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Contact Name
Lalu Rudyat Telly Savalas
Contact Email
telly@unram.ac.id
Phone
+6287878138831
Journal Mail Official
telly@unram.ac.id
Editorial Address
A Building 2nd floor, Faculty of Teaching Training and Education, Mataram University, Jalan Majapahit No 62 Mataram, Mataram 83125, Indonesia
Location
Kota mataram,
Nusa tenggara barat
INDONESIA
Acta Chimica Asiana
Published by Universitas Mataram
ISSN : 2550049x     EISSN : 25500503     DOI : -
Acta Chimica Asiana (online ISSN 2550-0503, print ISSN 2550-049x) is a peer-reviewed, open access journal that publishes high-quality original research articles as well as review articles and short communication in all areas of Chemistry, including Chemical Education and Chemical Engineering. The editors welcome original contributions that have not been published and are not under consideration elsewhere. This journal is published by the Himpunan Kimia Indonesia Cabang Nusa Tenggara (Indonesian Chemical Society, Nusa Tenggara Division). All papers published free of charge
Articles 25 Documents
ANALYSIS DOCKING OF PLASMODIUM FALCIPARUM ENOYL ACYL CARRIER PROTEIN REDUCTASE (PFENR) WITH ORGANIC COMPUNDS FROM VIRTUAL SCREENING OF HERBAL DATABASE Malau, Nya Daniaty; Azzahra, St Fatimah
Acta Chimica Asiana Vol 3 No 1 (2020)
Publisher : HKI Nusa Tenggara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (481.379 KB) | DOI: 10.29303/aca.v3i1.14

Abstract

Malaria is one of problematic infectious diseases worldwide. The absence of an effective vaccine and the spread of drug resistant strains of Plasmodium clearly indicate the necessity for the deveploment of new chemotherapeutic agents. Recent method being developed is searching a new drug of antimalarial using in silico screening, or also known as virtual screening. One of enzyme target that important for growth of the malaria parasite is Plasmodium falciparum Enoyl Acyl Carrier Protein Reductase (PfENR). Inhibition of this enzyme cause the fatty acid biosynthesis type II will be terminated. In this research, in silico screening was performed using AUTODOCK VINA software to find inhibitor candidates of PfENR by using ligands from the database of Medicinal Plants in Indonesia. On the AUTODOCK VINA software moleculer docking experiments were performed between ligands and macromolecule target PfENR. This target that has been optimized with residue removal and charges addition. Ligand is expected to be the PfENR inhibitors.
QSAR TREATMENT OF MEISOINDIGO DERIVATIVES AS A POTENTBREAST ANTICANCER AGENT Lestari, Evie Kama; Ananto, Agus Dwi; Septiyana, Maulida; Hadisaputra, Saprizal
Acta Chimica Asiana Vol 2 No 2 (2019)
Publisher : HKI Nusa Tenggara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (515.646 KB) | DOI: 10.29303/aca.v2i2.12

Abstract

A quantitative structure-activity relationship (QSAR) analysis of meisoindigo derivatives as a breast anticancer has been carried out. This study aimed to obtain the best QSAR model in order to design new meisoindigo based compounds with best anticancer activity. The semiempirical PM3 method was used for descriptor calculation. The best QSAR model was built using multilinear regression (MLR) with enter method. It was found that there were 19 new meisoindigo derivativeswith better predictive a potent anticancer agent. The best compound was (E)-2-(1-((3-ethylisoxazol-5-yl)methyl)-2-oxoindolin-3-ylidene)-N-(4-methoxyphenyl)acetamide with the value of IC505.31144 x10-15 (?M).
ANTIOXIDANT CAPACITY AND α-AMILASE INHIBITION BY AVOCADO (PERSEA AMERICANA MILL) PEEL AND RED GINGER (ZINGIBER OFFICINALE VAR. RUBRUM) BASED FUNCTIONAL DRINK Putra, I Made Wisnu Adhi; Sukesi, Ketut Ayu; Sulistyadewi, Ni Putu Eny
Acta Chimica Asiana Vol 3 No 1 (2020)
Publisher : HKI Nusa Tenggara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (386.24 KB) | DOI: 10.29303/aca.v3i1.22

Abstract

Avocado peel (Persea americana Mill) and red ginger (Zingiber officinale var. Rubrum) proved to have antidiabetic properties. However, there has been no research on the analysis of antidiabetic activity of the combination of avocado peel and red ginger in functional beverages. This study aims to make functional beverages from the combination of avocado peel and red ginger. Total phenolic content, antioxidant capacity, inhibition of the ?-amylase activity, and public preferences towards functional beverages (organoleptic) were then evaluated. Functional beverages were made by brewing the powdered avocado peel and red ginger with 200 ml of hot water (96oC) for 5 minutes. The results showed that the increase of avocado peels amount in the combination coukd increase total phenolic content. The high antioxidant capacity was also found in samples with high content of avoccado peels. The results of inhibition of ?-amylase enzyme activity did not show any significant differences. Organoleptic test results showed that there were no significant differences in each sample. The combination of avocado peel and red ginger has the potential to be an antidiabetic functional beverage.
THE UTILIZATION OF EDAMAME (GLYCINE MAX (L.) MERR) AND RED BEAN (PHASEOLUS VULGARIS) AS A FUNCTIONAL BEVERAGE Cornelia, Melanie; Lessy, Soraya Triesly
Acta Chimica Asiana Vol 1 No 1 (2018)
Publisher : HKI Nusa Tenggara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (679.269 KB) | DOI: 10.29303/aca.v1i1.4

Abstract

Indonesia had the big potency to produce red beans and edamame beans, but its utilization regarding functional food was not optimal. This research was intended for development combining red and edamame beans to become a new functional beverage product. The ratio of edamame milk to red bean milk (100:0, 75:25, and 50:50) and cooking temperature 90 oC has been selected based on SNI soymilk. During storage, a phase separation happened. Consequently, stabilizer should be added to improve its stability. Three types of stabilizers were used,CMC 0.1 %, 0.2%, and 0.3 %, xanthan gum (XG), and guar gum (GG) 0.025 %, 0.05 %, and 0.1 %, respectively. The best formulation was milk ratio 75:25 with 90 oC and addition of XG 0.05 %. The dietary fiber analysis for milk formulation was 4.46 % therefore it was categorized as a functional beverage.  
CHEMICAL CONSTITUENTS OF BUAH MAKASAR [BRUCEA JAVANICA (L) MERR] LEAVES AND SEED EXTRACT Muliasari, Handa; Hamdin, Candra D; Ananto, Agus Dwi; Ihsan, Muhsinul
Acta Chimica Asiana Vol 2 No 2 (2019)
Publisher : HKI Nusa Tenggara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (107.377 KB) | DOI: 10.29303/aca.v2i2.10

Abstract

Buah Makasar [Brucea javanica (L) Merr] is one of the local plants in Lombok Island that is traditionally used for diabetic medication. The purpose of this research was to identify the chemical constituents containing in methanol leaves and seed extract of Buah Makasar. The methods used were phytochemical screening for some groups of chemical compounds and GC-MS analysis. The result of phytochemical screening showed that methanol extract of B. javanica seed contains alkaloids, terpenoids, and tannin with a high intensity; while the leaves extract contains alkaloids, flavonoids, steroids, tannin, and saponin. The differences of chemical compositions in the leaves and seed extract may give them have different bioactivities. GC-MS analysis showed some fatty acids containing in the seed extract such as stearic acid and palmitic acid.
SYNTHESIS OF RICE HUSK MESOPOROUS SILICA AS PH RESPONSIVE RELEASE MATERIAL Aulia, Pidia; Hamdiani, Saprini; Sumarlan, Iwan
Acta Chimica Asiana Vol 2 No 2 (2019)
Publisher : HKI Nusa Tenggara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (392.026 KB) | DOI: 10.29303/aca.v2i2.21

Abstract

The synthesis of mesoporous silica as a delivery agent for the ethyl para-methoxycinnamate has been carried out. The study aims to determine the process of mesoporous silica synthesis from sodium silicate from the smelting of rice husk ash, determine the adsorption capacity of mesoporous silica in the ethyl para-methoxycinnamate and the pH responsive release of ethyl para-methoxycinnamate with mesoporous silica as a delivery agent in simulated intestinal and gastric fluids. It was found that mesoporous silica can be synthesized from rice husk ash with a 30% tartaric acid template. Characterization of mesoporous silica using FTIR spectroscopy showed the presence of silanol (Si-OH) and siloxane (Si-O-Si) functional groups. Mesoporous silica from rice husk ash is able as adsorbent for the ethyl para-methoxycinnamate with the adsorption capacity of 8.26 mg/g. The release test of gastric simulation fluid (pH 1.2) showed that the ethyl-para-methoxycinnamate was released from silica for a period of 12 hours. In the intestinal simulation fluid (pH 7.4), the release of the ethyl para-methoxycinnamate occurred slowly at the first hour, then gradually increased at 5 hour up to 12 hour.
PROTECTION OF COPPER CORROSION IN ACIDIC MEDIUM USING PINOSTROBIN Wati, Rosita; Hadisaputra, Saprizal; Asnawati, Dina; Hermanto, Dhony
Acta Chimica Asiana Vol 1 No 2 (2018)
Publisher : HKI Nusa Tenggara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v1i2.26

Abstract

The corrosion inhibition efficiency of copper was tested by the weight loss method in 1 M H2SO4 medium in the presence of pinostrobin as inhibitor. It shows that the addition of pinostrobin inhibitor reduce the corrosion rate. The nature of thermodynamic of pinostrobin adsorption on copper surfaces follows the Freundlich isotherm. The process of inhibition is endothermic, spontaneous and physisorption. It is proved by the Ea, ?H and ?S and ?G values in which the thermodynamic studies show that the values of Ea < 80 kJ.mol-1, ?H positive, ?S positive, and ?G < -20 kJ.mol-1.
PREDICTION OF XANTON DERIVATIVES AS ANTI HEART CANCER USING IN SILICO QUANTITATIVE STRUCTURE-PROPERTY RELATIONSHIPS Putri, Royana Ari Pratiwi; Ananto, Agus Dwi; Sudarma, I Made
Acta Chimica Asiana Vol 2 No 1 (2019)
Publisher : HKI Nusa Tenggara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v2i1.28

Abstract

Quantitative Structure-Activity Relationship (QSAR) study have been performed on Xanthone derivatives as anti-cancer activity. The objectives of this research is to design a new Xanthone derivatives from the best  QSAR equation model. The data set were taken from the previous study, involving 41 Xanthone derivatives and their biology activities in Inhibitor Concentration 50 % (IC50). The parameters (descriptors) were calculated by semiempirical PM3 method. The selection of the best QSAR equation models was determined by multilinear regression analysis. The best linear equation resulted from that analysis is: Log 1/IC50 = 13,099 + 2,837 qC1 + 0,098 qC2 + 11,214 qC10 + 2,065 qC13 ? 1,236 qC14 + 35,356 qO15 + 0,001 (vol) ? 0,025 (log P) + 0,283 (dipole) n = 41; r = 0.735; adjusted r2 = 0.360; Fhit/Ftab = 1.2911; PRESS = 5.0089. Based on that model, a new Xanthon derivatives has been design which show better predicted biology activity (log 1/IC50= 15,0863), new derivatives have the log 1/IC50 higher than the old one (log 1/IC50= 9). This result indicated that new Xanthone derivatives has potential to developed as new anti-cancer drug
THEORETICAL STUDY ON THE BINDING SELECTIVITY OF 18-MEMBERED AZACROWN ETHERS WITH ALKALINE EARTH METAL SPECIES Hamdiani, Saprini; Savalas, Lalu Rudyat Telly; Purwoko, Agus Abhi; Hadisaputra, Saprizal
Acta Chimica Asiana Vol 1 No 1 (2018)
Publisher : HKI Nusa Tenggara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (859.878 KB) | DOI: 10.29303/aca.v1i1.5

Abstract

The binding selectivity of 18-membered azacrown ethers (monoaza- N1, diaza- N2, triaza- N3, tetraaza- N4, pentaaza- N5, and hexaaza-18-crown-6 N6) with Ca2+, Sr2+, Ba2+ have been studied by density functional theory (DFT) calculations. The complex binding selectivity was analyzed in term of interaction energies, thermodynamic properties, second order interaction energies, and charge transfer effects. The geometrical study shows that Ca2+ and azacrown complexes acquire envelope like structure, leading to shorter bond lengths. As a result, these complex systems have the highest interaction energies. Theoretical study also showed that N6 complex with alkaline earth metal ion were shown to be more stable complex than those ligand with lower nitrogen number. The interaction energy order is N0 < N1 < N2 < N3 < N4 < N5 < N6. This trend shows that the presence of more nitrogen on the crown ether cavity increases the interaction energies by approx. 7.3 % in going from N0 to N6. It is clearly showed that the contribution of the number of nitrogen play a dominant role in the binding selectivity of these systems.  
SYNTHESIS OF BIODEGRADABLE SUPERABSORBENT POLYMERS FROM CARBOXYMETHYL CELLULOSE/HUMIC ACID Ismillayli, Nurul; Kamali, Siti Raudhatul; Hadi, Surya; Hermanto, Dhony
Acta Chimica Asiana Vol 2 No 2 (2019)
Publisher : HKI Nusa Tenggara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (197.828 KB) | DOI: 10.29303/aca.v2i2.8

Abstract

Superabsorbent polymer (SAP) blend has been synthesized from carboxymethyl cellulose (CMC), humic acid, and aluminum sulphate octadecahydrate cross-linker.  SAP is hydrophilic networks that can absorb and retain huge amount of water within their structures. Humic acid as starting material of polymer, was isolated from subgrade Batujai Dam by using IHSS method. Water Absorption Capacity (WAC) measurement, FTIR analysis, and agitation tests to investigate the cross-linking process and which of Al3+ and SO42-  ions causes the crosslinking are carried out. Optimum cross-linking ratio of CMC and cross-linker appeared to be 2wt% corresponded to WAC determination. FTIR spectrum of CMC/humic acid blend and agitation test showed that CMC react with humic acid during polymerization process via Al3+ ion.   Keywords: carboxymethyl cellulose; Al3+ ion; humic acid; superabsorbent polymer.

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