Burhanuddin Iskandar, Burhanuddin
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DIAGNOSTIC VALUE OF ELECTROCARDIOGRAPHY FOR VENTRICULAR SEPTAL DEFECT Sarmila, Besse; Iskandar, Burhanuddin; Daud, Dasril
Paediatrica Indonesiana Vol 59 No 2 (2019): March 2019
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (220.156 KB) | DOI: 10.14238/pi59.2.2019.87-91

Abstract

Background Congenital heart disease (CHD) in children requires attention from medical practitioners, because CHDs that are diagnosed early and treated promptly have good prognoses. Ventricular septal defect (VSD) is the most common type of congenital heart disease. Objective To compare the accuracy of electrocardiography (ECG) to echocardiography in diagnosing VSD. Methods This diagnostic study was conducted from November 2013 until July 2015. It involved patients with acyanotic CHDs who were suspected to have VSD at Dr. Wahidin Sudirohusodo Hospital, Makassar, South Sulawesi. Results Of 114 children screened, 97 were included and analyzed. The frequency of positive VSD was 69.1% based on ECG, and 99% based on echocardiography. There was a significant difference between ECG and echocardiography (P=0.000). However, when small VSDs were excluded, there was no significant difference between the two diagnostic tools [(P=1.000), Kappa value was 0.66, sensitivity was 98.5%, specificity was 100%, positive predictive value (PPV) was 100%, and negative predictive value (NPV) was 50%]. Conclusion There were significant differences between the ECG and echocardiography, for diagnosing VSD. However, if small VSDs were not included in the analysis, there was no difference between the two examinations, suggesting that ECG might be useful for diagnosing VSD in limited facilities hospitals.
Comparison of minimal inhibitory and bactericidal capacity of oral penicillin V with benzathine penicillin G to Streptococcus beta--hemolyticus group A in children with rheumatic heart disease Iskandar, Burhanuddin; Madiyono, Bambang; Sastroasmoro, Sudigdo; Putra, Sukman T.; Djer, Mulyadi M.; Karuniawati, Anis
Paediatrica Indonesiana Vol 48 No 3 (2008): May 2008
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (233.281 KB) | DOI: 10.14238/pi48.3.2008.152-5

Abstract

Background Injection ofbenzatine penicillin G (BPG) every 28days is still the drug of choice for secondary prevention of rheu-matic heart disease (RHD). BPG sometimes poses problems dueto pain at the injection site, possible anaphylaxis, and is not alwaysavailable. Some centers choose oral penicillin over BPG.Objectives To compare minimal inhibitory capacity (MIC) andminimal bactericidal capacity (MBC) of oral penicillin V serumwith those of BPG among SGA infected RHD.Methods This was a clinical trial with crossover design study tocompare MIC of penicillin V and BPG. Outcome measures wereMIC and MBC. Statistical analysis was performed using pairedt-test and wilcoxon test.Result There were 32 subjects consisted of 17 males and 15females. The mean value of MIC and MBC serum of penicillinV were 0.031 and 0.125. The mean value of MIC and MBCserum of BPG3 were 0.094 and 0.031. Respectively the MICof penicillin V was similar to that of BPGy The mean value ofMIC and MBC of BPG4 were 0.125 and 0.250. Respectively theMIC of penicillin V was significantly higher than that of BPG 4.The MBC of penicillin V was significantly higher than that ofBPG 4. The MIC ofBPG 3 was similar to that ofBPG 4• The MBCof BPG 3 was similar to that of BPG 4.Conclusions The MIC of penicillin V was similar to that ofBPG 3,the MBC of oral penicillin V was higher than that ofBPG 3• TheMIC and MBC of penicillin V was higher than those of BPG 4.
Faktor Risiko Serangan Berulang Demam Rematik/Penyakit Jantung Rematik NK, Rahmawaty; Iskandar, Burhanuddin; Albar, Husain; Daud, Dasril
Sari Pediatri Vol 14, No 3 (2012)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (72.574 KB) | DOI: 10.14238/sp14.3.2012.179-84

Abstract

Latar belakang. Serangan demam rematik/penyakit jantung rematik (DR/PJR) dapat berulang. Pada episode rekuren dapat terjadi kerusakan progresif pada katup. Gejala sisa dan deformitas katup yang progresif dapat menyebabkan manifestasi kronik bahkan kematian sehingga perlu dilakukan penelitian berbagai faktor risiko terjadinya rekurensi. Tujuan. Mengetahui faktor risiko terhadap serangan berulang pasien DR/PJR.Metode. Penelitian kohort retrospektif mengenai faktor risiko terhadap serangan berulang pasien DR/PJR. Data diperoleh dari rekam medik pasien DR/PJR yang dirawat di Bagian Ilmu Kesehatan Anak Rumah Sakit Dr. Wahidin Sudirohusodo periode Januari 2005 - Desember 2009.Hasil. Jumlah subjek yang memenuhi kriteria 80 pasien, terdiri dari 68 pasien DR/PJR-TR dan 12 pasien DR/PJR-R. Didapatkan frekuensi kejadian DR/PJR-R lebih tinggi pada kelompok dengan tingkat kepatuhan rendah dibandingkan dengan tingkat kepatuhan tinggi dengan nilai p=0,016 (p<0,05), COR = 5,97 dengan IK 95% 1,22- 29,3.Kesimpulan. Faktor risiko serangan berulang pasien DR/PJR adalah tingkat kepatuhan yang rendah terhadap pencegahan sekunder.