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Makbul Aman, Makbul
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ANALYSIS COLLAGEN DENSITY ON DIABETIC AND NON-DIABETIC ACUTE WOUND MODEL: ANIMAL TRIAL USING WISTAR RATS Maryunis, Maryunis; Bakri, Syakib; Patellongi, Ilhamjaya; Aman, Makbul; Tahir, Takdir; Rahayu, Ade Irma; Hasriyani, Hasriyani; Yusuf, Saldy
in process
Publisher : ETN Centre Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Neuropathy and peripheral vascular disease are two major factors that lead to diabetic wounds. Additionally, diabetic wound healing process takes a long time. Collagen is one indicator to assess wound healing. Aim: This study aimed to compare the wound healing process DM and non-DM In Wistar with acute wounds modeling that uses the density collagen as indicators. Methods: This study used a randomized design Post Test Control Group who uses Wistar as research objects. Wistar rats were divided into 2 groups: Wistar DM and Non-DM groups. The total sample were 30 individuals that consisted of 15 rats each group. Wistar DM was induced by injection of Streptozotocin (STZ) intraperitoneal single dose of 40-50 mg / kg. The wound were created by using punch biopsy of each group. The wound were followed up for 14 days. Data analysis was done using the Kolmogorov - Smirnov test with a confidence level of 95%. All data were analyzed by SPSS version 21.0 software (SPSS, Inc. Chicago, IL). Results: The density of collagen in DM group (20%) was lower than in non DM group (40%). However there were no significant difference in collagen density in both groups (p=0,375). Nevertheless, the percentage of collagen density is higher in non DM group compared with DM group (20.0%). This shows the tendency of the wound healing process in the group of Non - DM is better than DM group. This shows the tendency of the wound healing process in the group of Non - DM is better than DM group. Conclusion : There is a tendency that the wound healing in non –DM group is better than in DM groups. More studies are needed in the future to confirm this findings. Key Words: Collagen Density, Acute Wound Model, DM
EFEK EKSTRAK BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) TERHADAP PENYEMBUHAN LUKA AKUT DM DAN NON DM PADA WISTAR Tahir, Takdir; Bakri, Syakib; Patellongi, Ilhamjaya; Aman, Makbul; Miskad, Upik A.; Maryunis, Maryunis; Suryani, Ade Irma
in process
Publisher : ETN Centre Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pendahuluan: Penggunaan bahan alam sebagai penyembuhan luka merupakan alternatif yang banyak digunakan. Ekstrak Buah Naga Merah (EBNM) memiliki kandungan antioksidan dan anti-inflamasi yang dibutuhkan untuk mempercepat penyembuhan luka. Namun penelitian yang berhubungan dengan efek buah naga merah terhadap penyembuhan luka masih sangat terbatas. Tujuan penelitian ini adalah untuk mengetahui efek Ekstrak Buah Naga Merah terhadap penyembuhan luka DM dan luka Non DM pada wistar. Metode: Jenis penelitian ini adalah penelitian eksperimen dengan desain post test with control group design. Wistar jantan albino (n=30) berat badan (250-350 gr) dibagi menjadi 2 kelompok (kelompok A wistar DM + Eksisi dan kelompok B wistar Non-DM + Eksisi). Selanjutnya Wistar dilukai pada punggung kiri dan kanan dengan menggunakan punch biopsy 8 mm. Topikal krim EBNM 3.5%, 5% dan 7.5% dioleskan pada permukaan luka dengan menggunakan cotton bud. Jaringan diwarnai dengan Hematoksilin dan Eosin (HE) untuk mengetahui ketebalan granulasi, dan epitelisasi jaringan. Data dianalisis dengan menggunakan uji independent T test dan paired T test (SPSS 21, Chicago Inc.). Hasil: Skor granulasi lebih baik pada konsentrasi 7.5 % pada kelompok EBNM topikal dibandingkan dengan kelompok kontrol negatif untuk DM (p
ANALYSIS COLLAGEN DENSITY ON DIABETIC AND NON-DIABETIC ACUTE WOUND MODEL: ANIMAL TRIAL USING WISTAR RATS Maryunis, Maryunis; Bakri, Syakib; Patellongi, Ilhamjaya; Aman, Makbul; Tahir, Takdir; Rahayu, Ade Irma; Hasriyani, Hasriyani; Yusuf, Saldy
Jurnal Luka Indonesia Vol 2 No 3 Oktober 2016
Publisher : ETN Centre Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32538/jli.v0i0.29

Abstract

Background: Neuropathy and peripheral vascular disease are two major factors that lead to diabetic wounds. Additionally, diabetic wound healing process takes a long time. Collagen is one indicator to assess wound healing. Aim: This study aimed to compare the wound healing process DM and non-DM In Wistar with acute wounds modeling that uses the density collagen as indicators. Methods: This study used a randomized design Post Test Control Group who uses Wistar as research objects. Wistar rats were divided into 2 groups: Wistar DM and Non-DM groups. The total sample were 30 individuals that consisted of 15 rats each group. Wistar DM was induced by injection of Streptozotocin (STZ) intraperitoneal single dose of 40-50 mg / kg. The wound were created by using punch biopsy of each group. The wound were followed up for 14 days. Data analysis was done using the Kolmogorov - Smirnov test with a confidence level of 95%. All data were analyzed by SPSS version 21.0 software (SPSS, Inc. Chicago, IL). Results: The density of collagen in DM group (20%) was lower than in non DM group (40%). However there were no significant difference in collagen density in both groups (p=0,375). Nevertheless, the percentage of collagen density is higher in non DM group compared with DM group (20.0%). This shows the tendency of the wound healing process in the group of Non - DM is better than DM group. This shows the tendency of the wound healing process in the group of Non - DM is better than DM group. Conclusion : There is a tendency that the wound healing in non ?DM group is better than in DM groups. More studies are needed in the future to confirm this findings. Key Words: Collagen Density, Acute Wound Model, DM
EFEK EKSTRAK BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) TERHADAP PENYEMBUHAN LUKA AKUT DM DAN NON DM PADA WISTAR Tahir, Takdir; Bakri, Syakib; Patellongi, Ilhamjaya; Aman, Makbul; Miskad, Upik A.; Maryunis, Maryunis; Suryani, Ade Irma
Jurnal Luka Indonesia Vol 2 No 2 Juni 2016
Publisher : ETN Centre Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32538/jli.v0i0.26

Abstract

Pendahuluan: Penggunaan bahan alam sebagai penyembuhan luka merupakan alternatif yang banyak digunakan. Ekstrak Buah Naga Merah (EBNM) memiliki kandungan antioksidan dan anti-inflamasi yang dibutuhkan untuk mempercepat penyembuhan luka. Namun penelitian yang berhubungan dengan efek buah naga merah terhadap penyembuhan luka masih sangat terbatas. Tujuan penelitian ini adalah untuk mengetahui efek Ekstrak Buah Naga Merah terhadap penyembuhan luka DM dan luka Non DM pada wistar. Metode: Jenis penelitian ini adalah penelitian eksperimen dengan desain post test with control group design. Wistar jantan albino (n=30) berat badan (250-350 gr) dibagi menjadi 2 kelompok (kelompok A wistar DM + Eksisi dan kelompok B wistar Non-DM + Eksisi). Selanjutnya Wistar dilukai pada punggung kiri dan kanan dengan menggunakan punch biopsy 8 mm. Topikal krim EBNM 3.5%, 5% dan 7.5% dioleskan pada permukaan luka dengan menggunakan cotton bud. Jaringan diwarnai dengan Hematoksilin dan Eosin (HE) untuk mengetahui ketebalan granulasi, dan epitelisasi jaringan. Data dianalisis dengan menggunakan uji independent T test dan paired T test (SPSS 21, Chicago Inc.). Hasil: Skor granulasi lebih baik pada konsentrasi 7.5 % pada kelompok EBNM topikal dibandingkan dengan kelompok kontrol negatif untuk DM (p
EFEK EKSTRAK BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) TERHADAP PENYEMBUHAN LUKA AKUT DM DAN NON DM PADA WISTAR Tahir, Takdir; Bakri, Syakib; Patellongi, Ilhamjaya; Aman, Makbul; Miskad, Upik A.; Maryunis, Maryunis; Suryani, Ade Irma
Jurnal Luka Indonesia Vol 2 No 2 Juni 2016
Publisher : ETN Centre Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32538/jli.v0i0.26

Abstract

Pendahuluan: Penggunaan bahan alam sebagai penyembuhan luka merupakan alternatif yang banyak digunakan. Ekstrak Buah Naga Merah (EBNM) memiliki kandungan antioksidan dan anti-inflamasi yang dibutuhkan untuk mempercepat penyembuhan luka. Namun penelitian yang berhubungan dengan efek buah naga merah terhadap penyembuhan luka masih sangat terbatas. Tujuan penelitian ini adalah untuk mengetahui efek Ekstrak Buah Naga Merah terhadap penyembuhan luka DM dan luka Non DM pada wistar. Metode: Jenis penelitian ini adalah penelitian eksperimen dengan desain post test with control group design. Wistar jantan albino (n=30) berat badan (250-350 gr) dibagi menjadi 2 kelompok (kelompok A wistar DM + Eksisi dan kelompok B wistar Non-DM + Eksisi). Selanjutnya Wistar dilukai pada punggung kiri dan kanan dengan menggunakan punch biopsy 8 mm. Topikal krim EBNM 3.5%, 5% dan 7.5% dioleskan pada permukaan luka dengan menggunakan cotton bud. Jaringan diwarnai dengan Hematoksilin dan Eosin (HE) untuk mengetahui ketebalan granulasi, dan epitelisasi jaringan. Data dianalisis dengan menggunakan uji independent T test dan paired T test (SPSS 21, Chicago Inc.). Hasil: Skor granulasi lebih baik pada konsentrasi 7.5 % pada kelompok EBNM topikal dibandingkan dengan kelompok kontrol negatif untuk DM (p
ANALYSIS COLLAGEN DENSITY ON DIABETIC AND NON-DIABETIC ACUTE WOUND MODEL: ANIMAL TRIAL USING WISTAR RATS Maryunis, Maryunis; Bakri, Syakib; Patellongi, Ilhamjaya; Aman, Makbul; Tahir, Takdir; Rahayu, Ade Irma; Hasriyani, Hasriyani; Yusuf, Saldy
Jurnal Luka Indonesia Vol 2 No 3 Oktober 2016
Publisher : ETN Centre Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32538/jli.v0i0.29

Abstract

Background: Neuropathy and peripheral vascular disease are two major factors that lead to diabetic wounds. Additionally, diabetic wound healing process takes a long time. Collagen is one indicator to assess wound healing. Aim: This study aimed to compare the wound healing process DM and non-DM In Wistar with acute wounds modeling that uses the density collagen as indicators. Methods: This study used a randomized design Post Test Control Group who uses Wistar as research objects. Wistar rats were divided into 2 groups: Wistar DM and Non-DM groups. The total sample were 30 individuals that consisted of 15 rats each group. Wistar DM was induced by injection of Streptozotocin (STZ) intraperitoneal single dose of 40-50 mg / kg. The wound were created by using punch biopsy of each group. The wound were followed up for 14 days. Data analysis was done using the Kolmogorov - Smirnov test with a confidence level of 95%. All data were analyzed by SPSS version 21.0 software (SPSS, Inc. Chicago, IL). Results: The density of collagen in DM group (20%) was lower than in non DM group (40%). However there were no significant difference in collagen density in both groups (p=0,375). Nevertheless, the percentage of collagen density is higher in non DM group compared with DM group (20.0%). This shows the tendency of the wound healing process in the group of Non - DM is better than DM group. This shows the tendency of the wound healing process in the group of Non - DM is better than DM group. Conclusion : There is a tendency that the wound healing in non ?DM group is better than in DM groups. More studies are needed in the future to confirm this findings. Key Words: Collagen Density, Acute Wound Model, DM