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Pengaruh Jus Lidah Buaya (Aloe Vera) terhadap Kadar Glukosa Darah dan Malondialdehid (Mda) Tikus Wistar Diabetes yang Diinduksi Aloksan Astuti, Rini; Sugiarto, Sugiarto; Ardyanto, Tonang Dwi
Jurnal Gizi dan Kesehatan Vol 1, No 2 (2014)
Publisher : Program Studi Ilmu Gizi Pascasarjana Universitas Sebelas Maret

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Abstract

ABSTRAK Latar belakang : Diabetes Melitus (DM) adalah penyakit metabolik kronik yang meningkat prevalensinya di berbagai negara. Keadaan hiperglikemia pada DM menyebabkan terjadinya stres oksidatif yang ditandai dengan penurunan antioksidan tubuh. Lidah buaya bersifat teraupetik sebagai antidiabetik dan antioksidan. Penelitian ini bertujuan untuk mengetahui pengaruh jus lidah buaya terhadap kadar glukosa darah dan malondialdehid (MDA) pada tikus wistar diabetes yang diiinduksi aloksan. Metode : Penelitian ini adalah penelitian eksperimental laboratoris dengan rancangan pre and post randomized controlled group design. Sampel adalah tikus wistar jantan umur 2 - 2,5 bulan. Kontrol negatif (KN) tidak diinduksi aloksan dan jus lidah buaya. Kontrol positif (KP) diinduksi aloksan 120mg/kgBB tetapi tidak diberi jus lidah buaya. Kelompok K1, K2, dan K3 diinduksi aloksan dan diberi jus lidah buaya dengan dosis 5ml, 7,5ml, dan 10ml/200grBB/hari selama 14 hari. Kadar glukosa darah dan MDA diukur sebelum dan sesudah perlakuan. Data dianalisis dengan bantuan SPSS 19.0 for windows. Hasil : Terdapat perbedaan signifikan kadar glukosa darah dan MDA sebelum dan sesudah perlakuan pada ketiga dosis dengan nilai p K1 0,02; K2 <0,001; K3 <0,001 (p < 0,05). Kesimpulan : Jus lidah buaya dosis 5ml, 7,5ml, dan 10ml/200grBB/hari dapat menurunkan kadar glukosa darah dan MDA tikus wistar diabetes. Peningkatan dosis berpengaruh terhadap penurunan kadar glukosa darah. Peningkatan dosis tidak berpengaruh terhadap penurunan kadar MDA.  Kata kunci : lidah buaya, tikus wistar diabetes, glukosa darah, MDA
Indeks massa tubuh, asupan vitamin D, dan serum 25-hydroxyvitamin D pada pasien kanker payudara Damayanti, Amilia Yuni; Indarto, Dono; Wasita, Brian; Ardyanto, Tonang Dwi
Jurnal Gizi Klinik Indonesia Vol 14, No 2 (2017): Oktober
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, Fakultas Kedokteran UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (157.597 KB) | DOI: 10.22146/ijcn.17243

Abstract

Background: Breast cancer is the most common malignancy in women in the world. Vitamin D helps control the majority of gene expression in female reproductive tissues. Body mass index (BMI) influences the bioavailability of vitamin D. Diet is one of the main sources of vitamin D and it is directly converted into 25-hydroxyvitamin D [25 (OH) D] in the liver.Objective: This study aimed to analyze the relationship between BMI and vitamin D intake and 25 (OH)D serum in patients with breast cancer.Method: Analytic observational with cross sectional design was used in this study. A total of 37 breast cancer patient visited Dr. Moewardi Hospital in Surakarta was selected as research subjects using a purposive sampling technique. BMI data was obtained by measuring body weight and height. Vitamin D intake was determined using 1 x 24-hour food recall and semi-quantitative food frequency questionnaire. While, 25(OH)D serum was measured using enzyme-linked immunoabsorbent assay. Data analysis used Spearman correlation test.Results: The averages of BMI, vitamin D intake and 25(OH)D serum of breast cancer patients were 21.96±3.63 kg/m², 3.50±3.30 µg/day and 16.01±14.67 ng/mL respectively. Most breast cancer patients had less vitamin D intake and 25(OH)D serum deficiency. There was a weak relationship between BMI (r=0.188, p=0.266) and vitamin D (r=0.113, p=0.507) and 25 (OH)D serum in breast cancer patients.Conclusion: There were no significant correlations between BMI and vitamin D intake with 25(OH)D serum in breast cancer patients. Further study is required on the effect of chemotherapy regimens on vitamin D metabolism.
Indeks massa tubuh, asupan vitamin D, dan serum 25-hydroxyvitamin D pada pasien kanker payudara Damayanti, Amilia Yuni; Indarto, Dono; Wasita, Brian; Ardyanto, Tonang Dwi
Jurnal Gizi Klinik Indonesia Vol 14, No 2 (2017): Oktober
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, Fakultas Kedokteran UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.17243

Abstract

Background: Breast cancer is the most common malignancy in women in the world. Vitamin D helps control the majority of gene expression in female reproductive tissues. Body mass index (BMI) influences the bioavailability of vitamin D. Diet is one of the main sources of vitamin D and it is directly converted into 25-hydroxyvitamin D [25 (OH) D] in the liver.Objective: This study aimed to analyze the relationship between BMI and vitamin D intake and 25 (OH)D serum in patients with breast cancer.Method: Analytic observational with cross sectional design was used in this study. A total of 37 breast cancer patient visited Dr. Moewardi Hospital in Surakarta was selected as research subjects using a purposive sampling technique. BMI data was obtained by measuring body weight and height. Vitamin D intake was determined using 1 x 24-hour food recall and semi-quantitative food frequency questionnaire. While, 25(OH)D serum was measured using enzyme-linked immunoabsorbent assay. Data analysis used Spearman correlation test.Results: The averages of BMI, vitamin D intake and 25(OH)D serum of breast cancer patients were 21.96±3.63 kg/m², 3.50±3.30 µg/day and 16.01±14.67 ng/mL respectively. Most breast cancer patients had less vitamin D intake and 25(OH)D serum deficiency. There was a weak relationship between BMI (r=0.188, p=0.266) and vitamin D (r=0.113, p=0.507) and 25 (OH)D serum in breast cancer patients.Conclusion: There were no significant correlations between BMI and vitamin D intake with 25(OH)D serum in breast cancer patients. Further study is required on the effect of chemotherapy regimens on vitamin D metabolism.
AKTIVITAS CKMB DAN MASA CKMB TERKAIT KARDIAK TROPONIN-I DALAM GEJALA KORONER AKUT Ardyanto, Tonang Dwi; Tahono, Tahono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 1 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i1.434

Abstract

Coronary Heart Disease (CHD) is the leading cause of death recently, including in Indonesia which is raised to 25%. Acute Coronary Syndrome (ACS) is its common clinical manifestation. Therefore, the necessity for a sensitive as well as specific diagnostic biomarker for ACS should be addressed in discriminating the ACS patient and its related risks. The diagnostic sensitivity of characteristic electrocardiography pattern in ACS cases were reported to be variatively between 55?75%. In laboratory diagnostic, ACS markers among others are CKMB activity, CKMB mass as well as Cardiac Troponin-T and Troponin-I (cTnT and cTnI). Currently, cTnI is the gold standard. The present study is to know the analysing of the CKMB activity as well as the mass diagnostic performance in the detectionof ACS in the patient presenting with chest-pain at RSDM, by using cTnI as the standard of reference. As many 30 samples, 18?65 years old, were selected trough incidental sampling method from the subjects presenting with chest-pain no longer than 6 hrs before admission. The blood samples were drawn at admission and 6 hrs afterward. The CKMB activity (immunoinhibition assay), CKMB mass (ELFA) and cTnI (ELFA) measurement were performed on each sample. The analysis showed that cTnI cut-off on 0.1 ?g/L (ESC/ACC 2000) was most optimal in the laboratory diagnostic of ACS compared to that of 0.01 ?g/L (ESC/ACC 2007 update) and 1.0 ?g/L (WHO). Using the cTnI cut-off on 0.1 ?g/L, on admission (0 hr) the diagnostic efficiency of CKMB mass was 56.7% while that of CKMB activity was 60.0%. While on the serial measurement (6 hrs), the diagnostic efficiency of CKMB mass was 76.6% while that of CKMB activity was 56.7%. The results showed that by serial measurements, CKMB mass is superior than CKMB activity in the diagnosis of ACS in patient presenting with chest-pain. Further researches are necessary to elaborate the comparison elucidatively. The results of the study considered that in designing the protocol for laboratory examination should carried out in patient presenting with chest pain.
THE IMPORTANCE OF SOCIALIZATION IN ACHIEVING UNIVERSAL HEALTH COVERAGE: CASE STUDY OF JAMINAN KESEHATAN NASIONAL (JKN) IMPLEMENTATION IN TWO DIFFERENT REGION IN CENTRAL JAVA PROVINCE Fitriana, Ema Nur; Probandari, Ari Natalia; Pamungkasari, Eti Poncorini; Ardyanto, Tonang Dwi; Puspitaningrum, Rizky Amalia
Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 2, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss2.art3

Abstract

Background: Jaminan Kesehatan Nasional (JKN) is Indonesia's health policy to achieve universal health coverage (UHC). Towards 2019, not all regions have succeeded in achieving UHC. One of the reasons is the uneven distribution of information regarding JKN policies. Socialization is needed so that the JKN policy is understood by the people of Indonesia. Objective: This research was design to describe the importance of JKN policy socialization to reach UHC. Methods: Qualitative research was conducted in September 2018- February 2019 in two districts in Central Java, that were the district that had reached UHC and districts that had not yet reached UHC. The informants consisted of leaders of regional organizations and also the community. The researcher conducted an interactive model analysis on the interview transcript. Results: In districts that had reached UHC, socialization was conducted directly and indirectly through the government, community cadres and BPJS cadres. The district government provided support by issuing circulars letters. The district socialization effectively increases JKN participants. Meanwhile, in districts that had not yet reached UHC, there was found differences between community and the government. The government said that they had conducted effective socialization. But the community said that the information provided has not been effective and there is no detailed information about JKN.Conclusion: An effective socialization of JKN policies is needed to increase the understanding and awareness of the community to achieve UHC.