Nasrul Zubir
Bagian Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Andalas, Jl. Perintis Kemerdekaan, PO Box 49, Padang Sumatera Barat

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Helicobacter pylori in dyspeptic patients in M. Jamil Hospital-Padang Zubir, Nasrul; Elfina, Dona; Samban, Julius R.
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 1, NUMBER 1, December 2000
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

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Abstract

Objective: Helicobacter pylori infection is probably the most common infection caused by pathogenic bacteria and affects more than half of the world population. These bacteria caused many gastroduodenal pathology such as chronic active gastritis, peptic ulcer and gastric malignancy. This study investigated Helicobacter pylori infections in dyspeptic patients. Materials & Methods: Forty dyspeptic patients were examined using upper gastrointestinal endoscopy and biopsy for histopathologic examination. Results: The symptom of the dyspeptic patients were epigastric tenderness (100%). Endoscopic abnormalities were found in 39 (97.5%) cases. The gastric abnormalities were chronic antral gastritis in 24 (60%), esophagitis and gastritis in 7 (17.5%), and gastric ulcer in 3 (7.5%). Twenty four out of 40 patients had anti-Helicobacter pylori positive (60%) and histopathologic examination were positive 18 (45%). The histopathologic examination found atrophy in 18 (45%), MN in 18 (45%), PMN in 18 (45%), and metaplastic in 4 (10%). Conclusion : The prevalence of Helicobacter pylori in dyspeptic patients were 60% (serology) and 45% (histopathology).  Keywords: Helicobacter pylori, dyspeptic, serology, histopathology
Helicobacter pylori in dyspeptic patients in M. Jamil Hospital-Padang Zubir, Nasrul; Elfina, Dona; Samban, Julius R.
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 1, NUMBER 1, December 2000
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (0.036 KB) | DOI: 10.24871/1120005-8

Abstract

Objective: Helicobacter pylori infection is probably the most common infection caused by pathogenic bacteria and affects more than half of the world population. These bacteria caused many gastroduodenal pathology such as chronic active gastritis, peptic ulcer and gastric malignancy. This study investigated Helicobacter pylori infections in dyspeptic patients. Materials & Methods: Forty dyspeptic patients were examined using upper gastrointestinal endoscopy and biopsy for histopathologic examination. Results: The symptom of the dyspeptic patients were epigastric tenderness (100%). Endoscopic abnormalities were found in 39 (97.5%) cases. The gastric abnormalities were chronic antral gastritis in 24 (60%), esophagitis and gastritis in 7 (17.5%), and gastric ulcer in 3 (7.5%). Twenty four out of 40 patients had anti-Helicobacter pylori positive (60%) and histopathologic examination were positive 18 (45%). The histopathologic examination found atrophy in 18 (45%), MN in 18 (45%), PMN in 18 (45%), and metaplastic in 4 (10%). Conclusion : The prevalence of Helicobacter pylori in dyspeptic patients were 60% (serology) and 45% (histopathology).  Keywords: Helicobacter pylori, dyspeptic, serology, histopathology
Asupan Lemak dan Ekspresi Gen eNOS3 Alel Glu298Asp pada Penderita Hipertensi Etnik Minangkabau Sulastri, Delmi; NI, Lipoeto; Zubir, Nasrul; Jamsari, Jamsari
MEDIA MEDIKA INDONESIANA 2011:MMI Volume 45 Issue 1 Year 2011
Publisher : MEDIA MEDIKA INDONESIANA

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ABSTRACTIntake of fat and Gen eNOS3 Alel Glu298Asp expression in hypertensive Minangkabau personsBackground: eNOS 3 gene is one of the important genes which is related to the high prevalence of hypertension essensial. This gene expresses the nitric oxide synthase (NOS) enzyme which regulates the synthesis of nitric oxide (NO) in human body.Methods: A research has been done on hypertensive and normotensive patients aged 30-65 years old. The main purpose of this research was to evaluate the association of fat intake on eNOS3 gene Glu298Asp allel expression in hypertension subjects in Minangkabau ethnicity. One hundred thirty subjects had been interview about their eating habits, and measured their omega-3, eNOS3 gene and NO plasma level. The data were analysed with t-tes and chi-square.Results: The hypertensive’s plasma NO concentration was 26.91±15.40 μM/L and normotensive’s was 25.79±15.04 μM/L. 52.5% of the hypertensive subjects and 47.5% of the normotensive has eNOS3 gene heterozygotes GT allele. Mean rates for total fat, SFA, MUFA and PUFA consumption of hypertensive subjects are 28.05±6.57%, 12.31±4.21%, 4.21±1.79%, 3.77±1.97% and normotensive are 30.14±13.98%, 12.58±4.22%, 4.40±2.22%, 4.00±1.96%. Mean rate for plasma omega-3 concentration of hypertensive subjects is 14.45±0.10μg/dL and normotensive is 14.49±1.00 μg/dL. There is significant relationship between omega-3 with NO plasma level on hypertension with GT heterozygote alleles.Conclusion: In hypertensive patients with GT heterozygote alleles, only omega-3 plasma is associated with NO2 plasma.Keywords: Essensial hipertension, eNOS3 gene, NO plasma levelABSTRAKLatar belakang: Gen eNOS3 alel Glu298Asp merupakan salah satu gen yang berhubungan dengan kejadian hipertensi esensial. Kemampuan Gen eNOS3 alel ini untuk mensintesis enzim nitric oxide synthase (NOS) berkurang sehingga sintesis nitric oxide (NO) menurun.Metode: Penelitian pada subyek hipertensi dan normotensi berusia 30-65 tahun bertujuan untuk melihat hubungan asupan lemak dengan ekspresi gen eNOS3 alel Glu298Asp. Seratus tiga puluh subyek, diwawancara pola makannya lalu dilakukan pemeriksaan kadar omega-3 dan omega-6 plasma, gen eNOS3, serta kadar NO plasma. Data yang diperoleh dianalisis menggunakan uji T dan chi-square.Hasil: Kadar NO plasma subyek hipertensi adalah 26,91±15,40 μM/L dan normotensi 25,79±15,04 μM/L. 52,5% subyek hipertensi dan 47,5% normotensi mempunyai polimorfisme gen eNOS3 alel heterozigot GT. Rerata persentase asupan lemak total, ALJ, ALTJT, ALTJG pada subyek hipertensi adalah 28,05±6,57%, 12,31±4,21%, 4,21±1,79%, 3,77±1,97% dan pada subyek normotensi adalah 30,14±13,98%, 12,58±4,22%, 4,40±2,22%, 4,00±1,96%. Rerata kadar omega-3 plasma subyek hipertensi adalah 14,45±0,10 μg/dL dan normotensi 14,49±1,00 μg/dL. Terdapat hubungan kadar omega-3 dengan NO plasma pada penderita hipertensi dengan alel heterozigot GT.Simpulan: Pada penderita hipertensi dengan alel heterozigot GT, hanya omega-3 plasma yang berhubungan dengan kadar NO2 plasma.
Pengaruh Pemberian Kromium (III) Klorida Terhadap Kadar SGPT Darah Mencit Putih Dharma, Surya; BP, Zesfin; H, Irsan Ryanto; Zubir, Nasrul
Jurnal Sains dan Teknologi Farmasi Vol 15 No 1 (2010)
Publisher : Fakultas Farmasi Universitas Andalas

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The researh has been done on the influence of giving chromium (III) chloride on white mice blood SGPT.  The researh was divided into 5 groups, that is control,  doses ( 5,2; 6,37 and 7,8 ug/20 BW) with vitamin C and the dose of 7,8 ug/20 g BW without vitamin C. The observation was done for 42 days, that is day 7 th, 21 st and 42 nd with parameter SGPT concentration level. Results indicated that all doses showed the increase in SGPT concentration significantly (p<0,05).
PENGARUH PEMBERIAN KROMIUM (III) KLORIDA TERHADAP SPERMATOZOA MENCIT PUTIH Dharma, Surya; BP, Zesfin; Zubir, Nasrul; H, Irsan Ryanto.
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 5, No 2 (2010)
Publisher : Indonesian Research Gateway

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A study on the effect of chromium chloride on motility, viability and totality of spermatozoa the male with mice. The drugs was given  orally with doses 5,2 ; 6,37 and 7,8 µg/20 g BB with vitamin C and doses  7,8 µg/20 g BB without vitamin C. The treatment and giving of drugs were carried out  for 40 days and removal of spermatozoa was done at at the day 7, 21 and 42 were taken vas deferens and epididymis, until result the suspension of spermatozoa. The result indicated that the giving chromium (III) chloride with vitamin C give effect to decrease motility, viability and totality of spermatozoa the male wihite mice at p<0,05 ABSTRAK Telah dilakukan penelitian tentang pengaruh pemberian senyawa kromium (III) klorida terhadap motilitas, viabilitas dan jumlah spermatozoa mencit putih jantan. Hewan dibagi atas 5 kelompok  dengan 3 variasi dosis ( 5,2; 6,37 dan 7,8 µg/20 BB) dengan lama perlakuan selama 42 hari yang diamati pada hari ke 7, 21 dan 42.. Hasil menunjukan bahwa setelah pemberian senyawa kromium (III) klorida pada 3 variasi dosis terjadi penurunan motilitas, viabilitas dan jumlah spermatozoa mencit putih jantan secara bermakna
PENGARUH PEMBERIAN KROMIUM (III) KLORIDA TERHADAP SPERMATOZOA MENCIT PUTIH Dharma, Surya; BP, Zesfin; Zubir, Nasrul; H, Irsan Ryanto.
Jurnal Farmasi Indonesia Vol 5, No 2 (2010)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i2.43

Abstract

A study on the effect of chromium chloride on motility, viability and totality of spermatozoa the male with mice. The drugs was given  orally with doses 5,2 ; 6,37 and 7,8 µg/20 g BB with vitamin C and doses  7,8 µg/20 g BB without vitamin C. The treatment and giving of drugs were carried out  for 40 days and removal of spermatozoa was done at at the day 7, 21 and 42 were taken vas deferens and epididymis, until result the suspension of spermatozoa. The result indicated that the giving chromium (III) chloride with vitamin C give effect to decrease motility, viability and totality of spermatozoa the male wihite mice at p<0,05 ABSTRAK Telah dilakukan penelitian tentang pengaruh pemberian senyawa kromium (III) klorida terhadap motilitas, viabilitas dan jumlah spermatozoa mencit putih jantan. Hewan dibagi atas 5 kelompok  dengan 3 variasi dosis ( 5,2; 6,37 dan 7,8 µg/20 BB) dengan lama perlakuan selama 42 hari yang diamati pada hari ke 7, 21 dan 42.. Hasil menunjukan bahwa setelah pemberian senyawa kromium (III) klorida pada 3 variasi dosis terjadi penurunan motilitas, viabilitas dan jumlah spermatozoa mencit putih jantan secara bermakna