adawiah adawiah, adawiah
Departement of Chemistry Faculty Sciences and Technology Syarif Hidayatullah Islamic State University Jakarta

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KANDUNGAN FITOKIMIA DAN BIOAKTIVITAS EKSTRAK METANOL BIJI PALEM PUTRI (VEITCHIA MERILLII) adawiah, adawiah
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 2, No. 1, Mei 2016
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat Syarif Hidayatullah State Islamic Uni

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (277.505 KB) | DOI: 10.15408/jkv.v2i1.3076

Abstract

Palem putri (Veitchia merillii) is a kinds of Araceae plant which has been used by the community in cure myopic eyes and for woman who have pregnant. However, research on the content of secondary metabolites and bioactivity of palm putri has never been done. This study aims to determine the phytochemical content, total polyphenols and flavonoids and bioactivity include antioxidant activity DPPH free radical scavenging, antidiabetic method alpha-glucosidase enzyme inhibition and toxicity of the methods Bhrine Shrimp Lethal Test (BSLT). Palem putri contains secondary metabolites, alkaloids, flavonoids, terpenoids, polyphenols, phenolic hydroquinone and saponins. The methanol extract of palm putri seed has a total polyphenol content and total flavonoids respectively 642.8 mg gallic acid / gram sample extract and quercetin 543.3 mg / gram sample extract, has a very strong antioxidant activity with IC50 value of  0.82 ppm, the level of toxicity is very toxic with LC50 values ??of 11.535 ppm. As well as having antidiabetic activity using the enzyme alpha-glucosidase inhibition with IC50 values ??of 1.97 ppm is even higher than the activity of the compound quercetin as a positive control.  Keywords: Palem putri, bioactivity, antioxidant, antidiabetic, toxicity Palem putri (Veitchia merillii) is a kinds of Araceae plant which has been used by the community in cure myopic eyes and for woman who have pregnant. However, research on the content of secondary metabolites and bioactivity of palm putri has never been done. This study aims to determine the phytochemical content, total polyphenols and flavonoids and bioactivity include antioxidant activity DPPH free radical scavenging, antidiabetic method alpha-glucosidase enzyme inhibition and toxicity of the methods Bhrine Shrimp Lethal Test (BSLT). Palem putri contains secondary metabolites, alkaloids, flavonoids, terpenoids, polyphenols, phenolic hydroquinone and saponins. The methanol extract of palm putri seed has a total polyphenol content and total flavonoids respectively 642.8 mg gallic acid / gram sample extract and quercetin 543.3 mg / gram sample extract, has a very strong antioxidant activity with IC50 value of  0.82 ppm, the level of toxicity is very toxic with LC50 values ??of 11.535 ppm. As well as having antidiabetic activity using the enzyme alpha-glucosidase inhibition with IC50 values ??of 1.97 ppm is even higher than the activity of the compound quercetin as a positive control.   Keywords: Palem putri, bioactivity, antioxidant, antidiabetic, toxicity DOI: http://dx.doi.org/10.15408/jkv.v2i1.3076
INHIBITORY ACTIVITY OF HEP-2 CELLS BY HONEY FROM INDONESIA Sumarlin, La Ode; Muawanah, Anna; Afandi, Farhan Riza; Adawiah, Adawiah
Jurnal Kimia Sains dan Aplikasi Vol 22, No 6 (2019): Volume 22 Issue 6 Year 2019
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3698.421 KB) | DOI: 10.14710/jksa.22.6.317-325

Abstract

Indonesian local honey contains active compounds that have the potential as an antioxidant and anticancer, primarily as a laryngeal anticancer through the inhibition of HEp-2 cells. This study aims to determine the anticancer activity of several types of honey in Indonesia through the inhibition of HEp-2 cells. Samples used in the form of Trigona, Longan, Rambutan, and Kaliandra honey obtained from honey farmers in Sulawesi and Java, Indonesia. Honey samples extracted by using methanol, then liquids partition was carried out consecutively using n-hexane and ethyl acetate. The cytotoxicity test for HEp-2 cells was carried out using the MTT method (3- (4,5-dimethyl thiazol-2-il) -2,5-diphenyl tetrazolium bromide). The results showed that all honey samples were active against preventing HEp-2 cells with the highest inhibition activity from longan honey with ethyl acetate extract at 65.18% at 100 ppm. Longan honey has decreased HEp-2 cell inhibitory activity after fractionation. Indonesian local honey, namely trigona honey, kaliandra honey, rambutan honey, and longan honey, can be used as a supplementary supplement for patients with laryngeal cancer.
AKTIVITAS ANTIOKSIDAN DAN KANDUNGAN KOMPONEN BIOAKTIF SARI BUAH NAMNAM Adawiah, Adawiah; Sukandar, Dede; Muawanah, Anna
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 1, No. 2, November 2015
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat Syarif Hidayatullah State Islamic Uni

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (748.909 KB) | DOI: 10.15408/jkv.v0i0.3155

Abstract

Antioxidant is a compoud  inhibit that have an important role in protecting health due to it can absorb free radical molecules and inhibit oxidative reaction which cause anykinds of diseases. This study aims to determine the chemical compositition and antioxidant  activity of namnam juice, characteristic of namnam. In this experimental, proximat analysis, TPC, TFC, Vitamin C, antioxidant activity were evaluated. Namnam juice contains 996.03 mg/L of phenolics, 421.09 mg/Lof flavonoids, 121.44 mg/100mL of vitamin C and high antioxidant activity with IC50 5µL/mL.DOI :http://dx.doi.org/10.15408/jkv.v0i0.3155.
Aktivitas Antioksidan dari Batang Gandaria (Bouea macrophylla Griff) Rudiana, Tarso; Fitriyanti, Fitriyanti; Adawiah, Adawiah
EduChemia (Jurnal Kimia dan Pendidikan) Vol 3, No 2 (2018)
Publisher : Department of Chemical Education Faculty of Teacher Training and Education Universitas Su

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30870/educhemia.v3i2.3328

Abstract

Abstrak. Tumbuhan memiliki senyawa golongan metabolit sekunder yang dapat dimanfaatkan sebagai antioksidan. Gandaria (Bouea macrophylla Griff) merupakan salah satu tanaman asli Indonesia yang dapat dimanfaatkan sebagai sumber senyawa antioksidan. Penelitian ini bertujuan menentukan aktivitas antioksidan dari batang tumbuhan B. macrophylla melalui metode DPPH. Sampel batang B. macrophylla dibersihkan, dikeringkan, dan dihaluskan. Sampel halus batang B. macrophylla diekstraksi secara bertahap dengan pelarut n-heksana, etil asetat, dan metanol. Masing-masing ekstrak diuji total fenolik dan total flavonoidnya serta diuji aktivitas antioksidan dengan metode 2,2-diphenyl-1 picrylhydrazyl (DPPH) Free Radical Scavenger. Hasil pengujian menunjukkan ekstrak etil asetat memiliki aktivitas antioksidan paling baik yaitu sebesar IC50 4,89 μg/mL, dengan nilai total feolik dan flavonoid sebesar 22,62 mg GAE/g dan 32,28 mg kuersetin/g.
Characterization and antioxidant assay of yellow frangipani flower (Plumeria alba) extract Fathoni, Ahmad; Rudiana, Tarso; Adawiah, Adawiah
JURNAL PENDIDIKAN KIMIA Vol 11, No 1 (2019): April 2019
Publisher : JURNAL PENDIDIKAN KIMIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jpkim.v11i1.13034

Abstract

Yellow frangipani flowers (Plumeria alba) are plants that commonly found in the tropics, including Indonesia. Frangipani utilization has not optimum and research about it has not many conducted. This study aims to characterize and test the antioxidant activity of frangipani flower extract. The extraction conducted by maceration method using n-hexane, ethyl acetate, and methanol as solvents. Characterization includes phytochemicals assay (alkaloids, flavonoids, terpenoids, phenolic hydroquinone, tannin-polyphenols, and saponins), total phenolic assay, and total flavonoid assay. Antioxidant test using DPPH radical scavenging assay. The results of the characterization showed that frangipani flower extract positively contained alkaloid, flavonoids, tannins compounds in all solvent phases. Terpenoids are positive in n-hexane and ethyl acetate extract, while saponins are positive in methanol extract. The total phenolic content of n-hexane, ethyl acetate, and methanol extract were 3.6 mgGAE/g; 27.74 mgGAE/g; and 35.23 mgGAE/g. The total flavonoid content of n-hexane, ethyl acetate, and methanol extract were respectively 0.8 mgQE/g; 12.18 mgQE/g; 19.9 mgQE/g. The strongest antioxidant activity is possessed by ethyl extract, followed by methanol extract, and the last are n-hexane extract.Keywords:Antioxidant; frangipani flower; phytochemical; total phenolic; total flavonoid
GENOTYPIC SELECTION ON RED CHILI PLANTS RESISTANT TO ANTHRACNOSE DISEASE AT M2 GENERATION Sa'diyah, Nyimas; Adawiah, Adawiah; Prasojo, Ibnu; Rugayah, Rugayah; Ratih Dirmawati, Suskandini
JURNAL HAMA DAN PENYAKIT TUMBUHAN TROPIKA Vol 18, No 2 (2018): SEPTEMBER, JURNAL HAMA DAN PENYAKIT TUMBUHAN TROPIKA
Publisher : Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (277.843 KB) | DOI: 10.23960/j.hptt.218151-159

Abstract

Genotypic selection on red chili palnts resistant to anthracnose disease at m2 generation. A superior anthracnose resistant cultivar was sought to overcome the low production due to anthracnose in red chili. For the development of superior cultivars, it was necessary to select genotypes that were resistant to anthracnose. Selection effectiveness was determined by wide diversity and high reliability. The purpose of this study was to see the diversity and heritability of agronomic characters and resistance to anthracnose on chili plants, and to select genotypes that were resistant to anthracnose. This research was conducted with a design without repetition. The plant material used was the seed of the results of gamma ray mutations in generation M2. The results of this study were: the broad diversity of phenotypes found in all characters observed, while all characters of the genotype observed had broad criteria except plant height at flowering and harvest, and at seedling period. The genotype that should be planted in the next generation was genotype number 136. Genotype number 136 was very resistant to anthracnose infection.