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Contact Name
Trianokta Akbar Wardana
Contact Email
trianokta.akbar@yarsi.ac.id
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Journal Mail Official
jurnalkedokteran@yarsi.ac.id
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Kota adm. jakarta pusat,
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INDONESIA
YARSI Medical Journal
Published by Universitas Yarsi
ISSN : 08541159     EISSN : 24609382     DOI : -
Core Subject : Health,
Arjuna Subject : -
Articles 6 Documents
Search results for , issue " Vol 17, No 2 (2009): MEI - AGUSTUS 2009" : 6 Documents clear
Prevalensi bayi lahir cacat (Malformasi Kongenital) di Rumah Sakit Pendidikan Fakultas Kedokteran Universitas YARSI Mustofa, Samsul; Susmiarsih Panjiasih, Tri; Wikaningrum, Riyani
Jurnal Kedokteran YARSI Vol 17, No 2 (2009): MEI - AGUSTUS 2009
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (304.263 KB) | DOI: 10.33476/jky.v17i2.203

Abstract

Congenital Malformations was instrumental in perinatal morbidity and infant mortality. Patients with severe disorders are classified to be affected physically, mentally, and socially and require special attention. Prevalence data from various types of congenital malformations may be useful to plan primary prevention measures for such disorders. The purpose of this study was to examine the prevalence of congenital malformations at the teaching hospitals, Faculty of Medicine, YARSI University. In this study, data were obtained from medical records in four teaching hospitals i.e. Abdul Muluk Hospital in Bandar Lampung, Lampung, Serang General Hospital in Serang, Banten, Garut General Hospital in Garut, and Gunung Jati General Hospital in Cirebon, West Java, within a period of three years i.e. 2005 to 2007. Based on ICD-10 codes, eight groups involving 18 types of birth defects were recorded. Among 25,276 babies born in four previously mentioned hospitals, 283 babies were born with congenital malformation. The prevalence of congenital malformations in Abdul Muluk Hospital was 11.31% with the frequency of 5.961/1,000 live birth, Serang Hospital was 13.78% with the frequency of 7.163/1,000 live birth, Garut Hospital was 33.92% with the frequency of 9.777/1,000 live birth and Gunung Jati Hospital was 40.99% with the frequency of 24.98/1000 live birth. Various disorders were noted, being the most common was disorder in the digestive system (25.80%), followed by the musculoskeletal system (20.49%), and the nervous system (16.61%). In conclusion, the total prevalence of congenital malformations in the teaching hospital, Faculty of Medicine, YARSI University was 1.12% with the frequency of 11.2/1000 live births. Congenital malformations were particularly prominent in Gunung Jati General Hospitals Cirebon, West Java.
Perbedaan ekspresi TGF-B1 dan Fibrosis Interstisial pada kejadian Nefrotoksis Doxorubicin dan Nefroprotektif Pentoxifylin Purwanto, Bambang
Jurnal Kedokteran YARSI Vol 17, No 2 (2009): MEI - AGUSTUS 2009
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jky.v17i2.208

Abstract

Nephrotoxic effects of Doxorubicin (DXR) is still a problem in clinical practice. On the other hand Pentoxyfilline (PTX) as an electron-donor material can be nephroprotective. Therefore, combination of DXR and PTX would be expected to reduce nephrotoxic effects of DXR. In this study we examined the effects of PTX on TGF-B1 expression and interstitial fibrosis in an experimental model of DXR nephropathy in mice. Mice were divided into three groups of eight each i.e. untreated Swiss mice (controls), DXR treatment alone to induce nephropathy, and DXR treatment followed by PTX. Following 4 week treatment, each group was sacrificed. Examination of TGF-B1 expression was carried out by immunohistochemistry employing monoclonal antibody. Interstitial fibrosis examination was performed by a histopathologist using Verheoff van Giesen staining and the one way Anova was used for statistical analysis. It was observed that DXR treatment followed by PTX treatment prevented the increase of TGF-B1 expression and interstitial fibrosis in mice with DXRnephropathy (p<0.05). These findings suggested the beneficial nephroprotective effect of PTX.
Comparison between Image Correlation and Projection Correlation in CT Image Reconstruction with Limited Data Widita, Rena
Jurnal Kedokteran YARSI Vol 17, No 2 (2009): MEI - AGUSTUS 2009
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jky.v17i2.204

Abstract

Since the improvement in radiotherapy impacts on cancers at their most curable stages, radiotherapy-related research has a high strategic priority and a great capacity for improving the overall cure rates of the disease. However, some of the treatments involve the delivery of relatively high radiation dose to patients. Thus, it is important to be able to verify the success of the treatment by determining the dose deposited in the patient at each fraction. One possibility to achieve this would be to obtain an image while the patient is on the treatment couch. The aim of this study was to develop an image reconstruction algorithm by collecting limited information while the patient is on the treatment couch. Two methods, image correlation and projection correlation, were developed and compared here. The effectiveness and practicality of each of these methods were compared. The results showed that the projection correlation presents several advantages. It can be applied without any interations, and it produces a fast algorithm. With more advanced image reconstruction software, this method could potentially be used in a clinical environment.
Pola kuman pada penderita Infeksi Saluran Kemihdi RSUP Dr Kariadi Semarang Joni Karjono, Bambang; Susilaningsih, Neni; Damma Purnawati, Ratna
Jurnal Kedokteran YARSI Vol 17, No 2 (2009): MEI - AGUSTUS 2009
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jky.v17i2.205

Abstract

Urinary Tract Infection (UTI) is one of the most common bacterial infections found in clinical practice. The incidence of UTI increases with age. Despite various causes, the main causal agent is Escherichia coli.The aim of this study is to observe the pattern of bacteria underlying UTI in Dr. Kariadi Teaching Hospital, Semarang. A cross sectional design study was conducted using urine samples collected from 195 patients being diagnosed as UTI. Urine samples were cultured and counted according to microbiology standard method. Data obtained were analyzed employing descriptive approach. The result showed that 79 individuals (40.5%) were suffering from UTI, consisting of 31.6% male and 68.4%women. Most of the UTI patients were due to E. coli (65.8%) followed by E.coli and S. aureus (10.1%), S.Aureus (8.9%), Enterobacter sp. (7.6%), E. coli and Pseudomonassp. (2.5%), Enterobacter sp.E. coli (2.5%), Enterococcus sp. (1.3%) and E.coli, S. aureus and Enterobacter sp. (1.3%). It was concluded that the most common cause of UTI was E. coli and women were more frequently affected than men.
Analisis rasio IFNy - IL 4 pada berbagai kelompok Nefritis Lupus Handono, Kusworini
Jurnal Kedokteran YARSI Vol 17, No 2 (2009): MEI - AGUSTUS 2009
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jky.v17i2.206

Abstract

Lupus Nephritis (LN) is a serious manifestation of Systemic Lupus Erythematosus (SLE), that is classified into 6 different classes according to WHO criteria. It has been shown that histological pattern of LN varied significantly among the class and the etiology of the difference in the histological phenotypes remains unknown to date. Several studies indicatedassociation between Th1/Th2 cytokines balance with genetic factor. The present study aims to evaluate the interferron-? (IFNy) / interleukin 4 (IL4) ratio among different histologicalphenotype of LN patients in Indonesia. The study was conducted in 40 female SLE patients at Dr. Saiful Anwar Hospital, Malang, Indonesia. Histologic phenotypes classification was based on WHO criteria (1995). The serum level of IFNy and IL4 was assayed using ELISA and the association between IFNy-IL4 ratio with the histological phenotypes was statistically analyzed using ANOVA. The study revealed that among 31 SLE subjects undergone renal biopsy, class I/II, class III/IV and class V were observed in 13, 12 and 6 subjects respectively. The IFNy-IL4 ratio in class III/IV subjects was significantly higher compared to those in the other classes (p<0.000). However, the IL4 in the class III/IV was significantly lower than the other classes. The findings indicated that the activity of the Th1 immune response tend to be higher in class III/IV LN patients whereas in class V LN patients, the Th2 response prevail. In conclusion, the study indicated that the IFNy-IL4 cytokine ratio might influence the pathogenesis of LN.
Efek Pentagamavunon-0 terhadap Konsentrasi cAMP dan Progesteron pada Kultur Sel Luteal yang mengandung Teofilin Purwaningsih, Endang; Kadarsih Soejono, Sri; Dasuki, Djaswadi; Meiyanto, Edy
Jurnal Kedokteran YARSI Vol 17, No 2 (2009): MEI - AGUSTUS 2009
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jky.v17i2.202

Abstract

Curcumin analog (Pentagamavunon-0/PGV-0) can inhibit steroidogenesis of luteal cell culture. Corpus luteum secretes progesterone by LH stimulation. The main transduction signal of luteal cells steroidogenesis is through the cAMP/PKA. The objective of this study was to know the effect of PGV-0 on cAMP and progesterone concentration of luteal cell culture containing theophylline. The subject was corpus luteum of rat Sprague Dawley strain induced with PMSG (10 IU). PGV-0 was given shortly after the stimulation of LH and or PGF2? with or without theophyline. The cell culture then put into the incubator for 24 hours. Concentration of cAMP was assessed by ELISA whereas the progesterone concentration was determined by RIA. The result showed that LH stimulation caused cAMP and progesterone increase significantly. The inhibition of PGF2? on cAMP and progesterone concentrations showed no significant difference compared to the control. Theophylline increased the cAMP and progesterone concentration significantly but not to LH stimulation. PGV-0 did not inhibit cAMP concentration but PGV-0 inhibited the progesterone concentration by LH stimulation. In conclusion, PGV-0 inhibits signal transduction of lutheal cell in down stream cAMP.

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