Indonesian Journal of Chemistry
Vol 14, No 1 (2014)

Antibacterial Activity of Germacrane Type Sesquiterpenes from Curcuma heyneana Rhizomes

Diastuti, Hartiwi (Unknown)
Syah, Yana Maolana (Unknown)
Juliawaty, Lia Dewi (Unknown)
Singgih, Marlia (Unknown)

Article Info

Publish Date
01 Mar 2014


The isolation of terpenoids from C. heyneana rhizomes and their antibacterial activity have been conducted. The terpenoids were isolated by using vacuum liquid chromatography and radial chromatography. The structures of the compounds were determined based on spectroscopic data (1H-NMR, 13C-NMR (1D and 2D)). The antibacterial activity was carried out by using microdilution method and evaluated against eight bacteria. Three germacrane type sesquiterpenes have been isolated from C. heyneana rhizhomes and were identified as germacrone, dehydrocurdione, and 1(10),4(5)-diepoxygermacrone. Germacrone showed highest antibacterial activity against P. aeruginosa with MIC values of 15.6 µg/mL and MBC values 31.2 µg/mL. Dehydrocurdione showed highest antibacterial activity against B. subtilis with MIC values of 31.2 µg/mL and MBC values of 31.2 µg/mL. However, 1(10),4(5)-diepoxygermacrone showed a weak antibacterial activity.

Copyrights © 2014

Journal Info





Chemical Engineering, Chemistry & Bioengineering Chemistry


Indonesian Journal of Chemistry is an International, peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry including applied chemistry. The journal is accredited by The Ministry of Research, Technology ...