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NILAI UREUM, KREATININ, DAN PENYINGKIRAN KREATININ DI PENDERITA PENYAKIT GINJAL MENAHUN (KRONIK) Ismail, I.; ., Mutmainnah; ., Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 3 (2007)
Publisher : PERHIMPUNAN DOKTER SPESIALIS PATOLOGI KLINIK INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i3.910

Abstract

Chronically Kidney Disease (CKD) is still a health problem with a high incidence, complex aetiology, and often without complaintsor clinical symptoms except in the terminal stadium. To know the distribution of CKD according to age, sex group, aetiology, determiningstage of CKD based on creatinine clearance value, a retrospective study was conducted on 88 patients of CKD at Wahidin SudirohusodoPublic Hospital of Makassar from January to December 2004. The diagnosis of CKD was based on serum ureum value (ModifiedBarthelot), serum creatinine value (Jaffe) and creatinine clearance value (Cockroft Gault). Chronically Kidney Disease was found morefrequent in men 59.09% (52 of 88). The peak age prevalence was between 50 to less than < 60 years 29.55%. The eldest patient was 83years while the youngest was 16 years. The most fragment aetiology of CKD was hypertension 18.18% (16 of 88). Based on creatinineclearance values the medium group, severe group, and renal failure group were the age group respectively 3.41%, 19.32% and 77.27%.The prevalence of CKD is found more frequent in 50 less than 60 years of age. Hypertension seems to be the more predominant aetiology,and staging based on creatinine clearance value showed that most patients were in the renal failure group.
PROFIL LIPID PENDERITA DIABETES MELLITUS TIPE 2 P Josten, S; ., Mutmainnah; ., Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 1 (2006)
Publisher : PERHIMPUNAN DOKTER SPESIALIS PATOLOGI KLINIK INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i1.894

Abstract

Prevalence of type 2 diabetes mellitus (DM) tends to increasing worldwide. The main cause of death in type 2 DM is coronaryheart disease (CHD) and its mortality rate can increase 2 to 4 times compared to non-diabetics. One of the risk factors in CHD isdyslipidemia. To know the lipid profile based on age and gender and to assess the relation of total cholesterol, LDL, HDL, and TG levelto age. Descriptive retrospective study in patients with type 2 DM who are 45 years old and over. From 100 Type 2 DM patients, in theDepartment of Internal Medicine, Dr. Wahidin Sudirohusodo Hospital, Makassar, period of June to December 2005, the largest age groupwith dyslipidemia was > 59 years old, with increase LDL level, 32.73% in males and 46.67% in females. There was a significant relationbetween the in crease of TG (p = 0.03) and the decrease of HDL (p = 0.02) with age. Dyslipidemia in type 2 DM patients at age group> 59 years old was shown by an increase in LDL level. The increase of TG and decrease of HDL level were significant in all age groups.Restriction of this study was not to check the antilipidemic medicine used. Early dyslipidemia of Type 2 DM should be known by lipidfraction determination and further dyslipidemia study should be conducted to predict the risk of CHD.
NILAI TROPONIN T (cTnT) PENDERITA SINDROM KORONER AKUT (SKA) Nawawi, R A; ., Fitriani; Rusli, B; ., Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 3 (2006)
Publisher : PERHIMPUNAN DOKTER SPESIALIS PATOLOGI KLINIK INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i3.872

Abstract

Acute Coronary Syndrome (ACS) is an emergency cardiac condition manifested by chest pain or other symptoms as the result ofischemic myocardium. Myocardial damage can be detected by Creatine Kinase MB (CK-MB), Lactate Dehydrogenase (LDH) and cTnTtests. CTnT can be used as criteria of therapy determination. The combination of CK-MB and cTnT are the most effective tests if theearly myocardium damage is unknown, to evaluate cTnT, CK-MB, and LDH values in patients with Acute Coronary Syndrome (ACS) atWahidin Sudirohusodo Hospital, Makassar. Secondary data were collected from the medical records (from March to July 2005 period)at Wahidin Sudirohusodo Hospital, Makassar. Chi-square and Spearman correlation were carried out to analyze the collected data. Theinvestigators found 90 patients with ACS consisted of 57 males (63.33%) and 33 females (36.67%). The highest cTnT Value of 0.1 to2.0 ng/ml was found in 39 patients (43.33%), 30 females (52.63%). Significant correlation showed by Chi-square test between IMAEKG and cTnT values (p < 0.05). Spearman correlation test demonstrated significant correlation between cTnT value and CK-MB andLDH (p = 0.001). Most cTnT values were found in the male patients with ACS, aged 60 to 69 years and significantly correlated withIMA?s ECG, CK-MB and LDH.
NILAI SMALL DENSE LDL REMAJA DAN KAITANNYA DENGAN LIPID LAINNYA ., Nurahami; Aprianti, S; Arif, M.; ., Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 1 (2006)
Publisher : PERHIMPUNAN DOKTER SPESIALIS PATOLOGI KLINIK INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i1.892

Abstract

In Indonesia, coronary heart disease (CHD) as the cause of death is still the highest in number. It is estimated that the numberof deaths is about 535 per 100.000 population. Atherosclerosis represents the main risk factor which could be predicted through thepresence of small dense LDL (sdLDL) in youngsters. To determine the value of sdLDL in youngsters and its correlation with other lipids,a study was conducted cross sectionally in Makassar, from January to August 2006, on 125 youngsters aged 15 to 19 years. Their totalcholesterol, HDL, LDL, TG and ApoB was determined and sdLDL was derived from calculation of LDL/apoB ? 1.2. 69 (55.20%) patientsshowed sdLDL value and 56 (44.8%) patients did not show sdLDL value. Statistical calculation showed a significant correlation betweensdLDL and HDL level (p = 0.001), sdLDL and TG level (p = 0.003), and sdLDL and ApoB level (p = 0.036). Percentage of sdLDL valuewas higher in youngsters aged 15 to 19. This proves that the process of atherosclerosis happened early at a young age. Showed by theexistence of sdLDL and therefore sdLDL could be used as a predictor of atherosclerosis which can be prevented if detected earlier.
HUBUNGAN ANTARA KADAR HEMOGLOBIN DENGAN KADAR KREATININ SERUM PENDERITA PENYAKIT GINJAL MENAHUN (KRONIS) ., Rosnety,; Arif, M; ., Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 3 (2007)
Publisher : PERHIMPUNAN DOKTER SPESIALIS PATOLOGI KLINIK INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i3.908

Abstract

Chronically Kidney Disease (CKD) is the health problem of society worldwide, included Indonesia which its amount will increase.Clinical manifestation often following CKD is anaemia which will be severe with the increasing of serum creatinine values. To determinefrequent distribution of anaemia degree and assessing relationship between haemoglobin (Hb) and creatinine concentration in CKDpatients. Retrospective Descriptive Study in CKD patients with anaemia. In the period of May-September 2006, from 50 CKD patientsat the Department of Internal Medicine, Dr.Wahidin Sudirohusodo Hospital Makassar, 38 patients (76%) suffered severe anaemia(Hb < 8 g/dl). Mean value of Hb was 6,85 g/dl and serum creatinine concentration was 11.89 mg/dl. There was a significantrelationship between increasing of serum creatinine and decreasing of Hb (p = 0,013). Majority of CKD patients suffered from severeanaemia, there was relationship between increasing of serum creatinine and decreasing of Hb. To make routine blood tests and bloodsmears in CKD patients is needed, with large of samples to assess the relationship between Hb and serum creatinine.
EVALUASI AKTIVITAS TRANSAMINASE, DAN KADAR BILIRUBIN PADA PENDERITA VIRUS HEPATITIS B DAN C ., Yosepin; Rusli, Benny; ., Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : PERHIMPUNAN DOKTER SPESIALIS PATOLOGI KLINIK INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.996

Abstract

Hepatitis virus replicates only in hepatocyte. In hepatocyte injury, transaminase enzymes which normally intracellularly will transform to the blood circulation. And there are variation of increasing transaminase activities in HBV and HCV. To evaluatetransaminase activities, and bilirubin level in patients with HBV and HCV. Study design was cross sectional of 76 patients with HBVand HCV, data from medical record at Wahidin Sudirohusodo Hospital, Makassar, from January 2006 until July 2008 period. Datawas analyzed with Mann Whitney test using SPSS. windows versi on 12. of 76 patients with HBV and HCV were found 59 Men and 17women, age 15?72 years old. In there were no statistical significance between transaminase activites, bilirubin direct,indirect (p > 0.05),but there was significance difference of total bilirubin between HBV and HCV (p < 0.05). There were no statistical difference of AST,ALT, bilirubin direct and bilirubin indirect between HBV and HCV. Injury hepatocelluler because of HBV and HCV can not be identifiedjust by transaminase activities and bilirubin level, but there are other factor that influence.
GAMBARAN FUNGSI HATI DAN GINJAL PADA PENDERITA MALARIA ., Darmawaty; M, Fitriani; Pakasi, Ruland DN; ., Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 15, No 1 (2008)
Publisher : PERHIMPUNAN DOKTER SPESIALIS PATOLOGI KLINIK INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v15i1.950

Abstract

the prevalence of malaria disease is still high in Indonesia. It requires to be diagnosed and handled quickly to decrease themorbidity and the mortality. the purpose of this study was to evaluate the results liver and kidney function tests of malaria patients forcomplications and to know the etiology. A cross sectional method was used for this study by using medical record of malaria patientsthat at Wahidin Sudirohusodo hospital in Makassar during January to December 2006. Malaria was diagnosed based on pheripheralblood while the examination of Sgot, SgPt (DgKC method), ureum (Barthelots method) and creatinine (Jaffe's method) were doneby chemistry autoanalizer. the increasing concentration of Sgot was found on 14 patients (42.4%) which was consisted of high at 12patients, SgPt on 13 patients (39.4%), ureum on 2 patients (6.1%) and creatinine on 11 patients (33.3%). Plasmodium falciparum wasfound on 18 patients (54.5%) and Plasmodium vivax on 15 patients (45.5%). the Sgot, SgPt, ureum, and creatinine concentrationsmostly exist in normal range, this indicated that liver and kidney damage was still mild. the etiology of malaria disease was Plasmodiumfalciparum and Plasmodium vivax, it was found from examination of pheripheral blood. there was no significant different in this studyfor the increasing of Sgot, SgPt, ureum and creatinine concentrations based on plasmodium etiology.
POLA DAN SENSITIVITAS KUMAN DI PENDERITA INFEKSI SALURAN KEMIH ., Samirah; ., Darwati; ., Windarwati; ., Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 12, No 3 (2006)
Publisher : PERHIMPUNAN DOKTER SPESIALIS PATOLOGI KLINIK INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v12i3.869

Abstract

The bacterial and sensitivity pattern towards antimicrobials on urinary tract infections (UTI) patients are very important to beknown by clinicians to get a successful treatment. The bacterial and sensitivity pattern towards antimicrobials will be changed in differentplace and time, so that those should be analyzed routinely. To evaluate the bacterial and antimicrobials resistance pattern on urinarytract infections patients. A retrospective study on 220 urinary samples in January until December 2004 at Clinical Microbiology subunit of Dr.Wahidin Sudirohusodo hospital . Of 99 samples of UTI, Prevalence of UTI in woman (54.5%) were higher than man (45.5%).Most of sample (28 samples) were found in 0 to 15 years group. The most bacteries in urine were Escherichia coli (39.4%) and Klebsiella(26.3%). Amikacin was sensitive to all bacteries, while amoxicilin and ampicilin were resistance. Prevalence of UTI in women werehigher than in men. Incidens of UTI was highest in children group. The most bacteries in urine samples were Escherichia coli. Amikacinwas sensitive to all bacteries, while Amoxicilin and Ampicilin were resistance.
POLA KUMAN BERDASARKAN SPESIMEN DAN SENSITIVITAS TERHADAP ANTIMIKROBA ., Rostina; Rusli, B; Arief, M; ., Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 13, No 1 (2006)
Publisher : PERHIMPUNAN DOKTER SPESIALIS PATOLOGI KLINIK INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v13i1.890

Abstract

High prevalence of infectious diseases in Indonesia lead to the use of uncontrollable anti microbial treatment with less concern todrug resistance, marked with fewer requests for sensitivity testing. This leads to irrational anti microbial treatment and increasing drugresistance. With unsupported condition for using a sensitivity test prior to anti microbial treatment, a common guide for choosing ananti microbial agent for infection of specific organ system is needed. A descriptive study of retrospectively collected data of sensitivity testresults was done on 841 spesimens from sources of infected organs in Wahidin Sudirohusodo Hospital of Makassar during 2005?2006periods. Objectives of this study are to know the microbial pattern of specific organ infection (represented by microbes of the specimens),antimicrobial sensitivity pattern of the microorganisms, and whether there is shifting of the pattern within a 1 year period. Shiftingof microbial patterns during 2005?2006 period was found. Klebsiella aeroginosa, Enterobacter agglomerans, Alkaligenes faecalis andEscherichia coli were the most frequent micro organisms found from spesimens examined. Most of antimicrobial drugs commonlyused were found effective to most of micro organisms, while amikacin, cefepime, gentamycin, sulbactam, tobramycin, vancomycin andmeropene were still sensitive enough to the majority of the infectious agents.
CREATINE KINASE MYOCARDIAL BAND, MYELOPEROXIDASE, MATRIX METALLOPROTEINASE-9 DAN TROPONIN T PADA IMA Hutagalung, IA; Patellongi, I; Pakasi, R; Arif, M; Mappahya, AA; ., Hardjoeno
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 3 (2011)
Publisher : PERHIMPUNAN DOKTER SPESIALIS PATOLOGI KLINIK INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i3.1055

Abstract

In many patients presenting with chest pain symptoms at the emergency room, cardiac markers are measured not only to detect acutemyocardial infarction (AMI) but to exclude them too. Presently, the only biochemical markers used for diagnosis of MI are creatine kinasemyocardial band (CKMB) and troponin T (cTnT) as the markers of myocardial necrosis. Other biochemical markers have been sought tofind marker which can reflect the important, upstream processes in the pathophysiology of MI that therefore might give an earlier signalof ongoing MI. These markers are myeloperoxidase (MPO) and matrix metalloproteinase-9 (MMP-9) as markers of plaque destabilization.The aim of this study was to analyze the CKMB, MPO, MMP-9 activityies and troponin T level in MI. A cross sectional study had beendone at the Cardiovascular Centre Unit and Internal Ward of Dr. Wahidin Sudirohusodo Hospital during April up to August 2010 period.The laboratory tests were done at the Clinical Pathology Laboratory of Dr. Wahidin Sudirohusodo Hospital, Makassar and the Researchand Esoteric Unit of Prodia Clinical Laboratory, Jakarta. Ffifty-three patients with AMI had been examined. The results showed that themeans of CKMB, cTnT, MPO and MMP-9 were 52.4 U/L, 2.0 ng/mL, 217.9 ng/mL and 920.3 ng/mL, respectively. MMP-9 had positivelyvalue (69.8%) higher than cTnT (60.4%), MPO (58.5%) and CKMB (45.3%). Troponin T and MMP-9 were higher in patients with highCKMB. The higher level of CKMB will be the higher MPO, MMP-9 and cTnT. There were strong correlation between MPO and MMP-9, alsobetween CKMB and Troponin T. Troponin T and CKMB were lower in inferior wall infarction compared with anterolateral/anteroseptal wallinfarction. The most sensitive biochemical marker in patients with AMI is the MMP-9. The MMP-9 usage is suggested to assist the diagnosisof AMI. It is suggested a further study to establish the specificity of MMP-9 in all patients suffering with chest pain.