Berkala Ilmiah Kedokteran Duta Wacana
Vol 4, No 2 (2019): Berkala Ilmiah Kedokteran Duta Wacana

IMMUNOPROTECTIVE EFFECT OF MELATONIN ADMINISTRATION ON METHYLPREDNISOLONE-TREATED WISTAR MALE RAT (RATTUS NORVEGICUS)

Manus, Widya Christine (Fakultas Kedokteran Universitas Udayana )
Pangkahila, Wimpie (Universitas Udayana )
Aman, I Gusti Made (Universitas Udayana )



Article Info

Publish Date
27 Dec 2019

Abstract

Background: Immune system function decreases with age. Steroid use might accelerate this process, especially in adults in Indonesia. Melatonin is a natural hormone which show antioxidant effect and immunoprotective effect. Melatonin administration might help in reviving humane immune system due to aging and exogenous steroid exposure. Objective: This experiment is aimed to determine the effect of melatonin on leukocyte and lymphocyte count of methylprednisolone-induced immunosuppression on Wistar rat. Method: This study was true experimental with post-test only control group design using 32 male rats. Rats were divided into control and the intervention group. Control group was given methylprednisolone 0.144 mg/200 g rat 3 times a day and distilled water. The treatment group was given methylprednisolone 0.144/200 g rat 3 times a day and 0.054 mg/200 g melatonin once daily. The blood was taken after 14 days of treatment. Results: Intervention group shows higher lymphocytes count (4.95 ±1.58x103/?L) compared to the control group (3.09?1.33x103/?L), with p < 0.01. The intervention group also has higher leukocyte count (8.37± 2.02x103/?L) compared to the control group (6.70 ± 1.96x103/?L), with p

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Journal Info

Abbrev

bikdw

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Description

Berkala Ilmiah Kedokteran Duta Wacana is a Scientific Journal to publish medical research articles, and other scientific medical articles from Medical Faculty of Duta Wacana Christian University academic community and also receive articles from other resources with appropriate and related topics. ...