Widiastuti, Mentari
Faculty of Pharmacy, Universitas Gadjah Mada

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Dispensing Prescription Medicines without a Prescription in Pharmacy Rokhman, M. Rifqi; Widiastuti, Mentari; Suwarni, Satibi; Fatmawati, Ria Fasyah; Munawaroh, Nimatul; Pramesti, Yenda Ayu
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 7, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.33256

Abstract

A poor drug monitoring system in many developing countries makes patient easy to buy any prescription medicines without prescription. This research aimed to assess the compliance of pharmacy towards prescription medicine’s regulations, pharmacist knowledge toward a list of medicines as prescription or over the counter medicines, and the reasons associated with dispensing prescription medicines without a prescription in pharmacy. The research was a descriptive non-experimental study. The sample was taken using simple random sampling in Sleman and Kota Yogyakarta Regency from September 2016 to January 2017. Data were taken in 2 steps, using simulated patient and a questionnaire one week after the first step. The simulated patient would come to the pharmacy and requested amlodipine 5 mg 10 tablets and allopurinol 100 mg 20 tablets. The questionnaire assessed pharmacist knowledge in classifying of several medicines as prescription or over the counter medicines, information taken and given when dispensing prescription medicines without a prescription, and the reason associated with dispensing prescription medicines without a prescription. The data were analyzed descriptively. The results showed that from 138 pharmacies randomly selected, 132 pharmacies (95,7%) dispensed amlodipine and 127 pharmacies (92,0%) sold allopurinol without a prescription. Majority of pharmacists (more than 85%) hold a view that prescription medicines mainly for chronic diseases (glibenclamide, metformin, amlodipine, captopril, allopurinol, dan simvastatin) as the over the counter medicines, as the main reason was patients regularly taking this medication before. However, the majority of pharmacists (79,2%) perceived that antibiotics as prescription medicines that should be dispensed only with a medical prescription. This research showed that pharmacist does not fully implement applicable regulations.
Dispensing Prescription Medicines without a Prescription in Pharmacy Rokhman, M. Rifqi; Widiastuti, Mentari; Suwarni, Satibi; Fatmawati, Ria Fasyah; Munawaroh, Nimatul; Pramesti, Yenda Ayu
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 7, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1102.33 KB) | DOI: 10.22146/jmpf.33256

Abstract

A poor drug monitoring system in many developing countries makes patient easy to buy any prescription medicines without prescription. This research aimed to assess the compliance of pharmacy towards prescription medicine’s regulations, pharmacist knowledge toward a list of medicines as prescription or over the counter medicines, and the reasons associated with dispensing prescription medicines without a prescription in pharmacy. The research was a descriptive non-experimental study. The sample was taken using simple random sampling in Sleman and Kota Yogyakarta Regency from September 2016 to January 2017. Data were taken in 2 steps, using simulated patient and a questionnaire one week after the first step. The simulated patient would come to the pharmacy and requested amlodipine 5 mg 10 tablets and allopurinol 100 mg 20 tablets. The questionnaire assessed pharmacist knowledge in classifying of several medicines as prescription or over the counter medicines, information taken and given when dispensing prescription medicines without a prescription, and the reason associated with dispensing prescription medicines without a prescription. The data were analyzed descriptively. The results showed that from 138 pharmacies randomly selected, 132 pharmacies (95,7%) dispensed amlodipine and 127 pharmacies (92,0%) sold allopurinol without a prescription. Majority of pharmacists (more than 85%) hold a view that prescription medicines mainly for chronic diseases (glibenclamide, metformin, amlodipine, captopril, allopurinol, dan simvastatin) as the over the counter medicines, as the main reason was patients regularly taking this medication before. However, the majority of pharmacists (79,2%) perceived that antibiotics as prescription medicines that should be dispensed only with a medical prescription. This research showed that pharmacist does not fully implement applicable regulations.
Cardioprotective Effect of Kelor (Moringa oleifera) Leaf Ethanolic Extract against Doxorubicin-Induced Cardiotoxicity in Rats Fikriansyah, Fikriansyah; Widiastuti, Mentari; Wulandari, Nindi; Tirtanirmala, Prisnu; Murwanti, Retno
Indonesian Journal of Cancer Chemoprevention Vol 6, No 2 (2015)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev6iss2pp53-57

Abstract

The usage of doxorubicin (DOX) as an anticancer drug in cancer patient may cause several side effects. One of that is cardiotoxicity by inducing the expression of nitric oxide synthase which may release nitric oxide (NO) resulting reactive oxygen species (ROS) in the cardiac. DOX needs to be combined with antioxidant since it could supressed ROS in the cardiac and reduce cardiomyopathy. Kelor (Moringa oleifera) is known as the source of antioxidant. This study aim to observe the treatment effects of ethanolic extract of kelor (EEK) on histopathology profile and concentration of NO in rats cardiac. The result from the hematoxylin-eosin staining showed that EEK improved the histopathology profile of rats’ cardiac. Compared with the DOX-only treatment, the structure of cardiac muscle cells treated by ethanolic extract of kelor is more well-arranged and the cells’ nucleus still visible. Concentration of NO was measured by cardiac puncture method. The result showed that the concentration of NO was decrease in line with increasing dose levels of EEK in combination with DOX. But at rats only given with EEK, the concentration of NO is quite high. In conclusion, EEK could be a cochemotherapy agent by reducing the cardiotoxicity effect of DOX.Keywords : doxorubicin, Moringa oleifera, nitric oxyde, histopathology