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ANALISIS KANDUNGAN GARAM GUNUNG ASAL KRAYAN KABUPATEN NUNUKAN KALIMANTAN TIMUR Herman, Herman; Rusli, Rolan
Journal of Tropical Pharmacy and Chemistry Vol 1 No 4 (2012): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.012 KB) | DOI: 10.25026/jtpc.v1i4.38

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Has been studied composition of mountain salt from Krayan, Nunukan, East Kalimantan. This study aims to determine the composition of the minerals contained in the  mountain salt. Mountain salt is obtained from wells Krayan District residents were further prepared for analysis using a technique using Atomic Absorption Spectrometer (AAS), further by looking at the pattern of X-ray Diffraction (XRD) and Scanning electron microscopic (SEM). Based on the results obtained AAS has identified mineral deposits include: Na, K, Mg, Al, Cu, Zn, Fe, Ba, and Sr. From the results of XRD shows that the main peak of the salt Krayan shows major peaks for NaCl crystals with impurities such as KCl, CaCl2, MgCl2, and AlCl3. SEM observation showed that morphology of Krayan salt have cube shape which is the shape of NaCl crystals with space group Fm3m and lattice parameter (a) 5.620 Ã… Keywords : Mountain Salt, krayan, AAS, XRD, SEM   Abstrak Telah dilakukan penelitian analisis kandungan garam gunung asal Krayan Kabupaten Nunukan Kalimantan Timur. Penelitian ini bertujuan untuk mengetahui komposisi mineral yang terkandung dalam garam gunung. Garam gunung diperoleh dari sumur warga Kecamatan Krayan yang selanjutnya dipreparasi untuk dianalisis dengan menggunakan menggunakan teknik Spektrometer Serapan Atom (SSA), selanjutnya dengan melihat pola Difraksi Sinar X (XRD), dan Scanning Elektron Microscopy (SEM). Berdasarkan hasil SSA telah diidentifikasi diperoleh kandungan mineral antara lain: Na, K, Mg, Al, Cu,  Zn, Fe, Ba, dan Sr. Dari hasil XRD terlihat bahwa puncak utama dari  garam krayan tersebut menunjukkan puncak utama untuk Kristal NaCl, dengan impurities antara lain KCl, CaCl2, MgCl2, dan AlCl3. Selain itu hal ini didukung pula oleh pengamatan SEM, bahwa morfologi SEM garam krayan memperlihatkan bentuk kristal kubus yang merupakan  bentuk dari  Kristal NaCl  dengan  grup ruang  Fm3m  dengan panjang  kisi kristal 5,620 Ã…. Kata Kunci : Garam Gunung, Krayan, SSA, XRD,SEM
SINTESIS OKSIDA AURIVILLIUS Sr2Bi4Ti5-xFexO18 (x = 0,25; 0,5; 0,75; dan 1) Rusli, Rolan; Ismunandar, Ismunandar
Journal of Tropical Pharmacy and Chemistry Vol 1 No 1 (2010): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (72.294 KB) | DOI: 10.25026/jtpc.v1i1.9

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Aurivillius oxides Sr2Bi4Ti5-xFexO18 have been synthesized using the solid state reaction method. Powder X-ray diffraction data were refined using Le Bail method implemented in Rietica have space group B2cb, Z = 4, and parameter cell are a = 5.542(8), b = 5.474(9), c = 48.947(1); a = 5.565(5), b = 5.491(9), c = 49,097(1); a = 5.533(7), b = 5.464(7), c = 48.595(2) and a = 5.621(1), b = 5.492(9), c = 49.78(4); respectively for x = 0.25, 0.5, 0.75, and 1. The substitution of cation Fe3+ in these Aurivillius oxides was showed increasing of magnetic moment are μ = 2.67, 3.21, 3.98, and 4.62 for x = 0.25, 0.5, 0.75, and 1 respectively. Keywords: Aurivillus oxide, solid state reaction, Le Bail method, magnetic moment ABSTRAK Oksida Aurivillius Sr2Bi4Ti5-xFexO18 telah disintesis dengan menggunakan metode reaksi kimia padat. Data difraksi sinar-x serbuk yang penghalusan strukturnya menggunakan metode rietveld dengan program rietica menunjukkan bahwa oksida ini memiliki grup ruang B2cb, Z = 4, dan parameter selnya adalah a = 5,542(8), b = 5,474(9), c = 48,947(1); a = 5,565(5), b = 5,491(9), c = 49,097(1); a = 5,533(7), b = 5,464(7), c = 48,595(2) dan a = 5,621(1), b = 5,492(9), c = 49,78(4); berturut-turut untuk x = 0.25; 0,5; 0,75; dan 1. Substitusi kation Fe3+ pada oksida Aurivillius ini menunjukkan terjadinya peningkatan momen magnet oksida ini yaitu μ = 2,67; 3,21; 3,98; dan 4,62 berturut-turut untuk x = 0,25; 0,5; 0,75; dan 1. Kata kunci: Oksida Aurivillius, reaksi kimia padat, metode Le Bail, momen magnet
ANALISIS KADAR MINERAL DALAM ABU BUAH NIPA (NYPA FRUCTICANS) KALIWANGGU TELUK KENDARI SULAWESI TENGGARA Herman, Herman; Rusli, Rolan; Ilimu, Edi; Hamid, Rimba; Haeruddin, Haeruddin
Journal of Tropical Pharmacy and Chemistry Vol 1 No 2 (2011): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (62.464 KB) | DOI: 10.25026/jtpc.v1i2.17

Abstract

Research about Levels of ash analysis in Nipa Fruit (Nypa fructicans) Kaliwanggu Kendari Gulf South East Sulawesi have been done.  Research carried out by gravimetric method and AAS. The ash content of old nipa fruit at a temperature 450°C dan 550°C obtained amounted to 1.01% and 0.89%. while the young nipa fruits obtained ash content of 0.88% and 0.86% at450°C dan 550°C. Mineral content of old nipa fruit which had become ash at a temperature of 450°C obtained at 1.3769 ppm, 7.9167 ppm, 3.7876 ppm, 9.2365 ppm, respectively for Fe, Mg, K, and Na. On the other hand, at a temperature of 550°C obtained at 1.1153 ppm, 8.0127 ppm, 3.7990 ppm and 9.3634 ppm, respectively for Fe, Mg, K, and Na. On young fruit nipah obtained concentration of 0.8769 ppm, 7.9939 ppm, 3.8260 ppm, 9.4041 ppm, respectively for Fe, Mg, K, and Na at ash temperature 450°C. Meanwhile, at a  ash temperature of 550°C obtained concentration of 0.9230 ppm, 7.9738 ppm, 3.7468 ppm and 9.3861 ppm, respectively for Fe, Mg, K, and Na. The water content obtained from the old and young nipa flesh fruit obtained at 41.86% and 33.49%, respectively. Key words: Level of mineral analysis, Nypa fructicans, Gravimetric, AAS ABSTRAK Telah dilakukan penelitian dengan judul “Analisis Kadar dalam Abu Buah Nipa (Nypa fructicans)” Kaliwanggu Teluk Kendari Sulawesi Tenggara. Penelitian dilakukan dengan metode gravimetri dan AAS. Kadar abu buah nipa tua pada suhu 450°C dan 550°C diperoleh sebesar 1,01% dan 0,89%, sedangkan pada buah nipa muda diperoleh kadar abu sebesar 0,88% dan 0,86% berurut-turut untuk suhu 450°C dan 550°C. Kadar mineral buah nipa tua yang diabukan pada suhu 450°C diperoleh sebesar 1,3769 ppm, 7,9167 ppm, 3,7876 ppm, 9,2365 ppm, berturut-turut untuk Fe, Mg, K, dan Na. Sedangkan pada suhu 550°C diperoleh sebesar 1,1153 ppm, 8,0127 ppm, 3,7990 ppm, dan 9,3634 ppm, berturut-turut untuk Fe, Mg, K, dan Na. Pada buah nipa muda diperoleh kadar sebesar 0,8769 ppm, 7,9939 ppm, 3,8260 ppm, 9,4041 ppm, berturut-turut untuk Fe, Mg, K, dan Na pada suhu pengabuan 450°C. Sedangkan pada suhu pengabuan 550°C diperoleh kadar sebesar 0,9230 ppm, 7,9738 ppm, 3,7468 ppm, dan 9,3861 ppm, berturut-turut untuk Fe, Mg, K, dan Na. Adapun kadar air yang diperoleh dari daging buah nipa tua dan muda diperoleh sebesar 41,86% dan 33,49%.  Kata kunci: Analisis kadar mineral, Nypa fructicans, Gravimetri, AAS
IDENTIFIKASI GUGUS FUNGSI MINYAK BUAH NIPA (Nypa fructicans) KALIWANGGU TELUK KENDARI SULAWESI TENGGARA Rusli, Rolan; Rosniar, Rosniar; Haeruddin, Haeruddin; Nurlansi, Nurlansi
Journal of Tropical Pharmacy and Chemistry Vol 1 No 2 (2011): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (416.751 KB) | DOI: 10.25026/jtpc.v1i2.22

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Nipa is one of the vegetation mangroves in Southeast Sulawesi that optimal utilization by people in this region is not optimal because less of information. Attempt to provide information of oil component has done research with the title “Identification of Functional Group of Oil from Nipa Fruit (Nypa fructicans) at Kaliwanggu, Kendari Bay, Southeast Sulawesi”. Research was using the extraction technique, trans-esterification reactions, and FTIR measurements. The extracted oil is having characteristic aromatic, colourless, and volatile. The Oil content was obtain 13.72%, 10.57%, 7.73%, and 3.62% for oil from fiber seed fruit, fruit pulp, fruit cob, and epidermis seed fruit, respectively. The interpretation of FTIR spectrum was obtain vibrations of methylene (CH2) which overlap with vibration of the cis-alkene bond (cis-HC = CH), stretching vibration of ester group (C-O), bending vibrations of C-H, stretching vibration of ester group (C = O), and hydroxyl group (OH). Keywords: Nipa, oil, extraction, trans-esterification, FTIR ABSTRAK Nipa adalah salah satu vegetasi magrove di Sulawesi Tenggara yang pemanfaatannya oleh masyarakat belum optimal karena kurangnya informasi mengenai hal tersebut. Untuk memberikan informasi komponen minyak dilakukan penelitian dengan judul “Identifikasi Gugus Fungsi Minyak Buah Nipa (Nypa fructicans) Kaliwanggu Teluk Kendari Sulawesi Tenggara”. Penelitian dilakukan menggunakan ekstraksi dan reaksi trans-esterifikasi serta pengukuran FTIR. Minyak yang diekstraksi memiliki karakteristik berbau harum dan tidak berwarna (bening) serta mudah menguap (volatil). Kadar minyak diperoleh berturut-turut sebesar 13,72%, 10,57%, 7,73%, dan 3,62% untuk minyak dari bagian sabut, daging buah, tongkol buah, dan kulit ari daging buah nipa. Hasil interpretasi spektrum FTIR diperoleh gugus fungsi yaitu gugus vibrasi gugus methylene (CH2) yang overlap dengan vibrasi ikatan dari cis-alkena (cis-HC=CH), vibrasi ulur gugus (C-O) pada ester, vibrasi tekuk gugus C-H, vibrasi ulur gugus (C=O) dari ester, dan gugus hidroksil (OH).  Kata kunci: Nipa, minyak, ekstraksi, trans-esterifikasi, FTIR
AKTIVITAS IMUNOGLOBULIN M (IgM) EKSTRAK ETANOL KULIT BUAH KAKAO (Theobroma cacao L.) TERHADAP TIKUS PUTIH (Rattus norvegicus) Siregar, Vita Olivia; Rusli, Rolan; Ibrahim, Arsyik
Journal of Tropical Pharmacy and Chemistry Vol 2 No 5 (2014): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (52.709 KB) | DOI: 10.25026/jtpc.v2i5.74

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The research of Immunoglobulin M (IgM) activity of Theobroma cacao peel extract has been done to 20 rats. The parameter is agglutination between serum of rats and antigen. Rats were grouped to 4 group, which are group of negative control and 3 groups as experiment groups those given by extract in 250, 500 and 700 mg doses of rats. On the first day was given SDMK 2% by Intraperitonial and after 5 day the serum taken and tested. The data of agglutination then analyzed by Anova. The experiment showed that Theobroma cacao peel extract has activity as immunostimulant in 500 mg doses of rats effective dose. Keywords: Theobroma cacao peel extract, agglutination, immunostimulant, Immunoglobulin M (IgM) ABSTRAK Penelitian Aktivitas Imunoglobulin M (IgM) Ekstrak Kulit Buah Kakao (Theobroma cacao L.) telah dilakukan terhadap 20 ekor tikus uji. Parameter yang diamati adalah terjadinya aglutinasi antara serum tikus yang telah diberi perlakuan dengan antigen. Tikus putih dikelompokkan menjadi 4 kelompok yaitu kelompok kontrol negatif diberi Na CMC 0,5%, serta 3 kelompok uji yang diberikan ekstrak dengan konsentrasi 250, 500 dan 700 mg/200 g BB Tikus. Perlakuan secara per oral diberikan selama 5 hari. Pada hari ke-1 diinjeksikan Sel Darah Merah Kambing (SDMK) 2% secara intraperitonial dan setelah perlakuan, yaitu hari ke-7 serum diambil dan dilakukan pengujian dengan metode titer antibodi. Data hasil pengamatan aglutinasi di analisis menggunakan Anova. Hasil penelitian menunjukkan bahwa ekstrak kulit buah Kakao memiliki aktivitas sebagai imunostimulan dengan dosis terbaik 500 mg/200 g BB tikus. Kata kunci:    Ekstrak Kulit Buah Kakao, Theobroma cacao L., IgM tikus putih, Hemaglutinasi, Imunostimulan
KARAKTERISTIK DAN PENGOBATAN PASIEN DIABETES MELLITUS DI RUMAH SAKIT PANGLIMA SEBAYA PASER Septiani, Ade Purnama; Rusli, Rolan; Rijai, Laode
Journal of Tropical Pharmacy and Chemistry Vol 2 No 5 (2014): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (145.797 KB) | DOI: 10.25026/jtpc.v2i5.77

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Diabetes mellitus (DM) is one of the major health problems, every year the number of patients keep increase. DM can cause chronic complications, will degrade the quality of human resources. Drug interactions occur when the effect of a medication change because other drugs, food, or beverages. The best therapeutic treatment concerning the selection and administration of drugs is very beneficial for the patient. This study aims to determine the type and prevalence of DM, characteristics, and use of medications, and potential drug interactions in the treatment of Diabetes Mellitus. Observational study was conducted using retrospective data DM medical records of all patients in Panglima sebaya Paser’s hospital. Then the data are taken randomly 30 patients for further analysis. The Most type of Diabetes Mellitus is NIDDM ( Non Insulin Dependent Diabetes Melitus) as much 1.148 patients, the most characteristic is patients aged 45-59 years (76.66%), female (66.64%), primary school education (34.6%), and not work (86.9%), and has a family history of diabetes (55.6%). The most used drug in the treatment of diabetes is metformin (32.5%) of the biguanide class. Drug interactions are the most common is Insulin with captopril (46%). Keywords: Diabetes mellitus, patient characteristics, drug use, drug interactions ABSTRAK Diabetes mellitus (DM) merupakan salah satu masalah kesehatan yang besar, setiap tahunnya jumlah pasiennya terus meningkat. DM dapat menyebabkan komplikasi kronik, akan menurunkan kualitas sumber daya manusia.  Interaksi obat terjadi jika efek suatu obat berubah akibat adanya obat lain, makanan, atau minuman. Terapi pengobatan yang baik dan benar terkait pemilihan dan pemberian obat sangat menguntungkan bagi pasien. Penelitian ini bertujuan untuk mengetahui tipe dan prevalensi penyakit DM, karakteristik, dan penggunaan obat, serta potensi interaksi obat pada terapi penyakit DM. Penelitian dilakukan secara observasional menggunakan data retrospektif rekam medik seluruh pasien DM di Rumah Sakit Panglima Sebaya Paser tahun 2013. Kemudian diambil secara acak data 30 pasien untuk dianalisis lebih lanjut.  Tipe DM yang terbanyak adalah DM tipe 2 sebanyak 1.148 pasien, dengan karakteristik terbanyak adalah pasien berusia ≥45 tahun (76,66%), berjenis kelamin wanita (66,64%), berpendidikan Sekolah Dasar (34,6%), dan tidak bekerja (86,9%), serta memiliki sejarah keluarga pengidap DM (55,6%). Obat yang paling banyak digunakan pada terapi DM adalah Metformin (32,5%) dari golongan biguanid. Interaksi obat yang paling banyak terjadi yaitu Insulin dengan captopril  (46%). Kata kunci: Diabetes mellitus, karakteristik pasien, penggunaan obat, interaksi obat
PROFIL KROMATOGRAFI SENYAWA AKTIF ANTIOKSIDAN DAN ANTIBAKTERI FRAKSI N-HEKSANA DAUN LIBO (FICUS VARIEGATA BLUME) Rusli, Rolan; Hardina, Myra Puspha; Muflihah, Fairul; Rahmadani, Agung
Journal of Tropical Pharmacy and Chemistry Vol 3 No 2 (2015): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (363.666 KB) | DOI: 10.25026/jtpc.v3i2.98

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Research about chromatographic profile of antioxidant and antibacterial compounds in n-hexane fraction of Libo leaves (Ficus variegata Blume.) has been done in order to know the form of chromatographic profile of antioxidant and antibacterial compounds in n-hexane fraction of Libo leaves. Extraction was done by maceration using methanol. Isolation was done by 2 methods, vacuum liquid chromatography (VLC) then followed by conventional column chromatography. Eluent used are n-hexane-ethyl acetate and methanol-chloroform. The results based on conventional column chromatography are as many as 10 fractions. The fractions are being conducted then by a qualitative testing of the antioxidant activity using DPPH method and antibacterial activity test using bioautography TLC method. The results formed as a chromatographic profile of fraction that contain antioxidant and antibacterial activity, which are as many as 5 fractions (NHB1, NHB3, NHB4, NHC1, NHC3) active as an antioxidant and 4 fractions (NHB1, NHC1, NHC2, NHC3) which are active as an antibacterial. The secondary metabolite contents of the fractions are alkaloid, flavonoid and steroid/terpenoid.
PENGARUH JUS BUAH PEPAYA (Carica papaya L.) TERHADAP PROFIL FARMAKOKINETIK SIMETIDIN PADA TIKUS PUTIH (Rattus norvegicus) Julaicha, Siti; Ramadhan, Adam M.; Rusli, Rolan
Journal of Tropical Pharmacy and Chemistry Vol 3 No 3 (2016): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (385.933 KB) | DOI: 10.25026/jtpc.v3i3.101

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Drugs used with foods or drinks can affect the drug effects. This study aims to observe the effect of papaya juice (Carica papaya L.) to the pharmacokinetics profile of cimetidine in white rats. The animal were randomly in three group. Group 1 (cimetidine) was given a single oral cimetidine 3,6 mg/200gBW. Group 2 (cimetidine and papaya juice dose I) was given cimetidine 3,6 mg/200gBW together with papaya juice 4,5 g /200gBW. Group 3 (cimetidine and papaya juice dose II) was given cimetidine 3,6 mg/200gBW together with papaya juice 9 g /200gBW. The serial blood was collected for 4 hours on lateralis vein of rats tail. Determination of cimetidine in plasma performed by spectrophotometer UV. The pharmacokinetic parameters of cimetidine were calculated by regresi linear method and recidual method and were analyzed by One Way ANOVA using 95 % confidence interval. Based on research results showed that the group II and group III increased of ka, Cpmaks, tmaks, Cl, AUC and decreased ke, t½ab and t½el. Group III provides the most affect the cimetidine pharmacokinetics profile with decreased absorption and elimination and increased metabolism of cimetidine in rat.
OPTIMALISASI EKSTRAKSI DAN UJI METABOLIT SEKUNDER TUMBUHAN LIBO (FICUS VARIEGATE BLUME) Febrina, Lizma; Rusli, Rolan; Muflihah, Fairul
Journal of Tropical Pharmacy and Chemistry Vol 3 No 2 (2015): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.509 KB) | DOI: 10.25026/jtpc.v3i2.153

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Tumbuhan Libo (Ficus variegate Blume) merupakan salah satu tumbuhan liar, dan bagian daunnya tidak pernah dimakan oleh ulat. Pada Tahap ini dilakukan optimalisasi teknik ekstraksi dan menguji metabolit sekunder daun libo. Optimalisasi dilakukan dengan mengubah berbagai variabel yaitu metode ekstraksi, variasi jumlah pelarut, dan lamanya waktu ekstraksi. Efektivitas ekstraksi dilihat dari %rendemen yang dihasilkan. Metode yang digunakan adalah maserasi dan soxhlet, sedangkan pelarut yang digunakan adalah metanol dengan variasi jumlah pelarut 1:10, 1: 20, 1:30 serta variasi waktu ekstraksi (1,2,3 4 dan 5 hari untuk maserasi dan 1,2,3,4 dan 5 siklus untuk metode soxhlet). Hasil yang didapat dari penelitian ini adalah metode terbaik untuk ekstraksi daun libo adalah metode soxhlet dengan % rendemen 34,00 dengan perbandingan pelarut 1:30 dengan lama ekstraksi sebanyak 5 siklus. Dari pengujian metabolit sekunder diketahui daun Libo ini mengandung fenol, flavonoid dan alkaloid.