Marchaban ., Marchaban
Faculty of Pharmacy, Gadjah Mada University< Yogyakarta, Indonesia

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Evaluation of drug release from fatty based suppository: the difference between intrinsic and non-intrinsic dissolution methods ., Marchaban
INDONESIAN JOURNAL OF PHARMACY Vol 15 No 4, 2004
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (332.416 KB) | DOI: 10.14499/indonesianjpharm0iss0pp163-168

Abstract

Study on the difference of evaluation methods, namely intrinsic and non-intrinsic dissolution methods, on the drug release from fatty-based suppository has been performed. The study was done by producing the suppositories consisting of 50, 100, 150, 200 and 250 mg of sodium salicylate respectively. The drug release from the suppositories was then evaluated using intrinsic dissolution apparatus that limited the contact area of the suppository with the medium, and non-intrinsic that not limited its contact area. The aim of the study was to know the difference of the drug release profiles if they are evaluated using intrinsic and non-intrinsic dissolution methods.The results showed that the drug release using non-intrinsic dissolution method was always higher than that of the intrinsic method at any drug concentration, the drug concentration has not showed proportional relationship with their release although the drug release tend to be higher as the concentration was higher.Key words: suppository, dissolution
Mucous dilution activity of non soluble ethylacetate fraction syrup of hibiscus flowers (Hibiscus rosa-sinensis L.) at cow intestinein vitro Murrukmihadi, Mimiek; Wahyuono, Subagus; ., Marchaban; Martono, Sudibyo
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (195.07 KB) | DOI: 10.14499/indonesianjpharm0iss0pp251-256

Abstract

Previous  study  indicated  that  ethylacetate  insoluble  fraction  of  ethanol extract  of  Hibiscus  flowers  (Hibiscus  rosa-sinensis L.)  were  able  to  dilute intestine cattle mucous in vitrothat was often associated with mucolytic activity.In  this  study,  syrup  preparation  of  various  concentrations  of  these  fractions (1.20,  1.60  and  2.00%)  was  tested  for  its  ability  to  dilute  of  mucous.  Each  of syrup  concentrations  was  mixed  with  20%  buffer  Phosphate  (pH,  7)  at  equalproportion (1:1 v/v), the resulting mixtures were tested for their ability to dilute mucous  in  vitro. Mucous  dilution  was  observed  by  flow  time  recorded in  the viscosimeter.  The  study  showed  that  all  syrup  concentrations  (1.20,  1.60, 2.00%) exhibited mucous dilution effect compared tonegative control and syrup concentration  at  2.00%  was  comparable  to  positive  control  acetylsistein  0.1% (p&lt;0.05). Therefore, there was a possibility that thispreparation could be used as mucolytic.Keywords: Hibiscus rosa-sinensisL., viscosity, mucous dilution, mucolytic
Solubilization capacity of surfactant due to its different chain length of lipophile and hydrophile ., Marchaban
INDONESIAN JOURNAL OF PHARMACY Vol 16 No 2, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (138.422 KB) | DOI: 10.14499/indonesianjpharm0iss0pp105-109

Abstract

The aim of the study is to look at the influence of different chain length of hydrophile and lipophile of the surfactants to their solubilization capacity. The solubilization capacity of surfactants with different chain lengths of lipophile and hydrophile has been performed by preparing somesolubilization form formulas, using several kinds of lipophilic chain length, i.e. cetyl (C-16), stearyl (C-18), and oleyl (C=18 with unsaturated chain) alcohols and ethyleneoxyde chain length of 2, 10 and 20 respectively. After preparation, the solubilited forms were then stored at temperature of 25O and 45OC, and observed if there were any solubilization occurred. The results have showed that it needs an optimum length of ethyleneoxyde to have better solubilization; at certain longer ethylenoxyde the longer the length of lipophilic chain, the more solubilization would be, therefore, unsaturated hydrocarbon chain caused diminution of solubilization; whatever the surfactant used as an agent of solubilization, storage at a higher room temperature would facilitate the solubilization to occur.Key words : surfactant, solubilization
Evaluation of the implementation of the good manufacturing practice for traditional medicine industries in Central Java ., Marchaban; Fudholi, Achmad; Suryadi, Bambang
INDONESIAN JOURNAL OF PHARMACY Vol 15 No 2, 2004
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (197.896 KB) | DOI: 10.14499/indonesianjpharm0iss0pp75-80

Abstract

The study of the GMP implementation for the traditional medicine industries in Central Java has been performed. The GMP for traditional medicine industry is the guidance how to produce and to manage the quality of the product so that it meets to the quality of design and the quality of conformance. The aim of the study is to evaluate how far the GMP is implemented in the traditional medicine industries in Central Java.The method used of the study was a descriptive evaluative qualitative data collected from several traditional industries namely: M, N, O, P, Q, R and S by assessing the implementation level of the GMP in those industries. The evaluation instrument used was the primary data directly collected by interviewing the directors, the managers and the heads of department, and then followed by visitation to the industries to check the primary data and the actual condition.  The result showed that the evaluation of the GMP implementation for the traditional medicine industries in Central Java reached the score of 86.10% that meant of good category, although the quality control, the selfevaluation, and the documentation aspect had to be ameliorated.Key word : GMP, traditional medicine industries
PHYSICAL PROPERTIES OF WOUND HEALING GEL OF ETHANOLIC EXTRACT OF BINAHONG (Anredera cordifolia (Ten) Steenis) DURING STORAGE. Yuliani, Sri Hartati; Fudholi, Achmad; Pramono, Suwijiyo; ., Marchaban
INDONESIAN JOURNAL OF PHARMACY Vol 23 No 4, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (251.975 KB) | DOI: 10.14499/indonesianjpharm0iss0pp203-208

Abstract

Binahong  (Anredera  cordifolia (Ten)  Steenis)  has  been used  as  wound  healing  in  traditional  Indonesian  medicine.  The developing of the dosage forms using the formulation technology approach  has  been  done.  The  aim  of  this  study  was  to  examine the  physical  properties  of  the  wound  healing  gel  of  ethanolic extract of binahong during storage. The factorial design method 3 factors  and  2  levels  was  employed  to  achieve  this  study.  The three  factors  used  in this  study  were Carbopol, CMC-Na  and Caalginate  with  low  and  high  level  for  each  factor.  The  physical properties  of  the  wound  healing  gel  of  ethanolic  extract  of binahong was evaluated on day 1, 30, 60 and 90 for viscosity and bioadhesion  study.   The  result  showed  that  CMC-Na  and  Caalginate  increased  the  alteration  of  physical  properties  of  wound healing  gel  of  ethanolic  extract  of  binahong  during  storage.  The carbopol  maintained  the  physical  properties  of  the  gel  during storage.Key words: bioadhesion, binahong, viscosity, wound healing gel.
The influence of ethanol fractions of infusa of Plantago major L. leaves in effectivity of octyl methoxycinnamate as active ingredient of sunscreen Sugihartini, Nining; ., Marchaban; Pramono., Suwidjiyo
INDONESIAN JOURNAL OF PHARMACY Vol 16 No 3, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (157.076 KB) | DOI: 10.14499/indonesianjpharm0iss0pp130-135

Abstract

Octyl methoxycinnamate is an active ingredient of that is degraded by solar irradiation resulting it usage as sunscreen becomes less effective. An antioxidant has capability as a photo-protector. Flavonoid in the ethanolic fraction of Plantago major, L. leaves is reported to have an antioxidant. This research was aimed to examine the influence of the addition of the ethanolic fraction of Plantago major, L. leaves to the effectiveness of octyl methoxycinnamate as a sunscreen. In this research, two formulas were prepared. Formula I contained octyl methoxycinnamate per se and formula II contained a mixture (1:1) of octyl methoxycinnamate and ethanolic fraction of Plantago major, L. leaves. Both formulas were exposed to the sun light for 5 hours (09.00-14.00 WIB) in which samples were taken every hour. The effectiveness of octyl methoxycinnamate was calculated based on the percentage of erythema transmission and the percentage of pigmentation transmission, prior and after the irradiation by the sun light for 5 hours. The statistical data analysis was performed based on the Student t test with a confidence level of 95%. The addition of the ethanol fraction of Plantago major, L. leaves significantly reduced the percentage of the erythema transmission after solar irradiation (p