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Hang Tuah Medical journal
Published by Universitas Hang Tuah Surabaya
ISSN : 16931238     EISSN : 25984861     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Public Health
Hang Tuah Medical Journal is medical journal which is publish regulary every 6 month in Mei and November. This journal is online version of Hang Tuah medical journal with print issn number 1693-1238 and electronic ISSN number 2598-4861. The articles publishes in areas such as: Biomedicine, Biomedical Engineering, Healthcare and Pharmaceuticals, epidemiology, infections, biochemistry, molecular biology, applied microbiology, cellular physiology, cellular nutrition in health and disease, public health and biochemical engineering. Original scientific researches, timely reviews, short communications, and letters to the editor related to the research and practice of Hang Tuah Medical journal are encouraged. At present, there is no page charge for this journal.
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Search results for , issue " Vol 16, No 1 (2018)" : 9 Documents clear
Pengaruh Pemberian Ekstrak Jambu Biji (Psidium Guajava) Terhadap Kadar Trigliserida Darah Tikus Putih (Rattus Norvegicus) Jantan Galur Wistar Yang Diinduksi Deksametason PUTRI, MARIA EVANE NAVY CAHAYA; PRANITASARI, NITA
Hang Tuah Medical journal Vol 16, No 1 (2018)
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (431.387 KB) | DOI: 10.30649/htmj.v16i1.95

Abstract

Abstract Dexamethasone induction may result in increased of both triglyceride synthesis and VLDL plasma level, which contribute to the increase in triglyceride level. Guava (Psidium guajava) consists flavonoid (quercetin) compounds that can inhibit triglyceride synthesis and decrease blood triglyceride level.MethodeThis research used 24 rats divided into 3 groups: group of rats fed with standard food, group of rats induced by 0.13 mg/kgBW dexamethasone for 14 days starting from day 8, and group of rats induced by 0.13 mg/kgBW dexamethasone for 14 days starting from day 8 and received 3 gr/kgBW guava extract for 21 days. On day 22, blood triglyceride level was measured with glycerol blanking method.ResultThe result of Mann-Whitney U showed that blood triglyceride level of group of rats induced by dexamethasone (=198.25±55.296 mg/dl) was significantly higher (p=0.001) than group of rats fed with standard food (=68.50±16.062 mg/dl). Blood triglyceride level of group of rats induced by dexamethasone and received guava extract (=98.75±26.778 mg/dl) did not significantly decreased (p=0.487) compared to group of rats induced by dexamethasone (=198.25±55.296 mg/dl).ConclusionThe conclusion of this research showed that dexamethasone significantly increased blood triglyceride level and guava extract tend to decrease blood triglyceride level because guava consists flavonoid (quercetin) compounds. Keywords: Psidium guajava, triglyceride, dexamethasone
SGLT-2 Inhibitor: Pilihan Terapi Baru Untuk Penderita Diabetes Melitus Tipe 2 AMANDARI, EKAJAYA
Hang Tuah Medical journal Vol 16, No 1 (2018)
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (442.071 KB) | DOI: 10.30649/htmj.v16i1.77

Abstract

Penyakit diabetes melitus tipe 2 (DMT2) merupakan suatu kondisi medis yang ditandai dengan adanya peningkatan kadar glukosa darah melebihi batas normal. World Health Organization (WHO) menyebutkan bahwa jumlah penderita DM di Indonesia mengalami peningkatan dari 8,4 juta penderita pada tahun 2000 menjadi 21,3 juta penderita pada tahun 2030, dimana 90% diantaranya merupakan penderita DMT2. Patofisiologi dari penyakit DMT2 adalah suatu proses yang kompleks dan melibatkan banyak faktor. Konsep ominous octet yang dikemukakan oleh Ralph DeFronzo memegang peranan penting untuk menjelaskan patofisiologi dari DMT2. Ginjal merupakan organ yang memiliki peran signifikan untuk mengendalikan glukosa darah agar tetap dalam batas yang normal, sehingga dipertimbangkan untuk menjadi target terapi obat baru. Sodium  glucose co-transporters (SGLTs) diantaranya SGLT-2 memfasilitasi reabsorbsi glukosa kedalam plasma. Farmakokinetika dari SGLT-2 inhibitor secara umum menunjukkan bioavailabilitas yang baik saat diberikan melalui oral. Diabetes melitus merupakan faktor risiko terjadinya penyakit ginjal kronik (PGK) dan penyakit kardiovaskuler (PKV). Adanya mekanisme penghambatan pada SGLT-2 akan memberikan manfaat terhadap sistem reno-kardiovaskuler melalui penurunan glukosa darah, berat badan, dan tekanan darah. Penghambat SGLT-2 memiliki beberapa efek tambahan yang menguntungkan untuk sindrom metabolik, seperti penurunan berat badan, penurunan tekanan darah (terutama sistolik), serta penurunan asam urat serum
Gambaran Karakteristik Odha Berdasarkan Lingkungan Di Minangkabau Tahun 2018 HANDAYANI, SRI; ARMAN, ELIZA; AGELICA, INGE
Hang Tuah Medical journal Vol 16, No 1 (2018)
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (415.834 KB) | DOI: 10.30649/htmj.v16i1.97

Abstract

Ranah Minang (Provinsi Sumatera Barat) berada pada posisi ke 8 dari 34 provinsi dengan case rate sebesar 18,8 yang berada diatas case rate nasional (17,2). Minang merupakan suku yang berfalsafah Adat Basandi Syarak, Syarak Basandi kitabullah atau adat yang didasarkan/ditopang oleh syariat agama Islam yang berarti bahwasanya dalam kebudayaan minang kabau norma – norma yang ada dibuatkan berpedoman kepada syariat agama islam yang dianut oleh mayoritas orang minangkabau. Agama islam dalam kitabnya mengharamkan kegiatan zina Seperti LGBT, pengkonsumsian alkohol dan narkoba yang merupakan salah satu media penularan HIV/AIDS. Tujuan penelitian ini adalah  untuk melihat gambaran karakteristik ODHA berdasarkan lingkungan di Ranah Minang.Penelitian ini menggunakan pendekatan kuantitatif dengan desain cross sectional. Penelitian di lakukan di Ranah Minang (Provinsi Sumatera Barat). Data dikumpulkan melalui penyebaran koesioner dengan mengunakan teknik quota sampling dengan jumlah sampel 28 ODHA. Data dianalisis secara univariat menggunakan komputer dengan aplikasi SPSSHasil penelitian diperoleh pada lingkungan yang berisiko  yaitu peran teman sejawat yang berisiko sebanyak 96, 4 % pada kasus, Peranan keluarga yang berisiko sebanyak 60,7 %, dan peranan Peranan pemangku adat yang berisiko sehingga dapat mengakibatkan kejadian HIV/ AIDS pada kasus sebanyak 60,7 %.Masih tingginya perilaku berisiko bagi ODHA baik dari segi lingkungan baik dari penan teman sebaya, keluarga maupun peran ninik mamak. Diharapkan lingkungan sekitar ODHA termasuk dalam hal yang penting dalam penanganan kejadian HIV/ AIDS ini di Ranah minang.
Hubungan Konsumsi Makanan Kariogenik Dan Kebiasaan Menggosok Gigi Dengan Timbulnya Karies Gigi Pada Anak Usia 4-6 Tahun SETYAWAN, FEBRI ENDRA BUDI; CHANDRAWATI, PERTIWI FEBRIANA; MULYADI, NATALIA
Hang Tuah Medical journal Vol 16, No 1 (2018)
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (306.824 KB) | DOI: 10.30649/htmj.v16i1.78

Abstract

Faktor awal pencetus karies gigi adalah makanan kariogenik. Pada penelitian sebelumnya menyatakan ada hubungan antara pola makan dan kebiasaan menggosok gigi dengan prevalensi karies gigi. Penelitian ini bertujuan untuk mengetahui hubungan antara konsumsi makanan kariogenik dan kebiasaan menggosok gigi dengan timbulnya penyakit karies gigi pada anak usia 4-6 tahun di TK Tunas Mekar desa Mlajah Kecamatan Bangkalan. Metode penelitian adalah Deskriptif Observasional Analitik dengan pendekatan Cross Sectional. Populasi dalam penelitian ini adalah seluruh anak usia 4-6 di desa Mlajah Kecamatan Bangkalan. Sampel yang diambil sejumlah 68 anak dengan menggunakan teknik Total Sampling. Data primer yang diperoleh dari observasi dan kuesioner, diolah menggunakan statistik uji Koefisien Kontingensi dan uji Discriminant dengan derajat kemaknaan (α) = 0,05. Hasil penelitian menunjukkan 49 anak (84,5%) mengalami karies gigi pada konsumsi makanan kariogenik ≥3x sehari dengan kebiasaan menggosok gigi <2x sehari, Pada hasil uji Koefisien Kontingensi didapatkan nilai r=0,61 dengan nilai signifikansi pada uji Discriminant. Kesimpulan yang didapatkan adalah adanya hubungan antara konsumsi makanan kariogenik dan kebiasaan menggosok gigi dengan timbulnya penyakit karies gigi pada anak usia 4-6 tahun di TK Tunas Mekar desa Mlajah Kecamatan Bangkalan. Kebiasaan konsumsi makanan kariogenik lebih bermakna menimbulkan karies gigi dibandingkan dengan kebiasaan menggosok gigi. Kata Kunci: Konsumsi Makanan Kariogenik, Kebiasaan Menggosok Gigi, Karies Gigi.
Pengaruh Pemberian Ekstrak Umbi Bawang Dayak (Eleutherine palmifolia L. Merr.) Terhadap Kadar Mda (Malondialdehid) Serum Tikus Putih (Rattus norvegicus) Jantan Galur Wistar Yang Diinduksi Parasetamol SUGIHARTO, WILLIAM
Hang Tuah Medical journal Vol 16, No 1 (2018)
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (407.632 KB) | DOI: 10.30649/htmj.v16i1.100

Abstract

ABSTRACTBackground: Paracetamol induced hepatotoxic effect because paracetamol increased production of N-acetyl-para-benzoquinone imine (NAPQI). Dayak onion contains flavonoids that inhibits cytochrome P450 activity, increases Glutation S-transferase (GST) activity, and scavenges free radicals.Method: This study used 24 male wistar rats (Rattus norvegicus) divided into 3 groups: group of rats without paracetamol induction, group of rats induced by 1750mg/kgBW paracetamol on 14th day, and group of rats given 300mg/kgBW dayak onion bulb extract (Eleutherine palmifolia L. Merr) for 14 days and induced by 1750 mg/kgBW paracetamol on 14th day. Result: The result of One Way Anova showed that serum malondialdehyde level of group of rats induced by paracetamol ( =129,063±42,0497mg/dl) was significantly higher (p=0.006) than group of rats without paracetamol induction ( =85,688±15,9976mg/dl). Serum malondialdehyde (MDA) level of group of rats given dayak onion bulb extract induced by paracetamol ( =118,500±19,4054mg/dl) was not significantly lower (p=0,463) than group of rats induced by paracetamol ( =129,063±42,0497mg/dl).Conclusion: The conclusion of this study showed that paracetamol significantly increased serum malondialdehyde (MDA) level and dayak onion bulb extract was not significantly decreased serum malondialdehyde (MDA) level.Keywords: Eleutherine palmifolia L. Merr, malondialdehyde, paracetamol
Peta Kuman Dan Sensitifitasnya Pada Penderita Gangren Diabetikum Di Rumah Sakit Angkatan Laut Dr. Ramelan Surabaya UTAMI, NI LUH AYU INTAN EDYSARI PUTRI
Hang Tuah Medical journal Vol 16, No 1 (2018)
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (306.985 KB) | DOI: 10.30649/htmj.v16i1.92

Abstract

Background: Diabetic gangrene is one of the complications of Diabetes Mellitus (DM) characterized by open wounds on the skin surface to the dermis layer. One of the complicating factors of the wound healing process is the infection of germs. For infection therapy in diabetic gangrene often associated with the use of antibiotics. The purpose of this study was to determine the germs that found in diabetic gangrene and its sensitivity to antibiotic in diabetic gangrene patients at Naval Hospital Dr. Ramelan Surabaya.Methods: This study is a retrospective descriptive study using 60 data samples that have fulfilled the inclusion criteria and obtained from the result of pus culture in diabetic gangrene at the Clinical Pathology Laboratory of Naval Hospital Dr. Ramelan Surabaya.Results: The results obtained from this study indicate the presence of 13 types of germs found in pus culture of diabetic gangrene patients and the most common found were Escherichia coli (33,3%). While the results on the sensitivity test showed that antibiotics with the highest sensitivity were Cefoperazone/ Sulbactam, Meropenem, and Levofloxacin (92.3%), whereas the lowest sensitivity antibiotic was Ampicilin (15.3%).Conclusion: Diabetic gangrene is often followed by the occurrence of infections that can be caused by various germs, and each germ has a different sensitivity to antibiotics. The culture of gangrene must be done because it is used to determine the type of antibiotic used for the treatment of diabetic gangrene based on the type of germs that infects. However, Cefoperazone/ Sulbactam, Meropenem, and Levofloxacin antibiotics may be the primary antibiotic choice because they have a high level of sensitivity.Keywords: Diabetic gangrene, germ infections, antibiotic sensitivity. 
Pengaruh Pemberian Terapi Oksigen Hiperbarik Terhadap Kadar Kolesterol Total Pada Tikus Putih (Rattus novergicus) Jantan Galur Wistar Yang Di Induksi Diet Tinggi Lemak SAFRIZAL, AZRUL HILDAN
Hang Tuah Medical journal Vol 16, No 1 (2018)
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (549.241 KB) | DOI: 10.30649/htmj.v16i1.56

Abstract

The pattern and lifestyle of today's society with the presence of an interner facility makes people spend more time sitting out than on exercise and increased consumption of high-fat foods may increase the risk of cardiovascular disease. An effective therapy is needed in preventing the occurrence of cardiovascular disease. Hyperbaric oxygen now starts to develop for the treatment of several diseases, which in turn can increase the gene forming antioxidant enzymes and ROS. To determine effect of hyperbaric oxygen therapy on total cholesterol levels of wistar white rats (Rattusnovergicus) induced bye high fat. The study was carried out in an expeative post test only group control of three groups. One group is given standard feed. All groups induced high-fat diet and standard feed. Of the two groups induced, one group was given hyperbaric oxygen therapy with a dose of 3 x 30 minutes for six days on day 7 at a blood test to determine total cholesterol levels. One way Anova parametric statistic test showed that p = 0.007 < α proved hypothesis that hyperbaric oxygen therapy giving effect to total cholesterol level of white mice of jantangalurist rings induced by high fat diet. Total cholesterol was significantly different between K (-) and K (+) and between K (-) and P. It was found that hyperbaric oxygen therapy had an effect on total cholesterol level dose of 3x30 minutes for six days.
Gambaran X-Foto Schuller Pada Pasien Otitis Media Kronis Di Rumah Sakit Angkatan Laut Dr. Ramelan Surabaya Periode 2015-2016 AZHARI, SALSABILA IRBAH; MULYATI, SRI
Hang Tuah Medical journal Vol 16, No 1 (2018)
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (481.234 KB)

Abstract

Background: Chronic Otitis Media is an infection of the middle ear marked by discharge from the middle ear. A survey conducted in seven provinces in Indonesia in 1996 found the prevalence of chronic suppurative otitis media was 3% of the population of Indonesia. OMSK can cause complications such as mastoiditis, meningitis and epidural abscess. The presence of complicationscan be examined one with a Schuller photo.Objective: To determine how many cases of mastoiditis in patients with chronic otitis media.Methods: This research was a descriptive study. The research was held between December 2016-Januari 2017 at Dr. Ramelan naval hospital Surabaya. The samples used were chronic otitis media patients with and without complications of mastoiditis who had Schuller photo examination at Dr. Ramelan naval hospital Surabaya in 2015-2016 that met the inclusion criteria.Results: The samples consisted of 72 patients. The highest proportion of samples were in the group of 41-50 years as many as 17 samples (23,61%), 37 patients were male (51.39%) and 35 patients were female (48.61%). Complications of mastoiditis was found in 69 patients (95.83%) and kolesteatom in 5 patients (6.94%). Chronic Mastoiditis was found in 48 patients (66.67%), Acute Mastoiditis in 21 patients (29.17%) and 3 patients (4.16%) were normal.Conclusion: Chronic Mastoiditis was the most common complication in patients with chronic otitis media.Keywords: Chronic otitis media, mastoiditis, Schuller photo, Dr. Ramelan Naval  Hospital Surabaya
Aliskiren: Direct Renin Inhibitor Baru Pada Terapi Hipertensi DEWI, NI PUTU UMA SARI; AMANDARI, , I. G. A. A. E.; KRISNAYANTI, M. W.; SARASMITA, MA
Hang Tuah Medical journal Vol 16, No 1 (2018)
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (448.013 KB) | DOI: 10.30649/htmj.v16i1.76

Abstract

Hipertensi merupakan kondisi ketika tekanan darah meningkat secara kronis. Mengacu pada hasil Riset Kesehatan Dasar (Riskesdas), Bali memiliki proporsi hipertensi sebesar 19,9%. Beberapa studi epidemiologis menyebutkan bahwa risiko kerusakan berbagai organ vital secara langsung berkorelasi dengan peningkatan tekanan darah. Oleh karena itu, diperlukan keteraturan dalam mengontrol dan juga meminum obat antihipertensi. Obat antihipertensi yang umum digunakan saat ini adalah angiotensin converting enzyme inhibitor (ACEI) dan angiotensin receptor blocker (ARB). Akan tetapi, temuan sebelumnya menyatakan bahwa ACEI dan ARB belum sepenuhnya efektif dalam menurunkan tekanan darah. Untuk mengatasi kelemahan tersebut, ditemukan direct renin inhibitor baru yaitu aliskiren. Aliskiren dapat memblokade renin-angiotensin-aldosterone system (RAAS) pada level tertinggi, sehingga kemampuan aliskiren dalam menurunkan tekanan darah tidak dapat diragukan lagi. Aliskiren mampu menghambat konversi angiotensinogen menjadi angiotensin I, sehingga dapat menurunkan tekanan darah secara berkelanjutan.

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