cover
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kota medan,
Sumatera utara
INDONESIA
Buletin Farmatera
ISSN : 2528410X     EISSN : 2528410X     DOI : -
Core Subject : Health,
Arjuna Subject : -
Articles 72 Documents
COMPARISON OF ANTIOXIDANT AND ANTI-TYROSINASE ACTIVITY BETWEEN BLACK SOYBEAN (GLYCINE MAX (L.) MERR.) AND DAIDZEIN Kuswanto, Delken; Lister, I Nyoman Ehrich; Girsang, Ermi; Nasution, Ali Napiah; Widowati, Wahyu
Buletin Farmatera Vol 5, No 1 (2020)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v5i1.3492

Abstract

Free radicals in the body will increase with excessive of ultraviolet (UV) light exposure, induce oxidative stress with the formation of Reactive Oxygen Species (ROS). A visible effect on skin tissue known as photoaging, including the process of melanogenesis catalyzed by the tyrosinase enzyme, risked for pigmentation or melanoma disorder.The use of natural ingredients has been widely used by the community to prevent the aging process. Natural compounds from a plant can be a source of antioxidants and have anti-aging abilities through inhibition of the tyrosinase enzyme. Black soybean (Glycine max (L.) Merr.) are high in isoflavone compound, one of which is daidzein.This study evaluates the antioxidant and anti-aging potential of black soybean extract with daidzein. Antioxidants using the DPPH method and anti-aging tests carried out, namely the inhibition of the tyrosinase enzyme, are very important in the aging process.Daidzein has an IC50 value of DPPH scavenging activity around 109.34±2.80 µg/mL lower than black soybean extract with 116.52±2.50 µg/mL. Results on tyrosinase enzyme inhibition activity, black soybean extract had an IC50 value of 70.71±1.83 µg/mL lower compared to daidzein with 72.65±2.81 µg/mL. In contrast to the better antioxidant activity of daidzein, the black soybean extract are more potential to inhibit the enzyme tyrosinase
COMPARISON OF THE EFFECTIVENESS BETWEEN RED GALANGAL RHIZOME'S (ALPINIA PURPURATA K.SCHUM) EXTRACT AND KETOCONAZOL 2% TO INHIBIT GROWTH OF DERMATOPHYTE ​​FUNGI IN VITRO Pangestuti, Dewi; Harris, Bilkes; Rahman, Tuti Khairani
Buletin Farmatera Vol 5, No 1 (2020)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v5i1.3091

Abstract

Red galangal rhizome (Alpinia purpurata k. Scum) has a larger size and has more therapeutic properties. Red galangal has compounds that can inhibit fungal growth namely flavonoids and saponins which can interfere with the function of the fungal cytoplasmic membrane, besides that they can cause leakage and aggregation of the outer cell membrane, which can inhibit the growth of dermatophytes. This study is a laboratory experimental study, using antifungal activity test with diffusion method using paper discs to see the comparison of the red galangal extract effectiveness and ketoconazole 2% on the growth of dermatophytes fungi Microsporum canis, Microsporum gypseum, and Trichophyton metagrophytes by measuring the inhibition zone around the fungal colonies. The concentrations of red galangal extract used were 10%, 20%, 30%, 40%, and 50% and used 2% ketoconazole as control. The data was analyzed using the One Way Anova test. Result of this study shown that all concentrations without 10 % of red galangal have inhibited zones of Microsporum canis, Microsporum gypseum, and Trichophyton metagrophytes but not better than ketoconazole 2 % activities.
THE EFFECT OF WORK STRESS ON NURSE PERFORMANCE IN THE INPATIENT WARDS TANJUNG PURA HOSPITAL ON 2016 Nopa, Ika; Zulfendri, Zulfendri; Fauzi, Fauzi
Buletin Farmatera Vol 5, No 1 (2020)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v5i1.2679

Abstract

Nursing care in a hospital is an integral part of health service. A nurse has constant contact with patients within 24 hours, and her work demands can potentially cause stress. The main purpose of the research was to find out the influence of work stress on nurses' performance in the Inpatient Wards.The research was a survey with an explanatory research method to find out the influence of work stress on nurses' performance in the Inpatient Wards of RSUD (Regional General Hospital) Tanjung Pura. The population was 63 nurses in the Inpatient Wards, and all of them were used as the samples since their numbers were relatively small. The data were gathered by conducting in-depth interviews and reporting data were obtained from the hospital. The gathered data were analyzed by using a linear regression statistic test.The result of the research showed that 77.8% of the respondents had moderate performance, 14.3% of the respondents had a good performance, and 7.9% of the respondents had a bad performance. It was also found that the variable of work stress influenced the performance at p-value = 0.00001.It is recommended that the hospital management pay attention to the nurses? condition in each Inpatient Ward. On the other hand, the hospital management should give special attention to the work stress undergone by the nurses in the Inpatient Wards
CORRELATION OF NUTRITIONAL STATUS WITH THE INCIDENCE OF ACUTE DIARRHEA IN ONE TO THREE YEARS CHILDREN AT AMPLAS HEALTH CENTER IN 2015 Ginting, Ashry Ramadhana; Damayanty, Amelia Eka
Buletin Farmatera Vol 5, No 1 (2020)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v5i1.2327

Abstract

ANTIHIPERGLICEMIC THERAPY COMPLIANCE WITH HBA1C LEVELS IN TYPE 2 DIABETES MELLITUS PATIENTS AMONG PEKANBARU PROLANIS PARTICIPANTS Nugraha, Dimas Pramita; Asni, Eni Karmila; Sembiring, Ligat Pribadi Sembiring Pribadi
Buletin Farmatera Vol 5, No 1 (2020)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v5i1.4203

Abstract

One of the pillars in the management of Type 2 Diabetes Mellitus (DM) is pharmacotherapy, i.e. the use of antihyperglycemic drugs. Success in DM management is influenced by patient compliance to the pharmacotherapy given. One indicator of controlling Type 2 DM is HbA1c levels. This study aimed to analyze the relationship between antihyperglycemic therapy compliance and the HbA1c levels in Type 2 DM patients in the Chronic Disease Management Program in Pekanbaru. Method. This was a cross-sectional study. Samples were taken by consecutive sampling method. Laboratory examination was carried out to obtain HbA1c levels, the value of which was categorized controlled if <7%. The compliance with the use of antihyperglycemic drugs was assessed using Medication Possession Ratio (MPR). Patients were considered compliant if they had an MPR of ?80%. Data were analyzed using the Fisher Exact test. Results. Most of the 48 patients had uncontrolled HbA1c levels (87,5%). The level of non-compliant patients was also very high (91,7%). This study showed a significant relationship between pharmacotherapy compliance and HbA1c levels (p <0.05). Discussion. There was a relationship between pharmacotherapy compliance and the level of HbA1c in Type 2 DM patients.  Physicians should pay more attention to patients with low compliance as it may increase the risk to a high HbA1c level
PROFILE OF MICROORGANISMS CAUSING VAGINAL DISCHARGE IN REPRODUCTIVE WOMEN AT DR. PIRNGADI HOSPITAL IN MEDAN Zahara, Iqrina Widya; Roesyanto, Irma Damayanti; Amelia, Sri
Buletin Farmatera Vol 5, No 1 (2020)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v5i1.3934

Abstract

Leucorrhoea or Fluor albus or leukorrhea vaginal discharge is the discharge of fluid other than blood from the vaginal canal out of the ordinary, either smelling or not, and accompanied by local itching. There are two factors that cause leucorrhoea, namely endogenous factor such as abnormalities in the vagina and exogenous factor which are infection and non-infection. The aim of this study is to find the profile of microorganisms causing vaginal discharge in reproductive women. This is a descriptive study with cross-sectional method conducted at the Skin and Genital Polyclinic of the Sexually Transmitted Infectious Disease Division and the Obstetrics and Gynecology Clinic of Pirngadi Hospital, Medan. Populations that have met the inclusion and exclusion criterias were included in the study. Vaginal discharge samples will be sent to the microbiology laboratory and the parasitology laboratory of faculty medicine of University of North Sumatera to examine the gram staining, KOH staining, bacterial and fungal cultures and wet preparations for parasites. Out of a total of 50 people, the majority of the sample are in aged 31-40 years, with a history of high school education and working women. The most types of vaginal discharge are pathological (84%) and the most common cause of vaginal discharge is a fungal infection by Candida sp (90%) followed by bacterial infection by Staphylococcus aureus (64.8%) and Klebsiella (20.3%)
Abdominal Compartment Syndrome Assuyuthi Chalil, Muhammad Jalaluddin
Buletin Farmatera Vol 2, No 1 (2017): Buletin Farmatera
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (208.891 KB) | DOI: 10.30596/bf.v2i1.890

Abstract

Abstrak: Insiden dan penyebab Intra-abdominal Hypertension (IAH) dan Abdominal Compartment Syndrome (ACS) adalah penyakit-penyakit yang berkaitan dengan penyakit kritis. Dilaporkan bahwa insiden IAH dan ACS pada populasi yang dirawat pada Intensive Care Unit (ICU) gabungan masing-masing sekitar 32,1% dan 4,2%. Laju kejadian IAH juga telah dilaporkan pada pasien-pasien dengan luka bakar berat yaitu 36,7-70%, 2%-50% pada pasien trauma berat, dan 31,5%-40,7% pada pasien yang menjalani operasi abdominal mayor. ACS meningkatkan risiko terjadinya Acute Respiratory Distress Syndrome (ARDS) dan Multiple Organ Failure (MOF) sebesar 40%, dengan laju mortalitas 63-72%. ACS didefinisikan sebagai suatu keadaan dimana Intra-Abdominal Pressure (IAP) yang bertahan> 20 mmHg (dengan atau tanpa Abdominal Perfusion Pressure (APP) < 60 mmHg) yang dikaitkan dengan terjadinya disfungsi atau kegagalan organ. ACS primer terjadi akibat adanya cedera langsung pada regio abdomen dan pelvik, sedangkan ACS sekunder terjadi tanpa adanya cedera atau kelainan langsung pada abdomen sepertipada syok berat, pemberian cairan yang masif akibat perdarahan, sepsis, capillary leak, atau luka bakar hebat. Metode pengukuran tekanan bladder dikatakan sebagai baku emas dan merupakan pengukuran yang paling dapat dipercaya. Dengan menggunakan sebuah  manometer atau transduser tekanan dan monitor, maka tekanan intravesikal dapat diukur dan dapat digunakan sebagai refleksi IAP.Kata kunci: Abdominal Compartment Syndrome, Intra Abdominal Pressure  Abdominal Compartment SyndromeAbstract:Incidence and cause IAH and ACS are diseases related to critical illness. The reported incidence of IAH and ACS is about 32.1% and 4.2%, respectively, in the mixed intensive care unit (ICU) population. Rates of IAH have also been reported for patients with severe burns (36.7%–70%) and traumatic injuries (2%–50%), and for patients who had major abdominal procedures (31.5%–40.7%). ACS increases the risk of acuterespiratory distress syndrome/multiorgan failure by 40%, mortalityassociated with abdominal compartment syndromeis 63–72%. ACS is defined as a sustained IAP > 20 mmHg (with or without an APP < 60 mmHg) that is associated with new organ dysfunction/ failure. Primary ACS results from direct injury within the abdomen and pelvic region. Secondary ACS develops without direct abdominalinjuries or conditions.Secondary ACS can be seenin patients with severe shock and who have requiredmassive fluid loading due to haemorrhage, sepsis,capillary leak, or major burns.The bladder pressure method is described as the gold standard and is the most reliable measurementof IAP via indirect means.With the use of a manometer or monitoring equipmenta pressure measurement can be achieved toestablish a reflection of IAP.Keyword: Abdominal Compartment Syndrome, Intra Abdominal Pressure
Perbandingan Ketamin Dosis 0.5 mg/KgBB/IV dan 1 mg/KgBB/IV Sebagai Preemptif Analgesia pada Paska Operasi Ginekologi dengan Anestesi Umum Yunafri, Andri; Nasution, A Sani P
Buletin Farmatera Vol 3, No 2 (2018): Buletin Farmatera
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (94.688 KB) | DOI: 10.30596/bf.v3i2.1688

Abstract

Abstract: Excitatory amino acids participate in the activation of nociceptive dorsal horn neurons as agonists of the N-methyl-D-aspartate (NMDA) receptor. A series of experimental data provides evidence that NMDA receptors play a significant role in neuronal plasticity and processes leading to central sensitization to pain. The concept of preemptive analgesia on the assumption that the administration of an analgesic drug before the occurrence of nociceptive input can prevent sensitization and thus improve postoperative analgesia. The aim of our study was to test the hypothesis that preemptive ketamine administration would further reduce postoperative pain in gynecology  surgery. After institutional review board approved the study protocol, all patients gave informed, written consent. 60 patients were randomized to a preemptive Ketamine 0.5 mg/kg/iv (Group A) or Ketamine 1 mg/kg/iv (Group B). Preoperatively visual analog scale (VAS) for pain assessment. Patient received premedication with midazolam 0.1 mg/kg iv, sulfas atropin 0.01 mg/kg  at the operating room. Anesthesia was induced with propofol 2 mg/kg/iv, fentanyl 2 μg/kg/iv, and rocuronium 1 mg/kg/iv was administered to facilitate tracheal intubation. Maintenance of anesthesia consisted of O2:N2O = 50%:50% and isoflurane 1%. In both groups, ketamine bolus IV was administered after induction of general anesthesia and 10 minute before incision. HR and BP was recorded during operation. Post operative pain assessed with VAS at 0.5, 1, 2, 8, 16, and 24 hour. Time first analgesic (TFA) was recorded, and if VAS pain scores > 3 cm (0= no pain, 10 = worst pain imaginable). Total fentanyl consumption were recorded for the post surgery. The first analgesic required time was significantly shorter in groups A as compared with group B (p=0.0001).  Group B had significantly decreased postoperative pain scores (VAS) at 0.5, 1, and 2 hours (p<0.05). There were no statistically significant differences VAS score between the two grups at 8, 16, and 24 hours post surgery (p>0.05). Conclusion, ketamine 1 mg/kg intravena provide better preemptive analgesia in the first 2 hours post surgery, but both groups perform the same preemptive analgesia  within 24 hours of post gynecology operation.Key words: analgesia; ketamine; preemptive; gynecology; surgery pain
Mengenal Kelenjar Prostat Mirwan, Muhammad
Buletin Farmatera Vol 1, No 1 (2016): Buletin Farmatera
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (245.507 KB) | DOI: 10.30596/bf.v1i1.826

Abstract

Ketika berbicara tentang prostat, hal yang terlintas dipikiran adalah laki-laki. Kelenjar prostat adalah salah satu organ yang dimiliki oleh pria termasuk ke dalam sistem urogenital. Secara anatomi, prostat termasuk salah satu kelenjar yang letaknya berada di bawah kandung kemih, mengelilingi saluarn uretra, memiliki berat sekitar 18 sampai 20 gram. Berdasarkan McNeal (1972) prostat memiliki zona-zona yaitu zona perifer, zona sentral dan zona transisi. Sekitar 70% dari prostat merupakan kelenjar sedangkan 30% lainnya merupakan otot.
Pengaruh Pemberian Jus Nanas (Ananas comosus l.merr) terhadap Penurunan Kadar Trigliserida pada Tikus Putih Jantan (Rattus novergicus l.) yang Diinduksi Monosodium Glutamate Dalimunthe, Tosy Arna; Hariaji, Ilham
Buletin Farmatera Vol 2, No 2 (2017): Buletin Farmatera
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (57.017 KB) | DOI: 10.30596/bf.v2i2.1025

Abstract

Pengaruh Pemberian Jus Nanas (Ananas comosus l.merr) terhadap Penurunan Kadar Trigliserida pada Tikus Putih Jantan (Rattus novergicus l.) yang Diinduksi Monosodium GlutamateAbstrak: Penyakit jantung koroner (PJK) paling sering disebabkan karena sumbatan plak ateroma pada arteri koroner yaitu aterosklerosis yang terdapat penimbunan lemak dan zat-zat lain yang membentuk plak pada dinding arteri. Nanas (Ananas comosus L.Merr) memiliki serat (Dietary fiber) yang berasal dari dinding sel buah-buahan yang mengandung zat kimia polimer lignin, gumi dan mucilage yang mampu menurunkan kadar trigliserida darah. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian jus nanas terhadap kadar trigliserida darah tikus yang diinduksi MSG. Metode: Jenis penelitian adalah true experiment dengan pretest-posttest with control group design. Subjek penelitian adalah 24 tikus putih jantan (Rattus novergicus L.), dibagi menjadi 4 kelompok. Pemberian jus nanas dosis 1,5ml dan 2,5ml. Hasil: Ada penurunan kadar trigliserida setelah pemberian jus nanas pada kelompok-3 sebesar 44,16 mg/dl; kelompok-4 sebesar 51 mg/dl. Hasil uji T berpasangan adanya perbedaan rerata kadar trigliserida (p < 0,05) pada kedua kelompok. Kesimpulan: Pemberian jus nanas pada dosis 1,5ml dan 2,5 ml dapat menurunkan kadar trigliserida darah pada tikus jantan putih.Kata kunci: aterosklerosis, jus nanas (Ananas comosus L.Merr), trigliserida, tikus putih jantan (Rattus novergicus L.)    The Effectiveness of Pineapple Juice to Triglycerides in Rats with induced by Monosodium Glutamate Abstract: Coronary heart disease (CHD) is most often caused by a blockage in a coronary artery atheroma plaque namely atherosclerosis, which are the accumulation of fat and other substances that form plaque in the artery wall. Pineapple (Ananas comosus L.Merr) has dietary fiber derived from the cell walls of fruits that contain chemicals lignin polymer, gumi and mucilage that can reduce blood triglyceride levels. This study aimed to determine the effect of pineapple juice on blood triglyceride levels of rats induced MSG. Methods: The study is true experiment with pretest-posttest control group design. The subjects were 24 male white rats (Rattus novergicus L.), divided into 4 groups. Giving pineapple juice dose 1,5ml and 2,5ml. Results: There was a decrease in triglyceride levels after administration of pineapple juice on a group-3 is 44.16 mg / dl; Group-4 is 51 mg / dl. Paired T test result of differences in mean triglyceride levels (p <0.05) in both groups. Conclusion: Delivery of pineapple juice at a dose of 2.5 ml 1,5ml and can lower blood triglyceride levels in male white rats. Keywords: Atherosclerosis, pineapple juice (Ananas comosus L.Merr), high triglycerides, male white rats (Rattus novergicus L.)