Fadhilah Tia Nur, Fadhilah Tia
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PLATELET COUNTS IN EPILEPTIC CHILDREN RECEIVING VALPROIC ACID Indrayati, Lilik; Nur, Fadhilah Tia; Soebagyo, Bambang
Paediatrica Indonesiana Vol 60 No 1 (2020): January 2020
Publisher : Indonesian Pediatric Society

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Abstract

Background Epileptic seizures are a transient occurrence resulting from abnormal, excessive, or synchronous neural activity in the brain. Epilepsy requires long-term treatment, increasingly larger doses, and combination therapy. Anti-epileptic drugs (AEDs), especially valproic acid (VPA), are the main treatment of choice. Thrombocytopenia is the most common adverse event from AEDs. Objective To evaluate platelet counts in epileptic children receiving valproic acid monotherapy vs. polytherapy. Methods This analytic, observational, retrospective cohort study was conducted in children with epilepsy below 18 years of age and treated in Dr. Moewardi Hospital, Surakarta, Central Java. Subjects had received VPA treatment for at least 6 months, either as monotherapy or polytherapy. There were 40 subjects in each group (VPA monotherapy vs. VPA polytherapy). The exclusion criteria were patients who had thrombocytopenia and did not take valproic acid regularly. The data was taken from laboratory and the outcome assessed was decreasing of platelet count. Results  Administration of VPA as monotherapy vs. polytherapy was not significantly associated with incidence of thrombocytopenia. However, duration of VPA use > 2 years was associated with significantly greater proportion of thrombocytopenia, with OR 33.0 (95%CI 4.157 to 261.962; P=0.001) compared to VPA use < 2 years. Similarly, VPA dose of >30 mg/kg/day was significantly associated with greater proportion of thrombocytopenia, with OR 4.081 (95%CI 1.337 to 12.458; P=0.013) compared to <30 mg/kg/day dosage. Conclusion Incidence of thrombocytopenia is not significantly different between VPA as a  monotherapy and polytherapy. However, higher VPA dose and longer VPA duration are associated with higher proportion of thrombocytopenia.
AGE AT MENARCHE AND EARLY MENARCHE AMONG HEALTHY ADOLESCENTS Moelyo, Annang Giri; Wulandari, Anindita; Imas, Oktania; Rahma, Ulfa Puspita; Hidayah, Nurul; Kesumaningtyas, Cempaka; Nur, Fadhilah Tia; Nugroho, Hari Wahyu
Paediatrica Indonesiana Vol 59 No 1 (2019): January 2019
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (264.554 KB) | DOI: 10.14238/pi59.1.2019.33-7

Abstract

Background Menarche is an important indicator of female adolescents? health and also population health. Age at menarche tends to decrease in many countries. Early menarche that defined from the lowest quartile of age at menarche, associated with some physical and psychological problems. Objective To determine the mean age at menarche, the prevalence of early menarche among healthy adolescents in Surakarta and its association to nutritional status. Methods This cross-sectional study was conducted in 5 schools (3 junior and 2 senior high schools) in Surakarta, Central Java, Indonesia, from September 2016 to March 2018, by consecutive sampling technique. We included menarched healthy female students whose parent provided informed consent and without consuming any routine medication. Data were derived from self-reported questionnaire and measurements of body weight; body height; and body mass index (BMI) by calculated based on weight/height2(kg/m2). Results Of 835 eligible subjects, the mean age at menarche was 12.0 (SD 1.1) years (range 8.8-15.1 years) and the prevalence of early menarche was 11.1%. The peak of age at menarche were at 11,12, and 13 years (24.3%, 36.2%, and 23.9%, respectively) and almost 99.04% of subjects had menarche at 14 years old. The proportion of early menarche between subjects birth 1997-2001 and 2002-2007 were 8.4% and 16.1%. Early menarche associated with overweight-obese in adolescents (odd ratio 2.14; 95%CI 1.21 to 3.76). Conclusion The mean age at menarche of healthy adolescents in Surakarta is younger than other previous studies in Indonesia. Early menarche was significantly a risk for overweight/obese in adolescents.
Hubungan Kadar C-Reactive Proteindan Kadar Feritin Serum pada Gizi Kurang Usia 7-9 Tahun Lestari, Endang Dewi; Nur, Fadhilah Tia; Salimo, Harsono
Sari Pediatri Vol 13, No 4 (2011)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp13.4.2011.275-79

Abstract

Latar belakang. Kekurangan mikronutrien masih banyak terjadi di negara berkembang. Protein fase akut meningkat secara signifikan selama proses inflamasi akut.Tujuan. Penelitian bertujuan untuk menganalisis hubungan antara kadar C-reactive protein (CRP) dengan kadar feritin serum pada anak dengan gizi kurang usia 7-9 tahun di sekolah dasar di Surakarta.Metode. Penelitian uji potong lintang dilakukan di 10 SD di Surakarta pada 217 anak gizi kurang usia 7-9 tahun. Hubungan antara kadar CRP dan kadar feritin serum dinilai menggunakan analisis regresi logistik. Analisis statistik menggunakan SPSS versi 17.0.Hasil.Analisis regresi logistik menunjukkan terdapat hubungan secara signifikan antara rata-rata kadar feritin serum dengan kadar CRP>5 mg/L (OR=6,38, p= 0,006, 95% CI 1,7–23,9).Kesimpulan. Terdapat hubungan yang bermakna antara kadar CRP dengan kadar feritin serum.
Pengaruh Obat Anti Epilepsi Terhadap Gangguan Daya Ingat pada Epilepsi Anak Mustarsid, Mustarsid; Nur, Fadhilah Tia; Setiawati, Shinta Riana; Salimo, Harsono
Sari Pediatri Vol 12, No 5 (2011)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp12.5.2011.302-306

Abstract

Latar belakang. Epilepsi merupakan penyakit kronik yang dapat menurunkan kualitas hidup, di antaranyagangguan daya ingat.Tujuan. Mengetahui prevalensi gangguan daya ingat, serta pengaruh lama pengobatan, dan jumlah obatanti epilepsi.Metode. Penelitian potong lintang untuk mengetahui prevalensi gangguan daya ingat, serta pengaruh lamapengobatan, dan jumlah obat anti epilepsi terhadap gangguan daya ingat pada pasien epilepsi anak. Penelitinadilakukan di Poliklinik Neurologi Anak RSUD Dr Moewardi Surakarta dalam kurun waktu September2010 – November 2010, pada 50 subyek.Hasil. Gangguan daya ingat dialami 46% subyek di antara 50 subyek yang diteliti. Analisis bivariat mendapatkanpengaruh lama pengobatan lebih dari 2 tahun dengan OR 13,14 (CI 95% 3,29-2,47), jumlahobat anti epilepsi lebih dari satu obat dengan OR 0,6 (CI 95% 0,18-2,02). Analisis regresi logistik gandamendapatkan faktor yang mempengaruhi daya ingat adalah lama pengobatan lebih dari 2 tahun denganOR 17,3 (CI 95% 1,13- 279,17).Kesimpulan. Gangguan daya ingat dialami 46% pasien epilepsi anak. Lama pengobatan lebih dari duatahun berpengaruh terhadap terjadinya gangguan daya ingat pada pasien epilepsi anak.
Pengaruh Pemberian Obat Antiepilepsi terhadap Kadar Vitamin D pada Anak Penderita Epilepsi Tantri, Narulita Laksmia; Nur, Fadhilah Tia; Salimo, Harsono
Sari Pediatri Vol 19, No 2 (2017)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp19.2.2017.97-102

Abstract

Latar belakang. Pengobatan epilepsi dengan obat antiepilepsi (OAE) merupakan pengobatan jangka panjang dan berisiko terhadap berbagai efek samping, salah satunya defisiensi vitamin D. Selain berkaitan dengan permasalahan tulang, defisisensi vitamin D juga berhubungan dengan banyak penyakit yang lain.Tujuan. Menganalisis pengaruh pemberian obat antiepilepsi terhadap kadar vitamin D pada anak penderita epilepsi.Metode. Penelitian potong lintang dilakukan pada bulan Oktober–Desember 2016 di poliklinik anak RS Dr. Moewardi Surakarta. Subyek penelitian 40 anak diambil secara konsekutif. Data dianalisis menggunakan statistik uji t independen, Mann Whitney, dan Chi square dengan program SPSS 22.0.Hasil. Rerata kadar vitamin D 22,80±7,58 ng/ml. Angka kejadian defisiensi vitamin D 27,5%. Usia ≥ 5 tahun dan lama terapi ≥ 2 tahun berpengaruh terhadap kejadian defisiensi vitamin D (p< 0,05) pada anak penderita epilepsi.Kesimpulan. Terdapat penurunan kadar vitamin D pada anak penderita epilepsi yang mengonsumsi OAE.
RISK FACTORS OF BEHAVIORAL PROBLEMS IN PEDIATRIC EPILEPSY Nur, Fadhilah Tia; Azmi, Nurul; Hermasari, Bulan Kakanita
Indonesian Journal of Medicine Vol 5, No 2 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Epilepsy is the most common neurological disorders in children and the number of case for epilepsy still incre­asing. Epilepsy can affect children and their growth physically, psy­cho­logi­cally, and socially, yet the treatment of behavioral problems in pediatric epilepsy is still lacking. This stu­dy aimed to investigate the association of frequency of seizure, type of seizure, duration of illness, and use of antiepileptic drug with behavioral dis­order in children with epilepsy.Subjects and Method: This was an analytical observational study with a cross sectional design. The study was conducted at Pediatric Neurology Unit of Dr. Moewardi hospital, Sura­karta, from September to October 2016. A sample of 50 pediatric patients with epilepsy was selected for this study. Parents or care­givers completed behavioral problems screen­ing tool Pediatric Symptom Checklist-17 (PSC-17) and were interviewed about frequency of seizure, type of seizure, duration of illness, and use of antiepileptic drug. The data were ana­lyzed by a multiple logistic regres­sion.Results: Frequent seizure (OR= 3.09; 95% CI= 0.89 to 10.59; p= 0.068) increased beha­vioral problem. Being treated with ?1 anti-epileptic drugs (OR= 1.58; 95% CI= 0.44 to 5.71; p= 0.521) increased beha­vioral problem, but it was statistically non-significant. Type of seizure (OR= 1.01; 95% CI= 0.32 to 3.20; p= 0.991) and duration of illness ?1 year (OR= 1.03; 95% CI= 0.22 to 4.89; p= 1.000) were not associated with behavioural problem. Conclusion: Frequent seizure increase beha­vioral problemKeywords: epilepsy, behavioral problems, pediatricsCorrespondence: Fadhilah Tia Nur. Department of Child Health, Faculty of Medicine, Universitas Sebelas Maret. Jl. Ir. Sutami 36 A, Surakarta 57126, Central Java. Email: fadhilah.harris@gmail.comIndonesian Journal of Medicine (2020), 05(02): 162-169https://doi.org/10.26911/theijmed.2020.05.02.11