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Journal : Journal of Pharmaceutical and Medicinal Sciences

UJI AKTIVITAS EKSTRAK KULIT BATANG JAMBLANG (SYZYGIUM CUMINI) DENGAN VARIASI BEBERAPA PELARUT SEBAGAI ANTIHIPERGLIKEMIK PADA TIKUS PUTIH Indrisari, Maulita; Zulham, Zulham
Jurnal Farmasi dan Ilmu Pengobatan Vol 2 No 2 (2017): JPMS
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (141.686 KB)

Abstract

We reported the activity of jamblang (Syzygium cumini) bark extract as antihyperglycemic on rats. The goal of this study was to determine the effectiveness of S. cumini bark extract to decreasing glucose blood levels in hyperglycemic rats. Hyperglycemic rats induced by alloxan. Fifteen tails male rats were divided into 5 groups: negative control was given vehicle (Na.CMC), positive control (glibenclamide), group 23 to 5 were given ethanol 70% n-hexane, and ethyl acetate, respectively.  The result showed that ethanol extract can decrease glucose blood level significantly to all treatment groups.
FORMULASI EMULGEL EKSTRAK ETANOL DAUN MURBEI (MORUS ALBA L.) DENGAN VARIASI KONSENTRASI EMULGATOR SPAN 80® DAN TWEEN 80® Aisyah, Andi Nur; Zulham, Zulham; Yusuf, Nurul Arfiyanti
Jurnal Farmasi dan Ilmu Pengobatan Vol 2 No 2 (2017): JPMS
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (165.612 KB)

Abstract

Penelitian formulasi sediaan emulgel dari ekstrak etanol daun murbei (Morus alba L.) dengan variasi konsentrasi emulgator span tween 80® telah dilakukan. Penelitian ini bertujuan untuk menentukan konsentrasi emulgator (2%, 3%, 4% dan 5%) yang menghasilkan sediaan emulgel yang stabil secara fisika. Uji kestabilan dilakukan dalam dua kondisi yaitu kondisi sebelum dan setelah penyimpanan dipercepat selama 10 siklus dengan parameter pengujian meliputi organoleptik, homogenitas, daya sebar, daya lekat, pH dan viskositas. Hasil penelitian menunjukkan bahwa semua formula menunjukkan perubahan pada seluruh parameter uji akan tetapi hanya F3 yang perubahannya tidak signifikan setelah penyimpanan dipercepat.
UJI AKTIVITAS HIPOGLIKEMIK EKSTRAK ETANOL DAUN KERSEN (MUNTINGIA CALABURA L.) TERHADAP MENCIT (MUS MUSCULUS) YANG DIINDUKSI ALOKSAN Zulham, Zulham; Hendrarti, Wahyu; Wahyuni, Nurul
Jurnal Farmasi dan Ilmu Pengobatan Vol 3 No 2 (2018): JPMS
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32814/jpms.v3i2.70

Abstract

Diabetes mellitus (DM) is a chronic disorder that specifically involves the metabolism of carbohydrates (glucose) in the body, also causes disorders of fat and protein metabolism. The benefits of kersen (Muntingia calabura L.) which are well known, among others, overcome DM. This study was conducted to determine the hypoglycemic activity of ethanol extract of M. calabura leaves in reducing blood sugar levels and effective dose of reducing blood glucose in mice (Mus musculus) induced by alloxan 130 mg/kg BW. Distribution of experimental animals, group I was given a glibenclamide suspension 0.13 mg/kg BW as (positive control), groups II, III and IV were given ethanol extract of M. calabura leaves at a dose of 50, 100 and 150 mg/kg BW and the group V is given a 1% NaCMC suspension (negative control). Giving extracts carried out for 7 days. The results showed blood sugar levels before treatment, after induction, and after treatment, respectively, group I (81.00; 141.00; and 94.75 mg/dL), group II (79.00; 138.50; and 50.00 mg/dL), group III (102.50; 119.25; and 77.75 mg/dL), group IV (88.25; 146.00; and 61.00 mg/dL), and group V (108.00; 131.25; and 114.75 mg/dL). Based on the results of the study showed a decrease in blood sugar levels at all doses of ethanol extract of M. calabura leaves which has the potential as a diabetes drug.