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MICRONEEDLE ARRAY AS TRANSDERMAL DRUG DELIVERY SYSTEM Elfa Hendri, HURIYATUS TSANIYAH; Mita, Soraya Ratnawulan; Chaerunisaa, Anis Yohana
Farmaka Vol 16, No 1 (2018): Suplemen Juni
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (876.642 KB) | DOI: 10.24198/jf.v16i1.17477

Abstract

Microneedle adalah perangkat minimal invasif yang digunakan untuk menembus lapisan terluar kulit yaitu stratum corneum (SC) yang merupakan penghalang utama untuk obat yang diaplikasikan secara topikal. Untuk memungkinkan pengiriman obat yang dapat direproduksi, microneedle harus dimasukkan ke dalam kulit dengan cara yang terkontrol dan dapat direproduksi (Singh, 2010). Akhir akhir ini microneedles telah dibuat dengan mengadaptasi teknologi industri mikroelektronika untuk menghasilkan susunan silikon, logam dan jarum polimer (Henry, 1998)(McAllister, 2003). Penelitian ini bertujuan untuk membuat innovasi microneedles dari polimer biodegradable dengan menggunakan metode fabrikasi berbasis cetakan yang murah dan kuat. Pokok bahasan yang diuraikan pada penelitian kali ini adalah pembuatan susunan microneedle, microneedle pembentuk hydrogel, karakterisasi microneedle dan pengujian secara in vivo. Hasil yang didapat microneedle polimer biodegradable yaitu teknik yang tepat dan memiliki kekuatan yang cukup untuk dimasukkan ke kulit dan dapat meningkatkan transport molekul secara transdermal.Kata kunci : Microneedle, Biodegradable microneedle, Stratum corneum.
AKTIVITAS ANTIBAKTERI HERBAL TERHADAP SHIGELLOSIS (SHIGELLA DYSENTERIAE) JELITA, SHEILA FRIZQIA; Wardhana, Yoga Windhu; Chaerunisaa, Anis Yohana
Farmaka Vol 18, No 1 (2020): Farmaka (Januari)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (47.736 KB) | DOI: 10.24198/jf.v18i1.22028

Abstract

ABSTRAKObat tradisional dengan bahan dasar tanaman telah digunakan sejak lama secara turun temurun di berbagai negara di dunia. Berbagai penelitian telah menunjukkan aktivitas dan mekanisme kerja tanaman-tanaman tertentu dalam melawan patogen yang dapat menyebabkan infeksi pada manusia Shigellosis merupakan salah satu jenis infeksi akut yang disebabkan oleh bakteri Shigella dysenteriae dan berlokasi di usus. Kasus resistensi terhadap antibiotik juga telah terjadi pada S. dysenteriae, sulfonamid merupakan salah satu dari antibiotik tersebut. Oleh karena itu, pengembangan dan penelitian terkait pengobatan alternatif dengan bahan dasar tanaman sebagai penghambat pertumbuhan bakteri S. dysenteriae dapat menjadi suatu solusi untuk memecahkan masalah tersebut. Selain itu, beberapa penelitian menunjukkan bahwa aktivitas antibakteri dari tanaman terhadap S. dysenteriae sebanding dengan antibiotik konvensional, bahkan secara sinergis dapat meningkatkan aktivitas antibiotik konvensional. Maka, penelitian terkait penggunaan bahan alam sebagai antibakteri diharapkan dapat mewujudkan pengobatan yang lebih efektif, efisien, dan aman dalam dunia farmasi.ABSTRACTTraditional medicines with plant based ingredients have been used for a long time for generations in various countries in the world. Numerous studies have shown the activity and mechanism of action of certain plants against pathogens that can cause infection in humans. Shigellosis is one type of acute infection caused by the bacterium Shigella dysenteriae and is located in the intestine. Cases of antibiotic resistance have also occurred in S. dysenteriae, sulfonamide is one of the antibiotics. Therefore, the development and research related to alternative medicine with plant based ingredients as inhibitors of S. dysenteriae's growth can be a solution to solve this problem. In addition, several studies have shown that the antibacterial activity of plants against S. dysenteriae is comparable to conventional antibiotics, even synergistically increase conventional antibiotic activity. Hence, researches related to the use of natural ingredients as an antibacterial agent is expected to be able to objectify a more effective, efficient and safe treatment in the pharmaceutical world.
CELLULOSE NANOCRYSTALS PREPARATION AS PHARMACEUTICALS EXCIPIENT : A REVIEW Putri, Margaretha Efa; Chaerunisaa, Anis Yohana; Abdassah, Marline
Indonesian Journal of Pharmaceutics Vol 2, Issue 2, May - August, 2020 (In Press)
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v2i2.26422

Abstract

Cellulose nanocrystals is a cellulose derivates which has been widely researched and observed as an chemical agent. Different with cellulose that has been widely used as pharmaceutical excipient especially in solid dosage form, cellulose in nanocrystals form is not available in pharmaceutical grade. Cellulose nanocrystals have different characteristics and quality which is depend on its preparation including sourcing, isolation procedure, and hydrolysis reaction involved. This difference is very important to deeply observed its impact in pharmaceutical dosage form with different active ingredients. In addition, cellulose nanocrystals should meet FDA requirement as pharmaceutical excipient. This review  describe cellulose nanocrystals preparation and its characteristics, its application to active pharmaceutical ingredients, and its properties in order to meet FDA requirement.Keywords: Cellulose, nanocrystals, pharmaceutical excipient
FORMULATION OF ANTIOXIDANT EMULGEL CONTAINING BELUNTAS CHINA (GYNURA PSEUDOCHINA (L.) DC) Chaerunisaa, Anis Yohana; Rahmania, Fitriani Jati; Abdassah, Marline; Muhaimin, Muhaimin
Indonesian Journal of Pharmaceutics Vol 2, Issue 1, Jan - April 2020
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v2i1.26106

Abstract

Skin constantly exposed by the environmental stresses, such as pollutants, solar radiation, heat, and cold, which cause the free radicals that cause premature aging. This bad effects of free radicals can be reduced by natural antioxidants such as Beluntas china (Gynura pseudochina (L.) DC) extract. The antioxidants use of beluntas china extract for skin will be more optimal if it is applied by appropriate form, emulgel, which has stronger consistency and longer contact time than gel. The aim of this research was to formulate an antioxidant emulgel from beluntas china extract, which is effective, stable, and safe with the best gelling agent. The extract was formulated by variety types of gelling agents which were carrageenan, hydroxypropyl methylcellulose (HPMC), and carbomer 934. Then, the physical stability was evaluated, including organoleptic, homogeneity, pH, viscosity, and freeze thaw. The results showed that formulation of carbomer 934 1% 2xIC50 extract concentration give the best physical stability evaluation for 60 days storage time.Keywords: antioxidant, beluntas china extract, emulgel, free radicals, skin
Isolation And Characterization of Physicochemical Properties of Mucilago Gedi Leaf (Abelmoschus manihot L. Medik) Rindengan, Elvie Rifke; Abdassah, Marline; Chaerunisaa, Anis Yohana
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 3 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (444.952 KB) | DOI: 10.15416/ijpst.v5i3.16744

Abstract

The aim of this research was to isolation of mucilage from gedi leaf (Abelmoschus manihot L. Medik) and characterized physicochemical properties. The isolation result was yellowish brown powder that swelling and dissolves slowly in water, but does not dissolve in ethanol, methanol, acetone and ether. The yield is 1.33%. Swelling index value 100% and viscosity 28 ± 2.65 mpas, pH 7.1. Proximate analysis showed 10.46% water content, 38.80% ash, 14.66% protein, 0.69% fat, 35.38% carbohydrate Water holding capacity (WHC) and  oil holding capacity (OHC) of musilago are respectively 4.23 ± 0.18 and 0.65 ± 0.14. Viscosity, Swelling index, WHC and OHC mucilage gedi leaf  may be considered as pharmaceutical excipients.Keywords: Mucilage, Abelmoschus manihot, swelling, viscosity
MUCILAGO OKRA : VARIASI EKSTRAKSI DAN POTENSINYA SEBAGAI EKSIPIEN MULTIFUNGSI Rindengan, Elvie Rifke; Abdassah, Marline; Chaerunisaa, Anis Yohana
Farmaka Vol 15, No 2 (2017): Farmaka
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (428.086 KB) | DOI: 10.24198/jf.v15i2.12583

Abstract

Pembuatan bentuk sediaan farmasi memerlukan eksipien. Eksipien yang digunakan dalam suatu formula obat berasal dari bahan alam atau sintesis. Buah Okra (Abelmoschus esculentus) mempunyai kandungan mucilago yang dapat diperoleh melalui proses ekstrasi. Mucilago yang berasal dari tanaman dalam berbagai penelitian memiliki fungsi sebagai eksipien farmasi. Mucilago Okra dapat dimanfaatkan sebagai pengemulsi, pensuspensi, pengikat tablet, matrix tablet dalam pembuatan tablet lepas lambat.
REVIEW ARTIKEL: KANDUNGAN DAN AKTIVITAS FARMAKOLOGI TANAMAN TRENGGULI (CASSIA FISTULA L.) Khairunnisa, Atikah; Hendriani, Rini; Chaerunisaa, Anis Yohana
Farmaka Vol 17, No 3 (2019): Farmaka (Desember)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3657.225 KB) | DOI: 10.24198/jf.v17i3.22016

Abstract

Cassia fistula L. atau dikenal dengan trengguli merupakan tumbuhan yang termasuk pada keluarga Fabacae yang terdistribusi di berbagai belahan dunia seperti Asia, Afrika Selatan, India, Cina dan Brazil yang dapat digunakan sebagai pengobatan berbagai penyakit. Tujuan dari review literatur ini adalah mengetahui kandungan senyawa aktif yang terdapat dalam bagian tumbuhan dan aktivitas farmakologi dari Cassia fistula L. Review terhadap studi tentang kandungan senyawa aktif dan aktivitas farmakologi Cassia fistula L. dilakukan dengan cara penelusuran pustaka yang dapat diakses pada situs penyedia jurnal terpercaya dan dilanjutkan dengan memilih 20 jurnal dari tahun 2000 hingga 2019. Sehingga, diketahui bahwa tanaman trengguli memiliki bermacam ? macam kandungan senyawa aktif yaitu flavonoid, alkaloid, tanin, fenol, glikosida, steroid, terpen, dan biochanin A yang memiliki aktivitas farmakologi seperti antibakteri, antifungal, antidiabetes, antioksidan, antiinflamasi, antipiretik, analgesik, hepatoprotektif, hipolipidemik dan antiparasit.
Isolation and Characterization of Microcrystalline Cellulose Derived from Plants as Excipient in Tablet : A Review Belali, Nagina Gulab; Chaerunisaa, Anis Yohana; Rusdiana, Taofik
Indonesian Journal of Pharmaceutics Vol 1, Issue 2, May - August 2019
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (8834.148 KB) | DOI: 10.24198/idjp.v1i2.21515

Abstract

Microcrystalline cellulose (MCC) is a versatile and frequently used material in different industries such as pharmaceuticals production, medical, cosmetics, and food industry.  Its qualities of being inert, economic, compatibility, compatibility, non-toxicity, biodegradability, good mechanical properties, high surface area, variety and availability of different grades and biocompatibility has made it very popular. Many research has been done on MCC to isolate it from different plant sources that are economical and eco-friendly. MCC is extracted from α cellulose that is abundant in nature as most of MCC is produced from wood. However, new eco-friendly sources with changes in methods of isolation have been applied for the production of MCC. In this review MCC isolated from different plant-based resources, extraction process parameters, the origin of raw material and its influence on critical material attributes of MCC has been outlined and discussed thoroughly. Since these critical material attributes have a significant effect on tablet making process parameters (compressibility, compatibility and etc) and its post-compression characters.Keywords: Microcrystalline cellulose, isolation, characterization, raw material, tablet 
Solvent Evaporation as an Efficient Microencapsulating Technique for Taste Masking in Fast Disintegrating Oral Tablets Belali, Nagina Gulab; Chaerunisaa, Anis Yohana
Indonesian Journal of Pharmaceutics Vol 1, Issue 3, Sept - Dec 2019
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (593.367 KB) | DOI: 10.24198/idjp.v1i3.23491

Abstract

Microencapsulation is an extensively used technology of present era, that has been applied to various fields like pharmaceutical industry, agriculture, cosmetics and food technology. With the help of which liquid or solid material can be encapsulated inside a polymeric coating film for various reasons such as taste masking, control release and enhancing stability and etc. Microencapsulation can be achieved with different approaches and methods but one of the popular and frequently used feasible method is Solvent evaporation. Solvent evaporation is based on emulsification, solvent evaporation and extraction of microspheres, recently many variations have been made in this technology to improve the yield and properties of microspheres. Solvent evaporation has been widely used in microencapsulating for different purposes one of which is taste masking of bitter drugs in fast disintegrating oral tablets, for pediatric and geriatric use. FDTs are center of attraction due to their merits and feasibility of use for people with problem of dysphagia at the same time, it can also improve bioavailability and time of action of drugs. The main focus of current review is use of solvent evaporation technique for taste masking of bitter drugs in production of fast disintegrating oral tablets. In this review, we will summarize uses, novelties and variations in Solvent Evaporation technique, preparation technique, materials used, merits and demerits of this method over other microencapsulation method in taste masking.Keywords: Microencapsulation, Solvent Evaporation, FDTs, extraction, microspheres
KARAKTERISASI SERBUK SELULOSA MIKROKRISTAL ASAL TANAMAN RAMI (BOEHMERIA NIVEA L. GAUD) Widia, Ina; Abdassah, Marline; Chaerunisaa, Anis Yohana; Rusdiana, Taofik
Farmaka Vol 15, No 3 (2017): Suplemen Desember
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2087.59 KB) | DOI: 10.24198/jf.v15i3.15447

Abstract

AbstrakKarakteristik serbuk merupakan hal yang  penting untuk dipertimbangkan dalam proses pembuatan tablet, salah satunya akan mempengaruhi sifat alir massa cetak. Bahan pengisi tablet yang sering digunakan adalah selulosa mikrokristal. Penelitian ini bertujuan untuk mengetahui karakteristik serbuk selulosa mikrokristal hasil isolasi dari tanaman rami.  Metode penelitian ini meliputi penyiapan bahan baku serat rami, isolasi ?-selulosa, pembuatan selulosa mikrokristal, dan karakterisasi selulosa mikrokristal. Hasil penelitian menunjukan rendemen selulosa mikrokristal sebesar 56,103%. Hasil karakterisasi serbuk selulosa mikrokristal meliputi reaksi warna, organoleptis, kelarutan, titik lebur, dan pH menunjukan kemiripan karakteristik dengan Avicel® PH 102 sebagai pembanding, kadar kelembapan selulosa mikrokristal hasil isolasi dan Avicel® PH 102 sebesar 0,88% dan 0,56%, laju alir 1,487 g/s dan 2,524g/s, sudut istirahat 28,5o dan 26,194o, kerapatan sejati 1,561 g/cm3 dan 1,533 g/cm3, kerapatan curah 0,326 g/cm3 dan 0,374 g/cm3, kerapatan mampat 0,435 g/cm3 dan 0,483 g/cm3, kompresibilitas 25,057% dan 22,567%, ukuran partikel dengan PSA 81,34 µm dan 129,9 µm. Kata kunci : karakteristik, serbuk, selulosa mikrokristal, rami. AbstractPowder characteristics are important to consider in the process of making tablets, one of which will affect the mass flow properties of the prints. The most commonly used tablet filler material is microcrystalline cellulose. The purpose of this research is to know the characteristic of microcrystalline cellulose powder from isolation from ramie. Methods of this study include preparation of raw materials of ramie fiber, ?-cellulose insulation, microcrystalline cellulose manufacturing, and microcrystalline cellulose characterization. The result showed that microcrystalline cellulose yield was 56.103%. The results of characterization of microcrystalline cellulose powders include color reaction, organoleptic, solubility, melting point, and pH shown similarity in characteristic to Avicel® PH 102 as comparison, moisture content of microcrystalline cellulose and Avicel® PH 102 was 0.88% and 0.56%, flow rate at 1.487 g/s and 2.524 g/s, resting angle at 28.5o and 26.194o, true density at 1.561 g/cm3 and 1.533 g/cm3, bulk density at 0.326 g/cm3 and 0.374 g/cm3 , tapped density at 0.435 g/cm3 and 0.483 g/cm3, compressibility at 25.057% and 22.567%, particle size with PSA 81.34 ?m and 129.9 ?m.  Keywords : characteristics, powders, microcrystalline cellulose, ramie.