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INDONESIA
Journal of General-Procedural Dermatology & Venereology Indonesia
Published by Universitas Indonesia
ISSN : 24607991     EISSN : 24607991     DOI : -
Core Subject : Health,
The initiation of JDVI (Journal of General - Procedural Dermatology & Venereology Indonesia) was done by leading dermatologists and venereologists from Indonesia who aspired to contribute in the field of scientific publication and research. Knowledge and science continue to evolve in the field of dermatology and venereology, especially with new diagnostic methods, therapeutic and procedural approaches, and new emerging diseases.
Arjuna Subject : -
Articles 60 Documents
THE EPIDEMIOLOGY OF SKIN CANCER AT DR. CIPTO MANGUNKUSUMO NATIONAL CENTRAL GENERAL HOSPITAL FROM 2014 TO 2017 Larisa Paramitha Wibawa; Melody Febriana Andardewi; Inge Ade Krisanti; Riesye Arisanty
Journal of General-Procedural Dermatology & Venereology Indonesia Vol 4, No 1 (2019): December 2019
Publisher : Universitas Indonesia

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Background: The incidence of skin cancer has been increasing over the past decades globally. At present, there is no valid national cancer data in Indonesia. The purpose of this study is to evaluate the increment of skin cancer cases at Dr. Cipto Mangunkusumo National General Hospital, Jakarta.Methods: In this retrospective descriptive study, we evaluated all pigmented skin tumor cases from June 2014 to June 2017. Data were obtained from the Department of Anatomical Pathology and medical records at Dr. Cipto Mangunkusumo National General Hospital. Data were compared with previous reports.Results: From 263 skin cancer cases, the most frequent skin cancer was basal cell carcinoma (BCC; 66.9%), followed by squamous cell carcinoma (SCC; 27.4%), and malignant melanoma (MM; 5.7%). Most of the skin cancer were predominantly in the female population. In BCC and SCC, most of the patients were within the age group above 60 years (n = 106 and 18, respectively). In MM, the incidence is greater in age group of 41–50 years (n = 5). For BCC and SCC, the distribution sites of lesions were mostly in sun-exposed areas, whereas the distribution sites of MM were mostly in non-sun-exposed areas. Median diameters of BCC, SCC, and MM were 2, 4, and 6.5 cm, respectively. There was an increase of BCC incidence from 1996 to 2017. Conclusion: In comparison with other types, the incidence of BCC in Dr. Cipto Mangunkusumo National General Hospital is increasing. A well-documented skin cancer registry is required to establish national data of skin cancer in Indonesia. Keywords: epidemiology, incidence, basal cell carcinoma, malignant melanoma, squamous cell carcinoma  
ASSOCIATION BETWEEN OBESITY AND HISTORY OF ATOPY WITH ATOPIC DERMATITIS IN CHILDREN: A CROSS-SECTIONAL STUDY Nila Wardhani Batan; Ariana Ariana; Made Wardhana
Journal of General-Procedural Dermatology & Venereology Indonesia Vol 4, No 1 (2019): December 2019
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Background: The prevalence of atopic dermatitis (AD) has rapidly increased in the past 4 decades and has been mostly observed in children. The prevalence of obesity has also significantly increased worldwide, suggesting that the two conditions may be associated. Methods: This retrospective analytic study involved a cross-sectional design and used secondary data taken from the medical record of patients who visited the Pediatric Dermatology Subdivision at Dermatology and Venereology Polyclinic Sanglah General Hospital from January 2015 to December 2015. Thirty-two samples were selected. Results: The prevalence ratio of obesity among subjects with AD was 2.178 (95% CI = 1.034–4.587; p < 0.05), which indicated a significant association between obesity and AD. This study also found a significant association between the history of atopy and AD, and the prevalence ratio was 2.566 (95% CI = 1.099–5.990; p < 0.05). The risk of developing AD among children with obesity was higher than that among children without obesity. Conclusion: Obesity and history of atopy were significantly associated with AD in children.   Keywords: atopic dermatitis, children, history of atopy, obesity
PREVALENCE AND RISK FACTORS OF BACTERIAL VAGINOSIS AMONG FEMALE SEX WORKERS IN SURAKARTA Rini Hastuti; Danu Yuliarto; Agung Triana; Willa Damayanti; Rakhma Tri Irfanti; Mardiana Mardiana; Putti Fatiharani Dewi; Ambar Aliwardani; Ervianti Abas; Sulistiyo Sulistiyo; Prasetyadi Mawardi; Endra Yustin Ellistasari
Journal of General-Procedural Dermatology & Venereology Indonesia Vol 4, No 1 (2019): December 2019
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Background: Bacterial vaginosis (BV) is the most common vaginal infection in women of reproductive age and increases the risk of acquiring human immunodeficiency virus (HIV) and other sexually transmitted diseases (STDs). Data regarding the association between sexual activity and BV acquisition is contradictory. Thus, tracking the prevalence and associated risk factors of BV among female sex workers (FSWs) is necessary to improve our understanding and control of STDs and the HIV epidemic.Methods: The subjects of this study were FSWs in Surakarta. This study adopted a cross-sectional design, and diagnosis was established using Amsel criteria. Interviews were conducted using questionnaires to collect data of risk factors, including demographic factors (age, education level, daily income, marital status, location of sex), sociologic factors (age of first intercourse; age of first FSW encounter; duration of work as an FSW; number of clients/day; condom, contraceptive, and vaginal douching use; violence experienced as an FSW; smoking habits; alcohol consumption; and drug use), and knowledge factors (knowledge of STDs and HIV). Statistical analysis was performed by using bivariate analysis.Results: We interviewed 175 FSWs with an average age of 40.66 years. BV was detected in 28 subjects (16%). Risk factors associated with BV include alcohol (p = 0.022) and drug use (p = 0.022).Conclusion: Other than routine screening for STDs and HIV, FSWs should be encouraged to participate in prevention programs aiming to regulate alcohol and drug use to decrease the incidence of BV infection. Keywords: bacterial vaginosis, female sex workers, risk factors
A CASE OF ANA-NEGATIVE SYSTEMIC SCLEROSIS TREATED WITH METHYLPREDNISOLONE Carminda Rogacion; Veronica S. Uy; Reynaldo L. Ugalde; Emmerson Gale S. Vista
Journal of General-Procedural Dermatology & Venereology Indonesia Vol 4, No 1 (2019): December 2019
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Background: Systemic sclerosis is a multi-systemic disease characterized by excessive fibrosis, inflammation, and vasculopathy. Common clinical features include skin thickening, telangiectasias, salt and pepper skin, beak-shaped nose, and microstomy. We report a case of ANA-negative systemic sclerosis in a male patient.Case illustration: Our patient presented with a 10-month history of diffuse hyperpigmentation, skin tightening and decreased mouth aperture, accompanied by digital ulcers, hypopigmented macules and violaceous discoloration of the digits upon exposure to cold temperature. Punch biopsy done revealed mild acanthosis of the epidermis with basal cell layer hyperpigmentation, vacuolar alteration and thickening of the basement membrane zone. ANA was negative. Anti-Scl70 was positive. Patient was treated with methylprednisolone which was tapered over a course of 1 month, with noted decrease in tightening of the skin. Digital ulcers and discoloration of digits upon exposure to cold temperature were no longer observed.  Discussion: Diagnosis of systemic sclerosis is made on the presence of scleroderma proximal to the metacarpophalangeal joints, with two of the following minor criteria: sclerodactyly, digital ulcerations or bibasilar pulmonary fibrosis, as well as symptoms involving other organ systems; musculoskeletal, gastrointestinal, respiratory, cardiac, and renal. Conclusion: While the presence of certain distinct features are needed in the diagnosis of systemic sclerosis, a distinct subset of the disease may be ANA-negative and may correspond to better prognosis. A thorough physical and diagnostic examination is needed in order to provide the optimum treatment for each patient. This would prevent systemic complications and further progression of the disease.  Keywords: systemic sclerosis, diffuse hyperpigmentation, methylprednisolone, ANA-negative
TREATMENT OF MULTIBACILLARY LEPROSY FOLLOWING THE DEVELOPMENT OF DAPSONE HYPERSENSITIVITY SYNDROME Sudarsono Sudarsono
Journal of General-Procedural Dermatology & Venereology Indonesia Vol 4, No 1 (2019): December 2019
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Background: World Health Organization (WHO) multi-drug therapy (MDT) is the current standard treatment for leprosy. A wide range of frequency of adverse effects caused by MDT has been reported. Dapsone hypersensitivity syndrome (DHS) is a serious adverse effect caused by dapsone. Prompt withdrawal of dapsone is important aspect in the management of DHS. Alternative regimens are needed to treat leprosy patient with DHS. Case Illustration: A 37-year-old man with multibacillary (MB) leprosy developed DHS in 39 days after the initiation of WHO MDT. Dapsone was withdrawn and methylprednisolone of 75 mg/day was prescribed. Twelve days after admission the patient showed clinical and laboratory improvement and was discharged. Treatment for multibacillary leprosy was continued with rifampicin and clofazimine with standard dosage. The bacterial index (BI) and morphological index (MI) showed +1 and 0 respectively in one month after the completion of 12 pulses of modified MB-MDT.Discussion: In the event of severe dapsone toxicity like DHS, WHO recommends that no modification to MDT is required other than immediately stopping dapsone in the case of those receiving MB-MDT. Multiple doses of rifampicin, ofloxacin and minocycline (ROM) therapy can be used as another alternative in leprosy patient with severe adverse effect while taking dapsone.Conclusion: Combination of rifampicin and clofazimine may be effective in treating MB leprosy with dapsone toxicity.  Keywords: dapsone, dapsone hypersensitivity syndrome, leprosy, WHO MDT 
RECURRENT BASAL CELL CARCINOMA WITH MAXILLARY BONE INVASION Adhimukti Tathyahita Sampurna; Eva Riani; Inge Ade Krisanti; Yayi Dwina; Kuniaki Ohara
Journal of General-Procedural Dermatology & Venereology Indonesia Vol 4, No 1 (2019): December 2019
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Background: Basal cell carcinoma (BCC) is a malignant, slow growing, and locally invasive skin tumor. Advanced and neglected BCC may invade adjacent structures. The 5-year recurrence rates of facial BCCs are 4.1% after excision and 2.5% after Mohs Micrographic Surgery (MMS). The number of BCC cases invading the bones of the head and neck region is limited. Case Illustration: A 75-year-old male complained of bleeding and ulcer enlargement on the right cheek expanding to the right nasal ala for 1 month. The patient had a history of an enlarged and painful lenticular nodule with a hyperpigmented spot that appeared 10 years ago on the right cheek and was diagnosed as BCC. The patient was treated with a wide excision having a negative pathological margin 3 years ago. He noticed that the similar lesion reappeared at the same location 2.5 years ago. Post-operative histopathological results showed nodular infiltrative BCC and maxillary bone invasion. Discussion: Based on history taking, physical examination, and diagnostic evaluation, the diagnosis of the patient was recurrent nodular infiltrative BCC. The final histopathology confirmed that tumor cells invaded the maxillary bone. After considering the treatment options, the patient opted to proceed with radiotherapy. Conclusion: Recurrent nodular BCC with invasion to the maxillary bone is a rare and interesting case. Among 140 BCC cases that we treated with MMS in our hospital from June 2014 to September 2019, this case is the first recurrent BCC with maxillary bone invasion.   Keywords: basal cell carcinoma, skin tumor, MMS, bone invasion
THE USE OF SYSTEMIC MEDICATIONS IN PEDIATRIC DERMATOSES: A REVIEW Shanthi Narla; Githa Rahmayunita; Rinadewi Astriningrum; Tor Shwayder; Ariyati Yosi; Henry W. Lim
Journal of General-Procedural Dermatology & Venereology Indonesia Vol 4, No 1 (2019): December 2019
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Research has begun to illustrate a favorable efficacy and side-effect profile for many systemic agents used in pediatric dermatological conditions (i.e. atopic dermatitis, psoriasis, scleroderma, alopecia areata, chronic spontaneous urticaria, autoimmune blistering disorders, and hidradenitis suppurativa) despite not having extensive randomized clinical trials. The purpose of this article is to summarize the available data on the treatment regiments, safety, and efficacy of systemic immunosuppressants, including the newer biologics, focusing on the most up-to-date systematic reviews or randomized clinical trials.  The review demonstrates that many of the present studies lack data on long-term efficacy and consist of small patient populations. Further research into the long-term safety of these systemic medications is of vital importance especially due to the chronic nature of most pediatric dermatological conditions that require the use of systemic agents.   Keywords: systemics, immunosuppressant medications, biologics, pediatric dermatology conditions
LANGERHANS CELL HISTIOCYTOSIS: DIAGNOSIS AND MANAGEMENT Lusiana Lusiana; Hikari Ambara Sjakti; Githa Rahmayunita; Tjut Nurul Alam Jacoeb; Inge Ade Krisanti
Journal of General-Procedural Dermatology & Venereology Indonesia Vol 4, No 1 (2019): December 2019
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 Langerhans cell histiocytosis (LCH) is a rare disorder characterized by abnormal clonal proliferation of Langerhans dendritic cells. The incidence of LCH is 1 to 3 cases per 1 million children worldwide, and occurs most frequently in children of 1–4 years of age. The etiopathogenesis of LCH, whether it is neoplastic or reactive, is still controversial. Langerhans cell histiocytosis has a wide spectrum of clinical features, and dermatological abnormalities usually occur early. The most frequent lesions are elevated yellowish-red translucent papules about 1–2 mm in diameter and generally located in seborrheic areas. The most recent classification (the Histiocyte Society study 2017) categorized LCH into four groups; a single system with involvement of unifocal or multifocal organs, lung LCH, and multi-system LCH with either low- or high-risk multiorgan involvement. The definitive diagnosis of LCH are typical morphology along with Birbeck granules and/or positive results on CD1a antigen stain on cells found on lesions. Treatment of LCH is multimodal, determined based on age, extent of lesion, organ involvement, and organ location.   Keywords: histiocytosis, Langerhans cells, dendritic cells, children 
CORRECTION Shanthi Narla; Githa Rahmayunita; Rinadewi Astriningrum; Tor Shwayder; Ariyati Yosi; Henry W. Lim
Journal of General-Procedural Dermatology & Venereology Indonesia Vol 4, No 1 (2019): December 2019
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 Narla S, Rahmayunita G, Astriningrum R, Shwayder T, Yosi A, Lim HW. The use of systemic medications in pediatric dermatoses: A review. J Gen Proced Dermatol Venereol Indones. 2019;4(1):25-38   In the article above, Table 1 is reprinted from Journal of the American Academy of Dermatology, Vol 76, Totri CR, Eichenfield LF, Logan K, Proudfoot L, Schmitt J, Lara-Corrales I, Sugarman J, Tom W, Siegfried E, Cordoro K, Paller AS, Flohr C, Prescribing practices for systemic agents in the treatment of severe pediatric atopic dermatitis in the US and Canada: The PeDRA TREAT survey, Pages 281-285, Copyright 2016, with permission from Elsevier.   Table 2 is reprinted from Clinics in Dermatology, Vol 33, Slater NA, Morrell DS, Systemic therapy of childhood atopic dermatitis, Pages 289-299, Copyright 2015, with permission from Elsevier.   Table 3 is modified from Journal of the American Academy of Dermatology, Vol 82, Lansang P, Bergman JN, Fiorillo L, Joseph M, Lara-Corrales I, Marcoux D, McCuaig C, Pope E, Prajapati VH, Li SZJ, Landells I, Management of pediatric plaque psoriasis using biologics, Pages 213-221, Copyright 2019, with permission from Elsevier. 
Prevalence of Mycoplasma hominis and Ureaplasma urealyticum infection in female sex workers and its association with douching: A study in East Jakarta, Indonesia using Mycoplasma System Plus Caroline Padang; Tjut Nurul Alam Jacoeb; Hanny Nilasari; Sjaiful Fahmi Daili
Journal of General-Procedural Dermatology & Venereology Indonesia ##issue.vol## 1, ##issue.no## 1 (2015): August
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 Background: Mycoplasma hominis and Ureaplasma urealyticum are commonly involved in pathogenesis of bacterial vaginosis and non-specific genital infection, while doing vaginal douching also already known as predisposing factor. Methods: To evaluate the prevalence of Mycoplasma hominis and Ureaplasma urealyticum infection in female sex workers and its association with vaginal douching, we conducted a study through 180 female sex workers in East Jakarta, Indonesia. Vaginal fluid samples were collected from these women. It was revealed that most of the women used betel soap, baby soap, tooth paste, or herbal medicine as vaginal douching materials. The association of vaginal douching and prevalence of Mycoplasma hominis and Ureaplasma urealyticum was analyzed using cross sectional statistical methods. Results: There is a high prevalence of Mycoplasma hominis and Ureaplasma urealyticum infection (72%), but there are no association between vaginal douching practice and infection of Mycoplasma hominis and Ureaplasma urealyticum. Conclusions: The high prevalence of Mycoplasma hominis and Ureaplasma urealyticum infection in female sex workers in East Jakarta warrants a routine screening of these infections. Unusual1 materials used for vaginal douching in this study might cause the negative association between high prevalence of these bacteria with vaginal douching.   Keywords: Mycoplasma hominis, Ureaplasma urealyticum, female sex workers, vaginal douching