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INDONESIA
Jurnal Gizi Klinik Indonesia
ISSN : 1693900     EISSN : 25024140     DOI : -
Core Subject : Health, Science,
Jurnal Gizi Klinik Indonesia merupakan jurnal ilmiah nasional terakreditasi yang memuat artikel penelitian (research article) di bidang gizi dan kesehatan, yang terkait aspek gizi klinis, gizi masyarakat, gizi olahraga, gizi molekular, biokimia gizi, pangan fungsional, serta pelayanan dan manajemen gizi. Jurnal Gizi Klinik Indonesia (JGKI) diterbitkan empat bulan sekali sejak terbit Juli 2004 hingga Maret 2011 (Volume 1-7), kemudian sejak Juli 2011 (Volume 8) JGKI diterbitkan setiap tiga bulan. Jurnal Gizi Klinik Indonesia diterbitkan oleh Minat S2 Gizi dan Kesehatan, Prodi S2 Ilmu Kesehatan Masyarakat, Fakultas Kedokteran Universitas Gadjah Mada bekerjasama dengan Persatuan Ahli Gizi Indonesia (PERSAGI) dan Asosiasi Dietisien Indonesia (AsDI).
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Articles 6 Documents
Search results for , issue " Vol 9, No 4 (2013): April" : 6 Documents clear
Perubahan parameter biologik jaringan kanker payudara mencit akibat pemberian isoflavon tempe Bintari, Siti Harnina; Moeis, Siti Fatimah; Sarjadi, Sarjadi
Jurnal Gizi Klinik Indonesia Vol 9, No 4 (2013): April
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, Fakultas Kedokteran UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.18368

Abstract

Background: Cancer is severe diseases caused by the changing of deoxyribonucleic acid (DNA) structure. Women who consume soy products have a lower risk for breast cancer, but it cannot be explained the kind of biomolecular aspects of soy product which gives this role.Objective: The aim of this research was to analyze the biological parameter changing of AgNORs, p53, Cas-3 and Bcl-2 in mouse (Mus musculus) C3H strain with breast cancer, as the impact of injecting isoflavone of tempeh.Method: The laboratory experimental research was done by posttest only randomized controlled group design. Subject of study were 18 mice (Mus musculus) C3H strain that were divided into 3 groups, each of which consists of 6 mice. The first group, the control (K), was not injected by isoflavone, while the second group (P1) and the third group (P2) were injected by 1.000 mg and 10.000 mg of tempeh isoflavone/kg diet/day, respectively. All groups were given the transplanted breast cancer cells. AgNORs parameters were selected to determine the level of proliferation and p53 parameters, Cas-3 and Bcl-2 to determine the appearance of apoptosis. Data were analyzed by using Manova and discriminant test for each parameter of cell proliferation.Results: Concentration of isoflavones supplementation with 1,000 and 10,000 mg / kgdiet / day gave effect to the reduction of AgNORs blots, expression of p53 and Cas-3 and increased expression of Bcl-2 in group P1 and P2 compared with control group, as indicated by high statistical values (p=0.000) between both groups or within the group. Results of discriminant test showed that Bcl-2 and AgNORs had dominant role in increased apoptosis and inhibition of cancer cell proliferation in experimental animal.Conclusion: Tempeh isoflavones can be used as a biological parameter change agent that marks the proliferation and apoptosis of mice (Mus musculus) C3H strain towards the normal cell cycle progression.
Polimorfisme gen ferroportin (FPN1) -1355 G/C sebagai faktor risiko anemia defisiensi besi pada ibu hamil Istiqomah, Nor; Umarghanies, Sarah Safira; Farmawati, Arta; Sadewa, Ahmad Hamim; Soesilo, Yuliana Heri; Damayanti, Kusumadewi Eka; Indarto, Dono
Jurnal Gizi Klinik Indonesia Vol 9, No 4 (2013): April
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, Fakultas Kedokteran UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.18364

Abstract

Background: According to WHO data, prevalence of anemia pregnancy in Indonesia is 44.3%, it’s higher than world prevalence (41.8%). Ferroportin (FPN1) is one of important iron exsporter for iron absorption, release, and recycle inside the body. The varian of FPN1-1355 G/C in promoter region, leads to increased of ferroportin expression and iron export, increased cellular iron needs, overexpression of soluble transferrin receptor (sTfR), decrease hemoglobin (Hb) and erythrocyte indices that manifest to iron deficiency anemia (IDA).Objective: This research will study the frequency of FPN1-1355 G/C polymorphism as a risk factor of IDA in pregnant women in Indonesia.Method: The research design was a case and control study. Blood samples were taken from 26 pregnant women with anemia and 48 pregnant women without anemia. FPN1-1355G/C polymorphism were determined using PCR-RFLP method. sTfR and ferritin level were measured with ELISA. Hemoglobin, erythrocyte indices, and sTfR level were compared among genotype group, then statistically analyzed using independent sample t-test and one way ANOVA. Bivariat analysis of Pearson test was conducted to analyze correlation between level of blood Hb and ferritin in pregnant women (p<0.05).Results: FPN1-1355 G/C polymorphism with frequency in pregnant women with IDA and in pregnant women with anemia non IDA were 100% and 95.2%, respectively (p=0.710; OR=1.600; 95%CI: 0.296-8.653). The mean of Hb level and erythrocyte indices in subjects carrying C allele were lower than subjects carrying only G allele although Hb level is not significantly different (p>0.05). The sTfR and hepcidin level in subjects carrying C allele were higher than subjects carrying only G allele (p<0.05). Conclusion: In this study the FPN1 gene promoter -1355 G/C polymorphism was not a risk factor for anemia, but it was a risk factor for iron deficiency anemia in pregnant women.
Hipoalbuminemia praoperasi pasien kanker kolorektal terhadap risiko komplikasi pascaoperasi dan lama rawat inap Benny, Yohanes; Aryandono, Teguh; Susetyowati, Susetyowati
Jurnal Gizi Klinik Indonesia Vol 9, No 4 (2013): April
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, Fakultas Kedokteran UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.18365

Abstract

Background: Malnutrition is most commonly found in gastrointestinal cancer that affects the result of an operation. Albumin serum is an effective and simple way of assessing risk which is associated with malnutrition intensity so that it is generally used as the prognostic index for the development of the incidence of colorectal cancer postoperative complications.Objective: To identify the effect of preoperative hypoalbumin to the incidence of postoperative complications and length of stay of colorectal cancer in patients.Method: The study used the quantitative approach with a nonconcurrent cohort (retrospective analysis) design. The population was patients diagnosed having colorectal cancer who would undergo an operation at Kasih Ibu, Dr. Oen, and Panti Waluyo Hospital of Surakarta. Data analysis used Chi-Square test and logistic regression.Results: Hypoalbumin, either based on admission or pre-operation, was significant risk factor for the incidence of post operative complications in colorectal cancer patients as well as age and American Society of Anesthesiologist Physical Status Classification (ASA) status. The result of multivariate analysis showed age of 20-59 years (OR=2), hypoalbumin based on admission (2.1 times) and preoperation (1.9 times) were risk factors for the incidence of postoperative complication (infection). ASA status III-IV had risk 2.8 times for the incidence of postoperative sepsis complications and 3.7 times for mortality than ASA status I-II. Status of hypoalbumin did not influence total length of stay or postoperative length of stay but age influenced postoperative length of stay.Conclusion: Hypoalbumin influenced the incidence of postoperative complications in colorectal cancer patients, particularly infection complication; whereas factors of age and ASA status were external factors strongly influenced. Hypoalbumin did not influence length of stay. Age was an external factor that strongly influenced postoperative length of stay.
Asupan makan, sindrom metabolik, dan status keseimbangan asam-basa pada lansia Widyastuti, Nurmasari; Sulchan, Muhammad; Johan, Andrew
Jurnal Gizi Klinik Indonesia Vol 9, No 4 (2013): April
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, Fakultas Kedokteran UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.18366

Abstract

Background: Metabolic syndrome prevalence increases with age and obesity. The metabolic syndrome is associated with alterations in renal function. Low urine pH has been described as a renal manifestation of the metabolic syndrome. Urine pH is a simple and inexpensive method for determining acid-base status. Recent studies suggest that acid-base status is associated with dietary intake.Objective: To examine relationship between dietary intake, components of metabolic syndrome and urine pH among the elderly.Method: Subjects of this cross-sectional study consist of 49 elderly that were collected consecutively. Height, weight, waist circumference (WC), dietary intake, blood pressure (BP), fasting blood glucose and urine were obtained. Rank Spearman correlation test was used to examine the correlation of components of metabolic syndrome and dietary intake with urine pH. Mann-Whitney test was used to compare the urine pH of the metabolic syndrome group and the normal group. Chi-Square/fisher test was used to calculate prevalence ratio (PR) of metabolic syndrome components to low urine pH. Multivariate analysis was done by multiple linear regression.Results: The mean urine pH of the metabolic syndrome group was 6,06 and significantly lower than the normal group (6,50). WC was the only component of metabolic syndrome that related to urine pH (r=-0,325; p=0,023). Abdominal obesity significantly increases the risk of low urine pH (RP=1,6; p=0,023; CI=1,005-2,442). Urine pH was negatively associated with protein intake and proportion of protein on diet. In multivariate analysis, WC is the most significant factor that predicted urinary pH.Conclusion: Urine acidification is a characteristic of abdominal obesity and the metabolic syndrome. Protein intake and proportion of protein on diet contribute to urine pH.
Status kesehatan mulut dan asupan makan sebagai faktor risiko underweight pada lansia Angraini, Dian Isti; Supartinah, Al; Wachid, Deddy Nur
Jurnal Gizi Klinik Indonesia Vol 9, No 4 (2013): April
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, Fakultas Kedokteran UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.18367

Abstract

Background: Oral health status and dietary intake contribute to nutritional status in elderly. Missing teeth cause chewing disorder that reduces quality and quantity of food intake, which finally makes the elderly have underweight nutritional status.Objective: To determine the risk factors for underweight in the elderly at Yogyakarta Municipality.Method: The study was observational with case control design on elderly at Yogyakarta Municipality. Subjects consisted of 210 elderly matched in age and gender. Sampling was done by multistage random sampling. Oral health status was assessed through dental health status (index of missing teeth) and periodontal status (gingival index, periodontal index and oral hygiene index), dietary intake was collected by using semi quantitative food frequency questionnaire (SQ-FFQ) and underweight nutritional status was based on body mass armspan (BMA). Data were analyzed by using tests of X2 Mc.Nemar, X2 Stuart Maxwell, and conditional logistic regression.Results: Bivariate analysis showed the number of missing teeth ≥ 21 (OR=3.67, p<0.05) and 16-20 (OR=3.53, p<0.05) as risk factors of underweight, whereas the gingival index, periodontal index and oral hygiene index were not. Less intake of energy (OR=6.3), protein (OR=7.83), fat (OR=5.67) and carbohydrates (OR=7.5) were risk factors of underweight (p<0.01). Income less than Rp 808.000,00 was also risk factor for underweight (OR=4.5; p<0.01). Multivariate analysis showed the significant risk factors for underweight were the missing teeth ≥ 21 (OR=8.76) and 16-20 (OR=6.04) which increased by income less than Rp 808.000,00 (OR=5.94), less fat intake (OR=4.88), and less carbohydrate intake (OR=5.48). Income was confounding factor in the risk of missing teeth and protein intake for becoming underweight.Conclusion: Significant risk factors of underweight in elderly were missing teeth ≥ 16, less intake of fat and carbohydrate, and income less than Rp 808.000,00.
Status pemberian ASI terhadap status gizi bayi usia 6-12 bulan Normayanti, Normayanti; Susanti, Nila
Jurnal Gizi Klinik Indonesia Vol 9, No 4 (2013): April
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, Fakultas Kedokteran UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.18362

Abstract

Background: Coverage of exclusive breastfeeding in Indonesia fluctuate and showed a declining trend over the last three years. Coverage of exclusive breastfeeding of Palangka Raya city is still very low at around 23.30%. There are several variables suspected as the cause of the malnutrition problem, the variables are status of breastfeeding, mothers education level, mothers employment, mother’s knowledge of nutrition and counseling status of breastfeeding.Objective: This study aimed to determine the effect of breastfeeding status on the nutritional status of infants aged 6-12 months in the working area of UPTD Puskesmas Kalampangan Palangka Raya city.Method: The study design used was a case-control with 1:2 ratio, the case are infants aged 6-12 months with low nutritional status, whereas the comparison are infants aged 6-12 months with normal nutritional status. The dependent variable is the nutritional status and the independent variables are breastfeeding status, mothers education level, mothers employment, mother’s knowledge of nutrition, and breastfeeding counseling status. Data analysis was performed by univariate, bivariate (Chi-Square) and multivariate (logistic regression). Results: From the 5 (five) variables were analyzed, 2 (two) variables independently became risk factor for malnutrition are status of breastfeeding (OR=6.667) and the counseling status of breastfeeding (OR=3.215). But together (simultaneously), only breastfeeding status has an influence on the nutritional status of infants, and non-exclusive breastfeeding was significant as a risk factor for malnutrition (OR=5.126). Probability infant to experience malnutrition due to breastfeeding status no exclusive is at 25.54%.   Conclusion: Breastfeeding status has an influence on the nutritional status of infants and non-exclusive breastfeeding was significant as a risk factor for malnutrition among infants aged 6-12 months.

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