Muhammad Rizki Akbar, Muhammad Rizki
Unknown Affiliation

Published : 4 Documents
Articles

Found 4 Documents
Search

DIAGNOSIS DAN TATALAKSANA PNEUMONITIS HIPERSENSITIF Akbar, Muhammad Rizki; Sangging, Putu Ristyaning Ayu
Wellness And Healthy Magazine Vol 2, No 1 (2020): February
Publisher : Universitas Aisyah Pringsewu (UAP) Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (400.53 KB)

Abstract

Hypersensitive pneumonitis (HP), also known as extrinsic allergic alveolitis, is a complex pulmonary syndrome mediated by the immune system and caused by inhalation of various antigens that have previously been sensitized by the individual. The pathobiology of this disease is not fully understood, but in addition to the triggers that initiate the disease, genetic factors tend to be necessary, because only a small proportion of people are exposed to HP. Because of the lack of standard diagnostic standards, the diagnosis of HP is not directly established and depends on several factors, including the history of exposure, antibodies present in specific antigens, clinical features, bronchoalveolar lavage (LAB), and radiological and pathological features. However, in proper management, high suspicion is significant and can negate the need for more invasive tests. Clinical manifestations and allergic history vary greatly. Corticosteroids may be useful in acute episodes to relieve symptoms or chronic progressive disease, but their long-term effects have never been validated in prospective clinical trials. We conduct a systematic review of published journals about HP. The search uses the Pubmed database using the medical term (MeSH) until January 2020. A total of 13 journals and one textbook were identified.
HUBUNGAN KADAR LEPTIN SERUM DENGAN KOMPLEKSITAS LESI KORONER BERDASARKAN SKOR SYNTAX PADA PENDERITA PENYAKIT ARTERI KORONER STABIL Ashari, Fajar; Aprami, Toni Mustahsani; Akbar, Muhammad Rizki; Purnomowati, Augustine; Martha, Januar Wibawa; Achmad, Chaerul; Martanto, Erwan
Majalah Kedokteran Bandung Vol 48, No 1 (2016)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (165.975 KB) | DOI: 10.15395/mkb.v48n1.730

Abstract

Leptin memiliki peran penting dalam pembentukan plak ateroskleosis dengan mengaktifkan respons sel imun dan respons inflamasi ataupun peran langsung terhadap dinding pembuluh darah koroner. Penelitian terdahulu mengenai hubungan antara kadar leptin serum dan kompleksitas lesi koroner masih menunjukkan kontroversi. Penelitian ini bertujuan mengetahui hubungan antara kadar leptin serum dan kompleksitas lesi koroner berdasarkan skor SYNTAX pada penderita penyakit arteri koroner stabil. Metode penelitian berupa observasional, deskriptif, dan analisis korelasi dengan rancangan potong lintang. Subjek penelitian sebanyak 44 orang penderita penyakit arteri koroner (PAK) stabil yang memenuhi kriteria inklusi, menjalani pemeriksaan angiografi koroner di Rumah Sakit Dr. Hasan Sadikin Bandung selama bulan Januari?Mei 2014. Pengambilan sampel darah untuk pemeriksaan kadar leptin serum dilakukan sebelum tindakan angiografi. Kompleksitas lesi arteri koroner dinilai menggunakan skor SYNTAX. Hasil penelitian didapatkan subjek penelitian 84% laki-laki dengan usia rata-rata 54,68 (+10,24) tahun. Indeks massa tubuh rata-rata 24,71 (+ 3,05) kg/m2. Faktor risiko terbanyak adalah dislipidemia (84%), merokok (72%), hipertensi (38,4%), diabetes melitus (22,7%), dan obesitas (4,5%). Median kadar leptin serum 7.242 (780?36.929) pq/mL, nilai rata-rata skor SYNTAX sebesar 19,52 (+9,93). Analisis menggunakan uji korelasi rank-Spearman tidak didapatkan hubungan (p=0,61; r= 0,078). Perbedaan hasil penelitian ini dengan penelitian sebelumnya disebabkan oleh perbedaan subjek dan kriteria penilaian kompleksitas lesi arteri koroner. Simpulan, tidak terdapat hubungan antara kadar leptin serum dan kompleksitas lesi koroner berdasarkan skor SYNTAX pada penderita penyakit arteri koroner stabil. [MKB. 2016;48(1):26?31]Kata kunci: Kompleksitas lesi koroner, leptin serum, penyakit arteri koroner stabil, skor SYNTAXCorrelation between Serum Leptin Levels and Complexity of Coronary Artery Lesion based on SYNTAX Score in Patients with Stable Coronary Artery DiseaseAbstractLeptin has been shown to play a potential role in the atherosclerotic plaque formation by activating immune and inflammatory cells or directly acting on the vessel wall. Earlier reports of the correlation of serum leptin levels with the degree of coronary lesion stated are still controversial. This study determined the correlation between serum leptin levels and complexity of coronary artery lesion in patients with stable coronary artery disease (SCAD). This is an observational cross-sectional study. Data were collected from January to May 2014 in Dr. Hasan Sadikin Central General Hospital Bandung. Blood samples were collected before angiography procedures. The complexity of coronary artery lesion was assessed using SYNTAX score. There were 44 patients who met inclusion criteria, male 84%, median age 54.68 (+10.24) years. Mean body mass index 24.71 (+ 3.05) kg/m2. Dyslipidemia was the most common risk factor (84%), followed by smoking (72%), hypertension (38.4%), diabetes mellitus (22.7%), and obesity (4.5%). Median leptin level was 7,242 (780-36,929) pq/mL. Mean SYNTAX score was 19.52 (+9.93). Leptin level had no correlation with the complexity of coronary artery lesion (p=0.61, r=0.078). The difference between this study from prior studies might be caused by differences in subject selection and criteria used for complexity of coronary artery lesion. In conclusion, there is no correlation between serum leptin levels and complexity of coronary artery lesion in patients with stable coronary artery disease. [MKB. 2016;48(1):26?31]Key words: Complexity of coronary artery lesion, leptin, stable coronary artery disease, SYNTAX score
ASSOCIATION BETWEEN NEUTROPHIL-LYMPHOCYTE COUNT RATIO AND MATRIX METALLOPROTEINASE-9 IN PATIENTS WITH ACUTE MYOCARD INFARCTION Tiksnadi, Badai Bhatara; Akbar, Muhammad Rizki; Yahya, Achmad Fauzi; Hidayat, Syarief; Purnomowati, Augustine; Aprami, Toni Mustahsani
Majalah Kedokteran Bandung Vol 51, No 1 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (614.44 KB) | DOI: 10.15395/mkb.v51n1.1405

Abstract

The correlation between metalloproteinase-9 (MMP-9) level and neutrophil-lymphocyte count ratio (NLCR) in AMI patients has not been studied despite the fact that they are both known to predict ventricular remodeling. This study aimed to evaluate the correlation between the MMP-9 level and NLCR in patients with acute myocardial infarction. A cross-sectional study was conducted by recruiting acute coronary syndrome patients (onset within 24 hours) who were admitted to the emergency department in several hospitals around Bandung during October-December 2012. The relationship between the MMP-9 level and NLCR was analyzed using Pearson correlation test. Linear regression analysis was used to measure the strength of NLCR in MMP-9 level prediction. Thirty seven patients aged 55.8 + 11 years old were included in this study with mostly male patients (78%). Seventy-six percents of the sample were ST-elevation myocardial infarct (STEMI) patients with the onset of symptoms of 6 (3-14) hours. The mean lymphocyte-neutrophil ratio was 5.24 (1?±2.4) and the MMP-9 plasma concentration was 370 (240-530) ng/mL. One-sided Pearson correlation showed a positive correlation between the two variables (r=0.44, p=0.003). The linear regression analysis conceived the formula of MMP-9 = 40.87 (NLCR) + 211.3 which was used to show the relationship between the MMP-9 level and lymphocyte-neutrophil ratio. There was a positive moderate correlation between the MMP-9 level and NLCR in patients with AMI. Linear regression analysis shows that NLCR is the only independent variable to predict the MMP-9 plasma level.Key words: Acute myocardial infarct, left ventricular remodeling, matrix metalloproteinase (MMP)-9, neutrophyl-lymphocyte count Ratio (NLCR) Korelasi Rasio Neutrofil-Limfosit (NLCR) dengan Kadar Matriks Metaloproteinase-9 pada Penderita Infark Miokardium AkutKorelasi antara matriks metaloproteinase-9 (MMP-9) dan rasio netrofil-limfosit masih belum pernah dipelajari, meskipun kedua variable tersebut diketahui dapat memprediksi remodeling ventrikel kiri. Studi ini bertujuan mengevaluasi korelasi antara kadar MMP-9 dan rasio netrofil-limfosit pada penderita infark miokardium akut. Penelitian dilakukan secara potong lintang menggunakan sampel darah pasien dengan diagnosis kerja infark miokardium akut (IMA) (onset nyeri dada <24 jam) yang diambil dari beberapa rumah sakit di sekitar Kota Bandung dari periode Bulan Oktober?Desember 2012. Hubungan antara kadar MMP-9 dan rasio neutrofil leukosit dianalisis menggunakan uji korelasi Pearson. Analisis regresi linier digunakan untuk mengukur kekuatan pengaruh konsentrasi rasio neutrofil-limfosit pada kadar MMP-9. Sebanyak 37 pasien berusia 55,8 +11 tahun, dan 78% di antaranya adalah pria menjadi subjek dalam penelitian ini. Tujuh puluh enam persen sampel diantaranya merupakan pasien infark miokardium dengan elevasi ST dengan onset gejala 6 (3?14) jam.  Rerata rasio limfosit-neutrofil adalah 5,24 (1? ±2,4), dan kadar konsentrasi MMP-9 sebesar 370 (240?530) ng/ml. Uji Korelasi Pearson menunjukkan hubungan positif antara kedua variabel tersebut dengan nilai r=0,44 (p=0,003).  Dari analisis regresi linier didapatkan rumus MMP-9= 40,87 (NLCR) + 211,3, yang digunakan untuk menunjukkan hubungan antara kadar MMP-9 dan rasio limfosit-netrofil. Terdapat hubungan positif antara kadar MMP-9 dan rasio neutrofil-limfosit pada pasien penderita IMA. Analisis regresi linier menunjukkan bahwa hanya rasio neutrofil-limfosit yang menjadi variabel prediktor independen kadar MMP-9.Kata kunci: Infark neutrofil akut, matriks-metaloproteinase 9 (MMP-9), rasio limfosit-neutrofil, remodeling ventrikel kiri
INTERVENSI REHABILITASI JANTUNG FASE I PADA PASIEN YANG MENJALANI OPERASI BEDAH PINTAS KORONER (BPK): LITERATUR REVIEW Astuti, Indah Dwi; Akbar, Muhammad Rizki; Nuraeni, Aan
Jurnal Keperawatan Indonesia Vol 22, No 2 (2019): July
Publisher : Faculty of Nursing Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (33.28 KB) | DOI: 10.7454/jki.v22i2.886

Abstract

Pasien yang menjalani operasi Bedah Pintas Koroner (BPK) atau coronary artery bypass grafting (CABG) memiliki risiko terjadinya komplikasi pasca operasi yang berakibat pada hari rawat yang lama bahkan kematian. Intervensi berupa rehabilitasi jantung fase I diperlukan untuk membantu mempercepat proses pemulihan pasca operasi serta mencegah terjadinya komplikasi pasca operasi BPK. Meskipun penelitian terkait rehabilitasi jantung sudah banyak dilakukan, namun perlu dilakukan telaah lebih lanjut dari artikel penelitian mengenai intervensi yang dapat dilakukan dalam program rehabilitasi jantung yang aman dan mudah dilakukan pada pasien pasca operasi BPK. Tujuan penelitian ini adalah untuk melihat intervensi yang aman dan efektif dilakukan dalam rehabilitasi jantung fase I pada pasien yang menjalani operasi BPK. Studi literatur ini dibuat dengan melakukan analisis terhadap atikel-artikel ilmiah minimal penelitian retrospektif yang dipublikasi tahun 2008 sampai 2018 dan berbahasa Inggris. Data didapat dari database meliputi Google Scholar, PubMed, DOAJ, dan Proquest dengan kata kunci cardiac rehabilitation phase I, coronary artery bypass grafting, early ambulation, early mobilization, education pre operative, dan physical exercise.  Hasil studi literatur ini didapatkan 13 artikel yang sesuai dengan kriteria inklusi dan eksklusi. Hasil telaah ditemukan bahwa pelaksanaan rehabilitasi jantung fase I pada pasien yang menjalani operasi BPK dimulai dari fase praoperasi dan dilanjutkan pasca operasi sampai pasien akan pulang. Intervensi rehabilitasi jantung fase I, baik pre maupun pasca operasi, terdiri dari edukasi dan konseling, latihan/ aktivitas fisik, latihan bernapas, latihan batuk efektif, inspiratory muscle training, fisioterapi dada, dan respiratory muscle stretch gymnastics. Oleh karena itu, hasil telaah literatur ini dapat menjadi dasar dalam menentukan standar prosedur operasional terhadap pelaksanaan rehabilitasi jantung fase I untuk rumah sakit yang menyediakan pelayanan operasi BPK. Kata Kunci: ambulasi dini, coronary artery bypass grafting, mobilisasi dini, rehabilitasi jantung fase I Abstract Cardiac rehabilitation phase I in patient undergoing coronary artery bypass grafting surgery. A patient undergoing coronary artery bypass grafting CABG surgery has a risk of post operative complication, which can cause prolonged length of stay and even mortality. The patient necessarily needs to do intervention cardiac rehabilitation phase I to help the recovery process after surgery and prevent post operative complications. The articles related to cardiac rehabilitation have been carried out. However, it is necessary to review research articles about the effective and safe intervention of cardiac rehabilitation phase I for patients undergoing CABG surgery. The aim of this study was to explore the effective and safe intervention of cardiac rehabilitation phase I. This literature review was conducted by analyzing articles including randomized control trial until retrospective design which published between 2008 to 2018 with English language articles. Data was searched through Google Scholar, PubMed, DOAJ, and Proquest. The keyword was early ambulation, coronary artery bypass grafting, preoperative education, physical exercise, early mobilization, and cardiac rehabilitation phase I or inpatient cardiac rehabilitation. The finding in this literature review was 13 articles corresponding with the inclusion and exclusion criteria. The result of this study found that the intervention in cardiac rehabilitation phase I in patient who undergoing coronary artery bypass grafting surgery was started from preoperative and continued postoperative phases until the patient will leave the hospital. Interventions in cardiac rehabilitation phase I consisted of education and counseling, physical exercise/ activity, breathing exercises, effective cough exercises, inspiratory muscle training, chest physiotherapy, and respiratory muscle stretch gymnastics. Therefore, the result of this literature review can be the basis to determine standard operational procedure for the implementation of the cardiac rehabilitation phase I for the hospitals that provide CABG surgery.  Keywords: cardiac rehabilitation phase I, coronary artery bypass grafting, early ambulation, early mobilization