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INDONESIA
JFIOnline
Published by Ikatan Apoteker Indonesia
ISSN : 14121107     EISSN : 2355696X     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Farmasi Indonesia yang diterbitkan oleh Pengurus Pusat Ikatan Apoteker Indonesia. Isi website memuat seluruh jurnal yang telah diterbitkan mencakup semua aspek dalam ilmu pengetahuan dan teknologi kefarmasian antara lain farmakologi, farmakognosi, fitokimia,farmasetika, kimia farmasi, biologi molekuler, bioteknologi, farmasi klinik,farmasi komunitas, farmasi pendidikan, dan lain-lain.
Arjuna Subject : -
Articles 443 Documents
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PENGARUH JENIS LEMAK ALKOHOL SEBAGAI PENGENTAL TERHADAP STABILITAS FISIK SEDIAAN KONDISIONER RAMBUT BILAS (RINSE-OFF HAIR CONDITIONER) YANG MENGANDUNG EKSTRAK BUAH KIWI (Actinidia chinensis P.) Noviani, Yuslia; Noor, Siti Umrah; Raihanah, Raihanah
Jurnal Farmasi Indonesia Vol 10, No 2 (2018)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (723.373 KB) | DOI: 10.35617/jfi.v10i2.607

Abstract

Buah kiwi telah digunakan untuk perawatan rambut karena kandungan vitamin C, vitamin E dan arginin yang bermanfaat menjaga kesehatan rambut, membantu meningkatkan sirkulasi di kulit kepala dan melembutkan serta menutrisi rambut. Telah dilakukan penelitian formulasi sediaan untuk perawatan rambut yakni kondisioner rambut bilas (rinse-off hair conditioner) yang mengandung ektrak buah kiwi sebanyak 8 formula dengan variasi jenis lemak alkohol (setil alkohol, stearil alkohol, setostearil alkohol dan behenil alkohol) dengan konsentrasi masing-masing 4% untuk mendapatkan formula sediaan kondisioner rambut bilas dengan satu jenis lemak alkohol yang menghasilkan viskositas yang sesuai dan stabil secara fisik. Sediaan ini dibuat dengan cara pemanasan pada suhu 70-80oC dan pencampuran antara fase minyak dan fase air, yaitu fase minyak dicampurkan ke dalam fase air. Sediaan yang dihasilkan dievaluasi secara fisik dan kimia meliputi uji organoleptik, homogenitas, tipe emulsi, viskositas dan sifat alir, sentrifugasi dan ukuran partikel serta pH.
Analisis Selektivitas Senyawa Turunan Diosmetin Sebagai Antioksidan Baru dengan menggunakan Metode MolecularDocking Martati, Titiek; Mumpuni, Esti; Mulatsari, Esti; Maryanto, Kenny
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1421.953 KB) | DOI: 10.35617/jfi.v10i1.581

Abstract

Free radicals are compounds that have nofree electron pair, so it ws unstable and too reactive, to be able to ward off free radicals, required an antioxidant. Antioxidant can prevent the occurrence of oxidative reactions that can cause various diseases. The commonly used antioxidant compounds are vitamin C, vitamin E, and flavonoids. One of flavonoid compound that have the potential to be developed into antioxidants is diosmetin. The results of the study using the QSAR method, state that some of diosmetin derived compounds have better antioxidant activity than diosmetin. In this research, the selectivity of diosmetin derived compounds in several enzymes as an antioxidant was tested by using molecular docking methods. Software used for molecular docking were PLANTS, YASARA, MarvinSketch. This study used 15 diosmetin derived compounds, diosmetin as a parent compound, and comparison compounds used were vitamin C, vitamin E, and quercetin. Validated target proteins are 7 (seven) receptors with PDB codes 1QQW, 1V4S, 1XAN, 2BEL, 2C9V, 4K7O, and 5M2F. The results of this study have obtained the best selective compounds to receptors and compounds in each receptor. The best compounds are 6,8-difluoro diosmetin (1QQW), 8-amine diosmetin (1V4S), 6.8-difluoro diosmetin (1XAN), 6.8-diamine diosmetin (2BEL), 5'-amine diosmetin ( 2C9V), 5'-amine diosmetin (4K7O), and 8-amine diosmetin (5M2F). Free radicals are compounds that have nofree electron pair, so it ws unstable and too reactive, to be able to ward off free radicals, required an antioxidant. Antioxidant can prevent the occurrence of oxidative reactions that can cause various diseases. The commonly used antioxidant compounds are vitamin C, vitamin E, and flavonoids. One of flavonoid compound that have the potential to be developed into antioxidants is diosmetin. The results of the study using the QSAR method, state that some of diosmetin derived compounds have better antioxidant activity than diosmetin. In this research, the selectivity of diosmetin derived compounds in several enzymes as an antioxidant was tested by using molecular docking methods. Software used for molecular docking were PLANTS, YASARA, MarvinSketch. This study used 15 diosmetin derived compounds, diosmetin as a parent compound, and comparison compounds used were vitamin C, vitamin E, and quercetin. Validated target proteins are 7 (seven) receptors with PDB codes 1QQW, 1V4S, 1XAN, 2BEL, 2C9V, 4K7O, and 5M2F. The results of this study have obtained the best selective compounds to receptors and compounds in each receptor. The best compounds are 6,8-difluoro diosmetin (1QQW), 8-amine diosmetin (1V4S), 6.8-difluoro diosmetin (1XAN), 6.8-diamine diosmetin (2BEL), 5'-amine diosmetin ( 2C9V), 5'-amine diosmetin (4K7O), and 8-amine diosmetin (5M2F). Free radicals are compounds that have nofree electron pair, so it ws unstable and too reactive, to be able to ward off free radicals, required an antioxidant. Antioxidant can prevent the occurrence of oxidative reactions that can cause various diseases. The commonly used antioxidant compounds are vitamin C, vitamin E, and flavonoids. One of flavonoid compound that have the potential to be developed into antioxidants is diosmetin. The results of the study using the QSAR method, state that some of diosmetin derived compounds have better antioxidant activity than diosmetin. In this research, the selectivity of diosmetin derived compounds in several enzymes as an antioxidant was tested by using molecular docking methods. Software used for molecular docking were PLANTS, YASARA, MarvinSketch. This study used 15 diosmetin derived compounds, diosmetin as a parent compound, and comparison compounds used were vitamin C, vitamin E, and quercetin. Validated target proteins are 7 (seven) receptors with PDB codes 1QQW, 1V4S, 1XAN, 2BEL, 2C9V, 4K7O, and 5M2F. The results of this study have obtained the best selective compounds to receptors and compounds in each receptor. The best compounds are 6,8-difluoro diosmetin (1QQW), 8-amine diosmetin (1V4S), 6.8-difluoro diosmetin (1XAN), 6.8-diamine diosmetin (2BEL), 5'-amine diosmetin ( 2C9V), 5'-amine diosmetin (4K7O), and 8-amine diosmetin (5M2F).
Senyawa Asam 2-(4-(Klorometil)) Benzoiloksi)Benzoat Terhadap Agregasi Trombosit Dengan Metode Pengujian Thrombocyte Aggregation Test Dan Flow Cytometry Pada Plasma Manusia Jarra, Febrina Fatkiyah; Caroline, Caroline; YudyTjahjono, YudyTjahjono
Jurnal Farmasi Indonesia Vol 9, No 2 (2017)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1034.914 KB) | DOI: 10.35617/jfi.v9i2.587

Abstract

Asam asetilsalisilat (AAS) merupakan senyawa yang sering digunakan secara per-oral sebagai analgetika dan obat anti-agregasi trombosit. Penelitian ini  bertujuan untuk menguji pengaruh asam 2-(4-klorometilbenzoiloksi)benzoat terhadap proses agregasi trombosit manusia menggunakan PRP (trombosit rich plasma) manusia dengan metode Thrombochyte Aggregation Test (TAT) dan Immuno-flow cytometry. Diharapkan data yang diperoleh dapat digunakan untuk pengembangan senyawa baru yang lebih efektif dan kurang toksik jika dibandingkan dengan asam asetilsalisilat. Pada penelitian ini, darah diambil melalui venipunktur pada lengan pasien normal, atau aortapunktur pada mencit. Setelah PRP diisolasi dengan sentrifugasi darah, kemudian diklasifikasikan dalam beberapa kelompok: kontrol negatif (ditambahkan Buffer Hepes 50 mM), kontrol positif (ditambahkan AAS 277μM/Hepes 50 mM) dan kelompok senyawa uji (ditambahkan asam 2-(4-klorometilbenzoiloksi)benzoat 277μM/Hepes 50 mM). Konsentrasi senyawa 277 µM ekuivalen dengan dosis AAS 500mg/Kg BB. Setelah penambahan dan inkubasi, dilakukan uji TAT dan uji Immuno-Flow Cytometry (meliputi uji reaktivitas antibodi pada trombosit dan uji agregasi trombosit) dengan penambahan agonis Kolagen. Uji immuno-flow cytometry menggunakan antibodi PE anti human AP-3 dan Alexa Flour 488 anti human AP-3. Pada uji TAT diperoleh nilai rata-rata agregasi (vmax) pada senyawa uji (Asam 2-(4-(klorometil)benzoiloksi)benzoat+Buffer Hepes 50 mM) (0,311±0,031% detik), sebanding dengan kelompok kontrol negatif adalah (Buffer Hepes 50 mM) adalah (0,367±0,061% detik) dan dibawah kontrol positif (0,179±0,062% detik). Pada uji Immuno-Flow Cytometry diperoleh rata-rata % agregasi pada senyawa uji sebesar 17,02 ± 1,44%), sedikit diatas kontrol negatif ((16,18 ± 1,07%) dan signifikan di bawah kontrol positif (10,57 ± 2,13%). Dari kedua eksperimen diatas, dapat disimpulkan bahwa senyawa asam 2-(4-klorometilbenzoiloksi)benzoat tidak menunjukkan efek anti agregasi trombosit dalam metode pemeriksaan invitro.
Formulasi Sediaan Tablet Kunyah Kompleks Inklusi Dimenhidrinat–β-Siklodekstrin dengan Metode Pengeringan Semprot (Chewable Tablet from Inclusion Complexes of Dimenhydrinate– β-Cyclodextrine using Spray Drying Method) Faizatun, Faizatun; Joenoes, Luvita; Nafisa, Safira
Jurnal Farmasi Indonesia Vol 11, No 1 (2019)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2039.211 KB) | DOI: 10.35617/jfi.v11i1.593

Abstract

Taste becomes an important parameter in the delivery of a chewable tablet, primarily aimed for childrens. The purpose of this study is to mask the bitter taste and create dimenhydrinate chewable tabletas motion sickness drug that meet the physical and chemical quality. The method used to mask the bitter taste of dimenhydrinate is inclusion complexes with β-cyclodextrin in spray drying. Inclusion complex powders evaluation included flowcity and water content, and characterized by infrared spectrophotometry and DSC (Differential Scanning Calorimetry). Inclusion complex powders was made into chewable tablet with direct compression method. Chewable tablet was evaluated including tablets concentration (94.33-106,47%), the diversity of weights (85-115%), tablets diameter (1.013 cm), tablets thickness (0.49 cm), hardness (3.75-4.58 kg/cm2), friability (2,98-3,42%,). Dimenhydrinate chewable tablet taste test were statistically analyzed with non-parametric Kruskal-Wallis which results a significant differences of the bitter taste that masked among the five molar concentration differences of dimenhydrinate and β-cyclodextrine. The higher molar ratio of β-cyclodextrin (0,5-3) used, has the better result for masking the bitterness of dimenhydrinate. The used of β-cyclodextrin with the ratio in five molar concentration differences can not optimally mask the bitter taste of dimenhydrinate. Chewable tablet of formula IV has met the best physical and chemical quality. Taste becomes an important parameter in the delivery of a chewable tablet, primarily aimed for childrens. The purpose of this study is to mask the bitter taste and create dimenhydrinate chewable tabletas motion sickness drug that meet the physical and chemical quality. The method used to mask the bitter taste of dimenhydrinate is inclusion complexes with β-cyclodextrin in spray drying. Inclusion complex powders evaluation included flowcity and water content, and characterized by infrared spectrophotometry and DSC (Differential Scanning Calorimetry). Inclusion complex powders was made into chewable tablet with direct compression method. Chewable tablet was evaluated including tablets concentration (94.33-106,47%), the diversity of weights (85-115%), tablets diameter (1.013 cm), tablets thickness (0.49 cm), hardness (3.75-4.58 kg/cm2), friability (2,98-3,42%,). Dimenhydrinate chewable tablet taste test were statistically analyzed with non-parametric Kruskal-Wallis which results a significant differences of the bitter taste that masked among the five molar concentration differences of dimenhydrinate and β-cyclodextrine. The higher molar ratio of β-cyclodextrin (0,5-3) used, has the better result for masking the bitterness of dimenhydrinate. The used of β-cyclodextrin with the ratio in five molar concentration differences can not optimally mask the bitter taste of dimenhydrinate. Chewable tablet of formula IV has met the best physical and chemical quality. Taste becomes an important parameter in the delivery of a chewable tablet, primarily aimed for childrens. The purpose of this study is to mask the bitter taste and create dimenhydrinate chewable tabletas motion sickness drug that meet the physical and chemical quality. The method used to mask the bitter taste of dimenhydrinate is inclusion complexes with β-cyclodextrin in spray drying. Inclusion complex powders evaluation included flowcity and water content, and characterized by infrared spectrophotometry and DSC (Differential Scanning Calorimetry). Inclusion complex powders was made into chewable tablet with direct compression method. Chewable tablet was evaluated including tablets concentration (94.33-106,47%), the diversity of weights (85-115%), tablets diameter (1.013 cm), tablets thickness (0.49 cm), hardness (3.75-4.58 kg/cm2), friability (2,98-3,42%,). Dimenhydrinate chewable tablet taste test were statistically analyzed with non-parametric Kruskal-Wallis which results a significant differences of the bitter taste that masked among the five molar concentration differences of dimenhydrinate and β-cyclodextrine. The higher molar ratio of β-cyclodextrin (0,5-3) used, has the better result for masking the bitterness of dimenhydrinate. The used of β-cyclodextrin with the ratio in five molar concentration differences can not optimally mask the bitter taste of dimenhydrinate. Chewable tablet of formula IV has met the best physical and chemical quality.
KUALITASDAN AKTIVITAS ANTIBAKTERI MADU Apis dorsata YANG BERKOLONI PADA TIGA POHON BERBEDA DI KALIMANTAN UTARA Widowati, Retno; Camin, Yeremiah Rubin; Suryono, Annisa Nur’aini; Azkawati, Elok; Lusiana, Diana Intan Gabriella; Kusmaryeni, Siti; Sinaga, Ernawati
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2110.257 KB) | DOI: 10.35617/jfi.v10i1.580

Abstract

Honey has an important role as an anti-oxidant, anti-inflammatory and anti-bacterial agent, make it has high value for therapeutic puposes. North Kalimantan Indonesia is one of the honey producing regions of honey bee Apis dorsata, which colonizing on Gita tree (Alstonia scholaris), Menggeris tree (Koompasia malaccensis), and Pomatodon tree (Canarium decumanum). The aims of this research was to know the quality, phytochemistry and antibacterial activity of three types of honey produced byA. dorsata that colonized on three different trees in North Kalimantan. The honey quality test method was based on SNI 01-3454-2004. The phytochemicals tested included alkaloids, phenolics, hydroquinones, steroids and triterpenoids. Anti-bacterial activity was tested using well diffusion method with honey concentration 25%, 50%, 75% and 100%, against pathogenic bacteriaE.coli, S. typhi, S.aureus, S. epidermidis, and P. aeruginosa. The results showed that the honey tested complied with Indonesian honey quality standard SNI 01-3454-2004, except for water content, acidity and reducing-sugar content. The active compound present in all three types of honey are saponin. Honey from Gita treeat concentration 100% showed the strongest antibacterial activity against all of test bacteria. The antibacterial properties of the honey are probably derived from saponins and low pH of the honey. Honey has an important role as an anti-oxidant, anti-inflammatory and anti-bacterial agent, make it has high value for therapeutic puposes. North Kalimantan Indonesia is one of the honey producing regions of honey bee Apis dorsata, which colonizing on Gita tree (Alstonia scholaris), Menggeris tree (Koompasia malaccensis), and Pomatodon tree (Canarium decumanum). The aims of this research was to know the quality, phytochemistry and antibacterial activity of three types of honey produced byA. dorsata that colonized on three different trees in North Kalimantan. The honey quality test method was based on SNI 01-3454-2004. The phytochemicals tested included alkaloids, phenolics, hydroquinones, steroids and triterpenoids. Anti-bacterial activity was tested using well diffusion method with honey concentration 25%, 50%, 75% and 100%, against pathogenic bacteriaE.coli, S. typhi, S.aureus, S. epidermidis, and P. aeruginosa. The results showed that the honey tested complied with Indonesian honey quality standard SNI 01-3454-2004, except for water content, acidity and reducing-sugar content. The active compound present in all three types of honey are saponin. Honey from Gita treeat concentration 100% showed the strongest antibacterial activity against all of test bacteria. The antibacterial properties of the honey are probably derived from saponins and low pH of the honey. Honey has an important role as an anti-oxidant, anti-inflammatory and anti-bacterial agent, make it has high value for therapeutic puposes. North Kalimantan Indonesia is one of the honey producing regions of honey bee Apis dorsata, which colonizing on Gita tree (Alstonia scholaris), Menggeris tree (Koompasia malaccensis), and Pomatodon tree (Canarium decumanum). The aims of this research was to know the quality, phytochemistry and antibacterial activity of three types of honey produced byA. dorsata that colonized on three different trees in North Kalimantan. The honey quality test method was based on SNI 01-3454-2004. The phytochemicals tested included alkaloids, phenolics, hydroquinones, steroids and triterpenoids. Anti-bacterial activity was tested using well diffusion method with honey concentration 25%, 50%, 75% and 100%, against pathogenic bacteriaE.coli, S. typhi, S.aureus, S. epidermidis, and P. aeruginosa. The results showed that the honey tested complied with Indonesian honey quality standard SNI 01-3454-2004, except for water content, acidity and reducing-sugar content. The active compound present in all three types of honey are saponin. Honey from Gita treeat concentration 100% showed the strongest antibacterial activity against all of test bacteria. The antibacterial properties of the honey are probably derived from saponins and low pH of the honey.
Efek Antihipertensi Ekstrak Etanol Daun Sembung (Blumea balsamifera) pada Model Hewan Uji Induksi Epinefrin Sutjiatmo, Afifah Bambang; Bintussolihah, Falna; Vikasari, Suci Nar
Jurnal Farmasi Indonesia Vol 11, No 1 (2019)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1160.17 KB) | DOI: 10.35617/jfi.v11i1.592

Abstract

Hypertension is a non-communicable disease that has a high prevalence. Blumea balsamifera(Asteraceae) is one of the plants that has traditionally been used to treat high blood pressure. The aim of this study is to evaluate antihypertensive effect of ethanol extract of Blumea balsamiferaleaves on animal models induced epinephrine. The extract was made in 50% ethanol. Extraction was done using a set of Soxhlet tools. The antihypertensive effect test was carried out on male Wistar rats using epinephrine 0.25 mg/kg bwas inductor and blood pressure was measured indirectly through the tail using Kent Scientific's CODA system. The dose of extract was 8.75; 17.5 and 35 mg/kg bw, while propranolol at dose dose 1.8 mg/kg bw was used as comparator. The parameters were diastolic and systolic blood pressure. The results showed that the ethanol extract at doses of 8.75; 17.5 and 35mg/kg bw can prevent the increase in diastolic and systolic blood pressure in animals model induced epinephrine when compared to controls (p <0.05), where the best results is shown by the ethanol extract at dose of 17.5 mg/kg bw. The ability of the ethanol extract is equivalent to propranolol (p> 0.05). It can be concluded that Blumea balsamiferaleaves can be developed and have the potential to be antihypertensive.
UJI EFEKTIVITAS KOMBINASI EKSTRAK KULIT KAYU MANIS (Cinnamomum verum J. Presl) DAN DAGING BUAH MAHKOTA DEWA (Phaleria macrocarpa (Scheff.) Boerl.) TERHADAP PENURUNAN KADAR KOLESTEROL TOTAL DAN LDL PADA TIKUS PUTIH JANTAN YANG DIINDUKSI ALOKSAN DAN PAKAN Sunaryo, Hadi; Dwitiyanti, Dwitiyanti; Suriantika, Cipto
Jurnal Farmasi Indonesia Vol 10, No 2 (2018)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2465.789 KB) | DOI: 10.35617/jfi.v10i2.586

Abstract

Deficiency insulin results increased of lipid in people with diabetes. It happens because of the disruption of insulin function as a result complications of high blood fat levels, especially cholesterol and triglycerides. This research was conduct to determine effec of the combination of Cinnamomum verum extract (KM) and Phaleria macrocarpa extract (MD) on decreasing of total cholesterol and LDL in rat. The research divided into 8 treatment groups that is normal, negative, positive, dose combination 1 (KM 300 mg/kg BB+MD 1000 mg/kg BB), dose combination 2 (KM 300 mg/kg BB+MD 500 mg/kg BB), dose combination 3 (KM 300 mg/kg BB+MD 250 mg/kg BB), dose combination 4 (MD 1000 mg/kg BB+KM 150 mg/kg BB), dose combination 5 (MD 1000 mg/kg BB+KM 75 mg/kg BB). Tukey test results showed a decrease in the optimal combination 4 with a percentage decrease in total cholesterol and LDL by 42.83% and 35.01% but the decline is not comparable to the positive control (atorvastatin) amounted to 47.13% and 47.15%.
AMBARAN FUNGSI HATI PASIEN SKIZOFRENIA YANG MENGKONSUMSI RISPERIDONE DENGAN LORAZEPAM Kurniati, Tripeni; Darmawan, Endang; Anggriani, Hesti
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1329.822 KB) | DOI: 10.35617/jfi.v10i1.579

Abstract

Treatment with risperidone 1.5-6.0 mg/day provides good benefits for schizophrenia treatment, severe psychiatric disorder with long-term disability potential and limited availability of treatment options. According to the average percentage of patients with abnormal liver function tests, patients with clinically significant improvement (> 3 times of the normal upper limit for SGPT, aspartate aminotransferase.Abnormalities that are commonly without any symptom occur within 6 weeks of antipsychotic use (Correll et al., 2015). The purpose of this study is to analyze the liver function of schizophrenic in-patients who take risperidone and lorazepam in Amino Gondohutomo’s psychiatric hospital of Central of Java Province. The research subjects were 132 schizophrenic diagnosed patients who take risperidone and combination of risperidone and lorazepam. We used Chi Square Tests, Paried T Tests and One Sample Test.Based on the research results, it can be concluded that there is a correlation between readmisi and age group, in age group > 29 years more risk relapse than age group <29 years. Also, it can be concluded the combination of risperidone and lorazepam at risk 0,933 times will increase SGOT than get treatment with risperidone only and therapy the combination of risperidone and lorazepam at risk twice will increase SGPT rather than receive treatment with risperidone only.
KEJADIAN EFEK SAMPING PADA PENGGUNAAN OBAT-OBAT TANPA RESEP DI APOTEK KECAMATAN KOTAGEDE YOGYAKARTA 2016 Muhlis, Muhammad; Ghina, Ghina
Jurnal Farmasi Indonesia Vol 10, No 2 (2018)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1040.59 KB) | DOI: 10.35617/jfi.v10i2.585

Abstract

Swamedikasi yang tidak rasional dipengaruhi oleh rendahnya tingkat pengetahuan, keterampilan, dan perilaku masyarakat dalam pemilihan obat. Tujuan dari penelitian ini adalah untuk mengetahui efek samping apa saja yang paling sering muncul, serta mengetahui hubungan antara kejadian efek samping obat dengan cara penggunaan obat, dan mengetahui faktor apa saja yang menimbulkan efek samping dalam penggunaan obat bebas, obat bebas terbatas, OWA pada masyarakat di Kecamatan Kotagede, Yogyakarta. penelitian ini didisain secara observasional dengan metode survei,pengambilan data menggunakan kuisionerpada 100 pasien. Data yang diperoleh dianalisis dengan metode Uji Fisher dengan taraf kepercayaan 95%. Hasil penelitian diperoleh bahwa efek samping yang umum dirasakan oleh pasien adalah mengantuk, nyeri pada perut, dan jantung berdebar. Berdasarkan hasil Uji Fisher menunjukan bahwa tidak ada hubungan yang bermakna antara cara penggunaan obat dengan kejadian efek samping obat, faktor yang mempengaruhi efek samping pada penggunaan obat-obat tanpa resep adalah kurangnya pengetahuan masyarakat tentang bagaimana cara penggunaan obat yang baik dan benar, ketidak patuhan pasien dalam aturan pemakaian obat yang sudah dijelaskan oleh apoteker, danadanya perbedaan respon tubuh terhadap obat yang dikonsumsi tiap pasien. Kesimpulan, hasil uji statistik tidak terdapat hubungan yang bermakna antara penggunaan obat yang benar atau tidak benar dengan muncul atau tidak muncul efek samping obat, namun pada kenyataannya penggunaan obat-obat yang dibeli tanpa resep dokter dapat menimbulkan berbagai efek samping dan adanya perbedaan respon tubuh terhadap obat yang dikonsumsi tiap pasien.
PHYSICAL ACTIVITY AND VITAMIN D LEVEL IN ASTHMA AND NON-ASTHMA AKTIVITAS FISIK DAN KADAR VITAMIN D PADA PASIEN ASMA DAN NON-ASMA Lorensia, Amelia; Suryadinata, Rivan Virlando; Saputra, Rifaldi
Jurnal Farmasi Indonesia Vol 11, No 1 (2019)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2158.48 KB) | DOI: 10.35617/jfi.v11i1.591

Abstract

Worsen asthma symptoms is associated with low vitamin D levels that increases asthma attacks risk. Physical activity is one factor that affects vitamin D levels in the blood. This study aimed to identify relationship physical activities effects with vitamin d levels on asthma and non-asthma patients. The study was conducted in March-June 2018. The subjects were asthma patients and non-asthma adults and didn’t have other comorbidities. Data analysis used pearson test to determine physical activity effect with vitamin D levels. There were significant differences in vitamin D levels (P <0.000) and physical activity (P <0.000) in asthma and non asthma respondents. The results of the correlation test between vitamin D levels and physical activity in Approximate Significance value was 0.965, which means there were very strong relationships between vitamin levels and physical activity on the respondents of asthma and non asthma. So, the asthma patients with sufficient physical activity will have normal vitamin D levels to improve control of asthma symptoms. Worsen asthma symptoms is associated with low vitamin D levels that increases asthma attacks risk. Physical activity is one factor that affects vitamin D levels in the blood. This study aimed to identify relationship physical activities effects with vitamin d levels on asthma and non-asthma patients. The study was conducted in March-June 2018. The subjects were asthma patients and non-asthma adults and didn’t have other comorbidities. Data analysis used pearson test to determine physical activity effect with vitamin D levels. There were significant differences in vitamin D levels (P <0.000) and physical activity (P <0.000) in asthma and non asthma respondents. The results of the correlation test between vitamin D levels and physical activity in Approximate Significance value was 0.965, which means there were very strong relationships between vitamin levels and physical activity on the respondents of asthma and non asthma. So, the asthma patients with sufficient physical activity will have normal vitamin D levels to improve control of asthma symptoms.

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