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Uji Stabilitas Formula Sediaan Losio Dari Ekstrak Metanol Daun Mangkokan (Nothopanax scutellarium Merr) Suryani, Suryani; Hamsidi, Rini; Ikawati, Nurlena
PROSIDING SEMINAR NASIONAL AGRIBISNIS PROSIDING SEMINAR NASIONAL SWASEMBADA PANGAN (Indonesia Menuju Swasembada Pangan dalam Tiga Tahun K
Publisher : Jurusan Agribisnis Fakultas Pertanian Universitas Halu Oleo Kendari Sulawesi Tenggara

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Abstract

Daun mangkokan (Nothophanax scutellarium Merr.) memiliki kandungan senyawa yang berkhasiatsebagai antioksidan.Penelitian ini bertujuan untuk membuat formula losio dari ektrak metanol daun mangkokan untuk mengetahui kestabilan (pH, viskositas, ukuran globul)  losio dengan variasi konsentrasi ekstrak 1%; 2,5%; 5%; 7,5%; dan 10%. Pembuatan ekstrak daun mangkokan menggunakan pelarut metanol dengan metode maserasi. Ekstrak metanol daun mangkokan kemudian diformulasikan menjadi sediaan losio. Losio  yang telah selesai dibuat dilakukan pemeriksaan meliputimutu fisik losio (bentuk, warna, bau/aroma, tekstur, pH,viskositas). Produk losio diuji stabilitasnya dengan metode penyimpanan cycling test pada suhu 4°C selama 24 jam lalu dikeluarkan dan  ditempatkan pada suhu 40± 2°C selama 24 jam hingga 6 siklus. Selanjutnya dilakukan pemeriksaan meliputi stabilitas tampilan, pH, warna, bau/aroma, viskositas. Losio ekstrak metanol daun mangkokan yang dihasilkan stabil secara fisik. 
UJI AKTIVITAS TABIR SURYA FORMULA SEDIAAN LOSIO EKSTRAK METANOL DAUN MANGKOKAN (Nothophanax scutellarium Merr.) Suryani, Suryani; Hamsidi, Rini; Ikawati, Nurlena; Zaeni, Ahmad; Hasnawati, Hasnawati
Medula Vol 2, No 1 (2014)
Publisher : Medula

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Abstract

Leaves of mangkokan  (Nothophanax scutellarium Merr.) contain a potent antioxidant and sunscreen compounds. This plant potential to be developed into cosmetic products. One of cosmetic product that can be developed  using  natural  product  is  lotion.  This  research  aims  to  formulate  lotion  from  methanol  extracts  of leaves  mangkokan  and  determining  the  sunscreen  activity  of  lotion  with  various  concentration  of  the  extract 1%; 2.5%; 5%; 7.5%; and 10% using laboratory experimental design.  Preparation of mangkokan leaf extracts using methanol solvent by maceration method. Further tests conducted to determine the activity of sunscreen. Methanol extract of the leaves mangkokan then formulated to be lotion. Sunscreen activity of lotion was tested by  determaining  SPF  values.  Lotion  methanol  extract  of  leaves  mangkokan  resulting  the  highest  SPF  value contained in the methanol extract of the leaves mangkokan concentration of 10%. Keywords: mangkokan leaves, lotion, extract, lotion, sunscreen
The Anticholinergic Drug Effect on Decreasing Cognitive in Geriatric Patients at Kota Surakarta General Hospital Ikawati, Nurlena; Rahmawati, Fita
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 7, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1054.449 KB) | DOI: 10.22146/jmpf.33257

Abstract

This leads the geriatric patients to receive multiple drugs regimen (polypharmacy) which include using anticholinergic drugs. Risk of anticholinergics drug use is associated with cognitive impairments that have been demonstrated in experimental and cohort studies. The objective of this study is to determine the profile of anticholinergic drug use and its impact on cognitive reduction in elderly patients at Outpatient Unit Department of Kota Surakarta General Hospital. This study used cohort design. Data were collected through patient medication records and direct interviews to measure the cognitive status of patients using a six-item cognitive impairment test questionnaire (6-CIT). This study divided the respondents into two group; 178 patients (50,6%) took anticholinergic agents, and 174 patients (49,4%) did not use the anticholinergic drugs. Data analysis used Chi-square comparative test and linear regression test with SPSS (Statistical Package for Social Science). The results showed 136 patients or 58,12% use level one anticholinergic drug. The most widely used anticholinergic are diazepam (13,9%) and furosemide (12,5%). The anticholinergic drugs were extensively used by patients who suffer circulatory system diseases as much as 171 (32,1%), followed by endocrine disease, nutrition and metabolic diseases were 83 (15,6%). The number between women and men who take anticholinergics is not significantly different, 91 (51.41%) for women. Whereas by age, the number of most anticholinergic prescribed for patients who are 60 to 74 years is 124 patients (69,66%). There was a significant correlation between anticholinergic drug use in decreasing cognitive function of the geriatric at Outpatient Unit Department of Kota Surakarta General Hospital (p <0,005) proven by r value 0.631.
The Anticholinergic Drug Effect on Decreasing Cognitive in Geriatric Patients at Kota Surakarta General Hospital Ikawati, Nurlena; Rahmawati, Fita
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 7, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.33257

Abstract

This leads the geriatric patients to receive multiple drugs regimen (polypharmacy) which include using anticholinergic drugs. Risk of anticholinergics drug use is associated with cognitive impairments that have been demonstrated in experimental and cohort studies. The objective of this study is to determine the profile of anticholinergic drug use and its impact on cognitive reduction in elderly patients at Outpatient Unit Department of Kota Surakarta General Hospital. This study used cohort design. Data were collected through patient medication records and direct interviews to measure the cognitive status of patients using a six-item cognitive impairment test questionnaire (6-CIT). This study divided the respondents into two group; 178 patients (50,6%) took anticholinergic agents, and 174 patients (49,4%) did not use the anticholinergic drugs. Data analysis used Chi-square comparative test and linear regression test with SPSS (Statistical Package for Social Science). The results showed 136 patients or 58,12% use level one anticholinergic drug. The most widely used anticholinergic are diazepam (13,9%) and furosemide (12,5%). The anticholinergic drugs were extensively used by patients who suffer circulatory system diseases as much as 171 (32,1%), followed by endocrine disease, nutrition and metabolic diseases were 83 (15,6%). The number between women and men who take anticholinergics is not significantly different, 91 (51.41%) for women. Whereas by age, the number of most anticholinergic prescribed for patients who are 60 to 74 years is 124 patients (69,66%). There was a significant correlation between anticholinergic drug use in decreasing cognitive function of the geriatric at Outpatient Unit Department of Kota Surakarta General Hospital (p <0,005) proven by r value 0.631.