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Smart Medical Journal
ISSN : 26211408     EISSN : 26210916     DOI : -
Core Subject : Health,
Smart Medical Journal (SmedJour) is published by Faculty of Medicine Universitas Sebelas Maret. SMedJour publishes original research articles or article review in the basic medical sciences, clinic medical sciences, medical education and public health.
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Articles 35 Documents
PENGARUH PEMBERIAN EKSTRAK ETANOLIK AKAR KELOR (Moringa oleifera, Lam) TERHADAP KADAR ASAM URAT DAN INFILTRASI SEL RADANG JARINGAN GINJAL TIKUS PUTIH (Rattus norvegicus) MODEL DIET TINGGI LEMAK DAN INDUKSI STREPTOZOTOCIN-NICOTINAMIDE DAMAYANTI, YNES AULIA EKA; PESIK, RIZA NOVIERTA; WIDARDO, WIDARDO; BUDIANI, DYAH RATNA
Smart Medical Journal Vol 2, No 2 (2019): Smart Medical Journal
Publisher : Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1479.216 KB) | DOI: 10.13057/smj.v2i2.37941

Abstract

Latar Belakang. Insidensi obesitas yang tinggi akibat diet tinggi lemak serta keadaan hiperglikemia menyebabkan stress oksidatif yang berujung pada infiltrasi sel radang di ginjal dan hiperurisemia. Fitokimia akar kelor bersifat antioksidan dan antidiabetik pada jaringan hepar, pankreas dan ginjal. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak akar kelor terhadap kadar asam urat dan infiltrasi sel radang jaringan ginjal tikus putih model diet tinggi lemak dan induksi streptozotocin-nicotinamide.Metode. Penelitian eksperimental laboratorik dengan pretest-postest control group design untuk kadar asam urat dan postest only control group design untuk infiltrasi sel radang jaringan ginjal. Tikus jantan galur Wistar 30 ekor dibagi random menjadi 5 kelompok. K(1) kontrol negatif diberi pakan standard, K(II) diinduksi pakan tinggi lemak dan streptozotocin-nicotinamide, K(III), (IV) dan (V) setelah induksi diberi variasi dosis ekstrak akar kelor 150, 250 dan 350 mg/kgBB selama 28 hari. Kadar asam urat diukur dengan Spektrofotometer kit DiaSys selama empat kali. Analisis hasil dengan one-way ANOVA dan post hoc Tukey HSD test serta repeated ANOVA dilanjutkan pairwise comparison Bonferroni. Persentase infiltrasi sel radang jaringan ginjal dianalisis dengan Kruskal-wallis dan post hoc Man whitney test. Analisis hubungan keduanya menggunakan Spearman.Hasil: Terdapat perbedaan yang bermakna antara semua waktu pengukuran kadar asam urat (p < 0.05, kecuali kelompok K3 antara hari ke-25 dan hari ke-57). Terdapat perbedaan signifikan kadar asam urat setelah pemberian ekstrak akar kelor antar kelompok. Terdapat perbedaan signifikan setelah diberikan ekstrak akar kelor pada persentase infiltrasi sel radang jaringan ginjal glomerulus antara K(I) dengan K(II), K(II) dengan K(V); dan antara K(II) dan K(V) pada jaringan ginjal tubulus. Persentase infiltrasi sel radang jaringan ginjal dan kadar asam urat setelah pemberian ekstrak akar kelor menunjukan hubungan yang bermakna dan berkorelasi positif kuat.Simpulan: Ekstrak akar kelor dengan dosis 150, 250 dan 350mg/kgBB menurunkan kadar asam urat darah, dan dosis 350mg/kgBB mampu menurunkan infiltrasi sel radang jaringan ginjal.Kata Kunci: Ekstrak akar kelor; asam urat; infiltrasi sel radang; pakan tinggi lemak; Streptozotocin-NicotinamideBackground: The high incidence of obesity due to a high-fat diet and hyperglycemia causes oxidative stress which can lead to infiltration of inflammatory cells in the kidneys and hyperuricemia. Phytochemicals of Moringa root are antioxidant and antidiabetic in liver, pancreas and kidney tissue. This study aims to determine the effect of Moringa root extracts on uric acid levels and inflammatory cell infiltration of white rat kidney tissue in high-fat diet models and induction of streptozotocin-nicotinamide.Methods: Laboratory experimental research with pretest-posttest control group design for uric acid levels and posttest only control group design for infiltration of inflammatory cells of kidney tissue. Samples of 30 Wistar strain male rats were randomly divided into 5 groups. K(1) negatie control was given standard feed, K(II) was induced by high-fat feed and streptozotocin-nicotinamide, K(III), (IV) and (V) after induction was given various dosage variations of Moringa root extract 150 mg / kgBW, 250 mg / kg kgBB and 350 mg / kgBB for 28 days. Uric acid levels were measured with a DiaSys kit spectrophotometer four times. The results were analyzed by one-way ANOVA test and post hoc Tukey HSD test and repeated ANOVA test followed by pairwise comparison Bonferroni test. The percentage of inflammatory cells infiltration of kidney tissue was analyzed by the Kruskal-wallis test and the post hoc Man Whitney test. The relationship between the two was tested using the Spearman testResults: There was a significant difference between all time measurements of uric acid levels (p <0.05, except for the K3 group between the 25th day and 57th day). There was a significant difference in uric acid levels after administration of Moringa root extract between groups. There was a significant difference after Moringa root extract was given in the percentage of inflammatory cells infiltration of glomerular kidney tissue between K (I) with K (II), K (II) with K (V); and between K (II) and K (V) in tubular kidney tissue. The percentage of inflammatory cells infiltration of kidney tissue and uric acid levels after administration of Moringa root extract showed a significant relationship and a strong positive correlation.Conclusion: Moringa root extract with a dose of 150 mg / kgBW, 250 mg / kgBW and 350 mg / kgBW significantly reduced uric acid levels, and with a dose of 350 mg / kgBW significantly reduced infiltration of inflammatory cells of kidney tissue.Keywords: Moringa root extract; uric acid; infiltration of inflammation cells; high-fat feed; Streptozotocin-Nicotinamide
Hubungan Lingkar Pinggang dan Lingkar Panggul dengan Tekanan Darah pada Pasien Program Pengelolaan Penyakit Kronis (Prolanis) Sumardiyono, Sumardiyono; Pamungkasari, Eti Poncorini; Mahendra, Anton Giri; Utomo, Oki Saraswati; Mahajana, Devita; Cahyadi, Wakhid Ryan; Ulfia, Mila
Smart Medical Journal Vol 1, No 1 (2018): Smart Medical Journal
Publisher : Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (141.049 KB) | DOI: 10.13057/smj.v1i1.24504

Abstract

Introduction: Obesity is a state of excessive accumulation of fat in the body, which is a risk factor for cardiovascular disease. Obesity can be measured using anthropometric methods measuring waist circumference and hip circumference. This study aims to find the relationship between the size of waist circumference and hip circumference to blood pressure in prolanis participants in the working area of Kedawung I Public Health Center, Sragen Regency.Method: This study was an observational analytic study using a cross sectional design. The subjects were prolanis participant patient with a history of hypertension in the Kedawung I Community Health Center in Sragen in July 2017. Sampling was done by simple random sampling. The number of subject were 60 persons.Results: There were significant relationship between waist circumference and systolic/ diastolic blood pressure with weak strength (r = 0.304; p = 0.018 and r = 0.337; p = 0.008) and significant relationship between hip circumference with systolic/diastolic blood pressure with weak strength (r = 0.263; p = 0.042 and r = 0.306; p = 0.017).Conclusion: the increasing size of waist and hip circumference may increase blood pressure in prolanis participants.
HUBUNGAN ANTARA MEROKOK dan AKTIFITAS FISIK DENGAN PREVALENSI HIPERTENSI DI INDONESIA (ANALISIS DATA RISKESDAS DAN PROFIL KESEHATAN 2013) ali, balgis; Sumardiyono, Sumardiyono
Smart Medical Journal Vol 2, No 1 (2019): Smart Medical Journal
Publisher : Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (486.438 KB) | DOI: 10.13057/smj.v2i1.30846

Abstract

Introduction: Currently hypertension is a major health problem in the world, including in Indonesia. The prevalence of hypertension in various regions in Indonesia varies. several factors are thought to play a role in this variation including the health system, hypertension risk factors and the prevalence of diabetes mellitus. This study aims to analyze the relationship between the health system (health services, health personnel, finance), hypertension risk factors (smoking and physical activity) and the prevalence of diabetes mellitus with differences in the prevalence of hypertension in various provinces in Indonesia. Currently hypertension is a major health problem in the world, including in Indonesia. The prevalence of hypertension in various regions in Indonesia varies. several factors are thought to play a role in this variation including the health system, hypertension risk factors and the prevalence of diabetes mellitus. This study aims to analyze the relationship between the health system (health services, health personnel, finance), hypertension risk factors (smoking and physical activity) and the prevalence of diabetes mellitus with differences in the prevalence of hypertension in various provinces in Indonesia.Methods: This study used an observational analytic design with an ecological study approach. Data was obtained from 440 districts and 33 provinces in Indonesia. which is taken on a probability basis to size. Samples are men and women aged 18 and above. The independent variable is the prevalence of hypertension while the dependent variable is the health system (health services, health personnel, finance), hypertension risk factors (smoking and sedentary physical activity) and the prevalence of diabetes mellitus. The diagnosis of hypertension is made by a doctor. The data obtained were analyzed using multiple linear regression analysis.Results: Smoking (b = 0, 0.463; 95% CI = 0.042-0.884; p = 0.032), and sedentary physical activity of more than 6 hours (b = 0.196; 95% CI = 0.030-0.3362; p = 0.022) increased the prevalence of hypertension. R2 from the multiple liner regression model is = 27.1%, and overall the models differ significantly (p = 0.05).Conclusion: Smoking and sedentary physical activity are associated with the prevalence of hypertension  
Faktor Risiko Kejadian Recurrent Respiratory Infection pada Anak Usia 2-5 Tahun PUJOKUSUMA, NOPRIYAN; PAMUNGKASARI, ETI PONCORINI; RAHARDJO, SETYO S
Smart Medical Journal Vol 1, No 2 (2018): Smart Medical Journal
Publisher : Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (220.765 KB) | DOI: 10.13057/smj.v1i2.28702

Abstract

Introduction: Acute Respiratory Infection (ARI) is the most prevalent disease with high mortality and morbidity on infant. ARI that happens more than five times annually is called Recurrent Respiratory Infection (RRI). Some mortality of ARI comes from kind of ARI that developed from diseases that could be prevented by immunization. This study aimed to find correlation between immunization status, nutritional status, crowding, smoker in house, mother education level, family income level and RRI incident on children age 2-5 years old in Sibela Primary Health Care (PHC) work area, Surakarta.Methods: This was an observational analytic study with cross-sectional approach. Sample for this study was children age 2-5 years old from Sibela PHC work area, Surakarta. Sample was taken by cluster sampling method as much as 121 children, the parent interviewed using questioner and children was measured for their height and weight. Data of immunization history was obtained from Kesehatan Ibu dan Anak (KIA) Book and PHC data information system for ARI diagnosis. Data was analyzed using chi-square and logistic regression.Result: Chi-square result shows significant correlation between incomplete immunization status and incident of RRI (p=0,000) and OR = 18,774. Logistic regression results shows significant correlation between immunization status and incident of RRI (p=0,000; OR=21,3). Conclusions: Incomplete immunization status significantly correlate to increasing RRI incident 21,3 times on children age 2-5 years old than children which acquired complete immunization status. Nutritional status, crowding, smoker in house, mother educational level, and family income level has no significant correlation with RRI incidence.
Pengaruh Usia Menarche terhadap Tinggi Badan Wanita di Daerah Endemis Gondok Hidayat, Muhammad Taufiq; Handayani, Selfi; Munawaroh, Siti
Smart Medical Journal Vol 1, No 2 (2018): Smart Medical Journal
Publisher : Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (237.816 KB) | DOI: 10.13057/smj.v1i2.28882

Abstract

Introduction: Height affected by various factor. One factor that can affect female?s height is menarcheal age. Sexual hormone in female?s body will be activated at menarche and it will stimulate the closure of epiphyseal plate. Final height in female with late menarche is higher than female with early menarche. While in goiter endemic areas with Iodine Deficiency Disorder especially in mountain area, it has earlier menarcheal age than normal female that live in non goiter endemic area. This study aimed to analyze the relationship between age at menarche and height endemic goiter.Methods: This study was an observational study with cross-sectional design. It was held in the goiter endemic Ngargoyoso, Karanganyar. Samples of women aged over 20 years with upright posture that live in Ngargoyoso were obtained by simple random sampling, then measuring the height using statometer and obtaining menarcheal age by questioner. Data were analyzed using Pearson correlation test (? = 0.05), which had previously been tested for normality by Kolmogorov Smirnov.Results: The mean age of menarche sample was 13.38 years with the lowest age of 11 years and the highest age of 18 years. While the average height was 156.8 cm samples with the lowest height was 139 cm and the highest was 168 cm. Pearson correlation test results showed that height was significantly associated with age at menarche woman endemic goiter (p = 0.001).Conclusions: Age of menarche associated with height in an endemic goiter area.The earlier age of menarche will affect the final height of the woman. 
Hubungan antara Tingkat Pengetahuan dan Sikap dengan Tindakan Pencegahan Penyakit Rabies pada Warga di Wilayah Puskesmas Kuta II Sarjana, Ni Kadek Ayu Septiani; Prasetyawati, Arsita Eka; Budiani, Dyah Ratna
Smart Medical Journal Vol 1, No 1 (2018): Smart Medical Journal
Publisher : Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (171.022 KB) | DOI: 10.13057/smj.v1i1.24184

Abstract

Introduction: Rabies is a disease of animals (usually vertebrate) which is zoonotic (transmissible to humans). Rabies occurs in 24 out of the 34 provinces of Indonesia. Rabies is caused by a virus in the Family: Rhabdivoridae, Genus: Lyssavirus. Control the dog population and dog vaccination is effective and economical method to prevent the incidences of rabies in humans. This study aims to investigate the relationship between level of knowledge and attitude to the practice in prevention rabies infection in residents lived in area covered by Puskesmas Kuta II.Methods: This study was a cross-sectional study and carried out by simple random sampling of 96 residents in the area of Puskesmas Kuta II. In this study, the independent variables are knowledge of and attitudes towards rabies disease while the dependent variable is the practice to prevent rabies infection in human. Data were collected by a questionnaire-based interview. Analyses were then carried out using the chi-square (x2) followed by multivariate analysis using multiple logistic regressions.Results: This study showed that knowledge has a significant relationship with practice for rabies disease prevention (p = 0.013; OR 4.240; 95% CI 1.352 up to 13.296). Attitude has a significant positive relationship with the value of practice for rabies disease prevention (p = 0.015; OR 3.073; 95% CI 1.233 up to 7.627). The combined effect of knowledge and attitudes to practice for rabies prevention were approximately 20.90% (Negerkerke R square = 0.209).Conclusions: There was a significant relationship between knowledge and attitudes with the practice for rabies disease prevention in residents in the area of Puskesmas Kuta II, the higher level of knowledge and improved attitudes will improve practice for rabies disease prevention amongst residents in the area of Puskesmas Kuta II. Key words: Rabies;  Rabies;  Preventio; Knowledge; Attitude;  Practice
FORMULASI DAN UJI STABILITAS FISIK SEDIAAN TABLET EKSTRAK BUAH PARE (Momordica charantia L.) SECARA GRANULASI BASAH fadhilah, Ira nur; Saryanti, Dwi
Smart Medical Journal Vol 2, No 1 (2019): Smart Medical Journal
Publisher : Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (199.382 KB) | DOI: 10.13057/smj.v2i1.29676

Abstract

Bitter melon fruit is one type of medicinal plant used by the community. Charantin is one of the efficacious compounds contained in bitter melon fruit and can be used to reduce glucose levels in the blood. Tablets have advantage that are easy to consume and exactly the size, so in this study bitter melon is made from tablet preparations. The purpose of this study was to determine the concentration of gelatin binder which can produce tablets of bitter fruit extract (Momordica charantia L.) with good physical quality, and to determine the effect of gelatin as a binder on the physical stability test of bitter melon extract tablets (Momordica charantia L.) making bitter melon extract tablets is by wet granulation method, because the active ingredient of bitter melon fruit is not resistant to warming above 600C. Formulation tablets of bitter melon extract (Momordica charantia L.) with gelatin binder at a concentration of 5%, 7.5%, 10% able to produce tablets that meet the requirements of tablet physical examination for 28 days. Gelatin binding concentration has an effect on the physical properties of tablets, the best concentration of gelatin binder is formula III with 10% gelatin concentration. The higher the concentration of the binding material, the higher the hardness, and fragility decreases.Keywords: Bitter Melon Extract (Momordica charantia L.), Gelatin binder, Wet Granulation.
Hubungan Kualitas Tidur dengan Nyeri Kepala Primer pada Masyarakat Daerah Pesisir Desa Nusalaut, Ambon HABEL, PRISKILLA ROSSE GRATIA; SILALAHI, PARNINGOTAN YOSI; TAIHUTTU, YUNIASIH
Smart Medical Journal Vol 1, No 2 (2018): Smart Medical Journal
Publisher : Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (340.384 KB) | DOI: 10.13057/smj.v1i2.28698

Abstract

Introduction: Sleep disorders and primary headaches (NKP) is a common disease in the community and both relate reciprocally. Some of the factors associated with  the  onset  of  primary headache include poor sleep quality, fatigue, change in temperature. Coastal communities are groups of people who have high risk factors for developing such disorders. This study aimed to explore the relationship between quality of sleep and primary headaches in coastal communities in Nusalaut  which never held backward.Methods: Data was collected by using a cross sectional study conducted in communities in Nusalaut amounted to 190 people with data retrieval techniques cluster random sampling. Quality of sleep was assessed by The Pitssburg Sleep Quality Index (PSQI), while primary headache was assessed by questionnaire and Ong BK KH HO-C. Descriptive analysis to determine the characteristics of the subject while the correlation between sleep quality with primary headache is done by Spearman correlation test.Results: The results showed there is a significant association between factors such as gender, age and type of work with quality bedding and primary headaches while between quality of sleep and primary headaches do not have a meaningful correlation with the strength of the correlation was very weak (p = 0.323).  Conclusion: there was no significant correlation between quality of sleep and primary headaches.
Pengaruh Infeksi Kecacingan terhadap Kadar Hemoglobin pada Remaja Putri dengan Anemia RAHAYU, DWI
Smart Medical Journal Vol 1, No 2 (2018): Smart Medical Journal
Publisher : Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (183.681 KB) | DOI: 10.13057/smj.v1i2.28714

Abstract

Introduction: Anemia is one of the health problems in Indonesian. The government has launched anemia prevention programs, including for young women, but the prevalence of anemia is still high. Helminth infections can decrease hemoglobin (Hb) levels through gastrointestinal bleeding and decreased food intake. This study aimed to determine the effect of helminth infections on Hb levels in young women.Methods: This study was an observational analytic study with a case control approach. Research subject involved of 46 students of senior high school in Sukoharjo Regency and were divided into 26 young women with anemia and 20 young women without anemia. Helminth infection was determined using fecal examination. All collected data were analyzed by Chi square test and Independent sample t-test with p<0.05.Results: The mean of Hb levels in young women with anemia was 10.24±0.92g/dL and the mean of Hb levels in young women without anemia was 13.07±0.44g/dL. 7 young women suffered helminth infection, divided into 2 young women with anemia and 5 young women without anemia. However, there was not statistically significant relationship between helminth infection and anemia (p=0.11). The mean of Hb levels in young women with helminth infection were higher both those who suffered anemia (11.30± 0.56 g /dL) or not (13.08 ± 0.42g /dL) compared with Hb levels in young women without helminth infection (anemia 10.37±1.06g/dL; not anemia 11.34±1.52g/dL).Conclusion: Helminth infection was not related to the incidence of anemia in young women even though Hb levels in helminth infections were higher compared to Hb levels without helminth infections.
Kepekaan terhadap Humor berhubungan dengan Tingkat Kecemasan Mahasiswa Fakultas Kedokteran Saat Menghadapi Ujian Karim, Muhammad Yusuf; Suyatmi, Suyatmi; Afifah, Zulaika Nur
Smart Medical Journal Vol 1, No 1 (2018): Smart Medical Journal
Publisher : Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (308.348 KB) | DOI: 10.13057/smj.v1i1.24182

Abstract

Background:Medical students are facing examination in each topics to evaluate  learning achievement. An examination could be a trigger for anxiety. Uncontrolled anxiety could affect the learning achievement. Coping mechanism is needed to decrease the anxiety level. One of the coping mechanisms to decrease anxiety level is sense of humor. The aim of this study was to evaluate whether sense of humor could affect the anxiety level.Methods:This was an observational analytic with cross-sectional design study.The subjects were First Year Medical Students of Universitas Sebelas Maret. The sample was collected by simple random sampling method. Sense of Humor was assesed using Multidimensional Sense of Humor Scale (MSHS). Anxiety level was assesed using Taylor Manifest Anxiety Scale (TMAS). Collected data was analyzed with Kolmogorov-Smirnov Normality Test and Pearson Correlation Test.Results: There were 152 samples in this study. The mean of sense of humor and anxiety level were 69.90 ± 7.22 and 22.16 ± 6.93 respectively. The majority of the samples showed that 78.3% had a high sense of humor, while 21.7% had a moderate sense of humor. More than half of the samples (50.7%) were anxious and 49.3% were not anxious. The result of the Pearson correlation test showed r= -0.263 and p= 0.001.Conclusions:This study indicates a negative correlation between sense of humor and anxiety level towards examination on First Year Medical Student of Universitas Sebelas Maret. Keywords: sense of humor, anxiety level, examination

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