Articles

Found 8 Documents
Search

PERBANDINGAN KADAR ESTROGEN SERUM DAN TGF β-1 PLASMA PADA PENDERITA BPH-NON BPH DI ATAS 50 TAHUN DAN USIA MUDA Nugroho, Eriawan Agung; Budijitno, Selamat
MEDIA MEDIKA INDONESIANA 2013:MMI VOLUME 47 ISSUE 1 YEAR 2013
Publisher : MEDIA MEDIKA INDONESIANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (275.887 KB)

Abstract

ABSTRACT Comparison of estrogen serum and TGF ?-1 plasma levels in benign prostate hyperplasia (BPH) and non BPH patients, among 50-years old and young patients.Background: Benign prostatic hyperplasia (BPH) is often found in older men. This disease affects an estimated 70% of men over 60 years, increased by 90% in men over 80 years age. Many scientists tried explores the hypothesis of the mechanism of occurrence of BPH. The purpose of study compared the levels of estrogen and transforming growth factor (TGF) ß-1 in plasma related to the development of BPH, in BPH patients and non-BPH over 50 years and young age.Methods: A clinical analysis study was carried out on subjects who were divided into 3 groups: patients with BPH >50 years, non-BPH >50 years and younger non-BPH aged 30-40 years. T-test was used to analyze the data. Serum estrogen and plasma TGF ?-1 were assessed using ELISA method.Results: There was no significant difference (p=0.129) between the level of estrogen in BPH patients >50 years (140.091±43.649) and non BPH patients >50 years (63.69±18.757) but there was a significant difference (p=0.015) between level of plasma TGF ß-1 BPH patients >50 years (10.47±4.507) and non BPH patients >50 years of age (25.8±16.1103). No significant differences (p=0.348) were found between serum estrogen level of non-BPH >50 years (63.69±18.757) and the young age (57.17±10.2748), and between plasma TGF ß-1 non-BPH group >50 years (25.80±16.1103) and the younger age group (31.4±17,576)(p=0.496).Conclusion: There is difference in the level of TGF ß-1 between younger and older age groups. Elderly men are recommended for early prostate examination, because at the age of 50 years there is already a tendency of enlarged prostate gland. Levels of transforming growth factor ?-1 can predict prostate enlargement.Keywords: Estrogen, TGF ß-1, benign prostate hyperplasia (BPH)ABSTRAKLatar belakang: Benign prostate hyperplasia (BPH) sering ditemukan pada pria usia lanjut. Penyakit ini terjadi pada 70% pria di atas 60 tahun, dan meningkat hingga 90% pada pria di atas 80 tahun. Banyak ilmuwan mencoba mengetengahkan hipotesis faktor yang berpengaruh terjadinya BPH. Tujuan penelitian ini membandingkan tingkat estrogen dan transforming growth factor (TGF) ß-1 dalam plasma terkait pembentukan BPH.Metode: Penelitian klinik analitik dilakukan pada subyek yang dibagi 3 kelompok, pasien dengan BPH >50 tahun, pasien non-BPH berusia >50 tahun dan muda non-BPH berusia 30-40 tahun. Analisis data dengan uji beda kadar estrogen serum dan TGF ?-1 plasma ketiga kelompok. Kadar TGF ß-1 dan estrogen diukur dengan metoda ELISA.Hasil: Serum estrogen pasien BPH usia >50 tahun (140,091±43,649) lebih tinggi tetapi tidak berbeda bermakna (p=0,129) dibandingkan non BPH usia >50 tahun (63,69±18,757). Estrogen serum non-BPH usia >50 tahun (63,69±18,757) dibandingkan usia muda (57,17±10,2748) tidak berbeda bermakna (p=0,348). TGF ß-1 plasma pasien BPH usia >50 tahun (10,47±4,507) lebih rendah (p=0,015) dibandingkan pasien non BPH usia >50 tahun (25,8±16,1103). TGF ß-1 plasma kelompok non-BPH >50 tahun (25,80±16,1103) dibandingkan kelompok usia muda (31.04±17,576) tidak berbeda bermakna (p=0,496).Simpulan: Ada perbedaan antara tingkat TGF ?-1 pada kelompok yang lebih tua. Laki-laki usia tua disarankan lebih dini melakukan pemeriksaan prostat, usia >50 tahun cenderung didapatkan pembesaran kelenjar prostat. Pemeriksaan kadar TGF ?-1 dapat memprediksi risiko pembesaran kelenjar prostat.
THE EFFICACY OF DUTASTERIDE AND GREEN TEA TOWARDS BLEEDING ON BPH AFTER TURP: STUDY THEIR EFFECT ON HIF-1α EXPRESSION & HEMATOCRIT Irawan, Andry; Riwanto, Ignatius; Nugroho, Eriawan Agung
Indonesian Journal of Urology Vol 24 No 2 (2017)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v24i2.306

Abstract

Objective: This study proves differentiation of the combination of dutasteride and green tea, dutasteride, green tea, and placebo alone and their association with differences in hematocrit levels and the expression of hypoxia induced factor-1 alpha (HIF-1?) in patients with Benign Prostate Hyperplasia (BPH) were performed Trans urethral resection of the prostate (TURP) surgery. Material & method: Experimental study with the draft "randomized control trial". Comparing angiogenesis changes between groups of BPH patients who underwent TURP surgery to assess the expression of HIF-1? and ? Ht (Hematocrit) after administration of dutasteride, green tea with combination of dutasteride and green tea for 14 days. Results: The combination of dutasteride and green tea was not significant in reducing the expression of HIF-1?. Mean P1 group (59.32 ± 14.69); P2 group (59.11 ± 20.73); P3 group (64.21 ± 14.95); K group (58.16 ± 16.00). Kruskal test results obtained p=0.491 walis which means the difference percentage of HIF-1? among the 4 groups was not significant. The mean ? Ht P1 group (0.61 ± 0.204); P2 group (0.54 ± 0.250); P3 group (0.41 ± 0.275); group K (0.41 ± 0.275). In statistical test with Mann Whitney test comparing the percentage reduction obtained Ht levels dutasteride group against group of green tea obtained p=0.213 means that there is no significant difference. Where a significant difference to the other groups. Conclusion: The combination of dutasteride and green tea for 14 days before TURP surgery does not reduce the expression of HIF-1? in BPH patients who underwent TURP surgery. ? Ht significant decline in the combination group compared with other groups and might be influenced by several factors during TURP surgery.
Hospital Waste Management in Kidney Transplantation Procedure: Implications and Solutions Nugroho, Eriawan Agung; Nugroho, Leonardo Cahyo
Waste Technology Vol 7, No 1 (2019)
Publisher : Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (794.298 KB) | DOI: 10.12777/wastech.7.1.%p

Abstract

The number of patients diagnosed with end-stage renal disease (ESRD) in Indonesia is increasing annualy, showing a similar trend with the global prevalence. Withits superior outcome, kidney transplantation remains to be the traetment of choice for ESRD. The treatment with transplant kidney procedure makes extensive use of presterilized disposable items which, after use, are contaminated by blood. The preferred route of disposal of such items is by incineration. Disposal costs have risen and this increase in costs has not been matched by waste management programs in kidney transplantation procedure. Many of the waste items like container for blood products and intravenous infusion fluid contain erwhichiswidely used in kidney transplantation procedure generated alsoconta in polyvinylchloride (PVC) whose incineration is environmentally sensitive. Furthermore blood tubing sets contain plasticizers such as di(2-ethylhexyl) phthalate (DEHP), which is known to pose health risks to specific groups of patients. The generation of hospital waste in a kidney transplantation procedure is analyzed, issues associated with disposal are discussed, and approaches toward a cost effective environmentally sustainable hospital waste management program are reviewed.
THE CORRELATION BETWEEN TOTAL ISCHEMIC TIME WITH LENGTH OF HOSPITALIZATION : A SINGLE CENTRE REPORT Nugroho, Eriawan Agung; Kamar, Muhamad Azwin; Junita, Dila
International Journal of Science and Engineering Vol 13, No 1 (2019)
Publisher : Chemical Engineering Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (771.544 KB) | DOI: 10.12777/ijse.13.1.%p

Abstract

Kidney transplantation is recognized as an advanced modern therapeutic modality for patients with end stage renal failure. Cold Ischemic Time (CIT) has been found as an important independent risk factor for delay graft function (DGF) in kidney transplantation. Recent studies suggested that prolonged Warm Ischemic Time (WIT) may decrease graft?s survival in living kidney transplantation donor.This study aimed to evaluate the total ischemic time during recipient surgery and accessed its contribution for hospitalization time in kidney transplantation patients.This is an observational, cross sectional study. The datawas collected from medical record of patient who underwent kidney transplantation from 2014 until December 2018at Kariadi General Hospital Semarang. There were 28 patients, 18 were maleand 10 were female.Total ischemic time was compared with length of hospitalization. Data was analyzed with Spearman test in SPSS version 23. The study showed that total ischemic time was significantly correlated with hospitalization time (p < 0.001). However, donor?s age did not affect prolonged total ischemic time with p = 0.673, which is not significant (significant if p value < 0.05). In conclusion, total ischemic time has a significant correlation with hospitalization time. In contrary, no significant correlation between donor?s age and prolonged total ischemic time.
THE EFFICACY OF DUTASTERIDE AND GREEN TEA COMBINATION TOWARDS ANGIOGENESIS AND BLEEDING ON BPH AFTER TURP : STUDY THEIR EFFECT ON VEGF, MVD AND HB Nugroho, Eriawan Agung; Muslim, Rifki; Riwanto, Ignatius; Pranoto, Soetojo Wirjo
International Journal of Science and Engineering Vol 9, No 2 (2015)
Publisher : Chemical Engineering Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (978.937 KB) | DOI: 10.12777/ijse.9.2.80-84

Abstract

ABSTRACT Objectives: to find the efficacy dutasteride and green tea in reducing hemorrhage on TURP patients  and to evaluate the anti- angiogenesis effect. Methods: Double Blind Randomized Controlled Trial Post Test Only, with 80 samples, randomized into 4 groups: 1 control group and 3 treatment groups (P1 with 0.5 mg of dutasteride, P2 with a capsul of green tea, and P3 with combination of 0.5 mg dutasteride and a capsul green tea at least 14 days before TURP. We compared the ?Hb define the VEGF expression and MVD count to evaluate the angiogenesis changes between 4 groups. The difference is considered statistically significant with p<.05. Results: ?Hb (-0.40 + 0.246) pg/ml for control group, (-0.20 + 0.067) pg/ml for P1 group, (-0.18 + 0.081) pg/ml for P2 group, and (-0.14 + 0.092) pg/ml for P3 group. VEGF expression were (20.20 + 17.386), (12.90 + 15.509), (11.60 + 9.121), and (3.60 + 1.667) for control, P1, P2, and P3 group respectively. MVD count were (41.20  + 10.273), (32.75 + 9.318), (26.15 + 7.278), and (18.35 + 7.876) for control, P1, P2, and P3 group respectively. The result from between-subject effect tests showed statistically significant differences in ?Hb (p<0.001), VEGF expression (p<0.001), and MVD count (p<0.001). Dutasteride and green tea significantly reduce the hemorrhage during TURP by decreasing the MVD. Conclusion: Administration of  0.5 mg dutasteride and 725 mg of green tea, 14 days prior to TURP significantly reduce the hemorrhage during TURP (? Hb) by decreasing the MVD
Association between Hyperglycemia and Prostate Volume in Patients with Benign Prostate Enlargement : A Hospital Case-Control Study Nugroho, Eriawan Agung; Kurniawan, Rickky
Journal of Biomedicine and Translational Research Vol 3, No 2 (2017): December 2017
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (623.338 KB) | DOI: 10.14710/jbtr.v3i2.1971

Abstract

Introduction: Prostate is a male organ which might enlarge mostly, either benign or malignant. Hyperglycemia is one of the factor that increase the risk of  benign prostate hyperplasia. There is lack of studies which assessed the relationship between benign prostate hyperplasia and isolated hyperglycemia. The aim of this study was to evaluate the association between hyperglycemia and prostate volume in patients with benign prostate enlargement in dr. Kariadi Hospital Semarang.  Method: We conducted a retrospective analysis of clinical data which obtained from 640 men between 2010 and 2012 who admitted to the hospital with diagnosis of benign prostate enlargement. By their medical records, these patients were evaluated of their plasma glucose level and prostate volume by trans rectal ultrasound. The  presence  of  hyperglycemia  was  determined  based  on  the  American  Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Patients have already been diagnosed with controlled diabetes mellitus by an internist. We allocated the subjects into two groups: patients with hyperglycemia and non-hyperglycemia. Logistic regression analysis was used to assess whether hyperglycemia was associated with the increased risk of benign prostate enlargement.Results: Significant difference of prostate volume found between groups. Prostate volume was  significantly greater in hyperglycemia group compared with non-hyperglycemia ones in all sub-groups based on age (in decades). Odds Ratio (OR) in patients with hyperglycemia was 2.25 (95% CI: 1.23-4.11). By non-parametric Spearman test it obtained  Group 1 (P1) p = 0.000 and r = 0.669, group 2 (P2) it obtained p = 0.000 and r = 0.672, group 3 (P3) it obtained p = 0.000 and r = 0.415 which implied strong positive associationConclusion: Hyperglycemia and prostate volume were significantly associated in patients with benign prostate enlargement. Hyperglycemia became a significant risk factor  for  prostate  enlargement  in  patients  with  benign  prostate  enlargement  in dr. Kariadi Hospital Semarang.
KIDNEY TRANSPLANTATION IN SEMARANG: OUTCOMES AND PROGNOSIS Nugroho, Eriawan Agung; Supit, Tommy; Santosa, Ardy; Daniswara, Nanda; Addin, Sofyan Rais; Mukti, Anggun Ari
Medica Hospitalia : Journal of Clinical Medicine Vol 6 No 1 (2019): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v6i1.381

Abstract

Introduction &amp; objective:Kidney transplantationis increasingly performed acrossIndonesia, including in Semarang. However there are limited publications onrenal transplantationfrom Indonesia, especially from centers outside Jakarta. The objective of this case series is to give a brief overview on the transplantation performed in Semarang, discusscurrent issues and ongoing efforts to address them. Case series:Twenty-seven renal transplants in Dr. Kariadi General Hospital from January2012 until July 2018wereretrospectively analyzed. On average recipients were younger (32.5 years old) compared to the donors (46.8 years old). All kidneys were acquired from living donors with the majority of them to be blood-related(74.1%). The 3 leading etiologies of end-stage renal disease were hypertension (36.0%), diabetes mellitus (26.9%), and autoimmune disease (11.2%). The average total ischemic time was 36.9 minutes andthe average length of stay was 11 days. We report 5 cases of mortality, 3 cases of allograft rejection and no re-transplantation. Discussion: The demographics of kidney transplant patients in Semarang were similar compared to the National data. The limited number of transplant in Semarang contributes to the low number of survival rate and highlights the need of further training and expertise. Better survival rate can be achieved with more transplants number as well as reaching the plateau of learning curve within the coming years. Conclusion: The development of kidney transplant in Semarang follows the National milestones. In order to maximize the potentialthe institution, further improvements should concentrate on the development of integrated organ transplant infrastructure. The main goal of this institution is to establish a solid transplant center capable of covering Central Java, aiding the decentralization of kidney transplant in the Nation Keywords: Kidney transplantation, End-stage Renal Disease, Chronic Kidney Disease, Indonesia, Semarang, Epidemiology, Update
HUBUNGAN ANTARA TOTAL WAKTU ISKEMIK PADA TRANSPLAN GINJAL DENGAN LAMA PERAWATAN DI RUMAH SAKIT: A SINGLE CENTER REPORT Nugroho, Eriawan Agung; Kamar, Muhamad Azwin; Santosa, Ardy; Daniswara, Nanda; Addin, Sofyan Rais
Medica Hospitalia : Journal of Clinical Medicine Vol 7 No 1 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v7i1.426

Abstract

Latar Belakang : Transplantasi ginjal diakui sebagai kemajuan utama pengobatan modern yang memberikan kehidupan berkualitas tinggi kepada pasien penyakit ginjal stadium akhir (End Stage Renal Disease). Waktu iskemik dingin /Cold Ischemic Time (CIT) telah ditemukan sebagai faktor risiko independen yang penting untuk delay graft function (DGF) pada transplantasi ginjal. Terdapat informasi terbaru bahwa waktu iskemik hangat /Warm Ischemic Time (WIT) yang lama dapat mengurangi kelangsungan hidup graft dalam donor hidup transplantasi ginjal. Tujuan dari penelitian ini adalah untuk mengevaluasi hubungan total ischemik time selama operasi penerima dengan lama rawat inap. Metode : Penelitian ini merupkaan studi observational-cross sectional. Data didapatkan dari catatan medis pasien yang telah menjalani transplantasi ginjal dari Januari 2014 ? Desember 2018 du RS Umum dr. Kariadi semarang. Terdapat 28 pasien, 18 diantaranya adalah laki-laki dan 10 adalah wanita. Data total waktu iskemik dibandingkan dengan lamanya rawat inap. Data dianalisa dengan tes Spearman menggunakan software SPSS versi 23. Hasil : Pada studi ini menunjukkan adanya korelasi yang signifikan antara total waktu iskemik dengan lama perawatan di rumah sakit (p&lt;0.001). Akan tetapi, umur donor tidak mempengaruhi total waktu iskemik (p=0.673), tidak signifikan (signifikan jika p&lt;0.005). Simpulan : Adanya hubungan yang signifikan antara total waktu iskemik dengan lama perawatan rumah sakit. Namun, tidak ditemukannya hubungan yang signifikan pada usia donor dan total waktu iskemik. Kata kunci: total waktu iskemik, lama perawatan, transplantasi ginjal &nbsp; Background: Kidney transplantation is recognized as an advanced modern therapeutic modality, providing a better life for patients with end stage renal failure globally. Cold Ischemic Time (CIT) has been found as an important independent risk factor for delay graft function (DGF) in kidney transplantation. DGF also associated with patient?s survival post-operatively. Recent studies suggested that prolonged Warm Ischemic Time (WIT) may decrease graft?s survival in living kidney transplantation donor. This study aimed to evaluate the total ischemic time during recipient surgery and accessed its contribution for hospitalization time in kidney transplantation patients. Methods: This is a descriptive retrospective study. This study was started in 2014 until December 2018, including data from patients? medical record whom underwent kidney transplantation in Kariadi General Hospital Semarang. Data was collected from 28 patients, including 18 male patients and 10 female patients. The author found a significant correlation between patient?s age and total ischemic time. Total ischemic time also compared with hospitalization time. Data was processed using Spearman test in SPSS software. Results: Based on Spearman test, Total ischemic time was significantly correlated with hospitalization time (p &lt; 0.001). However, donor?s age did not affect prolonged total ischemic time with p = 0.673, which is not significant (significant if p value &lt; 0.05). Conclusion: Total ischemic time has a significant correlation with hospitalization time. In contrary, no significant correlation between donor?s age and prolonged total ischemic time. Key Words: Total ischemic time, hospitalization time, kidney transplantation