Jurnal Biologi Papua

Analisis Pertumbuhan Kartilago Epifisialis Os Tibia Fetus Mencit (Mus musculus L.) Swiss Webster Setelah Induksi Ochratoxin A Selama Periode Organogenesis

Setiawan, Arum ( Universitas Brawijaya )
Sagi, Mammed ( Universitas Gadjah Mada )
Asmara, Widya ( Universitas Gadjah Mada )
Istriyati, Istriyati ( Universitas Gadjah Mada )

Article Info

Publish Date
01 Apr 2012


The aims of this study were determined the effects of Ochratoxin A (OTA) on growth of fetus tibia epiphyseal cartilage during organogenesis period. Twenty four pregnant mice were divided randomly into 4 groups of 6. Ochratoxin A was dissolved in sodium bicarbonateand administered orally on seventh to fourteenth days of gestation at dosage of 0.5, 1.0, 1.5 mg/kg bw, respectively. The remaining were used as control. The fetal tibia was taken after the 18 th day of pregnancy. The growth of tibia epiphyseal cartilages were observed histologically using Erlich’s Haematoxylin-Eosin Stain. The result of this study indicated that OTA caused decreased thickness of the rest zone, proliferative zone, maturation zone and calsification zone of the fetus tibial growth plate significantly.Key words: Ochratoxin A, tibia, cartilage, and thickness

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