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Kholidha, Andi Noor

Published : 3 Documents

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Uji Aktivitas Ekstrak Etanol Daun Dadap Serep (Erythrina lithosperma Miq) sebagai Antibakteri terhadap Bakteri Salmonella typhi Kholidha, Andi Noor; Suherman, I Putu Wira Putra; Hartati, Hartati
Medula Vol 4, No 1 (2016)
Publisher : Medula

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Dadap serep (Erythrina lithosperma Miq) is one of the plants that grow in Indonesia. Dadap serep leaves are commonly used as a traditional medicin. It can be used as an antimicrobial. This study aims to determine the inhibition of Dadap Serep (Erythrina lithosperma Miq) Leaf Extract  on the growth of the bacteria Salmonella typhi. The methods used in this research was an analytic experimental test. The samples of this study are Leaf Extract of Dadap Serep (Erythrina lithosperma Miq), which is divided into eight concentration, i.e. the concentration of 200,000 ppm, 100,000 ppm, 50,000 ppm, 25,000 ppm, 12,500 ppm, 6,250 ppm, 3,125 ppm, 1,560 ppm and two control i.e. a positive controls and a negative controls. Each test was repeated three times. Antibacterial activity test performed by disc diffusion method, wherein the diameter of each extract was determined and assessed their effectiveness inhibitory zone with chloramphenicol. Minimum Inhibitory Concentration (MIC) was determined by disc diffusion method togeth er with the inhibition test. We then measured at the lowest concentration of extract that they can inhibit the bacteria Salmonella typhiTop of FormBottom of Form. The results showed that the leaves of Dadap Serep (Erythrina lithosperma Miq) has antibacterial activity against growth of bacteria Salmonella typhi. MIC seen from the leaves of Dadap Serep is 50,000 ppm with inhibition zone diameter of 1.3 mm were formed. Diameter of clear zone is highest at a concentration of 200,000 ppm with inhibition zone diameter formed is 4.83 mm. Phytochemical test results on Leaf of Dadap Serep (Erythrina lithosperma Miq) retrieved alkaloids, flavonoids, tannins and saponins are positive.From this research it can be concluded that the extracts from dadap serep leaves (Erythrina lithosperma Miq) has antibacterial activity against growth of bacteria Salmonella typhi.Keywords: Dadap serep leaves (Erythrina lithosperma Miq), Salmonella typhi, Minimum inhibitory concentration (MIC), Antibacterial test
Uji Antidiabetik Ekstrak Buah Pare (Momordica charantia L.) terhadap Penurunan Kadar Glukosa Darah pada Mencit yang Diinduksi Streptozotocin Parawansah, Parawansah; Nuralifah, Nuralifah; Kholidha, Andi Noor
Medula Vol 5, No 1 (2017)
Publisher : Medula

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ABSTRACT Diabetes mellitus is a chronic disease in which the patient has excess glucose levels in the blood. Pare (Momordica charantia L.) is one of the plants that have efficacy in treating various diseases one of them is antidiabetes. Activity of active substances from the pare may play a role in lowering blood sugar levels. This research is done to know the effect of increasing concentration of pare extract to decrease blood glucose level in mice induced by streptozotocin.This study was experimental laboratory, the study was done by measured  the initial blood sugar level in mice, sugar content after induction of steptozotosin, and after administration of 100 mg / kgBW extract test, 250 mg / kgBW and 400 mg / kgBW with observation time for 7 days , as well as gave metformin suspension as a positive control.The results showed that the optimum value of antidiabetic activity of ethanol extract of pare fruit at a concentration of 400 mg / kgBW and had an average decrease of 122 mg / dl.Keywords: Antidiabetes, Momordica charantia L., Streptozotocin
Hubungan Kadar Kolesterol Total dan Trigliserida dengan Kejadian Diabetes Mellitus Tipe 2 di Daerah Pesisir Kota Kendari Kholidha, Andi Noor; Tien, Tien; Aritrina, Pranita; Nirmala, Fifi
Medula Vol 5, No 2 (2018)
Publisher : Medula

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Background: Type 2 Diabetes mellitus is a common health problem which may result chronic complications. Risk factors such as dyslipidemia, obesity, family history, and genetics play important role in the pathogenesis of the disease. Study on total cholesterol and trygliseride have been carried out in several countries which show relations between total cholesterol and trygliseride with type 2 diabetes mellitus. Purpose: This study aims to determine the relationship between total cholesterol and trigliseride with type 2 diabetes mellitus in the coastal areas of Kendari City. Methods: This study used analytical observational method, with case control approach. The independent variables used in this research is cholesterol total and trigliseride meanwhile the dependent variable is the type2 diabetes mellitus. The location of this research is working area of Public Health Centre located in the coastal area of Kendari City. Result: total cholesterol levels show sig. p value 1,369 based on Chi Square Test, which showed there was no difference in total cholesterol levels. Meanwhile, the triglyceride levels also did not show a significant difference between case and control groups. (p = 0.101). Conclusion: There was no correlation between the increase of total cholesterol level and triglyceride levels with the incidence of DM Type 2 in Kendari City.Keyword: Total Cholesterol, Trigliseride, Type 2 Diabetes mellitus, Coastal Area.