Ziana Walidah, Ziana
Farmasi, Fakultas Farmasi, Universitas Gadjah Mada

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POTENSI BIJI LABU KUNING SEBAGAI AGEN FITOESTROGEN PADA WANITA POST MENSTRUAL Lestari, Beni; Hanif, Naisbitt Iman; Anggarany, Ariska Deffy; Ziyad, Thoriq; Walidah, Ziana; Murwanti, Retno
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (756.169 KB)

Abstract

Osteoporosis and hypercholesterolemia are prevalent condition in menopausal women. The common therapy to prevent the estrogen degrading condition is Hormone Replacement Therapy (HRT). However, HRT possessed various risks. Curcubita pepo L. seed (pumpkin seed) contains lignan secoisolariciresinol and lariciresinol which exhibit estrogenic effect. The aim of this study is to determine the estrogenic effect of Ethanolic Extract of Pumpkin Seeds (EEPS) through in silico and in vivo study. In silico study were conducted by molecular docking of lignan which is secoisolariciresinol and lariciresinol with Estrogen Receptor (ERα and Erβ). In vivo study conducted by using ovariectomized Sprague dawley female rats as a model of postmenopausal women. Blood lipid profile, bone density, and uterine weight were assayed after thirty days. Molecular docking score of secoisolariciresinol and lariciresinol were similar to estradiol. In vivo study found that EEPS increase bone density and uterine weight percentage while also improve the blood profile. In conclusion, these result showed that EEPS is potential to be developed as an osteoporosis and hypercholesterolemia prevention agent. Keywords:  Lime peel, Limonene, Aromatic candles, Repellent
A Comparison of Antimetastatic Activity between Nerium indicum and Cinnamomum burmannii on 4T1 Cells Lestari, Beni; Muntafiah, Laeli; Walidah, Ziana; Jenie, Riris Istighfari
Indonesian Journal of Cancer Chemoprevention Vol 8, No 2 (2017)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev8iss2pp85-93

Abstract

Metastatic process becomes a major problem in advanced cancer cases. Natural compounds found in several plants in Indonesia have a potency to be developed as chemoterapeutic agent which are targeted to metastatic process. Jure leaves (Nerium indicum) which contain oleandrin and cinnamaldehyde in cinnamon bark (Cinnamomum burmannii) reported to have cytotoxic activity on several cancer cells, but their activities on metastasic process have never been explored. This research aims to reveal and to compare their anti-metastatic effect toward 4T1 breast cancer cells. The cytotoxicity of jure leaves extract (JLE) and cinnamon essential oil (CEO) was obtained by MTT assay. Metastatic process mainly on cell migration was examined by scratch wound healing assay while MMP-9 expression that described the invassion process was observed by gelatin zymography assay. Molecular interaction between their active compounds and MMP-9 receptor was predicted by molecular docking. The result showed that treatment with JLE and CEO inhibited the growth of 4T1 cells with IC50 value of 125 µg/mL and 2.5 µg/mL, respectively. In addition, JLE performed inhibitory effect of cell migration better than CEO. Meanwhile, both JLE and CEO decreased MMP-9 protein expression. Thus, JLE and CEO have potentials to be developed as an anti-metastatic agent and JLE could be more effective.Key words: Nerium indicum, Cinnamomum burmannii, anti-metastasis, scratch assay, gelatin zimography
Anti-metastatic Profiles of Boesenbergia pandurata towards MCF-7/HER2 Cells Fadliyah, Hilyatul; Putri, Nindya Budiana; Walidah, Ziana; Nurhayati, Ika Putri; Ikawati, Muthi; Meiyanto, Edy
Indonesian Journal of Cancer Chemoprevention Vol 9, No 2 (2018)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev9iss2pp68-77

Abstract

The development of breast cancer at an advanced stage is signed with metastatic phenomenon, triggering the high mortality, mainly for Human Epidermal Growth Factor Receptor (HER)2 positive cancers. Boesenbergia pandurata is well known as medicinal plant possessing anticancer potential due to the cytototoxic and antimetastatic characteristic of its active compound. The aim of this study is to observe the inhibitory effect of Boesenbergia pandurata ethanolic extract (BPEE) in combination with doxorubicin on migration of MCF-7/HER2 cells. The BPEE was prepared by 96% ethanol maceration. Under MTT assay, BPEE decreased the cells viability with IC50 value of 23±3.9 μg/mL. Lamellipodia and wound healing assay analysis showed that 5 μg/mL BPPE and its combination with 10 nM doxorubicin inhibited cells migration after 48 hours observation, while gelatin zymography analysis showed that this combination did not affect the expression of Matrix Metalloproteinase (MMP)2 and MMP9, but single treatment of 5 μg/mL BPEE caused lower expression of both MMPs. The combination of 5 μg/mL BPPE and 10 nM doxorubicin inhibited the cells migration but not affect to the cells viability. Thus, BPEE is potential to be developed as an antimetastatic agent. The mechanism underlying the migratory inhibition effect needs to be explored further.Keywords : Boesenbergia pandurata, doxorubicin, MCF-7/HER2, migrationSubmitted:
Struktur Wacana dan Pesan Dakwah pada Lagu Lawlaka Maher Zaen Setiawan, Hendro Eko; Walidah, Ziana
Nusa: Jurnal Ilmu Bahasa dan Sastra Vol 15, No 2: Mei 2020
Publisher : Program Studi Sastra Indonesia, Fakultas Ilmu Budaya, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/nusa.15.2.159-173

Abstract

The purpose of this paper is to describe the structure that exists in the lyrics of the song Lawlaka so that readers especially song lovers can know, understand and know what is contained in the song lyrics Lawlaka as well as the linguistic aspects in it. The primary data is the Lawlaka text contained in the Youtube Awkening Music channel, while the secondary data uses Van Dijk's discourse analysis. The results show that there is a complex structure found in the lyrics of the song Lawlaka. In the text dimension it contains micro and macro structures: from the micro structure it contains the thematic elements of the hope of His grace, begging for forgiveness and praise. The superstructure that contains the schematic shows the title / lead. In the macro structure there are background elements, details and meanings. Whereas the social dimension of the Lawlaka song is not just textual but has meaning within it. As for the social context of his sinful state that others feel. Maher Zaen composed the song in reference to his words and hadith of the prophet Muhammad SAW for the public awareness of the importance of the mercy of Allah SWT. the message of the preaching contained: inviting man to return to the path of Allah SWT as written in the hadith and the word of Allah SWT.  IntisariTujuan tulisan ini ialah untuk mendeskripsikan struktur yang ada dalam lirik lagu Lawlaka sehingga pembaca khususnya penikmat lagu dapat mengetahui, memahami dan mengetahui apa yang terkandung dalam lirik lagu Lawlaka serta aspek-aspek kebahasaan didalamnya. Adapun data primer adalah teks Lawlaka yang ada didalam chanel Youtube Awkening Music, sedangkan data skunder menggunakan analisis wacana Van Dijk. Hasil penelitian menunjukan bahwa adanya struktur kompleks yang terdapat dalam lirik lagu Lawlaka. Pada dimensi teks memuat struktur mikro dan makro: dari struktur mikro memuat unsur tematik tentang pengharapan rahmat-Nya, memohon ampun dan pujian. Adapun superstruktur yang memuat skematik menunjukan adanya judul/lead. Pada struktur makro terdapat adanya elemen latar, detail dan maksud. Sedangkan pada dimensi sosial lagu Lawlaka tidak hanya  sebatas teks saja namun ada makna yang terkandung didalamnya. Adapun dalam konteks sosial berkenaan dengan keadaan dirinya yang merasa penuh dosa yang juga dirasakan oleh orang lain. Maher Zaen mencipta lagu tersebut merujuk pada firman-Nya dan hadits nabi Muhammad SAW untuk kesadaran masyarakat akan pentingnya rahmat Allah SWT. pesan dakwah yang terkandung: mengajak manusia kembali ke jalan Allah SWT sebagaimana tertulis dalam hadis rosul dan firman Allah SWT.