International Journal of Integrated Health Sciences
Vol 6, No 2 (2018)

ASSOCIATION OF KI-67 EXPRESSION AND RESPONSE OF NEOADJUVANT CHEMOTHERAPY IN INVASIVE BREAST CANCER PATIENTS IN BANDUNG

Rezano, Andri (Unknown)
Pan, Chen En (Unknown)
Istiqomah, Afrida Aizzatun (Unknown)
Zada, Almira (Unknown)



Article Info

Publish Date
01 Oct 2018

Abstract

Objective: To analyze the association of Ki-67 expression and response of neoadjuvant chemotherapy in patients with invasive breast cancer.   Methods: A retrospective observational study on the association of Ki-67 expression and response of neoadjuvant chemotherapy in patients with invasive breast cancer was conducted. This study included twenty-five female patients with invasive breast cancer who met the inclusion criteria. Parameters analyzed were age, tumor size, and immunohistochemical expression of Ki-67. Size of the tumor at pre- and post-neoadjuvant chemotherapy were obtained in cm3 and compared between 3 groups of Ki-67 expression levels. One way ANOVA was used to perform the statistical analysis. Results: A significant difference in changes of tumor size for Ki-67 level >20% compared to <14% and 14?20% was seen. Based on the result, neoadjuvant chemotherapy was proven to have similar effects in patients with Ki-67 expression of <14% and 14?20% but less effective in patients with Ki-67 expression of >20%. Conclusions: Low to modest expression of Ki-67 was a better biomarker to predict the response of neoadjuvant chemotherapy in patients with invasive breast cancer compared to high expression of Ki-67. However, the cut-off value of 20% could be ideal to predict the outcome of neoadjuvant chemotherapy in patients with invasive breast cancer. DOI: 10.15850/ijihs.v6n2.1374

Copyrights © 2018






Journal Info

Abbrev

ijihs

Publisher

Subject

Health Professions

Description

International Journal of Integrated Health Sciences (IJIHS) is a peer-review journal which publishes original articles, medical research, clinical research and case report. This journal is supported by Faculty of Medicine Universitas Padjadjaran and was launched on September 22nd 2012 and firstly ...