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Anthropometry-based Body Fat Percentage Predicts High hs-CRP in Chronic Kidney Disease Patients Thaha, Mochammad; Empitu, Maulana Antiyan; Kadariswantiningsih, Ika Nindya; Nugroho, Cahyo Wibisono; Hasanatuludhhiyah, Nurina; Rasyid, Haerani; Hakim, Zaky El; Suryansyah, Maulana Muhtadin; Alda, Rieza Rizqi; Alsagaff, Mohammad Yusuf; Amin, Mochammad; Santoso, Djoko; Suzuki, Yusuke
The Indonesian Biomedical Journal Vol 10, No 2 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i2.397

Abstract

BACKGROUND: Obesity is an important cardiovascular risk factor and associated with low grade inflammation in chronic kidney disease (CKD) patients. This study aims to assess the association between body fat with serum high sensitivity C-reactive protein (hs-CRP) level in CKD patients.METHODS: A cross-sectional study was performed in 71 CKD patients. Anthropometric measurements included body weight, height, body mass index (BMI), body fat percentage (BFP), skinfold thickness (SKF) of triceps and biceps were performed by trained physician. BFP was calculated using Kwok’s Formula and hs-CRP was measured by Particle enhanced Turbidimetry.RESULTS: The averaged BMI of our subjects was 25.8±4.4. There was no significant difference in BMI between pre-dialysis and hemodialysis CKD patients. Positive correlation was found between BFP and hs-CRP (r=0.266; p<0.05), while there was no significant correlation between BMI and hs-CRP.CONCLUSION: Body fat percentage was associated with hs-CRP. Hence, it will be more beneficial to assess nutritional status in CKD using BFP rather than BMI alone since it was demonstrated to correlate with hs-CRP in our studyKEYWORDS: CKD, obesity, inflammation, body fat, hs-CRP
Could Complete Blood Count Parameters and Non-fasting Cholesterol Profile Describe Inflammation and Oxidative Stress in Chronic Kidney Disease? Kadariswantiningsih, Ika Nindya; Thaha, Mochammad; Nugroho, Cahyo Wibisono; Hamidah, Berliana; Rasyid, Haerani; Hakim, Zaky El; Suryansyah, Maulana Muhtadin; Alsagaff, Mohammad Yusuf; Santoso, Djoko; Empitu, Maulana Antiyan; Suzuki, Yusuke
The Indonesian Biomedical Journal Vol 10, No 3 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i3.451

Abstract

BACKGROUND: Establishment of inexpensive clinical laboratory tests to evaluate inflammation and oxidative stress is urgently needed in the limited resources settings. This study aims to investigate the potential of complete blood count (CBC) parameters and non-fasting cholesterol profile parameters to describe inflammation and oxidative stress in chronic kidney disease (CKD) patients.METHODS: Measurement of CBC, non-fasting cholesterol profile, high sensitivity C-reactive protein (hs-CRP) and malondialdehyde (MDA) were performed in 71 CKD patients grouped into hemodialysis (HD) and non-hemodialysis (non-HD). Correlation analysis were performed to assess the potential of CBC and cholesterol profile to describe the level of hs-CRP and MDA.RESULTS: In the HD group, total cholesterol was moderately associated with hs-CRP while total cholesterol/HDL-C ratio, monocyte/HDL-C ratio, monocyte/LDL-C ratio, neutrophil/HDL-C ratio, neutrophil/LDL-C ratio, platelet/HDL-C ratio and platelet/LDL-C ratio were strongly associated with hs-CRP. In the non-HD group,only neutrophil/total cholesterol ratio and platelet/total cholesterol ratio that were associated with hs-CRP. Total cholesterol, monocyte/LDL-C ratio, neutrophil/LDL-C ratio and platelet/LDL-C ratio were moderately associated with MDA while total cholesterol/HDL-C ratio, monocyte/HDL-C ratio, neutrophil/HDL-C ratio and platelet/HDL-C ratio were strongly associated respectively with MDA in HD group. In the non-HD group, total cholesterol/HDL-C ratio, neutrophil/HDL-C ratio and platelet/HDL-C ratio were moderately associated with MDA in non-HD group while monocyte/HDL-C ratio was weakly associated with MDA.CONCLUSION: Some CBC parameters and non-fasting cholesterol profile such as cholesterol/HDL-C, monocyte/HDL-C, neutrophil/HDL-C and platelet/HDL-C ratio showed a potential to describe the inflammation and stress oxidative markers, given some strong associations with the level of hs-CRP and MDA. Further study is needed to assess whether this parameter represent long-term prognostic value among CKD patients.KEYWORDS: inflammation, oxidative stress, CRP, MDA, TAC, 8-OHdG, CBC, cholesterol
Conn’s Syndrome Akibat Adenoma Adrenal Rasyid, Haerani; Bakri, Syakib; Kasim, Hasyim; Hidayat, Andi Rahmat; Syarif, Syarif; Azis, Abd
Jurnal Penyakit Dalam Indonesia Vol 6, No 2 (2019)
Publisher : Internal Medicine Department, Faculty of Medicine Universitas Indonesia-RSCM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (445.018 KB) | DOI: 10.7454/jpdi.v6i2.205

Abstract

Conn’s syndrome merupakan sindrom yang ditandai dengan peningkatan kadar aldosteron yang menyebabkan retensi natrium dan peningkatan ekskresi kalium melalui urin. Sindrom ini ditandai dengan trias hipokalemia, hipertensi, dan alkalosis metabolik. Artikel ini membahas mengenai laporan kasus pasien hipertensi tidak terkontrol dengan gejala neuromuskular yang diakibatkan oleh hipokalemia berulang. Setelah dilakukan evaluasi tes pencitraan, ditemukan gambaran tumor adrenal kiri dan kemudian dilakukan tindakan adrenalektomi unilateral. Hasil pemeriksaan histopatologi tumor didapatkan gambaran yang sesuai dengan adenoma adrenal. Setelah tindakan adrenalektomi unilateral, pasien menunjukkan perbaikan klinis dan laboratorium. Kata kunci : Conn’s syndrome, Hipertensi, HipokalemiaConn’s Syndrome Due to Adrenal AdenomaConn's syndrome is characterized by an increase in aldosterone level causes sodium retention and an increase in urine excretion of potassium. This syndrome is characterized by trias hypokalemia, hypertension, and metabolic alkalosis. This article discussed a case report of a patient with uncontrolled hypertension with neuromuscular symptoms caused by recurrent hypokalemia. After an evaluation of the imaging test, we found a left adrenal tumor then we performed unilateral adrenalectomy surgery. Histopathology examination from the excised tumor revealed the adrenal adenoma. After unilateral adrenalectomy, the patient showed clinical and laboratory improvement.
ANTI-HYPERTENSIVE DRUGS AND SEXUAL DYSFUNCTION IN MEN Tarukallo, Noverio; Rasyid, Haerani
Jurnal Ilmiah Kesehatan Vol 13 No 01 (2020): Jurnal Ilmiah Kesehatan (Journal of Health Science)
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/jhs.v13i01.1335

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Salah satu faktor yang memiliki risiko yang terkait dengan kejadian disfungsi seksual pada pria adalah obat anti-hipertensi. Obat anti-hipertensi yang memiliki efek menyebabkan disfungsi seksual pada pria termasuk; diuretik, Clonidine, dan ?-blocker (kecuali nebivolol), tetapi ada beberapa obat anti-hipertensi yang memiliki efek netral, bahkan memiliki efek positif yang dalam hal ini dapat meningkatkan fungsi seksual pada pria. Obat anti-hipertensi yang memiliki efek netral pada fungsi seksual pria meliputi; Calcium Channel Blocker dan ACE-Inhibitor dan yang memiliki efek meningkatkan fungsi seksual pada pria termasuk; ARB dan ?-blocker yaitu nebivolol. Penggunaan obat anti-hipertensi dapat mempengaruhi fungsi seksual pada pria melalui mekanisme yang berbeda. Obat anti-hipertensi seperti diuretik, ?-blocker, dan clonidine dapat menyebabkan disfungsi seksual pada pria melalui mekanisme perubahan dalam aliran simpatis, efek pada kontraksi otot polos fisik, dan melalui pengaruh pada kadar hormon androgen. Angiotensin Receptor Blocker dan Nebivolol dapat meningkatkan fungsi seksual melalui mekanisme penghambatan pada Angiotensin II dan meningkatkan bioavailabilitas Nitric Oxide.
PENGARUH PEMBERIAN MINYAK IKAN TERHADAP KONSENTRASI ASAM LEMAK DAN GEJALA KLINIS MALARIA Rasyid, Haerani; Suwandi, Danny
Jurnal Kedokteran YARSI Vol 15, No 1 (2007): JANUARI - APRIL 2007
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (169.962 KB) | DOI: 10.33476/jky.v15i1.1003

Abstract

The aim of the study is to find out the effects of fish oil supplementation on fatty acids concentration (Eicosapentanoat Acid and Docosahexaenoat Acid), fever attacks and Dikke Drupple (DDR) interpretation of samples. This study was designed as ?A Randomized Double Blind Pretest and Post-test Controled Group?. Samples were divided into two groups, experiment group with fish oil suplementation (8% EPA, 35 DHA) and control group (placebo) for 8 weeks. This study was conducted in a malaria endemic, Kadaila village, subdistrict of Karossa, District of Mamuju in 2003. The result of the study showed significant increased concentration of EPA and DHA of the experiment group than the control group (p 0,05). The fever attack was significantly decreased (p 0,05) in experiment group than the control group, while DDR was not significantly different (p 0,05) between two groups.
EFFECT OF A SINGLE DIALYSIS ON COGNITIVE FUNCTION IN CHRONIC KIDNEY DISEASE STAGE 5 HEMODIALYSIS PATIENTS Hidayat, Andi Rahmat; Rasyid, Haerani; Bakri, Syakib; Kasim, Hasyim; Syamsuddin, Saidah; Seweng, Arifin
Indonesian Journal of Kidney and Hypertension Vol 2 No 2 (2019): May - August 2019
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v2i2.10

Abstract

Abstract Background: The incidence of cognitive impairment (CI) has been widely reported in various studies among chronic kidney disease (CKD) patients. Many factors influence cognitive function including hemodialysis (HD) process itself. There is much evidence that a single HD session brings about changes in the cognitive status of patients, but just a few studies assessing whether cognitive performance varies with dialysis. Aim: To know the effect of single dialysis session on cognitive function in HD patients. Method: Sixty medically stable CKD stage 5 patients on HD maintenance at least for three months were enrolled. Cognitive testing performed thrice, 1-2 hour prior dialysis (T1), 3-4 hour into the session (T2) and 24 hour after the session (T3) using a well-validated neuropsychological test battery, Montreal Cognitive Assessment (MoCA) Indonesian version which assess the domain of cognitive function including visuospatial, executive function, naming, memory, attention, language, abstraction, recall, and orientation. Result: among 60 patients complete testing, mean age 45,45 ± 11,28 years, dialysis vintage 10,12 ± 11,88 months, 44 patients (73,3%) had CI at baseline. Cognitive function decline during dialysis (T2) (MoCA INA score 21,65 to 19,67, p &lt; 0.001) and visuospatial, executive function, attention, language and recall was impaired during dialysis. While cognitive function reached its best 24 hour after dialysis (MoCA INA score 23,65, p &lt; 0.001) and all the domain of cognitive function was improved except naming that didn?t change over the dialysis session. Age and dialysis &nbsp;adequacy were associated with the decline. &nbsp;&nbsp;&nbsp;&nbsp; Conclusion: There is effect of a single HD session on global cognitive function where cognitive function was deteriorated during HD and reached its best 24 hour after HD. Keywords: cognitive function, chronic kidney disease, hemodialysis