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Contact Name
Mohammad Rizki Fadhil Pratama
Contact Email
mohammadrizkifadhilpratama@gmail.com
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mohammadrizkifadhilpratama@gmail.com
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Kota palangkaraya,
Kalimantan tengah
INDONESIA
Borneo Journal of Pharmacy
ISSN : 26214814     EISSN : -     DOI : -
Core Subject : Health,
The publication of Borneo Journal of Pharmacy certainly participates in disseminating the results of research and review of science and technology development conducted by lecturers and researchers especially from UM Palangkaraya and other universities. This edition contains 12 articles consisting of Pharmacognosy-Phytochemistry, Natural Product Development, Clinical-Community Pharmacy, and Management Pharmacy.
Arjuna Subject : -
Articles 50 Documents
COVER, CONTENT, AND EDITORIAL NOTE FROM BORNEO J PHARM VOL. 3 NO. 1 FEBRUARY 2020 Borneo J Pharm, Chief Editor of
Borneo Journal of Pharmacy Vol 3 No 1 (2020): Borneo Journal of Pharmacy
Publisher : ?Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i1.1269

Abstract

Alhamdulillahirabbil ?alamin. The next edition of Borneo Journal of Pharmacy (Borneo J Pharm), has been published in February 2020. Starting from this edition, Borneo J Pharm increases the frequency of publishing four times a year. This change aims to improve the circulation of the best articles published by Borneo J Pharm. Also, starting from this edition, Borneo J Pharm applying the publish-as-you-go issue to present the title of the article that has been received as early as possible in order to increase the chances of readability and quotation of articles in Borneo J Pharm.Starting in the 2019 edition, Borneo J Pharm has been accepted for indexing in EMBASE by Elsevier. This is an acknowledgment of the quality of the publications presented by Borneo J Pharm. In addition, Borneo J Pharm has also been accredited at SINTA in rank 3. In the future, Borneo J Pharm will try to improve the accreditation rank and register with other indexers such as ESCI and ASEAN Citation Index.This edition contains six articles consisting of Pharmacology-Toxicology, Pharmacognosy-Phytochemistry, Pharmaceutical, Analytical Pharmacy-Medicinal Chemistry, and Natural Product Development. This edition includes writings from four countries including Indonesia, India, Ukraine, and Costa Rica. The authors come from several institutions, including Sekolah Tinggi Ilmu Kesehatan Mitra Bunda Persada Batam, Bharathi College of Pharmacy, Sekolah Tinggi Ilmu Kesehatan Borneo Lestari, Universidad de Costa Rica, Kharkiv National Medical University, National University of Pharmacy, Hon. Prof. M. S. Bokarius Kharkiv Research Institute of Forensic Examinations, and Universitas Muhammadiyah Pekajangan Pekalongan.
PRELIMINARY PHYTOCHEMICAL ANALYSIS AND ANTIOXIDANTS ACTIVITIES OF ETHANOLIC EXTRACT FROM GOMPHRENA SERRATA WHOLE PLANT Nandini, Kodukothanahalli Naganna; Palaksha, Mekerahalli Narayanappa; Mamatha, Belakavadi Shivalingu; Lekhana, Anasosalu Ramesh
Borneo Journal of Pharmacy Vol 3 No 1 (2020): Borneo Journal of Pharmacy
Publisher : ?Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i1.1250

Abstract

The present study was designed to investigate the phytochemical analysis and antioxidant activities of the whole plant of Gomphrena serrata. Gomphrena serrata widely distributed in South America, North America, and India. These plant parts are used as traditional medicine for the treatment of several ailments. This study aims to assess the phytochemical and free radical scavenging of ethanolic extract of G. serrata present in the plant. The preliminary phytochemical study was performed by standard method. The whole plant of G. serrata proved the presence of bioactive constituents such as carbohydrates, alkaloids, steroids, glycosides, triterpenoids, protein and amino acids, saponins, as well as flavonoids. The in-vitro antioxidant study was performed on the ethanolic extract of shade-dried of the whole plant, which determined by hydrogen peroxide, hydroxyl radical, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) 100 µg/ml assay and was compared to ascorbic acid. The ethanolic extract of the whole plant of G. serrata shows the strong free radical scavenging activity. The present study was the proof for ethanol extract of G. serrata which have medicinally significant and bioactive compounds since these plant species are used as traditional medicine for the treatment of various diseases.
EFFECT OF BROCCOLI (BRASSICA OLERACEA L. VAR. ITALICA) EXTRACT ON BLEEDING TIME IN MALE WHITE MICE (MUS MUSCULUS L.) Sammulia, Suci Fitriani; Almahdy, Almahdy; Rezky, Aldo Wahyu
Borneo Journal of Pharmacy Vol 3 No 1 (2020): Borneo Journal of Pharmacy
Publisher : ?Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i1.1246

Abstract

Cessation of bleeding is influenced by many factors including the type of medication used. The use of drugs to stop bleeding can be done in various ways, one of which is the use of traditional medicine. One of the traditional plants that can be used as a stop bleeding is broccoli (Brassica oleracea L. var. italica) which has a fairly high vitamin K content, where is efficacious as hemostatic. This study aims to determine the effect of broccoli on the bleeding time of mice tail cuts. The first group was negative control (Na-CMC), the second group was positive control (tranexamic acid), while groups three, four, and five were broccoli extract dose of 20, 40, and 60 mg/kg BW, respectively. All treatments were given orally for seven days. Bleeding time was calculated from the initial blood loss until the blood stopped (tail bleeding I method) and the data were analyzed with the ANOVA one way test and the post hoc Least Significant Difference (LSD) statistical test. The results showed that there were differences in the time to stop bleeding in the treatment control group at a dose of 20 mg/kg BW (122.60 ± 29.535 seconds), 40 mg/kg BW (102.40 ± 9.607 seconds) and 60 mg/kg BW (90.40 ± 3.845 seconds). From these results, it can be concluded that the extract of broccoli at a dose of 60 mg/kg BW gives the best results as hemostatic, while the effect is almost similar to the positive control group.
PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY OF ETHANOLIC EXTRACT OF CAWAT HANOMAN STEM (BAUHINIA ACULEATA L.) USING DPPH METHOD Muthia, Rahmi; Hidayatullah, Muhammad; Hidayati, Rahmi
Borneo Journal of Pharmacy Vol 3 No 1 (2020): Borneo Journal of Pharmacy
Publisher : ?Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i1.1245

Abstract

The free radical is an unstable molecule because contains one or two unpaired electrons. The antioxidant substance is a simple way to decrease the illness caused by free radicals. Cawat hanoman (Bauhinia aculeata L.) was known to contain tannin components one of the benefits as an antioxidant. This research aims to determine the antioxidant activity of the B. aculeata stem tested by qualitatively used thin-layer chromatography (TLC) and quantitatively using the DPPH method. Bauhinia aculeata stem was extracted using a maceration extract method with 96% ethanol. Antioxidant activity test was done qualitatively by eluent of ethyl acetate : methanol : purified water (6 : 2 : 1) using TLC and quantitatively using the DPPH method. The result of antioxidant activity from 96% ethanol extract of B. aculeata stem qualitatively showed the presence of yellow spots on a purple background at TLC after syringed DPPH 0.5 mM and quantitative test that resulted in an IC50 of 21.862 ?g/mL. These results indicate that 96% ethanol extract of B. aculeata has very strong antioxidant activity.
TEST ON THE ANTIOXIDANT ACTIVITIES OF METHANOL EXTRACT OF BIDARA LEAVES (ZIZIPHUS SPINA-CHRISTI L.) USING THE DPPH RADICAL IMMERSION METHOD Pambudi, Dwi Bagus; Fajriyah, Nuniek Nizmah; Shalekhah, Vidiah Rizka
Borneo Journal of Pharmacy Vol 3 No 1 (2020): Borneo Journal of Pharmacy
Publisher : ?Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i1.1242

Abstract

Bidara (Ziziphus spina-christi L.) is a tropical tree originating from Sudan in which it is commonly known as "Nebeq" in Saudi Arabia. It is of a bioactive compound - a flavonoid compound, which is the potential to be used as an antioxidant. It is capable of inhibiting any cell damages caused by free radicals. This study aimed to measure the activities of the free radicals in methanol extracts of Z. spina-christi leaves. The process of extracting the Z. spina-christi leaves was carried out through the maceration method using methanol as a solvent. The qualitative analysis of chemical compounds with certain eluents using thin-layer chromatography (TLC) was purposely to determine the groups of active compounds in extracts. The measurement of antioxidant activities was carried out using the 1,1-Diphenyl-2-picryl Hidrazyl (DPPH) immersion method in which absorption was measured at a maximum wavelength of 513 nm. The results showed that the methanol extract of Z. spina-christi leaves had a very weak antioxidant activity with the IC50 value of 466.804 ?g/ml. The results of the bioautographic profile showed the presence of flavonoid compounds, phenols, saponins, and tannins.
DESIGN OF EXPERIMENTS ASSESSMENT FOR THE DETERMINATION OF MOISTURE CONTENT IN FIVE HERBAL RAW MATERIALS CONTAINED IN TEA PRODUCTS Castillo, Luis; Baltodano, Eleaneth; Ramírez, Nils; Vargas, Rolando; Hanley, Georgia
Borneo Journal of Pharmacy Vol 3 No 1 (2020): Borneo Journal of Pharmacy
Publisher : ?Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i1.1236

Abstract

Research interest in natural raw materials is rapidly growing due to the high demand for natural products like herbal teas. Their quality control has a direct impact on safety and efficacy. The aim of this study was to evaluate the impact of sample?s mass and temperature on moisture content in Camellia sinensis (Black tea), Cassia fistula (Senna), Chamaemelum nobile (Chamomille), Lippia alba (Juanilama) and Tilia platyphyllos (Linden) with a gravimetric method developed through a full factorial 32 DoE. A response optimizer was executed in order to establish the test conditions that allow obtaining a response according to a target value from a certified method. DoE?s ANOVA shows reproducibility for Camellia sinensis, Cassia fistula, and Lippia alba. Also, the method?s model is able to explain the response variability for all samples based on the R2 (adj). The composite desirability for the proposed conditions of analysis for the five herbal materials is satisfactory according to each target value. However, the lack of reproducibility in Chamaemelum nobile and Tilia platyphyllos and also, the response prediction problems according to the R2 (pred) for Cassia fistula and Chamaemelum nobile, suggest the execution of further studies for them. Therefore, the present method is considered to be adequate for the analysis of moisture content in Camellia sinensis and Lippia alba raw herbs.
PREDICTION OF THE ANTIINFLAMMATORY ACTIVITY OF NEW S-ALKYL DERIVATIVES OF 1,2,4-TRIAZOL-3-THIONES USING THE PASS COMPUTER PROGRAM AND MOLECULAR DOCKING Chalenko, Natalya Mykolaivna; Syrovaya, Anna Olegovna; Kobzar, Natalya P; Rakhimova, Maryna V; Sych, Irina A; Sych, Igor Vladimirovich
Borneo Journal of Pharmacy Vol 3 No 1 (2020): Borneo Journal of Pharmacy
Publisher : ?Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i1.1082

Abstract

The strategy of rational approaches to the search for selective COX-2 inhibitors as potential antiinflammatory agents has been proposed and elaborated. It is based on the use of PASS-prediction and molecular docking. The choice of the basic structure of 4-amino-3-thio-1,2,4-triazole as a promising object of chemical modification has been substantiated. Using a modification of the primary molecule, a virtual library of S-derivatives of 5-substituted 4-amino(pyrrol)3-thio-4H-1,2,4-triazoles in the amount of 100 compounds (ten groups) has been obtained by introducing various pharmacophore fragments. Based on the analysis of the results of the PASS-prediction and molecular docking, six of the ten planned groups of compounds have been selected for the synthesis as promising selective COX-2 inhibitors. The reliability of the prediction results has already been confirmed for one of the promising group 4-amino-5-(pyridine-4-yl)-1,2,4-triazole (4?)-3-yl-thioacetamides.
Pengaruh Penggunaan Media Video Pembelajaran terhadap Pemahaman tentang Komunikasi dan Konseling Obat pada Mahasiswa S1 Farmasi Mardiati, Nurul; Restapaty, Ratna
Borneo Journal of Pharmacy Vol 1 No 1 (2018): Borneo Journal of Pharmacy
Publisher : ?Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v1i1.175

Abstract

Teaching-learning activities by lecturers are expected can use creative learning media with the use of appropriate media for the concepts to be conveyed to achieve the desired educational goals. Learning media is a tool used by lecturers to facilitate the delivery of learning materials. Learning media that can be used alone vary widely, one of which is learning video. This study aims to determine the influence of the use of video learning media on the understanding of communication and counseling drug on undergraduate students Pharmacy High School of Health Sciences Borneo Lestari Semester V Academic Year 2016/2017. This research is using the experimental method. The research design used was The Randomized Control-Group Pretest-Posttest Control Group Design. In this design, there are two groups that first randomly selected one class for the experimental group (using learning video) and one class for the control group (not using instructional video media). Sign value based on Wilcoxon test shows 0,025 <0,05. This indicates that there is the influence of t use of video learning media on the understanding of communication and counseling drug on undergraduate students Pharmacy High School of Health Sciences Borneo Lestari Semester V Academic Year 2016/2017.
Inventarisasi Tumbuhan Obat di Desa Pelangsian Kecamatan Mentawa Baru Ketapang Kabupaten Kotawaringin Timur Qamariah, Nurul; Mulyani, Evi; Dewi, Nurmila
Borneo Journal of Pharmacy Vol 1 No 1 (2018): Borneo Journal of Pharmacy
Publisher : ?Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v1i1.235

Abstract

Indonesia is a large archipelagic country and it is a tropical country with a huge variety of plants. Borneo as one of five major islands has tropical rainforest with a high level of plants diversities in the world. Traditional treatment by medicinal plants is still used by the people in Pelangsian village. The purpose of this study was to find out how the way the people in Pelangsian village use the traditional medicines, also about the type and the benefits of medical plants there, and which parts of the plants that used to be the traditional medicines. This research uses the descriptive method with a qualitative approach, data collecting is done by making an observation and interviews. Sampling in this research used purposive sampling technique in order to determine key informant with criteria that have been determined by the researcher and snowball sampling that determines the next informant who has already recommended by the key informant before. The result of the research was there are 52 species of medicinal plants that have been determined, the leaves, trunks, peels, fruit, seeds, roots, woods, rhizomes, are the parts of the plants that usually used by the people there and the way to use those herbs is boiled, stacked, rubbed and consumed directly.
Uji Daya Hambat Ekstrak Etanol Daun Jerangau Hijau terhadap Staphylococcus aureus Novaryatiin, Susi; Pratomo, Guntur Satrio; Yunari, Cindia
Borneo Journal of Pharmacy Vol 1 No 1 (2018): Borneo Journal of Pharmacy
Publisher : ?Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v1i1.236

Abstract

Jerangau Hijau is a medicinal plant believed by the people of Central Kalimantan to have an efficacy of treating fever, postpartum injuries, and anti-inflammatory. Based on previous research, Jerangau Hijau is known to contain chemical compounds namely flavonoids and saponins that have activity as an antibacterial. The purpose of this study was to find out whether the ethanolic extract of Jerangau Hijau leaves able to inhibit the growth of Staphylococcus aureus bacteria and to know the concentration of ethanolic extract of Jerangau Hijau leaves that able to inhibit the growth of Staphylococcus aureus bacteria. This research was conducted using the Kirby-Bauer method with disc paper. The extraction process was carried out by percolation method using 96% ethanol solvent. The results showed that the ethanolic extract of Jerangau Hijau leaves was able to inhibit the growth of Staphylococcus aureus bacteria, at concentrations of 1%, 5%, 10%, and 15% with mean inhibitory zones respectively 22±0.2 mm; 32.3±1.4 mm; 26.5±3.8 mm; and 13.1±3 mm.