Berkala Ilmu Kedokteran
Vol 41, No 04 (2009)

The effect of zinc supplementation on collagen of periodontitisrat

Soeharyo Hadisaputro, Suryono, Praptiwi, Siti Fatimah Muis (Unknown)

Article Info

Publish Date
18 Nov 2015


Background: Zinc,cofactors of DNA-and RNA-polymerase, having great role in tissue heal-ing. In periodontitis, collagen type 1 the main fiberconstituting periodontal structure is des-troyed and be the main cause of lost of teeth among adult in Indonesia. Zndeficiency is still a nutritional problem. The aim of the study is to obtain the influence of 500 pg Zn supplementation (Zn,1and 200 pg (Zn2)per day for 7 days to periodontal collagen of Periodontitis (PI rat through histologic feature. Method: inthe experimental study with factorial design, 29 adult male Wistar rat were used. Subjects were grouped simple randomly into 6 i.e Healthy (H)at the start, Hatthe end, p, P+Te-tracycline IT), ,P + T+ Zn" and P+ T+ Zn2.Subject other than Hgroups were induced periodontitisby Porphyromonasgingivalisbacteria. Zn concentration was measured by AAS Flame, Periodontal tissue was stained with Mallory,s. T test and ANOVAwas used to analyse difference between mean of Znconcentration of groups studies. Result: There were similarity in the feature of groups H at the start, Hat the end, and P+ T+ Zn" in sense of regularity, length, and solidity of collagen. P group had irregular, and short collagen. Groups of P+ T with shorter collagen, had similarity to Health at the end. P+ T+ Zn2with shorter collagen similar to P+T+ Znl. There was significant difference inZn concentrat-ion between Hat the end and Pgroup. Nosignificant differencies among Zn concentrations of Psubject groups. Great variety of Zn concentration found among subjects of groups prob-ably were the cause of absence of difference, although means of the Zn concentration values depicted it. Conclusion: Zn supplementation dosage 500 pg/day given to periodontitis rat beside Tetra-cycline, gives better effect to collagen structure compared to 200 pg/day.

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