sikap (RP = 0,216) dengan nilai p < 0,0001. Intervensi terpadu ini terbukti berhasil mengubah perilaku merokok pada kawasan rumah tangga sehingga diperlukan partisipasi masyarakat dan dinas kesehatan setempat untuk menindaklanjuti penerapan intervensi ini dalam jangka panjang.AbstractSmoking behavior has negative impacts, both for active and passive smokers, as reviewed from health and economic perspectives. Regulation concerning non-smoking area issued has not yet arranged implementation of non-smoking area at household level. This study aimed to identify any behavior change through integrated intervention of non-smoking area at household level. This study was conducted on July - September 2014 using cluster trial design in four villages at Ogan Ilir District, South Sumatra. Then 200 household head samples were selected through cluster random sampling method. The intervention included integrated counseling, distribution of candy as substitute for cigarette, and healthy saving. Results of study showed that proportion of respondents who smoked every day in a recent month and had a commitment not to smoke in the future reached 71.6% and 62% in the intervention group, then 91% and 38% in the non-intervention group respectively. This intervension had opportunity worth 46% reducing the smoking behavior of the respondents (RP= 0.46) after controlled by the variable of education (RP = 0.152) and attitude (RP = 0.216) with p value < 0.0001. This integrated intervention was profoundly successful changing smoking behavior at household level. So that, public participation and health agency need to follow up the implementation of this intervention in a long term.
KNOWLEDGE AND HISTORY OF NON COMMUNICABLE DISEASES AMONG HOUSEWIVES IN THE YEAR 2013 OGAN ILIR-SOUTH SUMATERA-INDONESIA Najmah, Najmah; Mutahar, Rini; Yeni, Yeni
Jurnal Ilmu Kesehatan Masyarakat Vol 6, No 1 (2015): Jurnal Ilmu Kesehatan Masyarakat
Publisher : Faculty of Public Health Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (213.926 KB)

Abstract

Background: Indonesia as a developing country experiencing epidemiologic transition in which communicable diseases are still main concern in Indonesia, while non-communicable diseases (degenerative) is starting to increase and to be major cause of death. Degenerative diseases are caused by many risk factors including lifestyle, eating habits, smoking, physical inactivity, genetics and other causes. Basic Health Research in 2007 showed the prevalence of the disease in Indonesia among other degenerative joint disease (30.3%), hypertension (29.8%), stroke (0.8%), heart (7.2%), diabetes mellitus (1,1%), and cancer (0.4%).Methods: This research is a descriptive study with a quantitative approach. The study design used was a cross sectional study. The samples in this study were 99 housewives in Ogan Ilir. Sampling technique in this study is a cluster random sampling to select four villages as clusters. The analyses conducted in this study are univariate analysis and correlation tests.Results: The results of this study were 29 (29.3%) of respondents had received counseling on non-communicable diseases, 40.4% of respondents considered overweight (obesity) can reduce the risk of non-communicable diseases, 79.8% knew that reducing caffeine consumption may decrease the risk of non-communicable diseases, and 77% know that reducing smoking can reduce the risk of non-communicable diseases. The disease is the most common rheumatic respondents (20.2%), traffic accidents (19.2), and hypertension (17.2%). Non-communicable diseases most suffered by the elderly respondents were hypertension (42.4%), arthritis (38.4%), and heart (19.2%). Correlation test results demonstrate a positive correlation between the respondent and the history of disease in the elderly (r = 0.172).Conclusion: Health promotion in order to improve the knowledge of the risk factors of non-communicable diseases in the housewife needs to be done both through education and the mass media. This encourages housewives to avoid the risk factors of non-communicable diseases which mainly caused by unhealthy eating patterns.Keywords: Non communicable diseases, knowledge, disease history, risk factors, prevention, housewives.
PREDICTIVE MODELS OF NEONATAL MORTALITY INCIDENCE IN SUB PURBOLINGGO EAST LAMPUNG REGENCY OF LAMPUNG PROVINCE Oktarina, Silvia; Fajar, Nur Alam; Yeni, Yeni
Jurnal Ilmu Kesehatan Masyarakat Vol 8, No 1 (2017): Jurnal Ilmu Kesehatan Masyarakat
Publisher : Faculty of Public Health Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (468.289 KB)

Abstract

Background: The infant mortality rate is one of indicators in determining children’s health status. Neonatal mortality rate in Indonesia on 2012 is 19 per 1000 live births. Meanwhile, neonatal mortality rate at Lampung Province is 20 per 1000 birth. The aim of this research is to predict the most influential variable to the case of neonatal mortality. Methods:This study is quantitatif research by case-control approach with 45 cases and 45 controls. The sample of this research is mothers who gave birth to a live infant. The data obtained were processed by using computer’s application for statistic and it is done by univariat, bivariat, and multivariat analysis. Result:Based on the results of this research, it can be known that there is correlation between birthweight to neonatal mortality (OR = 29,421), mother’s age to neonatal mortality (OR = 2,957), parity to neonatal mortality (OR = 6,143), ANC frequency (OR = 7,818), childbirth complications to neonatal mortality (OR = 9,250). Birthweight is the most influential variable to neonatal mortality (OR = 17,969; 95% CI = 3,507-92,053; p = 0,001) after being controlled by variable child birth complications, birth order, parity and ANC frequency. Conclusion:This research expected health workers to be more focus on monitoring maternal health passively and actively, conducting supplementary feeding for pregnant women, and socialization to pregnant women about the importance of family planning through counseling, role play, booklets, leaflets.Keywords: neonatal mortality, low birth weight, childbirth complication DOI: https://doi.org/10.26553/jikm.2017.8.1.49-55  
THE EFFECT OF ANTENATAL VISITS TO THE OCCURANCE OF MATERNAL NEAR MISS IN INDONESIA (ADVANCED ANALYSIS IDHS 2012) Susanti, Deni; Sitorus, Rico Januar; Yeni, Yeni
Jurnal Ilmu Kesehatan Masyarakat Vol 6, No 3 (2015): Jurnal Ilmu Kesehatan Masyarakat
Publisher : Faculty of Public Health Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (547.548 KB)

Abstract

Background: Health services especially for pregnant women in Indonesia is manifested in the form of antenatal care done at least four times during pregnancy. This study aims to determine the effect of antenatal visits is one protective factor for the occurrence of maternal near miss or close to death in Indonesia. Method: This study used cross sectional design study and used secondary data from the Demographic and Health Survey 2012. The study population in this study were women 15 to 49 years who were interviewed is 45.607 people. The sample was women aged 15-49 years who had pregnancy / childbirth in the time between 2008-2012 in Indonesia and answered questions about the complications of pregnancy and childbirth. Data analysis was performed using univariate, bivariate and multivariate risk factor model. Result: The prevalence of maternal near miss in Indonesia is 2,9% or 29 per 1000 live births. The results of the bivariate analysis showed that no significant relationship between antenatal visits (RP: 0.591 95% CI: 0.411 to 0,851) and the type of delivery (RP:2,010; 95% CI: 1,381 to 2.926) with the incidence maternal near miss. Multivariate results indicate there is an influence antenatal visits on maternal near miss after controled by the type of birth (RP: 0,612; 95% CI: 0,423 to 2.847). Conclusion: Antenatal visit has the effect for events MNM after controlling for the type of birth. For the improvement of the quality of antenatal care is very good for preventing any cases of maternal near miss. Keywords: Antenatal visits, maternal near miss