The purpose of this study was to develop a handout included a glossary on protists material for class X SMA that is valid and practical. The type of this research is the development research that uses three phases of 4D model that consisting of define phase (definition), design (design), and develop (development), the fourth phase is phase of disseiminate (deployment) is not done. This handout is validated by 5 validators, for the practicalities conducted by two teachers and 30 students of class X IPA 2 SMAN 7 Sijunjung. The data of this research is primary data that is obtained from the questionnaire validity and practicalities, then analyzed with descriptive analysis. Handout generated from terms of content feasibility, language, presentation, and chart has an average value of 84.17% and categorized (valid). Handout that is produced called practically by teacher if the average value is 89.58% (practical) and has been produced by students with 83.91% (practical) of average value.
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