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Contact Name
Rachmat Hidayat
Contact Email
dr.rachmat.hidayat@gmail.com
Phone
+6288225053819
Journal Mail Official
scientiapsychiatrica@gmail.com
Editorial Address
Dr. Moh Ali street
Location
Kota adm. jakarta pusat,
Dki jakarta
INDONESIA
Scientia Psychiatrica
ISSN : -     EISSN : 27159736     DOI : https://doi.org/10.37275/scipsy
Core Subject : Health, Science,
Scientia Psychiatrica covers the latest developments in various fields of psychiatric : biological psychiatry, neuropsychiatry, child psychiatry, psychiatry of community, psychotherapy, drugs-related mental illness, psychiatry of geriatric, psychosomatics medicine, psychology, cultural psychiatry, military psychiatry, forensic psychiatry, consultation liaison psychiatry and all medicine fields related psychiatry. Genetics, immunology, environmental health, toxicology, bioinformatics and biotechnology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact of psychiatry.
Articles 15 Documents
Haloperidol and Risperidone Induce Apoptosis Neuronal Cell : Invivo Study Panserga, Ester G; Kristanto, Cecep S; Pratiti, Budi; Wulandari, Patricia
Scientia Psychiatrica Vol. 1 No. 1 (2020): Scientia Psychiatrica
Publisher : Indonesian Psychiatrist Association (PDSKJI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (271.205 KB) | DOI: 10.37275/scipsy.v1i1.5

Abstract

Abstract Introduction Antipsychotics are drugs that are widely prescribed for mental disorders, such as schizophrenia and psychosis. Recent in vitro studies show antipsychotics play a role in the initiation of neuronal cell apoptosis. This study aims to determine the effect of haloperidol and risperidone on neuronal cell apoptosis in Wistar white rats. Methods Male wistar rats aged 8 weeks (n = 30) were used in this study. Wistar rats were randomized into 6 groups. Group A: 5 wistar rats as a control without induced schizophrenia, aquades and drugs. Group B: 5 Wistar-induced psychotic mice (using 30 mg / kgBB ketamine, intraperitoneal injection for 5 days) and aquadest. Group C: 5 rats were induced psychotic and were given haloperidol or 0.05 mg / kgBB orally, for 28 days. Group D: 5 mice were induced psychotic and were given haloperidol 0.1 mg / kg orally, for 28 days. Group E: 5 mice were induced psychotic and were given risperidone 0.05 mg / kgBB orally, for 28 days. Group F: 5 mice were induced psychotic and given risperidone 0.1 mg / kgBB orally, for 28 days. Apoptosis of neuronal cells in the ventral tegmental area was assessed by caspase-3 immunohistochemistry. The colored area will be calculated as a total percentage using the imageJ program. Results Risperidone and haloperidol increase caspase-3 activity, but haloperidol increases caspase-3 activity more than risperidone. Conclussion Risperidone and haloperidol induce apoptosis of neuronal cells and tardive dyskinesia in Wistar rats with psychotic models.
Video Game Increases Depression in Students Humries, Edith; Pratiti, Budi; Wulandari, Patricia; Hidayat, Rachmat
Scientia Psychiatrica Vol. 1 No. 1 (2020): Scientia Psychiatrica
Publisher : Indonesian Psychiatrist Association (PDSKJI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (148.035 KB) | DOI: 10.37275/scipsy.v1i1.3

Abstract

Abstract Introduction The effects of exposure to violence in newspaper and electronic media to children and adolescents were being an awareness various parties, namely, researchers, health practitioners and policy makers. Depression is a mental problem that is always found due to exposure to video games. Method This study was an observational study with a cross-sectional research design. The subjects of the study were teenagers aged 15-18 years, students of Vocational School  Yogyakarta, Indonesia. Data analysis was performed with IBM SPSS 16. Data analysis to assess the relationship between length and video game content with depression levels (Children?s Depression Inventory -2) used Independent student T-test analysis and linear regression analysis. Results The study subjects consisted of 4.3% men and 95.7% women. There were no significant differences between subjects with male and female sex related to CDI-2 score, p> 0.05. The sexes of men and women have CDI-2 scores of 26.92 ± 5.02 and 26, 42 ± 3.32, respectively. There is a significant relationship between the intensity of playing video games with a CDI-2 score. Research subjects who had the intensity of playing video games for more than 2 hours a day had a higher mean CDI-2 score (28.62 ± 2.62, p <0.05) when compared to research subjects who played video games for less than 2 hours per day (26.13 ± 3.38, p <0.05). There was a significant relationship between video game content and the average CDI-2 score. Research subjects who played violent video games had higher CDI-2 scores (29.91 ± 2.07, p <0.05) when compared to groups who played video games with non-violent game themes (26, 29 ± 3.37 , p <0.05). Based on linear regression analysis, there is a relationship between the intensity of playing video games with the average CDI-2 score (? = 1.87, SE = 0.72, p = 0.01). Meanwhile, for video game content there is no relationship between video game content containing violence and the average CDI-2 score (? = 1.91, SE = 1.21, p = 0.11).   Conclusion There is a relationship between the intensity of playing video games with the average CDI-2 score.
Co-occuring Toxoplasma Infection and Psychotic Symptoms : Case Report Marchira, Carla R; Kusumadewi, Andrian F; Wulandari, Patricia
Scientia Psychiatrica Vol. 1 No. 1 (2020): Scientia Psychiatrica
Publisher : Indonesian Psychiatrist Association (PDSKJI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (41.958 KB) | DOI: 10.37275/scipsy.v1i1.4

Abstract

Abstract   Introduction Schizophrenia is a neuropsychiatric disease that is global and is experienced by 1% of the population in the United States and Europe. This study raises awareness of the role of infectious agents in the initiation of psychotic symptoms in schizophrenia. Case Presentation A 20-year-old man is taken by the family to the emergency department because he has decreased consciousness, and the body suddenly stiffens. Patients begin to experience changes in behavior in the form of difficulty sleeping, when invited to talk quietly, laughing alone and whispering without the other person. TORCH examination found an increase in anti-toxoplasma IgM and IgG. This patient is then given basic life support in the form of ABC (airway, breathing, circulation support) and seizure management. Also given risperidone 2 mg / 12 hours, pyrimethamine 1-II (1x200 mg), pyrimethamine day III-XXI (1x 25 mg), intravenous Cefotaxim 2g / 8 hours, Clindamycin 500 mg / 8 hours. The patient experienced improvement after the second week of treatment. Conclusion Toxoplasmosis causes lesions in the brain that cause changes in brain neurotransmitter pathways, which lead to changes in patient behavior.
Comorbid of Obsessive Compulsive Disorder and Schizophrenia: A Case Report Pratiti, Budi; Wulandari, Patricia; Hidayat, Rachmat
Scientia Psychiatrica Vol. 1 No. 1 (2020): Scientia Psychiatrica
Publisher : Indonesian Psychiatrist Association (PDSKJI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (104.855 KB) | DOI: 10.37275/scipsy.v1i1.1

Abstract

Abstract Introduction                 Schizophrenia was a chronic mental disorder that marked by abnormal social and impairment in reality testing ability. A person diagnosed with schizophrenia may experience amount of symptoms including hallucinations, delusions, and disorganized thinking, bizzare speech and behaviour. Obsessive compulsive disorder are well known as a comorbid of schizophrenia. Comorbid OCD will affect treatment of schizophrenia and others mental disorder. Case Presentation A 14-year-old student Muslim boy from a rural household in Central Java, Indonesia who had 8 years of formal education and live with his parent was brought to emergency department of mental hospital by his parents who reported a one year history of excessive washing of his body, soaking his body for hours in bathtub and sleep in bathroom. The patient first fell in January 2019; over a six-month period he became progressively deteriorated, lost interest in his hobby, stopped going to school and reduced his food intake. After one week treatment of venlafaxine and risperidone, He became more cooperative and interactive to the examiner. At that time, the patient reported delusional beliefs about contamination, paranoid delusion and there were several indications of formal thought disorder, including derailment, neologisms, concrete thinking, circumstantiality, and illogicality. An intelligence test revealed average intelligence (IQ=100). The total score of the Brief Psychiatric Rating Scale (BPRS) 3 dropped from 42 to 24, the score on the Yates-Brown Obsessive Compulsive Symptoms (YBOCS)4 scale dropped from 24 to 18, and the score on the Global Assessment of Functioning scale (GAF)5 increased from 25 to 55. After discharge the patient adhered to his medication regimen and at three months after discharge his clinical improvement persisted; he was able to maintain is his personal hygiene and take care of his daily needs, but he remained socially isolated and was unable to return to school.   Conclusion Obsessive compulsive disorder and schizophrenia could happen together in one individual. The treatment should consider underlying condition and cognitive function, especially if patient in productive age.
Evidence-Based Electroconvulsive Therapy for Major Depression Disorder Khan, Zahra D; Marchira, Carla R; Wulandari, Patricia
Scientia Psychiatrica Vol. 1 No. 1 (2020): Scientia Psychiatrica
Publisher : Indonesian Psychiatrist Association (PDSKJI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (161.242 KB) | DOI: 10.37275/scipsy.v1i1.2

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Abstract Electroconvulsive Therapy (ECT) is a treatment that steals medical attention and the public. Memory disturbance after ECT is a special consideration for the Food and Drugs Administration (FDA) of the United States to classify ECT, whether it belongs to class III (high risk). Psychiatrists or anesthesiologists (who are experienced with ECT) tend to change this classification, while neurologists, psychologists, biostatistics experts, and public representatives agree to maintain ECT status in class III. Contrary to unexpected effects, ECT can induce a transition in severe melancholic patients and suicide to normal functioning humans, after other treatments have failed. With the aim of balancing effectiveness and safety, this paper provides modern evidence of the benefits and risks of ECT.
PSYCHOTIC SYMPTOMS RELATED ANTI NMDA RECEPTOR IN OVARIAN TERATOMA Kristianto, Cecep Sugeng
Scientia Psychiatrica Vol. 1 No. 2 (2020): Scientia Psychiatrica
Publisher : Indonesian Psychiatrist Association (PDSKJI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v1i2.6

Abstract

Abstract Psychotic symptoms related ovarian teratoma are uncommon but has been well known in previous medical literature. Psychotic problems experienced by patients are often mistaken for psychological causes without organic causes, because commonly patients do not show symptoms associated with teratomas. Diagnosis of teratoma-related psychotic illnesses is often delayed due to the nature of the symptoms, that is leading to delayed treatment and worsen long-term neurological outcomes. Neuropsychiatric symptoms in teratoma can occur if it contains brain tissue inside and antibody anti-NMDA (N-methyl-D-Aspartate) receptor. The occurrence of psychotic symptoms in ovarian teratomas is based on cellular mechanisms. Antibodies bind to the NMDA receptor, which leads to the internalization of the cell surface and the relative state of the NMDA receptor hypofunction. While the impact of specific regions and circuit circuits of anti-NMDA receptor antibodies remains to be explored, the mechanism of anti-NMDA receptor encephalitis strengthens the hypothesis that NMDA receptor hypofunction may have a role in schizophrenia and psychosis.
PROFILE OF PERSONALITY AND PSYCHOPATHOLOGY DIMENSIONS OF INDONESIAN MEDICAL STUDENTS WHO FAILED IN MEDICAL DOCTOR COMPETENCY EXAMS (UKMPPD) Wulandari, Patricia; Hidayat, Rachmat; Marchira, Carla R
Scientia Psychiatrica Vol. 1 No. 2 (2020): Scientia Psychiatrica
Publisher : Indonesian Psychiatrist Association (PDSKJI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v1i2.7

Abstract

Abstract Introduction                 Medical doctor competency exams (UKMPPD) in Indonesia is a final test that should be followed by medical student before being declared worthy of a medical doctor?s degree. This exam is certainly intended with good intentions, in order to improve the standards and quality of graduates of Indonesian doctors. However, each policy turns out to have two opposite sides of the situation, on the one hand it is profitable but on the other it often creates new problems. Students? fear of the competency test often causes new psychological problems for students. No doubt the failure of the competency exam causes students to experience prolonged disappointment and sadness, which in turn will cause depression. This research is the first research that aim to present a description of personality and psychopathology dimension data from UKMPPD participants who failed the test.   Method This study was an exploratory descriptive study by presenting narratives of personality and psychopathology dimensions of unsuccessful UKMPPD participants. This research was conducted at the Faculty of Medicine, Universitas Sriwijaya Palembang, Indonesia. Each participant was assessed personality and psychopathology dimensions using MMPI-2 (Minnesota Multiaxial Personality Inventory-2). The results of analysis with MMPI-2 present data in the form of clinical psychic conditions, the work capacity, interpersonal relationships, the work abilities and the ability to change the self  potential of the research subjects.   Result The research subjects were UKMPPD participants who did not successfully pass the first exam. From 7 research subjects, there were 2 subjects who successfully passed the second exam (28.5%) and there were 3 people who successfully passed after the third exam (43%). Meanwhile, 2 research subjects have not successfully passed the UKMPPD exam until the fifth exam (28.5%). The results are quite surprising that of the 7 participants who failed to pass the UKMPPD exam, all of them felt depression.   Conclusion Medical students who experienced UKMPPD failures have an inability to develop their own potential which result in depression due to failure of the exam
NEURONAL CELL DEATH INDUCES DEPRESSIVE DISORDER IN RATS DEPRESSION-LIKE BEHAVIORS CAUSED BY CHRONIC STRESS Hidayat, Rachmat; Saleh, Mgs Irsan; Parisa, Nita
Scientia Psychiatrica Vol. 1 No. 2 (2020): Scientia Psychiatrica
Publisher : Indonesian Psychiatrist Association (PDSKJI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v1i2.8

Abstract

Abstract Introduction Depression is believed to be a disorder in which an increase in serotonin activity in the brain. This has implications for the development of various antidepressant drugs that work to increase serotonin levels, by inhibiting serotonin reuptake. However, management with antidepressants is still believed to be not optimal, there are still various problems that have not been able to be solved only by increasing serotonin levels in the brain. Therefore, it is necessary to do further exploration to find out other possible pathophysiology of depressive disorders. This study intended to explore the role of apoptosis of neuronal cells in the prefrontal cortex to answer the hypothesis that depression was not only caused by increased serotonin levels but also  there was a role of dead neuronal cells in the prefrontal cortex which will trigger the body's homeostatic efforts to compensate by increasing serotonin levels.   Methods A total of 30 male Wistar rats (200 ± 20 g) were obtained from Eureka Research Laboratory (Palembang, Indonesia). Experimental animals were placed in cages under controlled conditions (12 hours of light / dark cycles with temperatures of 22 ± 1?C and humidity of 40-60%), fed and drank ad libitum. Experimental animals with depression model were induced using Chronic Mild Stress (CMS). CMS procedures were performed with mild stressors such as repeated cold stress (4 ° C), space reduction in the homecage, changed cages and social interaction with other animals of the CMS group. To assess wether animal were being depression or not, the animal were tested using Forced Swimming Test (FST). After induction, rats were randomly divided into two groups which each contained 15 animals: the normal control group (not induced CMS) and the CMS group (negative control). Furthermore, the animal model was performed perfusion to maintain organ when evacuation was done, cell damage did not occur. To evaluate cell organ, immunohistochemistry examination and ELISA examination was performed. All data are presented as mean ± standard deviation and all statistical analyzes are performed with the SPSS 25 (IBM) program. Result This research showed that CMS animal model has a greater duration of immobility than the normal group and serotonin level in CMS animal models decreased almost threefold compared to the normal group. In addition, there were increased expression of caspase-3 indicates that more neuronal cells suffered from apoptosis. So, in this research, it was clearly stated that in depressive disorder, there were elevation of neuronal cell apoptosis in the prefrontal cortex. Conclusion Neuronal cell apoptosis in the prefrontal cortex plays a role in the pathophysiology of depression through activation of negative feedback on serotonin production.
PANIC DISORDER WITH CHOKING PHOBIA : A CASE REPORT Wulandari, Patricia
Scientia Psychiatrica Vol. 1 No. 2 (2020): Scientia Psychiatrica
Publisher : Indonesian Psychiatrist Association (PDSKJI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v1i2.11

Abstract

Abstract   Panic disorder is a form of anxiety disorder characterized by repeated panic attacks and preoccupied with worrying that a panic attack will occur. Panic attacks are characterized by fears of a disaster or loss of self-control even though there is really nothing to worry about. Other symptoms experienced during a panic attack are heart palpitations (similar to a heart attack), shortness of breath, feelings of suffocation, and the body feels weak. If this disorder is not detected early, it will affect the daily life of the patient. This case report presents the case of a 34-year-old woman who experiences symptoms of panic disorder with choking phobia that is managed with antidepressants and cognitive behavior therapy. In addition, there is discussion of differential diagnosis and the role of cognitive behavior therapy in handling this case. 
TENSION TYPE HEADACHE COMORBID WITH MODERATE DEPRESSION : A CASE REPORT Pratiti, Budi
Scientia Psychiatrica Vol. 1 No. 2 (2020): Scientia Psychiatrica
Publisher : Indonesian Psychiatrist Association (PDSKJI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/scipsy.v1i2.12

Abstract

Abstract Introduction. Tension type headaches (TTH) are generally caused by psychological factors and psychiatric disorders. Anxiety disorders and depression are more often associated with TTH than other disorders. This case report discusses the tension type headache accompanied by depression and its management. Case Presentation. Miss Y, a 17 year old girl, 2nd in birth order, an undergraduate student living in a boarding house with her sister and coming from a low socio-economic background, came to Dr. Sardjito General hospital, Indonesia with complaints of severe headache since 2 months ago. Family history shows that there is a conflict in the patient's parents which makes the patient disappointed. In the examination found inferiority feelings, guilt and worry will disappoint everyone. She was then agreed to do cognitive behavior therapy and take medication according to doctor's orders. After 8 sessions, she developed confidence and started to carry out daily similar sessions at home. Conclusion.Tension-type headache in this case is accompanied by a dominant psychological factor. Collaboration between pharmacotherapy and psychotherapy in treating patients with tension type headaches is a fairly effective choice.

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