Najma Annuria Fithri, Najma Annuria
Department of Pharmacy, Faculty of Mathematic and Natural Sciences, Sriwijaya University, Kampus UNSRI Indralaya, Jl. Palembang Prabumulih Km 32 Ogan Ilir 30662, South Sumatera

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Furosemide self nano emulsifying drug delivery system (SNEDDS) formulation comprising of capryol-90, polysorbate-80, and peg-400 with simplex-lattice-design Fithri, Najma Annuria; Mardiyanto, Mardiyanto; Novita, Rennie Puspa; Andrean, Vicky
Science and Technology Indonesia Vol 2 No 4 (2017): October
Publisher : ARTS Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (371.588 KB) | DOI: 10.26554/sti.2017.2.4.85-88

Abstract

Preparation of SNEDDS aims to improve solubility and absorption of furosemide in the body to reduce the dosage and minimize the side effects of drugs. Ternary diagram constructed from composition mixture produced nanoemulsion in the range of 20-40% of capryol-90, 20-40% polysorbate-80 and 40-60% PEG-400. Formulations of SNEDDS using Design-Expert®10 with simplex-lattice-design method in the study was aimed to investigate the effect of SNEDDS each components proportions towards test responses. Emulsification time, drug content and viscosity were best demonstrated by run-7 with consecutive values of 131.68±2.14 seconds, 99.89±2.68% and 0.87±0.0043 mm2/s. The optimum formula was obtained through entering test response parameter data of all thirteen formula. Drug content and emulsification time was 107.0 ± 1.44% and 155.59±1.56 seconds with viscosity value 0.91±0.00 mm2/s. From the physical stability studies, SNEDDS formulas were stable and did not show phase separation when exposed to temparature stress testing.  
Oxidation of Cyclohexane to Cylohexanol and Cyclohexanone Over H4[a-SiW12O40]/TiO2 Catalyst Lesbani, Aldes; Fatmawati, Fatmawati; Mohadi, Risfidian; Fithri, Najma Annuria; Rohendi, Dedi
Indonesian Journal of Chemistry Vol 16, No 2 (2016)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (404.462 KB) | DOI: 10.22146/ijc.21161

Abstract

Oxidation of cyclohexane to cyclohexanol and cyclohexanone was carried out using H4[a-SiW12O40]/TiO2 as catalyst. In the first experiment, catalyst H4[a-SiW12O40]/TiO2 was synthesized and characterized using FTIR spectroscopy and X-Ray analysis. In the second experiment, catalyst H4[a-SiW12O40]/TiO2 was applied for conversion of cyclohexane. The conversion of cyclohexane was monitored using GC and GCMS. The results showed that H4[a-SiW12O40]/TiO2 was successfully synthesized using 1 g of H4[a-SiW12O40] and 0.5 g of TiO2. The FTIR spectrum showed vibration of H4[a-SiW12O40] appeared at 771-979 cm-1 and TiO2 at 520-680 cm-1. The XRD powder pattern analysis indicated that crystallinity of catalyst still remained after impregnation to form H4[a-SiW12O40]/TiO2. The H4[a-SiW12O40]/TiO2 catalyst was used for oxidation of cyclohexane in heterogeneous system under mild condition at 2 h, 70 °C, 0.038 g catalyst, and 3 mL hydrogen peroxide to give cyclohexanone as major product.
Oxidative Desulfurization of Dibenzothiophene Using Dawson Type Heteropoly Compounds/Tantalum as Catalyst Mohadi, Risfidian; Teresia, Lusi; Fithri, Najma Annuria; Lesbani, Aldes; Hidayati, Nurlisa
Indonesian Journal of Chemistry Vol 16, No 1 (2016)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (372.893 KB) | DOI: 10.22146/ijc.21185

Abstract

Catalyst (NH4)6[b-P2W18O62]/Ta has been synthesized by simple wet impregnation at 30-40 °C under atmospheric conditions using Dawson type polyoxometalate (NH4)6[b-P2W18O62] and tantalum. The catalyst was characterized by FTIR spectrophotometer, XRD, SEM, and N2 adsorption desorption methods. FTIR spectrum of (NH4)6[b-P2W18O62]/Ta showed that Dawson type polyoxometalate (NH4)6[b-P2W18O62] and Ta was successfully impregnated which was indicated by vibration spectrum at wavenumber of 900-1100 cm-1 for polyoxometalate and 550 cm-1 for Ta. The surface area of the (NH4)6[b-P2W18O62]/Ta after impregnation was higher than (NH4)6[b-P2W18O62]•nH2O and its morphology was found to be uniform. The catalytic activity of (NH4)6[b-P2W18O62]/Ta toward desulfurization of dibenzothiophene was three times higher than the original catalyst of (NH4)6[b-P2W18O62]•nH2O without impregnation. The catalytic regeneration test of catalyst (NH4)6[b-P2W18O62]/Ta showed that the catalytic activity for first regeneration of catalyst has similar catalytic activity with the fresh catalyst without loss of catalytic activity indicated by almost similar percent conversion.
Characterization and Optimization of Capryol-90, Polysorbate-80, And Peg-400 Proportion in Mefenamic Acid Self Nanoemulsifying Drug Delivery System (SNEDDS) With Simplex-Lattice-Design Mardiyanto, Mardiyanto; Fithri, Najma Annuria; Tandry, Martina
Science and Technology Indonesia Vol 3 No 4 (2018): October
Publisher : ARTS Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1825.421 KB) | DOI: 10.26554/sti.2018.3.4.164-172

Abstract

Mefenamic acid as pain relief drug belongs to the biopharmaceutics classification system (BCS) class II which is practically insoluble in water causing extremely low dissolution in gastrointestinal tract. The self nanoemulsifying drug delivery system (SNEDDS) is a new innovation pharmaceutical dosage form that has effectively known to increase solubilization of hydrophobic drug in polar solvent. In this study the capryol-90 was selected as oil phase in SNEDDS as it showed maximal solubility of mefenamic acid (20 mg/mL). Combination of polysorbate-80 and PEG-400 as a generally regarded as safe (GRAS) excipient were used as surfactant and co-surfactant in SNEDDS due to its high HLB property that can increase mefenamic acid solubility in water. The ternary phase diagram of capryol-90, polysorbate-80, and PEG-400 was constructed in advance to obtain the component concentration of spontaneous nanoemulsion region. Model simplex-lattice-design cooperated in Design-Expert®10 was used to define SNEDDS mefenamic acid formula. Optimized mefenamic acid SNEDDS formula consisted of 20% capryol-90, 31.62% polysorbate-80, and 48.38% PEG-400. Characterization study of Optimized mefenamic acid SNEDDS formula showed improvement of drug content (102.820 ± 4.950)%, emulsification time (421.015 ± 1.290) second, and viscosity (0.927 ± 0.017) mm2/s 30oC. One way ANOVA statistical analysis result of optimal formula SNEDDS (105.210 ± 4.425)% of drug content, commercial generic caplet (0.917 ± 0.094)%, and mefenamic acid powder capsule (10.446 ± 0,333)% gave significant value (sig*) below than 0.05. Optimal formula proved that SNEDDS can significantly increase mefenamic acid dissolution of pH 7.4 (ileum fluid). The optimal formula of mefenamic acid SNEDDS successfully formed an uniformity droplet size (PDI 0.18) with mean size 241.9 nm and  the surface charge has a value of -16.5 mV respectively.
Antioxidant Activity Analysis and Standardization of Parkia speciosa (Petai) Pods Ethanol Extract Fithri, Najma Annuria; Fitrya, Fitrya; Shabrina, Tia; Yulanri, Diva
Science and Technology Indonesia Vol 4 No 1 (2019): January
Publisher : ARTS Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (796.735 KB) | DOI: 10.26554/sti.2019.4.1.5-10

Abstract

Parkia speciosa (petai) pods are rarely used and considered as waste despite their phenolic and flavonoid content. Phenolic and flavonoid content in plants are known to exhibit antioxidant activity. Antioxidants are known to potentially act agains radical and mediate the damage by structural stabilization. This research was conducted to analyze the antioxidant potential of petai pods using DPPH method. Analysis showed the IC50 of petai pods ethanolic extract was 75.72 ppm, which indicate strong acting antioxidant. Standardization of extracts were determined to manage the quality of extract, including the analysis of density, water content, ash values, and quantification of total phenolic and flavonoid content. Research outcome indicate the extract retain its quality during storage and use which confrmed to standardization requirements of water content and ash values. Total phenolics and flavonoid obtained were 272.45 mg/gGAE and 243.2029 mg/gQE respectively. Based from this research, petai pods ethanolic extract present strong antioxidant activity which was contributed by high existing content of flavonoid and phenolic compounds.
The submicron particles FORMULATION OF IONIC-GELATION SUBMICRON PARTICLES LOADING EXTRACT PAPAYA LEAVES (Carica papaya L.) WITH LACTIC ACID ISOLATES Mardiyanto, Mardiyanto; Untari, Budi; Fithri, Najma Annuria; Sandi, Sofia; Mawaddah, Zahrul
Science and Technology Indonesia Vol 4 No 3 (2019): July
Publisher : ARTS Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1762.875 KB) | DOI: 10.26554/sti.2019.4.3.77-81

Abstract

A study regarding ionic-gelation submicron particle of papaya leaves (Carica papaya L.) extract with lactic acid of weeds potentially for antidiarrhea has been conducted. Preparation of papaya leaves ethanolic extract and lactic acid isolate into particles was done by ionic gelation method. This study aimed to determine: the major compound of extract, the total quercertine of extract, the percent value of encapsulation efficiency of the optimum formula which was varied by (CaOH)2 of the three formulas, and physical properties of particles. Formula 1 was using (CaOH)2 of 12.5 gram; formula 2 (CaOH)2 of 17,5 gram; formula 3 (CaOH)2 of 22.5 gram. The results showed formula 1 as the optimum formula that has the highest %EE. The average %EE values ??of F1; F2; F3 respectively were 80,82%; 80,41%; 80,31%. The results of particle characterization using the PSA in the optimum formula produced particle size values ??with an average of 253.6 nm, PDI of 0.218, and zeta potential +8 mV respectively.
Formulasi dan Evaluasi Sediaan Submikro Partikel Gelasi-Ionik Pembawa Ekstrak Daun Pluchea indica Sebagai Antibakteri pada Kulit Tikus Putih Jantan Galur Wistar Mardiyanto, Mardiyanto; Herlina, Herlina; Fithri, Najma Annuria; Rahmi, Yutry
Jurnal Sains Farmasi & Klinis Vol 6, No 2 (2019): J Sains Farm Klin 6(2), Agustus 2019
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.6.2.171-179.2019

Abstract

Telah dilakukan penelitian mengenai formulasi dan evaluasi sediaan submikro partikel gelasi inonik pembawa ekstrak Beluntas (Pluchea indica L) sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui efektivitas anti bakteri submikro partikel terhadap Staphylococcus aureus dengan melihat penurunan jumlah dan diameter abses pada kulit tikus putih jantan galur wistar. Preparasi ekstrak daun beluntas menjadi sediaan submikro partikel menggunakan polimer kitosan dan natrium alginat serta kalsium klorida (CaCl2) sebanyak 40 mL dengan konsentrasi 18 mM sebagai crosslinker dengan metode gelasi ionik. Tiga formula (F1-F3) dibedakan atas jumlah ekstrak 450, 900, dan 1350 mg untuk masing-masing formula. Formula optimum submikro partikel yang didapatkan memiliki persen efisiensi enkapsulasi terbesar yaitu 86,742% (formula 1). Hasil karakterisasi submikro partikel seperti diameter, distribusi ukuran partikel (PDI), dan zeta potensial dengan menggunakan alat particle size analyzer pada formula optimum (F1) yaitu 529,5 nm; 0,567; dan-27,6 mV. Pengujian in vivo menggunakan 6 kelompok diantarannya: kontrol normal (tanpa perlakuan), kontrol positif (salep tetrasiklin HCl 3%), kontrol negatif (tanpa bahan uji), kelompok uji I (submikro partikel), kelompok uji II (ekstrak), dan kelompok uji III (plasebo). Kulit tikus dioleskanStaphylococcus aureus selama 3 hari untuk mengindikasikan terbentuknya abses, kemudian pemberian bahan uji terhadap masing masing kelompok diberikan selama 7 hari berikutnya..Hasil penelitian in vivo menunjukkan bahwa submikro partikel kitosan dan natrium alginat pembawa ekstrak daun beluntas pada dosis 450 mg menghasilkan penurunan diameter abses sebesar85%, sedangkan pada ekstrak murni sebesar 60%, dan salep tetrasiklin-HCl sebesar 100%.