Istriati Istriati, Istriati
Lab. embriologi dan Fisiologi Fak. Biologi UGM

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Existence of Antibiotics in Stalls at Jatiroke Village, Jatinangor Sub District Jaelani, Elan; Istriati, Istriati; Sunjaya, Deni Kurniadi
Althea Medical Journal Vol 3, No 2 (2016)
Publisher : Althea Medical Journal

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Background: Improper use of antibiotics can lead to lack of drug efficacy against bacteria, and cause resistance to the antibiotics itself. Antibiotics are classified into prescription drugs that should not be available over the counter because of its dangerous effect. It is important to study the presence of antibiotics in traditional stalls. Objective of this study was to investigate existence of antibiotics in stalls, and to investigate reasons of stall- owners for selling antibiotics.Methods: This study used mixed method design, and sequential explanatory approach, and conducted direct observation, spatial mapping, and interview with stall-owners selling drugs in Jatiroke village, Jatinangor sub district from September to November 2013. Total sampling was conducted in this study.Results: Fifty percent from 24 surveyed stalls sold Antibiotics Amoxicillin. The map showed stalls selling antibiotics at roadside. Amoxicillin sold package with Dexamethasone and Non-Steroid Anti Inflammatory Drugs (NSAID) was soldby several stalls. Shopkeepers sold antibiotics due to lack of knowledge about thedrug, need for self-medication, demand, and availability of drugs supply.Conclusions: Antibiotics can be found in several stalls in Jatiroke village, and improper of use of this drug can lead to resistance and less efficacy for treating infections. Although the Act for prescription drugs still exists, low of monitoring and enforcement the regulation by the Badan Pengawas Obat dan Makanan (BPOM) may be one of many factors that influence the existence of antibiotics in the stalls. [AMJ.2016;3(2):239–43]DOI: 10.15850/amj.v3n2.779
Analisis Pertumbuhan Kartilago Epifisialis Os Tibia Fetus Mencit (Mus musculus L.) Swiss Webster Setelah Induksi Ochratoxin A Selama Periode Organogenesis Setiawan, Arum; Sagi, Mammed; Ismara, Widya; Istriati, Istriati
JURNAL BIOLOGI PAPUA Vol 4, No 1 (2012)
Publisher : JURNAL BIOLOGI PAPUA

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The aims of this study were determined the effects of Ochratoxin A (OTA) on growth of fetus tibia epiphyseal cartilage during organogenesis period. Twenty four pregnant mice were divided randomly into 4 groups of 6. Ochratoxin A was dissolved in sodium bicarbonateand administered orally on seventh to fourteenth days of gestation at dosage of 0.5, 1.0, 1.5 mg/kg bw, respectively. The remaining were used as control. The fetal tibia was taken after the 18 th day of pregnancy. The growth of tibia epiphyseal cartilages were observed histologically using Erlich’s Haematoxylin-Eosin Stain. The result of this study indicated that OTA caused decreased thickness of the rest zone, proliferative zone, maturation zone and calsification zone of the fetus tibial growth plate significantly. Key words: Ochratoxin A, tibia, cartilage, and thickness.
Coverage of Vitamin A Supplementation among Under-Five Children in Hegarmanah Village, Jatinangor in August 2014 Putri, Nadia Asmarani Hidayat; Istriati, Istriati; Djais, Julistio T.B.
Althea Medical Journal Vol 4, No 2 (2017)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (208.48 KB) | DOI: 10.15850/amj.v4n2.1079

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Background: The vitamin A supplementation program conducted every February and August  aims to reduce children morbidity and mortality. Mother’s knowledge on the importance of vitamin A is crucial to succeeding this program. This study aimed to examine the coverage of the program among under-five children and the mother’s knowledge about vitamin A supplementation in Hegarmanah Village, Jatinangor in August 2014.Methods: This was a descriptive cross-sectional study involving mothers of children aged 6−59 months in eight RWs in Hegarmanah Village. The mothers were interviewed to find out whether their children received vitamin A supplementation. Additional questionnaire-based data about mother’s knowledge on vitamin A was also collected. The subjects in this study were the mothers of 220 under-five children. Data collection was obtained by direct interviews with the mothers during their visit to the Puskesmas or during home visits to  children who missed the Posyandu appointments.Results: Two hundred and fourteen (97.27%) children received vitamin A supplementation and only 6 (2.73%) did not. The questionnaires revealed that 94 children (96%) received vitamin A, while 4 (4%) did not. The mother’s level of knowledge in vitamin A was either poor (1%), moderate (37%), or good (62%).Conclusions: The coverage of vitamin A supplementation in Hegarmanah Village reaches 97.27% and the mother’s understanding about vitamin A is generally good. DOI: 10.15850/amj.v4n2.1079
Knowledge and Attitude towards Antibiotic Use among College Students in Jatinangor Fimanggara, Brama; Istriati, Istriati; Diposarosa, Rizki
Althea Medical Journal Vol 3, No 2 (2016)
Publisher : Althea Medical Journal

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Background: Lack of knowledge about antibiotics cause people to have a misconception about the use of antibiotics. This may potentially lead to inappropriate use of antibiotics in the community, which is themajor reason for the spread of antibiotic resistance. This study aimed to assess knowledge and attitudes toward antibiotic usage among non-medical students in Jatinangor.Methods: This study used a cross-sectional, questionnaire based survey conducted among non-medical college students in Jatinangor, sub-district of Sumedang regency, from September to October 2013. Samples were selected using convenience sampling method, with a total number of 250 samples.Results: More than half of the respondents (56.4%) had a poor knowledge regarding antibiotic use. Respondents who knew that antibiotics was indicated to treat bacterial infections reached 75.2%, although 58.4% of respondents still believed that antibiotics could be used in viral infection. In terms of antibioticresistance, 72% of respondents were aware that overused of antibiotics could cause antibiotic resistance. In addition, respondents were generally found to have more positive attitudes toward antibiotics with results over 50%, whereas more than one-third of the respondents wrongly self-medicated themselves withantibiotics.Conclusions: This study reveals that most of the respondents have poor knowledge regarding antibiotics. Almost half of the respondents have a negative attitude regarding the use of antibiotics. Educational interventions are needed to promote prudent use of antibiotics among the college students.[AMJ.2016;3(2):269–74]DOI: 10.15850/amj.v3n2.792
Relationship between Socioeconomic Demographic Characteristics with Antibiotic Self-Medication in Community Dwelling Adults Aditya, Michael; Istriati, Istriati; Cahyani, Aih
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Althea Medical Journal

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Background: Infectious diseases escalation in developing countries especially in Indonesia lead to increasing  use of antibiotics in the community. Self-medication with antibiotics may increase the risk of resistant bacteria and irrational use of antibiotics. This study was conducted to determine the relationship between socioeconomic -demographic characteristics with antibiotic self-medication. Methods: An analytical cross sectional study was conducted on people from Sayang Village in West Java Indonesia  aged over 18 years and had experience in using antibiotics. A total of 146 respondents were selected as the sample of this study. A validated questionnaire was used to collect data. Data were analysed by using descriptive statistics and Chi-Square test to analyze the relationship between socioeconomic demographic characteristics with antibiotic self-medication.Results: Out of 146 questionnaires that were completed, 111 were female and 35 male respondents, 75 respondents had experience in using antibiotics without prescription. The survey showed significant relation between antibiotics use with monthly income (p=0,031) and source of income (p=0,009).Conclusions: The study confirms that there is relation between monthly income and source of income with antibiotic self-medication. [AMJ.2017;4(1):73–7]DOI: 10.15850/amj.v4n1.1023
Solanum muricatum Aiton Juice as A Hepatoprotective Agent in Wistar Rats Induced With Carbon Tetrachloride Yang, Justine Sim Wei; Istriati, Istriati; Rostini, Tiene
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Althea Medical Journal

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Background: Liver participates in various metabolic processes in human body. Exposures to toxins such as carbon tetrachloride (CCl4) results in hepatocyte destruction and release the cell contents. Enzymes such as serum glutamic pyruvic transaminase (SGPT) were used as a parameter to diagnose liver damage. Pepino (Solanum muricatum Aiton) contains antioxidants that protect liver from hepatoxicity. The aim of this experiment is to determine the effect of pepino in protecting the hepatocyte from hepatotoxic effect of CCl4.Methods: A total of 16 Wistar rats used as the subject were divided into Control and Therapeutic Group. The Control group was induced with CCl4 but was not given pepino juice. Meanwhile, the Therapeutic Group was given pepino juice for 10 days. For induction of hepatotoxicity, CCl4 10% was given at a dosage of 2.0 ml/kg intra-peritoneal. Each Wistar rat in Therapeutic Group was given 1.0 ml of 300 g/ml pepino juice via oral feeding. Spectrophotometer with adjusted wavelength of 340 nm was used to measure SGPT level of the Wistar rats and statistical T-test was used to analyze the data.Results: Wistar rats in Therapeutic group showed a larger decrease (6898.9 IU/L–79.1 IU/L) in SGPT level compared to the Control group (6469.8 IU/L–418.5 IU/L). The SGPT level of the Wistar rat in Therapeutic group reached normal baseline (50 IU/L–150 IU/L). The significance of the experiment was supported by the T-test, P-value <0.05Discussion: Pepino juice had antioxidants that protect the hepatocyte of Wistar rats from free radicals. The synergistic action of antioxidants and hepatocyte regeneration of Wistar rats in Therapeutic group caused a decrease in SGPT level. Therefore, the experiment concluded that pepino juice at the dosage of 300 g/ml has hepatoprotective effect.Key words: Carbon tetrachloride, hepatotoxicity, Pepino, Solanum muricatum Aiton, SGPT DOI: 10.15850/amj.v2n4.484
Relationship between Menstrual Profile and Psychological Stress with Dysmenorrhea Maryam, Maryam; Ritonga, Mulyanusa Amarullah; Istriati, Istriati
Althea Medical Journal Vol 3, No 3 (2016)
Publisher : Althea Medical Journal

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Background: Dysmenorrhea or menstrual cramps is the most common menstrual complaint among reproductive women in developing countries. The prevalence of dysmenorrhea is ranged from 19–91%. Many studies showed that factors associated with dysmenorrhea include a younger age, nulliparity, family history of dysmenorrhea, prolonged menstrual duration, high menstrual flow, psychological factors, and lifestyle. The objective of this study was to compare female medical students with dysmenorrhea and without dysmenorrhea regarding menstrual profile and psychological stress, also to examine the relationship between psychological stress and dysmenorrhea specifically..Methods: This cross-sectional study was conducted among 136 fourth year female medical students of Universitas Padjadjaran. It used a structured, self-assessment, validated, and reliable questionnaire, such as Wong Baker Faces® Pain Rating Scale in combination with Numeric Scale Pain, and Depression, Anxiety, Stress Scale (DASS-42). Then, the descriptive data analysis and chi-square hypothesis test were used to explore the relationship between the severity of psychological stress and the presence or severity of dysmenorrhea.Results: Family history of dysmenorrhea had a strongest relationship with dysmenorrhea. Nevertheless, there was no statistically significant interaction between the severity of stress and the presence of last menstrual cramps (p 0.745, Odd Ratio 1.15, 95% Confidence Interval 0.5–2.66). However, a positive relationship between the severity of stress and dysmenorrhea in last menstruation was found in this study (p 0.033, Odd Ratio 3.69, 95% Confidence Interval 1.06–12.8).Conclusions: The severity of stress and dysmenorrhea in last menstruation is related among the subjects with dysmenorrhea. [AMJ.2016;3(3):382–7]DOI: 10.15850/amj.v3n3.884 
COMPARISON OF TRUWINIST INTERDIGITAL METHOD AND CONVENTIONAL IN LEARNING APPROPRIATE DRUG SELECTION AND PRESCRIBING FOR TYPE 2 DIABETES MELLITUS Sitorus, Trully Deti Rose; Kuswinarti, Kuswinarti; Istriati, Istriati
Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Vol 7, No 3 (2018): November 2018
Publisher : Asosiasi Institusi Pendidikan Kedokteran Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (227.74 KB) | DOI: 10.22146/jpki.41841

Abstract

Background: Medical education in Indonesia has been using Problem Based Learning curriculum. Meanwhile, the patient management ability evaluation showed the lowest result among all evaluation in Ujian Kompentensi Mahasiswa Program Pendidikan Dokter (UKMPPD).  Truwinis Interdigital Method (TIM) has been developed to improve student ability in choosing the appropriate drug and prescribing for Diabetes Mellitus type 2. The purpose of this research is to compare the effectiveness of TIM toward Conventional Method (CM).Methods: This research used cross-sectional design. The subject is 82 student who attend Clinical Skill Laboratory of Endocrine and Metabolism System of Faculty Medicine of Universitas Padjadjaran. The subject is divided into two groups, Group I: CM (control), Group II:  TIM (Intervention). TIM consist of e-learning and audiovisual material. Parameters in this research were ability of choosing appropriate drugs test and Objective Skill Clinical Examination (OSCE). The data is analyzed statistically. Results: The data showed   homogenousity in both groups (p>0,05). The average test score for CM group was 25,11 ± 10,84 and for TIM group was 80,06 ± 14,19. This was statistically significant (p < 0,0001). The average   test score of OSCE for CM group was 39,63   11,73 and for TIM group was 62,74 ±14 ,07. This was also statistically significant (p<0,0001).Conclusion: Truwinist Interdigital Method is more effective than the Conventional Method in learning appropriate drugs selection and prescribing for type 2 Diabetes Mellitus.
Knowledge and Attitude towards Antibiotic Use among College Students in Jatinangor Fimanggara, Brama; Istriati, Istriati; Diposarosa, Rizki
Althea Medical Journal Vol 3, No 2 (2016)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (129.023 KB)

Abstract

Background: Lack of knowledge about antibiotics cause people to have a misconception about the use of antibiotics. This may potentially lead to inappropriate use of antibiotics in the community, which is themajor reason for the spread of antibiotic resistance. This study aimed to assess knowledge and attitudes toward antibiotic usage among non-medical students in Jatinangor.Methods: This study used a cross-sectional, questionnaire based survey conducted among non-medical college students in Jatinangor, sub-district of Sumedang regency, from September to October 2013. Samples were selected using convenience sampling method, with a total number of 250 samples.Results: More than half of the respondents (56.4%) had a poor knowledge regarding antibiotic use. Respondents who knew that antibiotics was indicated to treat bacterial infections reached 75.2%, although 58.4% of respondents still believed that antibiotics could be used in viral infection. In terms of antibioticresistance, 72% of respondents were aware that overused of antibiotics could cause antibiotic resistance. In addition, respondents were generally found to have more positive attitudes toward antibiotics with results over 50%, whereas more than one-third of the respondents wrongly self-medicated themselves withantibiotics.Conclusions: This study reveals that most of the respondents have poor knowledge regarding antibiotics. Almost half of the respondents have a negative attitude regarding the use of antibiotics. Educational interventions are needed to promote prudent use of antibiotics among the college students.[AMJ.2016;3(2):269–74]DOI: 10.15850/amj.v3n2.792
Relationship between Socioeconomic Demographic Characteristics with Antibiotic Self-Medication in Community Dwelling Adults Aditya, Michael; Istriati, Istriati; Cahyani, Aih
Althea Medical Journal Vol 4, No 1 (2017)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (540.836 KB)

Abstract

Background: Infectious diseases escalation in developing countries especially in Indonesia lead to increasing  use of antibiotics in the community. Self-medication with antibiotics may increase the risk of resistant bacteria and irrational use of antibiotics. This study was conducted to determine the relationship between socioeconomic -demographic characteristics with antibiotic self-medication. Methods: An analytical cross sectional study was conducted on people from Sayang Village in West Java Indonesia  aged over 18 years and had experience in using antibiotics. A total of 146 respondents were selected as the sample of this study. A validated questionnaire was used to collect data. Data were analysed by using descriptive statistics and Chi-Square test to analyze the relationship between socioeconomic demographic characteristics with antibiotic self-medication.Results: Out of 146 questionnaires that were completed, 111 were female and 35 male respondents, 75 respondents had experience in using antibiotics without prescription. The survey showed significant relation between antibiotics use with monthly income (p=0,031) and source of income (p=0,009).Conclusions: The study confirms that there is relation between monthly income and source of income with antibiotic self-medication. [AMJ.2017;4(1):73–7]DOI: 10.15850/amj.v4n1.1023