Fitriani, Victoria Yulita
Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

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STUDI EFEK SAMPING OBAT PADA PASIEN NEONATUS YANG MENJALANI RAWAT INAP DI RUMAH SAKIT ANGKATAN LAUT DR. RAMELAN SURABAYA Fitriani, Victoria Yulita; Widyati, Widyati; Huibeis, Azis; Wisanti, Retno
Journal of Tropical Pharmacy and Chemistry Vol 1 No 1 (2010): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (53.302 KB) | DOI: 10.25026/jtpc.v1i1.11

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ABSTRACT   Rational drug treatments to avoid adverse drug reactions in neonates are depend on physiologic immaturity and age-related changes in pharmacokinetic and pharmacodynamic factor. This condition lead neonates more prone to adverse drug reaction than adults.The aim of this study was to estimate the prevalence of adverse drug reactions that occured at Dr. Ramelan Navy Hospital's NICU observed in November 26th 2007 to January 26th 2008. It was also to analyze kind of medication that caused adverse drug reactions.The study employed 94 patients (5 premature neonates and 89 term neonates) who were observed perspectively from November 26th 2007 to January 26th 2008. Demographic data, drug therapy, relevant medical histories, laboratory data were recorded in this study. The study result was assessed by literature study. The study result were analysed with Descriptive analysis. The most common adverse drug reaction occurred in this population was potential adverse drug reaction (99.5%). The most adverse drug reaction generated from this study was come from the use of ampicillin sulbactam (42.7%), gentamisin (31.4%), ceftriaxone (16.2 %), amikacin (7.6 %), aminofilin (1.1 %), ampicillin (0.5 %), and dexamethasone (0.5 %). The study showed that almost all of adverse drug reaction occurred in this study was potential adverse drug reaction (99.5%).   Keywords: neonates; adverse drug reactions; NICU   ABSTRAK   Terapi obat yang rasional untuk menghindari efek samping dari obat pada neonatus bergantung pada ketidakmatangan fisiologik dan perubahan faktor farmakokinetika dan farmakodinamika yang terkait usia. Kondisi ini membawa neonatus lebih mudah terpapar efek samping obat daripada orang dewasa. Tujuan dari penelitian ini adalah untuk memperkirakan angka kejadian efek samping obat yang terjadi di NICU Rumah Sakit Angkatan Laut Dr. Ramelan Surabaya diamati secara prospektif sejak 26 November 2007 hingga 26 Januari 2008. Penelitian ini juga menganalisa jenis obat yang menyebabkan efek samping obat. Penelitian ini melibatkan 94 pasien (5 neonatus premature dan 89 neonatus term) yang diamati secara prospektif sejak 26 November 2007 hingga 26 Januari 2008. Penelitian ini mencatat data demografi, terapi obat, sejarah penyakit yang terkait, dan data laboratorium. Data tersebut dianalisa melalui studi literatur. Hasil penelitian dianalisa dengan menggunakan analisis deskriptif. Efek samping obat yang sering muncul pada penelitian ini adalah efek samping potensial (99.5%). Efek samping yang terjadi pada penelitian ini terjadi akibat penggunaan ampisilin sulbaktam (42.7%), gentamisin (31.4%), ceftriaxon (16.2%), amikasin (7.6%), aminofilin (1.1%), ampisilin (0.5%), dan deksametason (0.5%). Penelitian ini menunjukkan bahwa sebagian besar efek samping obat yang terjadi pada penelitian ini adalah efek samping obat potensial.   Kata kunci: neonatus; efek samping obat; NICU
STUDI PENGGUNAAN ANTIBIOTIKA PADA NEONATUS DI NICU RSAL DR. RAMELAN SURABAYA Fitriani, Victoria Yulita
Journal of Tropical Pharmacy and Chemistry Vol 1 No 2 (2011): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (52.521 KB) | DOI: 10.25026/jtpc.v1i2.24

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ABSTRACT   Neonatal sepsis and nosocomial infection are the most common diagnosis of neonatal infections. Selections of antibiotics in neonatal infection should be based on type of bacteria, antibiotics dose and safety in neonates. The aim of this study was to explored type of antibiotics used in Neonatal Intensive Care Unit. Researchers conducted a prospective study of antibiotics used at Dr. Ramelan Navy Hospital neonatal intensive care unit Surabaya. From November 26th 2007 to January 26th 2008, 94 patients (5 preterm neonates and 89 term neonates) were included in this study. Demographic data, antibiotics used, relevant medical histories, laboratory data was recorded prospectively at the wards. Charts for all cases were reviewed.  Early antibiotic use was defined as therapy within 72 hours of life. The most frequently used empiric antibiotic regimens were ampicillin sulbactam with gentamicin (60.2%), ampicillin sulbactam (30.1%), ceftriaxone (6.5%), ampicillin sulbactam with amikacin (1.1%), ampicillin sulbactam with ceftriaxone (1.1%), gentamicin with ceftriaxone (1.1%).  Late antibiotic events also occurred in neonates. Fourty eight point four percent of late antibiotics events were used of ceftriaxone. Antibiotics are prescribed appropriately but earlier discontinuation or switches, which may be complicated either by the inability to confirm causative organism or patient’s condition that showed no improvement, should be practiced.   Key words: Neonatus, antibiotic   ABSTRAK   Diagnosa infeksi pada neonatus umumnya berupa sepsis neonatorum dan infeksi nosokomial. Pemilihan antibiotika pada kondisi tersebut perlu didasarkan kepada jenis bakteri yang umumnya terlibat, dosis antibiotika dan tingkat keamanan pada neonatus. Penelitian ini bertujuan untuk mengeksplorasi jenis antibiotika yang digunakan pada pasien neonatus. Penelitian ini merupakan penelitian prospektif dengan melakukan pengamatan secara langsung selama 3 bulan di NICU RSAL Dr. Ramelan Surabaya. Peneliti mengobservasi pasien secara langsung dan mengambil data pemakaian antibiotika melalui rekam medik. Semua pasien neonatus yang menjalani rawat inap di NICU periode (Oktober – Desember 2007) disertakan sebagai sampel penelitian. Hasil penelitian di dapat antibiotika untuk penanganan tahap awal yang sering digunakan adalah kombinasi ampisilin sulbaktam dengan gentamisin (60.2%), ampisilin sulbaktam (30.1%), ceftriaxonee (6.5%), kombinasi ampisilin sulbaktam dengan amikasin (1.1%), kombinasi ampisilin sulbaktam dengan ceftriaxonee (1.1%), kombinasi gentamisin dengan cetriaxone (1.1%). Antibiotika untuk penanganan tahap akhir adalah  ceftriaxonee (48.4%), kombinasi ceftriaxone dengan amikasin (25.6%), amikasin (9.3%), ampisilin sulbaktam (4.7%), kombinasi ceftriaxone dengan gentamisin (4.7%), kombinasi ampisilin sulbaktam dengan gentamisin (4.7%), kombinasi ampisilin dengan amikasin (4.7%), kombinasi ampisilin sulbaktam dengan amikasin (4.7%), kombinasi ceftriaxone dengan amikasin (4.7%).   Kata Kunci: neonatus, antibiotika  
KARAKTERISTIK PASIEN DAN PENGOBATAN PENDERITA SKIZOFRENIA DI RSJD ATMA HUSADA MAHAKAM SAMARINDA Nisa, Aulia; Fitriani, Victoria Yulita; Ibrahim, Arsyik
Journal of Tropical Pharmacy and Chemistry Vol 2 No 5 (2014): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (127.153 KB) | DOI: 10.25026/jtpc.v2i5.78

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Schizophrenia is a combination of psychotic symptoms with personality disorders typical distortion. The frequency of schizophrenia in Indonesia is 1-3 people per 1000 people , and in developed countries is 1 in every 100 people with schizophrenia. The research Patient Characteristics and Treatment of Patients with Schizophrenia in Mental Health Hospital Atma Husada Mahakam Samarinda was done by analyzing the data obtained from the medical records unit. Analysis method used is descriptive qualitative method. The results are 62,05% male patients and 37,95% female patients, 96,97% patients in productive age and 76,51% does not have job. The causes of schizophrenia are 19,28% genetic and 80,72% non genetic. The selection of medication given to patients consists of antipsychotics, hypnotics and sedatives, antiparkinson, antihistamines, antiepileptic, and antidepressants. Keyword: Schizophrenia, Patient Characteristics, Medication. Abstrak Skizofrenia merupakan serangkaian gejala psikotik dengan gangguan kepribadian distorsi khas pada proses pikir. Frekuensi skizofrenia di Indonesia adalah 1-3 orang setiap 1000 orang, dan pada negara maju terdapat 1 orang skizofrenia pada setiap 100 orang. Penelitian Karakteristik Pasien dan Pengobatan Penderita Skizofrenia di RSJD Atma Husada Mahakam Samarinda telah dilakukan dengan menganalisa data yang diperoleh dari unit rekam medik. Metode analisa yang digunakan adalah metode deskriptif kualitatif. Hasilnya adalah pasien pria 62,05% dan pasien wanita 37,95%, pasien rentang usia produktif 96,97% dan tidak memiliki pekerjaan 76,51%. Penyebab skizofrenia 19,28% genetik dan 80,72% non genetik. Pemilihan obat yang diberikan kepada pasien penderita skizofrenia terdiri dari antipsikotik, hipnotik dan sedatif, antiparkinson, antihistamin, antiepilepsi, dan antidepresan. Kata Kunci: Skizofrenia, Karakteristik Pasien, Pengobatan.
AKTIVITAS ANTIOKSIDAN KOMBINASI DAUN CEMPEDAK (Artocarpus champedan) DAN DAUN BANDOTAN (Ageratum conyzoides L) Halimatussa’diah, Fauziah; Fitriani, Victoria Yulita; Rijai, Laode
Journal of Tropical Pharmacy and Chemistry Vol 2 No 5 (2014): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (34.898 KB) | DOI: 10.25026/jtpc.v2i5.71

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Research has been conducted with a purpose to find out the potential of the extracts of leaves Ageratum conyzoides and Artocarpus champedan  as an antioxidant compared with vitamin C. Research was done by infused extraction method, and combination both of them with a partition 1:1, 1:2, 2:1. Keywords: Ageratum conyzoides L, Artocarpus champeden, DPPH, antioxidant   ABSTRAK Kombinasi ekstrak daun bandotan (Ageratum conyzoides L) dan daun cempedak (Artocarpus champeden) memiliki aktivitas antioksidan harga IC50 yang kuat dengan menggunakan kombinasi daun bandotan : daun cempedak perbandingan 1:1, 1:2, dan 2:1. Kata kunci:    daun bandotan (Ageratum conyzoides L), daun cempedak (Artocarpus champeden), DPPH, antioksidan