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Contact Name
Salman, S.Si, M.Farm
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Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot SUbroto Gg. Rasmi No.28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123
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Kota medan,
Sumatera utara
INDONESIA
Journal Pharmaceutical And Sciences
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490
Core Subject : Health, Science,
Jurnal Journal of Pharmaceutical and Sciences (JPS) adalah jurnal elektronik yang diterbitkan Fakultas Farmasi Universitas Tjut Nyak Dhien. Jurnal ini dapat diakses secara online di https://www. journal-jps.com . Jurnal Journal of Pharmaceutical and Sciences (JPS) merupakan media publikasi ilmiah bagi dosen, mahasiswa, peneliti bidang farmasi dan sains terapan, juga bagi pratiksi farmasi baik di industri, rumah sakit maupun dilembaga penelitian lainnya. Jurnal Journal of Pharmaceutical and Sciences (JPS) menerima artikel berupa hasil penelitian, telaah atau tinjauan literatur, penelitian singkat atau short communication yang terkait dengan bidang pengetahuan tentang teknologi farmasi, manajamen farmasi, farmasi klinis, analisa kimia, bioteknologi, kimia bahan pangan, farmakologi, kimia bahan alam, material farmasi, kesehatan dan sains terapan yang relevan dengan bidang farmasi. Jurnal Journal of Pharmaceutical and Sciences (JPS) terbit 2 (dua) kali setahun yaitu nomor 1 di rentang waktu bulan Januari sampai Juni dan nomor 2 di bulan Juli sampai Desember setiap tahunnya.
Articles 36 Documents
UJI EFEKTIVITAS AFRODISIAKA EKSTRAK ETANOL ALBEDO (MESOCARP) SEMANGKA (Citrullus lanatus (Thunb.) Matsumura & Nakai) PADA MENCIT (Mus musculus) Gunawan, Muhammad; Saputri, Muharni; Sari, Suci Indah
Journal of Pharmaceutical And Sciences Vol 3 No 1 (2020): JPS Volume 3 Nomor 1 (2020)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v3i1.43

Abstract

Sexual dysfunction is a condition where sexual intercourse is difficult. Sexual dysfunction includes erectile dysfunction, impotence, premature ejaculation and disorders of desire (libido). One of the ways to overcome sexual disorders is by using aphrodisiac. Aphrodisiac is a kind of stimulating substance that can increase sex drive. One of the fruits that has an aphrodisiac effect is watermelon, precisely on the white layer on the skin that contains citrulline. This study aims to determine the aphrodisiac potential and the number of effective doses of watermelon albedo (mesocarp) ethanol extract (WAEE) against mice using ICC (Introducing, Climbing and Coitus). This research is an experimental study using 30 mice and divided into 5 groups. Group I (negative control) CMC 0.5%; group II (positive control) Pasak Bumi herbal medicine; group III; IV; V WAEE at a dose of 7; 13; and 27 g / kgBB. The mice were given orally and the ICC intensity was calculated. ICC intensity was statistically analyzed using the One Way ANOVA method and Duncan's Post-Hoc test using SPSS 24.0. The results of the ICC intensity statistical test between the Pasak Bumi herbal medicine and EEAS groups showed no significant difference with a value of α> 0.05. From the results of the study it can be concluded that EEAS has the potential as an aphrodisiac in mice with the most effective dose of 13 g / kgBW.
Pemilihan Skabisida dalam Pengobatan Skabies Trasia, Reqgi First
Journal of Pharmaceutical And Sciences Vol 3 No 2 (2020): JPS Volume 3 Nomor 2 (2020)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v3i2.41

Abstract

Scabies is a skin infection caused by the Sarcoptes scabiei mite. In 2017, WHO included scabies in the list of neglected tropical diseases. Treatment of scabies is currently still having problems due to incorrect drug selection. The difficulty of diagnosing scabies has made the drugs prescribed were not appropriate. The purpose of this article is to discuss the types of scabicide that can be used and to review the advantages and disadvantages of using them. Scabies can be treated with scabies, such as sulfur presipitatum, gamma benzene hexachloride, benzyl benzoate, crotamitone, permethrin, ivermectin, and herbal therapy. Of these several scabies, permethrin is the most widely used drug due to its higher efficacy. It is hoped that this article will become a reference for clinicians in choosing the right scabicide for patients.
Isolation and Antibacterial Activity Test of The Extract Ethyl Acetate of Endophytic Fungi from Kencur (Kaempferia Galanga L.) Efendi, M. Rifqi; Rusdi, Mesa Sukmadani; Anisa, Fitria
Journal of Pharmaceutical And Sciences Vol 3 No 2 (2020): JPS Volume 3 Nomor 2 (2020)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v3i2.42

Abstract

The aim of this research was to isolate the endophytic fungi found in leaves and rhizomes of Kaempferia galanga L. and to test its antibacterial activity. Isolation of endophytic fungi is carried out by cultivating and sub-cultivating fungi that found in leaves and rhizomes of Kaempferia galanga L. Identification of endophytic fungi is done by its morphology macroscopically and microscopically. Antibacterial activity testing is carried out by using the agar diffusion method. From the leaves and rhizome of Kaempferia galanga L., five isolates of endophytic fungi were identified as Torulla sp. (KG001), Mucor sp. (KG002), Fusarium sp. (KG003), Geotricum sp. (KG004), and Drechslera sp. (KG005). Three ethyl acetate extracts of the endophytic fungi Torulla sp. (KG001), Fusarium sp. (KG003), and Drechcera sp. (KG005) had antibacterial activity against Gram positive (Staphylococcus aureus and Vibrio cholera) and Gram negative bacterias (Bacillus subtilis and Eschericia coli) at concentration of 3.75%. The ethyl acetate extract endophytic fungi that had strong antibacterial activity (10-20 mm in diameter) were Torulla sp. (KG001) and Drechslera sp. (KG005). Meanwhile, the endophytic fungi that had moderate antibacterial activity (inhibition diameter 5-10 mm) was the ethyl acetate extract Fusarium sp. (KG003).The strongest antibacterial activity was shown by the ethyl acetate extract Drechslera Sp. with an inhibitory diameter 16 mm against Vibrio cholera .
FORMULASI NANOEMULSI EKSTRAK KUNYIT (Curcuma longa L.) SEBAGAI ANTIOKSIDAN Larasati, Shinta Putri; Jusnita, Nina
Journal of Pharmaceutical And Sciences Vol 3 No 1 (2020): JPS Volume 3 Nomor 1 (2020)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v3i1.38

Abstract

Turmeric (Curcuma longa L.) is a plant commonly used as traditional medicine by the community. Curcumin from turmeric is known to have bioactive compounds that have antioxidant properties but have low solubility and bioavailability activity. Nanoemulsion was made to improve stability andbioavailability of turmeric (Curcuma longa L.). The preparation of nanoemulsion were use homogenization method at 30° C and 10° C. The extract concentration used was 30% and Tween 3% as an emulsifier. The results of this study indicate that the nanoemulsion particle size at a temperature of 30°C has a smaller size of 18.1 nm. The antioxidant activity of turmeric extract nanoemulsion preparations had IC50 of 31.16%, and 32.11%. This result is higher than the extract that is equal to 30.01%. Turmeric extract nanoemulsion is stable at high storage 40°C, and the solubility of nanoemulsion is increased
Studi Fisikokimia Ekstrak Kulit Buah Manggis (Garcinia mangostana L.) Sebagai Pewarna Pada Formulasi Tablet ASRA, RIDHO; Rusdi, Rusdi; Nofrianti, Riri
Journal of Pharmaceutical And Sciences Vol 3 No 1 (2020): JPS Volume 3 Nomor 1 (2020)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v3i1.37

Abstract

The mangosteen peel (Garcinia mangostana L.) contains anthocyanin pigments, which has an important role in coloring. This study aims to determine the physicochemical properties of mangosteen peel extract (Garcinia mangostana L.) with two methods, which is an examination with UV-Vis and FTIR spectrophotometry. Then the extract was characterized, identified, and analyzed for its stability against temperature, pH, and applied as a coloring agent in the formulation of pharmaceutical preparations (tablets). The results showed that the yield of mangosteen peel extract obtained 13.0975 %, drying losses 5.2822 %, total ash content 14.488 %, acid insoluble ash content 0.684 %, water-soluble extract content 29.58 %, extract content dissolved in ethanol 37.78 %, total anthocyanin content with λmax = 367 nm which is = 9.58 mg / 100 g and with λmax = 289 nm which is = 52.43 mg / 100 g. In this study, the anthocyanin pigment content in mangosteen peel extract cannot be used as an alternative to natural dyes for pharmaceutical preparations (tablets).
STUDI FISIKOKIMIA BETASIANIN DAN AKTIVITAS ANTIOKSIDAN DARI UMBI BIT MERAH (Beta vulgaris L.) ASRA, RIDHO; Yetti, Rina Desni; Ratnasari, Desi; Nessa, Nessa
Journal of Pharmaceutical And Sciences Vol 3 No 1 (2020): JPS Volume 3 Nomor 1 (2020)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v3i1.35

Abstract

Red beet tubers (Beta vulgaris L.) contain 5-O-beta-glycoside betacyanin compounds which have many benefits. One of which is an antioxidant. Activity study, have been done antioxidant acting test from red beet tubers (Beta vulgaris L.) was extracted using the Ultrasonic Assisted Extraction (UAE) method using a water solvent and dried by freeze-drying method for 48 hours. Betacyanin was identified by thin-layer chromatography with Rf value 0.7166 and a wavelength of 535 nm analyzed by UV-Vis spectrophotometry. The FTIR spectrum shows that isolates contain functional groups that ware similar to betacyanin standard (Sigma Aldrich). Betasianin obtained in red beetroot extract with levels of 98.6474%. The red beetroot is stable at 40 °C and pH 5. Test its antioxidant activity using the DPPH method (1,1-diphenyl-2-picrylylhydrazyl) with a wavelength of 515.50 nm. The results of this study indicate the antioxidant activity from of red beet tubers (Beta vulgaris L.) with IC50 values of 21.8878 µg/mL, compared to IC50 values of vitamin C 7.1099 µg/mL. it can be concluded that the red beet tubers have a potent antioxidant activity (high antioxidant <50 µg / mL).
PROFIL FITOKIMIA SENYAWA METABOLIT SEKUNDER EKSTRAK ETANOL BUNGA SENDUDUK (Melastoma malabathricum L) Noviyanty, Yuska; Linda, Asri Mei
Journal of Pharmaceutical And Sciences Vol 3 No 1 (2020): JPS Volume 3 Nomor 1 (2020)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v3i1.34

Abstract

Indonesia is one of the countries that has a diversity of drugs in the world. Indonesia's tropical forest area has the second highest biodiversity in the world after Brazil. Plant (Melastoma malabathricum L) is one of the natural ingredients that can be used as traditional medicine. this study was to identify secondary metabolites contained in the extract of senduduk flower ethanol (Melastoma malabathricum L).Extraction was carried out by maceration using 96% ethanol for 7 days. The extraction obtained is then concentrated with a rotary evaporator. Secondary metabolite content was identified by flavonoid color reaction tested with Mg and HCL reagents, alkaloids were tested with mayer, dragendrof, and Wagner saponin tested by foam reaction, tannin was tested with Fecl3 reagent and triterpenoid / steroid was tested with anhydrous acetic acid reaction. Then the assertion test was carried out using thin layer chromatography (TLC).The results showed that a positive color change was shown in the presence of flavonoids, tannins, and saponins, and based on the results of the assertion test, the pleated layer chromatography test (TLC) showed positive results of flavonoids, saponins.
Uji Aktivitas Anti-inflamasi Dan Daya Hambat Siklooksigenase-2 ekstrak etanol Daun Malur (Brucea javanica (L.) Merr.) Ifora, Ifora; Haryani, Diana; Abdillah, Rahmad
Journal of Pharmaceutical And Sciences Vol 3 No 1 (2020): JPS Volume 3 Nomor 1 (2020)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v3i1.33

Abstract

Inflammation is a normal protective response to tissue damage mediated by Cyclooxigenase-2 (COX-2) enzyme. This study aims to determine the anti-inflammatory activity ethanol extract of (Brucea javanica (L.) Merr.) and its inhibitory effect on COX-2 enzyme. The animals used in this study were male white rats which were divided into 5 groups, dose250 mg/kg BB, dose 500 mg/kg BB, comparative control (Celecoxib), positve control and negative controls. Determining of anti-inflammatory activity was carried out by inducing the soles of the Rats with carragen and then measuring the edema volume using a pletismometer and measuring COX-2 inhibiton using a microplate Reader. The results showed that the ethanol extract of malur leaves doses 250 mg/kg BB and 500 mg/kg BB had significant anti-inflammatory activity (p <0.05). The dose 500 mg/kg BB has a significant inhibitory effect on COX-2 (p <0.05), but dose 250 mg/kg BB does not have significant inhibitory effect on COX-2. It can be concluded that the ethanol extract of malur leaves has anti-inflammatory effects at doses 250 mg/kg BB and 500 mg/kg BB and inhibitory effect against COX-2 at a dose 500 mg/kg BB.
Pengaruh Gaya Hidup Terhadap Status Gizi Pegawai Direktorat Politeknik Kesehatan Kementerian Kesehatan Medan Siregar, Emi Inayah Sari
Journal of Pharmaceutical And Sciences Vol 2 No 2 (2019): JPS Volume 2 Nomor 2 (2019)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v2i2.30

Abstract

Lifestyle as one of the factors indirectly plays an important role in influencing nutritional status. The objective of this research was to find out the influence of lifestyle on nutritional status. The research used a cross-sectional design. The sample was 70 employees of Health Polytechnic Directorate, Health Ministry Medan, and taken by using a total sampling technique. The measured factors were eating patterns (adequate carbohydrate and fat intake, the type of food, and the frequency of eating), physical activity, sleep duration, and nutritional status. The data were obtained based on the measurement of BMI and interviews with using food recall, FFQ and questionnaires, then analyzed by using the chi-square test and logistic regression test in order to identify the most dominant factors which influence the nutritional status. The results of the research showed that there was a sufficient effect of carbohydrate intake (p < 0.001), adequate fat intake (p = 0.022), physical activity (p < 0.001) and sleep duration (p < 0.001) on the nutritional status. The results of the logistic regression test showed that the most dominant factor in influencing the nutritional status was the amount of carbohydrate intake.
Uji Daya Hambat Sediaan Sampo Air Perasan Jeruk Purut (Citrus hystrix) Terhadap Pertumbuhan Microsporum gypseum Maimunah, Siti; Zega, Rita Marthalena; sapitri, Alfi
Journal of Pharmaceutical And Sciences Vol 2 No 2 (2019): JPS Volume 2 Nomor 2 (2019)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v2i2.29

Abstract

The shampoo is a dosage material used as a hair cleanser and epicarp head, especially the problem of dandruff caused by fungus. Kaffir lime has the content of essential oils, flavonoids and tannins are efficacious as an antifungal. The purpose of this study was to test the shampoo of kaffir lime and to know its inhibitory power to growth of Microsporum gypseum fungus. The type of this research is experiment with using agar diffusion method. Samples studied were epicarp juice of lime and mesocarp of kaffir lime with concentration respectively 10%, 20%, 30%, 40%, 50%. Shampoo dosage evaluation tests include inhibitory test, organoleptic test, pH test, high foam test and wetting test. The results showed that the lime mesocarp juice had inhibitory at 10% (13,09 mm) concentration, 20% (14,9 mm) concentration, 30% (18,52 mm) concentration, 40% concentration (20,86 mm ) and a concentration of 50% (22.53 mm). While the results of epicarp water of lime juice have a weak inhibitory power with a concentration of 10% (5,66 mm), Concentration of 20% (7,09 mm), concentration of 30% (8,09 mm), concentration of 40% (10,19), and concentration of 50% (11,36). Effective concentration on the preparation of shampoo preparations is the concentration of 20% and 30% of the lime juice mesocarp juice. The results of the evaluation test of two anti-dandruff shampoo formulations meet the requirements of a good shampoo and have respective inhabitants of F1 (20%) has a resistance of 14,54 mm and F2 (30%) has a resistance of 19,12 mm. Both dosage preparations are anti-dandruff.

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