Journal of Dentistry Indonesia
Vol 18, No 1 (2011): April

Bisphosphonate: Brief Review of Its Development for Usage in Dentistry

Utari, Tita Ratya ( Faculty of Medical and Health Sciences, Muhammadiyah Yogyakarta University, Yogyakarta 55813 )

Article Info

Publish Date
02 May 2013


Bisphosphonate (BP) is a class of drug that prevent the loss of bone mass. It inhibits the resorption of bone by encouraging osteoclast to undergo apoptosis. Considering that oral diseases and dental procedures may lead to teeth instability whereas alveolar bone is the main tooth supporting tissue, forceful indication of this drug is for preventing and minimizing bone resorption following oral surgery and relapse movement in orthodontic treatment. Clinical use of BP in dentistry is limited by risk of osteonecrosis of the jaw (ONJ) and of its systemic effects such as an increase of the bone mineral density in another bone area. Topical application with local effect would seem the choice of administration route for usage in dentistry. Until recently, no clinical usage of topical BP has been studied, however some experimental laboratory studies proved that this drug would be beneficial in a wide scope of dental treatments.DOI: 10.14693/jdi.v18i1.154

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Journal Info





Dentistry Medicine & Pharmacology


Journal of Dentistry Indonesia (JDI) is a scientific journal that is published three times annually (April, August and December). This journal aims for continuous dissemination of updates in relation to dentistry and its related fields in the form of original articles, case reports and reviews. Its ...