Hening Tuti Hendarti, Hening Tuti
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TATALAKSANA STOMATITIS ALERGICA PADA PENDERITA YANG MENGALAMI STRESS (MANAGEMENT OF ALLERGIC STOMATITISIN PATIENT WITH STRESS) Ganesha, Raziv; E, Diah Savitri; Hendarti, Hening Tuti
ODONTO : Dental Journal Vol 6, No 2 (2019): December 2019
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.6.2.134-140

Abstract

Introduction: Allergic stomatitisis ahypersensitivity reaction caused by allergens, such as drugs, food, and dental materials. Manifestation allergic reaction to food in oral cavity can be recurrent ulcer. Purpose: This case report pupose to report management allergic stomatitis in Stress condition.Case: female was a 44-year-old with complaintmany stomatitis in oral cavity. Patients say often since ± 6 years ago without knowing the cause. Stomatitis often moving location but also in the same site. On intra oral examination found ulcer multiple, variant size, irregular shape, paintfull.Management: the patient performed examination of total IgE with a result of 642.98 (normal<150), skin prick test in patients results positive on dust house, dog hair, cotton, beef, cow's milk, chicken egg yolk, shrimp, milkfish, pindang, chocolate, and peanuts.Patients given aloe vera extract oral rinse at the first visit, then after skin prick test was given methylprednisolone, hepaprotector caplet, multivitamin B-Complex plus Zinc. Patients are also given education and instruction to avoid a food become allergic. Conclusion: Allergic Stomatitis diagnosis requires a complete history and supportive examination. In this case, the treatment requires good cooperation between the patient and the dentist so that treatment can be done thoroughly.
CORRELATION OF KI67 EXPRESSION TO DEGREE OF DYSPLASIA IN LINGUAL EPITHELIAL DYSPLASIA IN RATTUS NORVEGICUS EXPOSURED BY CIGARETTE SMOKE (HUBUNGAN EKSPRESI KI67 TERHADAP DERAJAT DISPLASIA PADA EPITEL MUKOSA LIDAH RATTUS NORVEGICUS YANG DIPAPAR ASAP ROKOK) Sari, Rina Kartika; Hendarti, Hening Tuti; Soebadi, Bagus; Hadi, Priyo; Radithia, Desiana; P, Adiastuti Endah
ODONTO : Dental Journal Vol 6, No 2 (2019): December 2019
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.6.2.76-87

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Background: Dysplasia is malignant transformation of stratified squamous epithelium characterized by cellular atypia and loss of stratification and maturation. It can caused by cigarette smoke. Measuring the activity of cell proliferation as the beginning of dysplasia is very useful to know the development of malignancy. One of proliferation marker is Ki67 that expressed in all cell cycle phase except G0.Methods: 30 male wistar rats divided into: control grup (n=10), exposed to cigarette smoke for 4 weeks (n=10), 8 weeks (n=10) as much as 20 cigarettes/group/day/exposure used smoking pump. Specimen were stained HE to see dysplasia and Ki67 expression seen immunohistochemically. Statistical analyzed by Spearman correlation.Result: There was an increase in mean of Ki67 expression and significant differences between groups (p=0,000) and also significant difference of degree of dysplasia between groups (p=0,000). There was a strong correlation between Ki67 score to degree of dysplasia (p=0.001).Conclusion: Increased of Ki67 expression proportional to the Increase in degrees of dysplasia
Sensitivity difference of Streptococcus viridans on 35% Piper betle linn extract and 10% povidone iodine towards recurrent apthous stomatitis Apriasari, Maharani Laillyza; Soebadi, Bagus; Hendarti, Hening Tuti
Dental Journal (Majalah Kedokteran Gigi) Vol 44, No 3 (2011): (September 2011)
Publisher : Faculty of Dental Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (539.967 KB) | DOI: 10.20473/j.djmkg.v44.i3.p159-163

Abstract

Background: Oral ulceration often becomes the main reason for the patients to see a dentist. Therapy of the oral ulceration is by giving the palliative therapy with topical antiseptic. Nowadays, there are many researches concerning with the traditional medicines as alternative therapy. One of them is Piper betle linn which contains the antiseptic agent. Purpose: This research is aimed to observe the sensitivity difference of Streptococcus viridans on 35% Piper betle linn extract and 10%povidone iodine. Methods: This laboratory research was conducted by the post test only design with random complete design. The research sampel is Streptococcus viridans culture that was scrapped from the ulcer of the recurrent aphthous stomatitis patient, then it was replicated by using the Federer theory. Results: Inhibitory zone of 35% Piper betle linn extract is bigger than 10% povidone iodine. Conclusion: Streptococcus viridans are more sensitive to 35% Piper bittle linn extract than 10% povidone iodine. 35% Piper betle linn extract has more antibacterial effect than 10% povidone iodine.Latar belakang: Ulserasi rongga mulut seringkali menjadi alasan utama bagi pasien untuk memeriksakan diri ke dokter gigi. Terapi ulserasi rongga mulut adalah pemberian terapi paliatif kepada penderita, seperti: pemberian obat topikal yang mengandung antiseptik. Saat ini banyak penelitian dalam pengembangan obat tradisional yang dapat dijadikan sebagai obat alternatif. Salah satu diantaranya adalah daun sirih yang mengandung zat antiseptik. Tujuan: Penelitian ini bertujuan mengetahui perbedaan sensitivitas Streptococcus viridans terhadap ekstrak daun sirih 35% jika dibandingkan dengan povidone iodine 10%. Metode: Penelitian laboratoris yang dilakukan dengan post test only design dengan rancangan acak lengkap. Sampel penelitian adalah kultur Streptococcus viridans yang diambil melalui swab dari hapusan ulser pada pasien yang menderita stomatitis aftosa rekuren, kemudian dilakukan replikasi dengan rumus Federer. Hasil: Zona hambat ekstrak daun sirih 35% lebih besar daripada zona hambat povidone iodine 10%. Kesimpulan: Streptococcus viridans lebih sensitif terhadap ekstrak daun sirih 35%. Ekstrak daun sirih 35% memiliki efek daya antibakteri yang lebih tinggi jika dibandingkan dengan povidone iodine 10%.
Effects of citrus limon essential oil (Citrus limon L.) on cytomorphometric changes of Candida albicans Prabajati, Rina; Hernawan, Iwan; Hendarti, Hening Tuti
Dental Journal (Majalah Kedokteran Gigi) Vol 50, No 1 (2017): (March 2017)
Publisher : Faculty of Dental Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (848.512 KB) | DOI: 10.20473/j.djmkg.v50.i1.p43-48

Abstract

Background: The most common fungal infection found in oral cavity is oral candidiasis, largely caused by Candida species, particularly Candida albicans (C. albicans). Candida infection can get worse since it is difficult to be treated and resistant with antifungal drugs. Therefore, new drugs and compounds as well as alternative therapies involving natural sources that have antifungal activities have continually been developed. Limonene, β-pinene, and ɣ-terpinene contained in Citrus limon essential oil have been known to have quite good antifungal activities against C. albicans. Purpose: This research aimed to examine and analyze the effects of Citrus limon essential oil on cytomorphometric changes of C. albicans. Method: The research used post test only control group design. Based on the results of the pre-elementary research on antifungal activities of Citrus limon essential oil against C. albicans, Citrus limon essential oil used in this research was on concentrations of 1.56%, 1.37%, 1.17%, 0.98%, and 0.78%. Citrus limon essential oil by C. albicans inoculum and incubated for 24 hours and 48 hours. After the incubation, those C. albicans cells were fixed, dried, and then observed using a scanning electron microscopy. Result: The most effective concentrations of Citrus limon essential oil triggering cytomorphometric changes of Candida albicans were at 1.37% and 1.56% with the incubation period of 48 hours. Conclusion: C. albicans can undergo necrosis process through cytomorphometric changes after the administration of Citrus limon essential oil at concentrations of 1.56% and 1.37% with the incubation period of 48 hours.
Managementof squamos cell carcinoma of tongue in young men: case report Israyani, Israyani; Argadianti, Ayu F.; Hendarti, Hening Tuti; P, Adiastuti E.
Journal of Case Reports in Dental Medicine Vol 1, No 1 (2019)
Publisher : Journal of Case Reports in Dental Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1654.443 KB)

Abstract

Background: Oral Squamous cell carcinoma is the most common malignant neoplasm of the oral cavity, usually affecting individuals over 50 years of age. It rarely occurs in patients who are less than 40 years old. Purpose: This case report aim is to focuses on establishment of diagnosis, differential diagnosis, predisposition, and treatment planning related to the case. Case: This report describes a case of oral squamous cell carcinoma, staged T1N1M0 (stage III), involving the lateral border and ventral surface of the tongue of a 32-year old male patient, with no smoking or drinking habits. Initial tumor presentation was of deep ulceration and intense pain. Case Management: Patient has examination with autofluorence LED light, presence of bacterial growth, and FNA for establised diagnosis. Patient was given chlorine dioxide mouthwash and education for further treatment one of them is tomoterapi. Conclusions: Clinical features of deep ulceration, pain and induration may be a suspicious feature of oral cavity cancer, therefore early diagnosis of oral squamous cell carcinoma determines prognosis.Keywords: malignant, autofluoresence, tomoterap
EFFECTS OF SIDESTREAM TOBACCO SMOKE ON P53 EXPRESSIONS IN RATTUS NOVERGICUS TONGUE EPITHELIAL MUCOSA Angriany, Dian; Ernawati, Diah Savitri; Parmadiati, Adiastuti Endah; Hendarti, Hening Tuti; Zain, Rosnah Binti
Dental Journal (Majalah Kedokteran Gigi) Vol 52, No 3 (2019): (September 2019)
Publisher : Faculty of Dental Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v52.i3.p138-141

Abstract

Background: Smoking, both active and passive, has been widely recognised as toxic to the human body, since it induces several forms of cancer, including that affecting the oral cavity. Benzopyrene, the carcinogen contained in tobacco smoke, can even lead tocarcinogenesis which potentially affects the regulation of cell apoptosis in both active and passive smokers. Purpose: This study aims to investigate the carcinogenic effects of cigarette smoke on apoptosis of rat tongue mucosae through p53 expression. To determine the risk of malignant transformation through tumor suppressor genes in the apoptotic pathway. Methods: Rattus norvegicus subjects were divided into four groups, namely Treatment Group 1 exposed to sidestream cigarette smoke for four weeks (P1), Treatment Group 2 exposed to sidestream cigarette smoke for eight weeks (P2), Control Group not exposed to sidestream cigarette smoke for four weeks (K2), and Control Group (K) not exposed to sidestream cigarette smoke for eight weeks (K2). The exposure process was conducted using a smoking pump and alternating exposure. Four micron-thick sections of formalin were subsequently fixed together with paraffin embedded biopsy material from tongue mucosa of Rattus norvegicus. The tissue sections from the treatment groups were then analyzed immunohistochemically to compare the expressions of p53 and Bcl-2 proteins with those of the control groups. Results: The T-test results indicated statistically significant differences in the expressions of p53 between the 4-week control group (K1) and the 4-week treatment group (P1) (p=0.01, p<0.05) as well as between the 8-week control group (K2) and the 8-week treatment group (P2) (p=0.03, p<0.05). Conclusion: Exposure to cigarette smoke can induce changes in tumor suppressor genes and also affect the regulation of cell apoptosis, thus changing cell structure and leading to malignancy.
RECCURENT TRAUMA-INDUCED APHTHOUS STOMATITIS IN ADJUSTMENT DISORDER PATIENTS Yuliana, Y.; Winias, Saka; Hendarti, Hening Tuti; Soebadi, Bagus
Dental Journal (Majalah Kedokteran Gigi) Vol 52, No 3 (2019): (September 2019)
Publisher : Faculty of Dental Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v52.i3.p163-167

Abstract

Background: Adjustment disorder is a temporary psychological condition related to emotional responses or behaviour in reaction to stress resulting from certain changes in a specific period of an individual?s life yet which does not significantly affect his/her daily life. Recurrent aphthous stomatitis (RAS) constitutes recurrent inflammation of the oral mucosa, in the form of an ulcer, frequently associated with psychological stress. Occasionally, a patient does not realise that she/he is suffering from a psychological disorder until the emergence of clinical symptoms, among them recurrent ulcers the causes of which are unknown. Purpose: This article presents a case of adjustment disorder diagnosed from symptoms observable in the oral cavity. Case: The case involved a 21-year-old student who presented with the symptoms of large, painful ulcers on her tongue, the inside of her cheek, and the floor of her mouth. These symptoms had been observable for one month but remained untreated. The patient only ate once a day or even once every two days. An introverted personality, she did not associate with other people. Case management: The procedure covered anamnesis, clinical examination, blood laboratory tests, total immunoglobulin E (IgE), an Antinuclear Antibody (ANA) test, bacterial and fungal culture in ulcus, questionnaire screening on psychological disorders, cortisol level examination and referral to a psychiatrist. Symptomatic therapy administered to the patient led to recovery of the ulcer in 29 days. Conclusion: RAS can be triggered by psychological stress which induces changes in the immune system and oral mucosa tissue.
Kandidiasis oral sebagai penanda infeksi HIV/AIDS: laporan kasus Oral candidiasis as a warning sign of HIV/AIDS infection: case report Usman, Nur Asmi; Prasetyaningtyas, Neken; Endah P., Adiastuti; Hendarti, Hening Tuti; Soebadi, Bagus
MDJ (Makassar Dental Journal) Vol. 6 No. 2 (2017): Vol 6 No 2 Agustus 2017
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (878.091 KB) | DOI: 10.35856/mdj.v6i2.22

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Latar belakang: Kandidiasis oral merupakan infeksi oportunistik yang sering ditemukan pada penderita yang terinfeksi human immunodeficiency virus (HIV) atau acquired immune deficiency syndrome (AIDS) ditandai dengan adanya penurunan jumlah CD4 + . Tujuan: Melaporkan kandidiasis oral pada pasien yang terinfeksi HIV/ AIDS. Kasus: Pasien wanita 40 tahun mengeluh langit-langit dan lidahnya terasa panas dan sakit sejak 3 bulan lalu. Gambaran klinis menunjukkan pseudomembran putih dapat dikerok, daerah sekitar kemerahan pada palatum kanan dan lidah, nodul multipel warna kemerahan pada palatum kanan dan kiri. Pemeriksaan jamur menunjukkan bentukan yeast dan pseudohifa. Pemeriksaan darah lengkap menunjukkan penurunan jumlah limfosit. Kandidiasis oral yang meluas ke orofaring disertai penurunan jumlah limfosit menimbulkan kecurigaan adanya infeksi HIV/AIDS sehingga dilakukan pemeriksaan CD4 + dan anti HIV. Hasil uji laboratorium menunjukkan jumlah CD4 + = 95 sel/mL, dan anti HIV reaktif. Pasien kemudian dirujuk ke Unit Perawatan Intermediate Penyakit Infeksi (UPIPI) RSUD Dr Soetomo untuk mendapatkan perawatan dengan anti retroviral (ARV). Kandidiasis oral dirawat menggunakan obat antijamur sistemik golongan azole. Simpulan: Kandidiasis oral yang telah diderita pada pasien dewasa muda dalam jangka waktu lama, sulit disembuhkan dan melibatkan daerah orofaring dapat menjadi penanda adanya infeksi HIV/AIDS.
Kebiasaan merokok dan konsumsi alkohol pada pasien dengan diagnosis oral lichen planus: Laporan kasus: Smoking habits and alcohol consumption in patients diagnosed with oral lichen planus: Case report Angriany, Dian; Aquina, Meilia; Hendarti, Hening Tuti; Soebadi, Bagus
MDJ (Makassar Dental Journal) Vol. 8 No. 1 (2019): Volume 8 No 1 April 2019
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (427.722 KB) | DOI: 10.35856/mdj.v8i1.266

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Pendahuluan: Oral lichen planus (OLP) merupakan suatu penyakit inflamasi kronis yang dimediasi oleh sel T sitotoksik CD8 + pada rongga mulut. Daerah yang sering terkena adalah mukosa bukal. Salah satu faktor predisposisi terjadinya OLP adalah merokok dan konsumsi alkohol. Penggunaan kortikosteroid secara topikal merupakan pilihan dalam pengobatan lichen planus, karena efek memodulasi inflamasi dan respon imunologi yang dapat mengendalikan lichen planus. Kasus: Pasien laki-laki usia 24 tahun mengeluhkan sariawan pada mukosa bukal kanan dan kiri yang muncul kembali setelah sembuh + 3 tahun yang lalu. Terdapat riwayat merokok sejak 7 tahun yang lalu dan konsumsi alkohol sejak 6 tahun yang lalu. Diskusi: Biopsi untuk pemeriksaan histopatologi dilakukan untuk menegakkan diagnosis klinis, utamanya untuk mengecualikan atipia epitel dan tanda-tanda keganasan. Simpulan: Diagnosis OLP dilakukan melalui anamnesis, pemeriksaan klinis dan penelitian. Kolaborasi multidisiplin juga dibutuhkan pada saat perawatan dan diagnosis OLP.
THE CORRELATION BETWEEN EXPOSURE TO CIGARETTE SMOKE AND THE DEGREE OF MUCOSAL EPITHELIUM-BASED DYSPLASIA IN RATTUS NORVEGICUS TONGUES Prijaryanti, Dorisna; Ernawati, Diah Savitri; Radithia, Desiana; Hendarti, Hening Tuti; Zain, Rosnah Binti
Dental Journal (Majalah Kedokteran Gigi) Vol 52, No 4 (2019): (December 2019)
Publisher : Faculty of Dental Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v52.i4.p187-191

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Background: Cigarette smoke contains various carcinogenic substances such as polycyclic aromatic hydrocarbons and nitrosamines. These chemicals not only have the potential to damage DNA, but can also induce genetic mutations and activate genes that function during apoptosis. Thus, if the gene is dysregulated, it will cause cells to survive, proliferate and subsequently lead to the development of cancerous ones. Histologically, the carcinogenic process affecting the oral cavity starts with hyperplasia and dysplasia, followed by severe dysplasia then leading to invasive cancer and metastatic processes in other bodies. Purpose: This study aims to reveal the correlation between exposure to cigarette smoke and the degree of epithelial dysplasia evident in research subjects. Methods: This study used 27 samples of Rattus norvegicus tongue, divided into three groups, namely; a control group, a treatment group subjected to four weeks? exposure to cigarette smoke, and a treatment group subjected to exposure lasting eight weeks. Each rat was placed in an individual chamber and exposed to smoke from 20 cigarettes introduced by a pump via a pipe for 7.5 minutes. The degree of epithelial dysplasia in each case was subsequently observed microscopically using HE staining technique. Results: Mild epithelial dysplasia increased by 0.82%, during the fourth week of exposure to cigarette smoke and by 2.99% during the eighth week. Similarly, moderate epithelial dysplasia rose by 5.29% during the fourth week of exposure and 5.99% during the eighth week. Severe epithelial dysplasia also increased by 2.2% during the fourth week of exposure and by 2.66% during the eighth week. Conclusion: The longer the exposure to cigarette smoke, the higher the degree of ensuing dysplasia.