Andi Triawan, Andi
Universitas Muhammadiyah Yogyakarta

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The Newly Bone Formation with Carbonate Apatite-Chitosan Bone Substitute in the Rat Tibia Dewi, Anne Handrini; Triawan, Andi
The Indonesian Journal of Dental Research Vol 1, No 3 (2011)
Publisher : The Indonesian Journal of Dental Research

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Abstract

Large bone defect still represent a major problem in orthopedics. A tissue engineering approach has been proposed where osteogenic cells, bioceramic scaffolds and growth factors can play in a role to the bone repair. Bone consist a mineral phase such as carbonate apatite and an organic phase such as collagen. Synthetic carbonate apatite ceramics are considered as promising alloplastic materials for bone substitute. Chitin is the organic matrix of the hard parts of exoskeleton of insect, crustacean and present in a small amounts in mushrooms. It is an insoluble, similar to cellulose and composed of N-acetylglucosamine unit. Partial deacetylation from chitin result in the formation of chitosan. Chitin’s properties as a flexible and strong material make it favourable as surgical thread. It has novel properties such as biocompatibility, biodegradability, anti bacterial, wound healing activity, tissue regeneration and hemostatic activitities. The composit from carbonate apatite and chitosan may have a great impact on human health care system as bioresorbable bone substitute. The aim of the study was to evaluate the newly bone formation on the bone healing of defect tibia treated with carbonate apatite-chitosan bone substitute. Eighteen Sprague Dawley rats, male, 3 months, weighing 250-300g used in this study. Bilateral defect were created in each tibia rat. The defects were filled with carbonate-apatite chitosan bone substitute. The rats were sacrificed after respectively 1, 2 and 3 weeks. The result of this study showed that carbonate apatite-chitosan significantly increased a number of osteoblast (p<0.05). Carbonate apatite-chitosan group showed that matrix deposition faster than the other groups and have a good interface with the old bone. These data indicate that carbonate apatite-chitosan are potential candidate for bone substitute
Perbandingan Pemberian Ekstrak Kayu Siwak (Salvadora Persica) 50% Dan Larutan Sodium Fluorida 2% Terhadap Ketahanan Email Gigi Rattus Norvegicus Diana, Sherli; Triawan, Andi
Insisiva Dental Journal Vol 1, No 2 (2012)
Publisher : Insisiva Dental Journal

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Abstract

Miswak (Salvadora Persica) Has A Substance Of Anti Bacterium Which Can Decrease The Amount Of Bacteria In Mouth So That The Tooth Become Health And Prevent Dental Caries And Also The Disinfectant Effect Of Miswak That Can Discontinue Gum Bleeding. While Sodium Fluoride Pursue Decalcification And Enamel Condensation In Mouth And Also Remineralization Of Tooth Enamel. The Aim Of This Research Is To Compare The Effect Between Extract Of Wood Miswak 50% And Solution Of Sodium Fluoride 2% To Enamel Resistant In Rattus Norvegicus On Tooth. The Subjects This Research Are 10 Rattus Norvegicus Which 20 Days Old. During 30 Day Of Rattus Norvegicus Is Given The Same Feed And Drink With Different Intervention That Is Lower Jaw Teeth Of 5 Rattus Norvegicus Was Dabbing With Extract Of Wood Miswak 50% And Other Lower Jaw Teeth Of 5 Rattus Norvegicus Was Dabbing With Solution Of Sodium Fluoride 2%. After 30 Day, All Rattus Norvegicus Were Decapited By Using Ether. Afterwards, Lower Jaw Of Rattus Norvegicus Was Extracted, Next Nub With 37% Phosphoric Acid Gel During 60 Second Then Cleaned With Refine Water And Digitally Periapical Roentgen. Then, They Were Scored To Get Data Of Each Variable And Statistical Test With Mann-Whitney Test. Statistical Test With MannWhitney Test Resulted ( P=0,419) Because ( P>0,05) Means There Is Influence Which Not Significantly Different Between Extract Of Wood Miswak 50% And Solution Of Sodium Fluoride 2%. Research Result Indicates That Extract Of Wood Miswak 50% And Solution Of Sodium Fluoride 2% Have Influence Which Not Significantly Different To Enamel Resistance Of Rattus Norvegicus Tooth Which Assessed With Score Using 5 Point Of Belief Scale.
Uji Temperatur Air Pencampur Terhadap Setting Time Bahan Cetak Kulit Buah Manggis (Garcinia Mangostana) Yosi Arinawati, Dian; Triawan, Andi
Insisiva Dental Journal Vol 1, No 1 (2012)
Publisher : Insisiva Dental Journal

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Abstract

Bahan cetak gigi adalah bahan yang digunakan untuk membuat replica (model)gigi dan jaringan sekitarnya. Bahan cetak harus memenuhi syarat, salah satunyaharus memiliki setting time yang cukup sehingga operator dan pasien dapatmelakukan pencetakan gigi dengan baik. Penentuan waktu gelasi bisa ditentukanoleh beberapa faktor yaitu temperatur air, W/P ratio dan bahan pengisi yangdipakai. Namun cara modifikasi tersebut banyak memberikan efek pada sifat gelseperti elastisitas, dan mempengaruhi kekuatan terhadap robekan. Cara lain yanglebih aman ialah dengan mengubah temperatur air pencampur. Pada bahan cetakalginat, terbukti bahwa semakin tinggi temperatur, semakin pendek waktu gelasi.Namun belum ada pembuktian bahwa sifat-sifat tersebut berlaku untuk bahancetak kulit Buah Manggis (Garcinia mangostana). Penelitian ini bertujuan untukmengetahui bagaimana pengaruh temperatur air pencampur terhadap setting timebahan cetak kulit Buah Manggis (Garcinia mangostana). Dua puluh lima spesimendibagi menjadi 5 kelompok : kelompok 1 (10°C), kelompok 2 (15°C), kelompok 3(20ºC), kelompok 4 (25°C) dan kelompok 5 (30°C). Pengukuran setting timemenggunakan alat ukur indikator setting time berbentuk batang silindris daribahan poly (methyl methacrylate). Hasil uji statistik ANAVA satu jalurmenunjukkan bahwa temperatur air pencampur berpengaruh terhadap setting timebahan cetak kulit buah Manggis (Garcinia mangostana) (p < 0,05). Hasil uji LSD0,05 menunjukkan adanya perbedaan setting time yang bermakna antar setiapkelompok tempetatur air pencampur yang digunakan, kecuali pada kelompoktemperatur air pencampur 20°C dan 25°C. Kedua kelompok temperatur airpencampur tersebut tidak menunjukkan perbedaan yang bermakna karena keduakelompok temperatur air pencampur tersebut berada pada temperatur air padasuhu ruangan. Kesimpulan dari penelitian ini adalah temperatur air pencampursuhu 10°C, 15°C, 20°C, 25°C dan 30°C mempengaruhi lama setting time bahancetak kulit Buah Manggis (Garcinia mangostana) dan semakin tinggi temperaturair pencampur yang diuji, setting time semakin pendek (cepat). Setting timetercepat terdapat pada kelompok suhu (temperatur) air pencampur 30° C.
The effect of nanochitosan hydrogel membrane on absorbtion of nickel, inhibition of Streptococcus mutans and Candida albicans Triawan, Andi; Pudyani, Pinandi Sri; HNE, Soesatyo Marsetyawan; -, Sismindari
Dental Journal (Majalah Kedokteran Gigi) Vol 48, No 1 (2015): (March 2015)
Publisher : Faculty of Dental Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (256.037 KB) | DOI: 10.20473/j.djmkg.v48.i1.p26-30

Abstract

Background: The use of fixed orthodontic appliance for a long time can potentially cause nickel ion release, increase in the growth of Streptococcus mutans (S. mutans) and Candida albicans (C. albicans). Chitosan has the ability to bind metal, antibacterial and antifungal. Physical modification of chitosan into the nanoparticles size will expand the surface of the chitosan so that the absorption of nickel ions and the inhibition of growth bacteria and fungi can be increased. Purpose: The purpose of the study was to determine the effect of nanochitosan hydrogel membrane to the absorption of nickel ions, and the inhibition of S. mutans and C. albicans growth. Methods: Nanochitosan hydrogel membrane with chitosan weight variation of 0.6; 0.8 and 1 g immersed in artificial saliva containing nickel 0.075 mg / L for 15, 30 and 45 minutes. The nanochitosan hydrogel membrane was tested for nickel ion absorption by Atomic Absorption Spectrophotometry, whereas the antibacterial and antifungal tests were done by exposing the nanochitosan hydrogel membrane - nickel on S. mutans and C. albicans in the wells of plate. Results: Demonstrated that absorption of nickel ions was related with the increase in weight of chitosan and soaking time. Inhibition of growth of S. mutans and C. albicans showed a positive correlation with the increase in weight of chitosan. Conclusion: Variation on chitosan weight on hydrogel membrane and variation on immersion time have effect on nickel ion absorption, inhibition of S. mutans and C. albicans growth.