Cherry Azaria, Cherry
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Protective Effect of Ethanol Extract Tempuyung Leaf (Sonchus arvensis L.) Against Gentamicin Induced Renal Injury Viewed from Blood Ureum Level Imelda, Imelda; Azaria, Cherry; Lucretia, Teresa
Journal of Medicine and Health Vol 1, No 6 (2017)
Publisher : Maranatha Christian University

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Abstract

Acute renal injury is characterized by decrement of glomerular filtration rate (GFR), resulting in nitrogen metabolic end product retention such as blood ureum. Aminoglycoside nephrotoxic injuries are common in elderly, with mortality rate 50-70%. Tempuyung has been empirically used in relieving renal problems as it contains several active antioxidants. This study aimed to analyze the protective effect of ethanol extract tempuyung leaf (EET) against gentamicin induced renal injury viewed from blood ureum level. The method used was true experimental laboratory, 16 wistar male rats, divided into 4 groups (n=4): negative control group (CMC), positive control group (Gentamicin 80 mg/kgBW), 1st treatment group (EET 100 mg/kgBW + Gentamicin), 2nd treatment group (EET 200 mg/kgBW + Gentamicin) for ten days. On the 11th day, blood serum were taken and the ureum level were analyzed. Data was analyzed by ANOVA and post hoc LSD test. Result showed positive control group had the highest blood ureum level (29.50  1.29 mg/dL) compared to negative control group (14.25  1.26 mg/dL), 1st treatment group (26.50  0.58 mg/dL), and 2nd treatment group (22.25  1.26 mg/dL) with significance difference (p<0,001). In conclusion, the result suggested the protective effect of EET against gentamicin induced renal injury.Keywords: acute renal injury, gentamicin, glomerular filtration rate, tempuyung, ureum
The Effect of Jati Belanda Leaves (Guazuma ulmifolia Lamk.) Ethanol Extract on Microscopic Features of Atherosclerotic Animal Model’s Aorta Permana, Ryan J.; Azaria, Cherry; Rosnaeni, Rosnaeni
Journal of Medicine and Health Vol 1, No 4 (2016)
Publisher : Maranatha Christian University

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Abstract

“Jati Belanda” leaves (Guazuma ulmifolia Lamk.) possesses antidyslipidemia effect and in this study we assessed the effect of "Jati Belanda” leaves ethanol extract in delaying the progression of atherosclerosis in aorta of the rats.Thirty atherosclerosis animal models were divided into six groups, which are three variant dose of “Jati Belanda” leaves (EEDJB 1-2-3), standard control (SC), negative control (NC) and Comparative control/ CC (simvastatin). The parameters measured were the wall thickness and lumen diameter (both in mm), and the amount of foam cells. The result for Kruskal Wallis test showed highly significant differences (p=0.00) of wall thickness Dose2 (0.056 mm) and Dose3 (0.056 mm) compared to NC (0.075 mm) and non-significant compared to CC (0.055 mm). ANOVA result for lumen diameter, p=0.773.  ANOVA result for foam cells amount, p=0.000, Duncan test showed significantly different between EEDJB and NC group.It is concluded that “Jati Belanda” leaves ethanol extract reduced aortic wall thickness and the amount of foam cells, but did not increase lumen diameter on the athersclerotic aorta, and had an equal therapeutic effect compared to simvastatin in delaying the progression of atherosclerosis. Keywords: atherosclerosis, Jati Belanda, wall thickness, lumen diameter, foam cell
Topical Effect of Pinneaple (Ananas comosus) Juice in Combustio Healing Process Measured by Granulation Process, Reepitelialisation and Angiogenesis Azaria, Cherry; Achadiyani, Achadiyani; Farenia, Reni
Journal of Medicine and Health Vol 1, No 5 (2017)
Publisher : Maranatha Christian University

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Abstract

Skin protects the body from various trauma, such as high temperature trauma known ascombustio. Pineapple (Ananas comosus) contains lots of substances such as bromelain,antioxidants, and zinc shown to accelerated healing process in previous experiments. Aim ofthis research was to analize the effect of topical pinneaple juice application in combustiohealing process. The method was true experimental laboratory. Wistar rats’ back skin wereinduced by 100 o C iron plat untill 2 nd degree combustio occured, then divided into two groups(n=20). The treatment group were given topical application of pinneaple juice, then the healingprocess were observed macroscopically and microscopically on day 0, 3, 7, and 14. The resultshowed better wound healing in treatment group on day 14. MANOVA test showed topicalapplication of pinneaple juice accelerated healing process (p=0.001). Treatment group showedbetter histological structure changes, as seen from better granulation tissue formed (p=0.003)and reepithelization (p=0,000), but not from angiogenesis (p=0.733). Conclusion, topicalapplication of pinneaple (Ananas comosus) juice accelerated healing process in 2 nd grade ofcombustio animal model measured by granulation maturation process and reepithelizationprocess, but has no effect on angiogenesis.Keywords : Ananas comosus juice, 2 nd degree combustio, granulation tissue, reepitelisation,angiogenesis.
Topical Effect of Pinneaple (Ananas comosus) Juice in Combustio Healing Process Measured by Granulation Process, Reepitelialisation and Angiogenesis Azaria, Cherry; Achadiyani, Achadiyani; Farenia, Reni
Journal of Medicine & Health Vol 1 No 5 (2017)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (513.844 KB) | DOI: 10.28932/jmh.v1i5.539

Abstract

Skin protects the body from various trauma, such as high temperature trauma known ascombustio. Pineapple (Ananas comosus) contains lots of substances such as bromelain,antioxidants, and zinc shown to accelerated healing process in previous experiments. Aim ofthis research was to analize the effect of topical pinneaple juice application in combustiohealing process. The method was true experimental laboratory. Wistar rats’ back skin wereinduced by 100 o C iron plat untill 2 nd degree combustio occured, then divided into two groups(n=20). The treatment group were given topical application of pinneaple juice, then the healingprocess were observed macroscopically and microscopically on day 0, 3, 7, and 14. The resultshowed better wound healing in treatment group on day 14. MANOVA test showed topicalapplication of pinneaple juice accelerated healing process (p=0.001). Treatment group showedbetter histological structure changes, as seen from better granulation tissue formed (p=0.003)and reepithelization (p=0,000), but not from angiogenesis (p=0.733). Conclusion, topicalapplication of pinneaple (Ananas comosus) juice accelerated healing process in 2 nd grade ofcombustio animal model measured by granulation maturation process and reepithelizationprocess, but has no effect on angiogenesis.Keywords : Ananas comosus juice, 2 nd degree combustio, granulation tissue, reepitelisation,angiogenesis.
Protective Effect of Ethanol Extract Tempuyung Leaf (Sonchus arvensis L.) Against Gentamicin Induced Renal Injury Viewed from Blood Ureum Level Imelda, Imelda; Azaria, Cherry; Lucretia, Teresa
Journal of Medicine & Health Vol 1 No 6 (2017)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (408.598 KB) | DOI: 10.28932/jmh.v1i6.555

Abstract

Acute renal injury is characterized by decrement of glomerular filtration rate (GFR), resulting in nitrogen metabolic end product retention such as blood ureum. Aminoglycoside nephrotoxic injuries are common in elderly, with mortality rate 50-70%. Tempuyung has been empirically used in relieving renal problems as it contains several active antioxidants. This study aimed to analyze the protective effect of ethanol extract tempuyung leaf (EET) against gentamicin induced renal injury viewed from blood ureum level. The method used was true experimental laboratory, 16 wistar male rats, divided into 4 groups (n=4): negative control group (CMC), positive control group (Gentamicin 80 mg/kgBW), 1st treatment group (EET 100 mg/kgBW + Gentamicin), 2nd treatment group (EET 200 mg/kgBW + Gentamicin) for ten days. On the 11th day, blood serum were taken and the ureum level were analyzed. Data was analyzed by ANOVA and post hoc LSD test. Result showed positive control group had the highest blood ureum level (29.50  1.29 mg/dL) compared to negative control group (14.25  1.26 mg/dL), 1st treatment group (26.50  0.58 mg/dL), and 2nd treatment group (22.25  1.26 mg/dL) with significance difference (p<0,001). In conclusion, the result suggested the protective effect of EET against gentamicin induced renal injury.Keywords: acute renal injury, gentamicin, glomerular filtration rate, tempuyung, ureum
The Effect of Jati Belanda Leaves (Guazuma ulmifolia Lamk.) Ethanol Extract on Microscopic Features of Atherosclerotic Animal Model’s Aorta Permana, Ryan J.; Azaria, Cherry; Rosnaeni, Rosnaeni
Journal of Medicine & Health Vol 1 No 4 (2016)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (551.68 KB) | DOI: 10.28932/jmh.v1i4.527

Abstract

“Jati Belanda” leaves (Guazuma ulmifolia Lamk.) possesses antidyslipidemia effect and in this study we assessed the effect of "Jati Belanda” leaves ethanol extract in delaying the progression of atherosclerosis in aorta of the rats.Thirty atherosclerosis animal models were divided into six groups, which are three variant dose of “Jati Belanda” leaves (EEDJB 1-2-3), standard control (SC), negative control (NC) and Comparative control/ CC (simvastatin). The parameters measured were the wall thickness and lumen diameter (both in mm), and the amount of foam cells. The result for Kruskal Wallis test showed highly significant differences (p=0.00) of wall thickness Dose2 (0.056 mm) and Dose3 (0.056 mm) compared to NC (0.075 mm) and non-significant compared to CC (0.055 mm). ANOVA result for lumen diameter, p=0.773.  ANOVA result for foam cells amount, p=0.000, Duncan test showed significantly different between EEDJB and NC group.It is concluded that “Jati Belanda” leaves ethanol extract reduced aortic wall thickness and the amount of foam cells, but did not increase lumen diameter on the athersclerotic aorta, and had an equal therapeutic effect compared to simvastatin in delaying the progression of atherosclerosis. Keywords: atherosclerosis, Jati Belanda, wall thickness, lumen diameter, foam cell
Efek Konsumsi Suplemen Kalsium dan Magnesium terhadap Dismenore Primer dan Sindrom Premenstruasi pada Perempuan Usia 19–23 Tahun Fen Tih, Fen Tih; Azaria, Cherry; Gunadi, Julia Windi; Rumanti, Rizna Tyrani; Susanto, Alfred Tri; Santoso, Alissa Amelia; Evitasari, Firsty Tasya
Global Medical & Health Communication (GMHC) Vol 5, No 3 (2017)
Publisher : Faculty of Medicine Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v5i3.2161

Abstract

Dismenore merupakan gangguan menstruasi dengan prevalensi terbesar diikuti gejala sindrom premenstruasi yang mencakup gejala fisik dan psikologis. Asupan mikronutrien kalsium dan magnesium dapat membantu mengatasi keluhan ini. Penelitian ini dilakukan untuk mengetahui pengaruh konsumsi suplemen kalsium dan magnesium terhadap dismenore dan gejala sindrom premenstrual pada perempuan berusia 19–23 tahun. Penelitian ini merupakan eksperimental kuasi dengan rancangan pretes dan postes. Penelitian dilakukan di Universitas Kristen Maranatha Bandung pada bulan Juli–Desember 2016. Subjek penelitian adalah 60 orang perempuan berusia 19–23 tahun, dibagi menjadi dua kelompok secara acak untuk pemberian bahan uji kalsium (1.000 mg/hari) atau magnesium (250 mg/hari) yang diberikan mulai hari kedua menstruasi sampai siklus menstruasi yang berikutnya. Kadar kalsium atau magnesium serum diukur dengan metode spektrofotometri. Dismenore diukur dengan skala nyeri visual analog scale (VAS), sedangkan skor sindrom premenstrual diukur dengan shortened premenstrual assessment form sebelum dan sesudah pemberian bahan uji. Konsumsi kalsium menurunkan skor skala VAS rata-rata pada dismenore dari 6,97 menjadi 3,80 (p=0,000) dan skor total gejala sindrom premenstrual rata-rata dari 15,07 menjadi 10,80 (p=0,000). Konsumsi magnesium mengurangi skor skala VAS rata-rata pada dismenore dari 7 menjadi 4 (p=0,000) dan skor total gejala sindrom premenstrual rata-rata dari 12,27 menjadi 9,87 (p=0,001). Simpulan penelitian ini adalah konsumsi suplemen kalsium atau magnesium mengurangi keluhan dismenore dan gejala sindrom premenstrual pada perempuan usia 19–23 tahun.EFFECT OF CALCIUM AND MAGNESIUM SUPPLEMENTS ON PRIMARY DYSMENORRHEA AND PREMENSTRUAL SYNDROME IN 19–23 YEARS OLD WOMENDysmenorrhea is a menstrual disorder with the greatest prevalence followed by premenstrual syndrome that includes physical and psychological symptoms. Micronutrients intake of calcium and magnesium can help overcome these complaints. This research was conducted to find out the effect of calcium and magnesium supplements consumption on dysmenorrhea and premenstrual syndrome symptoms in 19–23 years old women. This was quasi experimental research with pre- and post-test design. The research was conducted in Maranatha Christian University Bandung from July to December 2016. The subjects of research were 60 women aged 19–23 years old, divided into two groups randomly. One group given calcium (1,000 mg/day) or magnesium (250 mg/day), which was given at the second day of menstruation until the next menstrual cycle. Serum levels of calcium or magnesium were measured with spectrophotometry method. Dysmenorrhea was measured with visual analog scale (VAS), whereas score of premenstrual syndrome was measured with shortened premenstrual assessment form, before and after treatment. The consumption of calcium lowers the VAS score average on dysmenorrhea from 6.97 to 3.80 (p=0.000) and the mean score of premenstrual syndrome from 15.07 to 10.80 (p=0.000). Consumption of magnesium reduces the VAS score average on dysmenorrhea from 7 to 4 (p=0.000) and the mean score of premenstrual syndrome from 12.27 to 9.87 (p=0.001). In conclusion, consumption of calcium or magnesium supplements reduce dysmenorrhea and premenstrual syndrome in women aged 19–23 years old.