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Contact Name
Viskasari P. Kalanjati
Contact Email
majalahbiomorfologi@fk.unair.ac.id
Phone
+6285649348098
Journal Mail Official
majalahbiomorfologi@fk.unair.ac.id
Editorial Address
Departemen Anatomi dan Histologi Fakultas Kedokteran, Universitas Airlangga, Surabaya, Indonesia Jl. Prof Dr Moestopo 47 Surabaya 60132 Indonesia
Location
Kota surabaya,
Jawa timur
INDONESIA
Majalah Biomorfologi
Published by Universitas Airlangga
ISSN : 02158833     EISSN : 27160920     DOI : 10.20473/mbiom.v30i1.2020.1-7
Core Subject : Health, Science,
Majalah Biomorfologi publishes articles in the form of original research report, excel-literature review, communication and special case report. The scope of this journal includes Medicine and Health sciences, focusing in basic and applied Anatomy and Histology (i.e., neuroscience, medical and health education, anthropology, clinical genetics, embryology, medical education, clinical anatomy, histotechnics, and photomicroscopy) although other correlated topics are also welcomed.
Arjuna Subject : Kedokteran - Anatomi
Articles 45 Documents
INFEKSI VIRUS HERPES SIMPLEX PADA BELL’S PALSY Hidayaturrahmi, Hidayaturrahmi; Kalanjati, Viskasari Pintoko
Majalah Biomorfologi Vol 26, No 2 (2013): Majalah Biomorfologi
Publisher : Department of Anatomy and Histology, Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (243.343 KB) | DOI: 10.20473/mbiom.v26i2.2013.22-26

Abstract

Bell?s palsy  disease  is  an acute  idiopathic  peripheral  facial  paralysis  involving  the facial nerve. This disease. This disease is characterized by paralysis and weakness of the facial muscles unilateral with sudden onset and  peak symptoms within a few days.  The etiology  of  this disease  can not be explained  properly. However, some clinical data and immunology shows that the bell?s palsy is  thought to be caused by latent Herpes simplex virus tipe 1 (HSV-1) which is  reactivated  at ganglia  geniculatum  so may provoke an autoimmune reaction against peripheral nerve myelin, leading to the demyelination of facial nerve (N.VII). In the acute phase,  examination of peripheral blood lymphocytes was found a significant reduction of  the percentage of peripheral T lymphocytes and an increase in the percentage of B lymphocytes. In this review, we will also discuss steroids and antiviral therapy as a treatment of Bell?s palsy is currently.
EFFECTS OF LOW DOSE EXPOSURE OF BORAX FOR 8 WEEKS ON GASTRIC ULCER FORMATION Faza, Audi Salman; Dewanti, Linda; Qurnianingsih, Ema
Majalah Biomorfologi Vol 30, No 1 (2020): MAJALAH BIOMORFOLOGI
Publisher : Department of Anatomy and Histology, Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (490.038 KB) | DOI: 10.20473/mbiom.v30i1.2020.8-15

Abstract

Background: Borax, a carcinogenic toxicant, is illegally used as food additives frequently. Previous researches shown that high dose of borax exposure (300 mg/kg of BW) caused gastric ulcer, but low dose of borax, as found as usual dose in food, has not been frequently researched. Objective: The aim of this study was to analyze the effects of low dose of borax for 8 weeks on the formation of gastric ulcer. Material and Method: Twenty four young adult rats (Rattus norvegicus) were divided into 4 groups (Control, Group 1, 2, and 3). Borax doses of 50 mg/kg, 150 mg/kg, and 300 mg/kg were administered on groups 1, 2, and 3 respectively through sonde for 8 weeks; Control group was not exposed with borax. Body weight was monitored every 2 weeks. On the last day of the experiment, rats were euthanized and gastric ulcers were histopathologically analyzed using a microscope. The data were analyzed by the comparative test of Mann-Whitney and the significancy was set on p <0.050. Result: The results showed that body weight was significantly different on the 6 th week between Control vs Group 1 (p= 0.010) and Control vs Group 3 (p= 0.043). The grade of gastric ulcer was found higher in Group 2 and Group 3 compared to Control (p= 0.019 and 0.011 respectively). Conclusion:  Both of low dose (150mg / kg BW) and high dose (300mg / kg BW) of borax exposure for 8 weeks cause microscopic gastric ulcer on rats.  
FOCAL CORTICAL DYSPLASIA Purwidyastuti, Desy; Kalanjati, Viskasari Pintoko
Majalah Biomorfologi Vol 25, No 1 (2012): Majalah Biomorfologi
Publisher : Department of Anatomy and Histology, Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (123.74 KB) | DOI: 10.20473/mbiom.v25i1.2012.8-12

Abstract

Cortical dysplasia or  focal  cortical dysplasia (FCD) is one of the most common causes of seizures and childhood epilepsy. It is one of some malformation types of cortical development. By using magnetic resonance imaging (MRI) or another radiographic modality, it is not easy to detect its abnormalities. Focal cortical dysplasia was firstly recognized by surgery of intractable epileptic patients. This review is written to describe malformation cortical development (MCD) especially focal cortical dysplasia, its embryology and abnormalities. Cerebral cortex has 6 layer which characteristically different in each of them. Neurons from those layers come from subpial neurons which had migrated to cortical layers according to its ages and functions. The younger ages of neurons will be placed more superficially. Disrupting at any stages of cortical development will be manifested in abnormalities of brain cortex. There are some classifications of MCD according to those cell morphology, Electro Encephalography (EEG), embryology and genetic. Focal cortical dysplasia  might be caused by disrupting in late stages of cortical development.  Focal cortical dysplasia can be distinguished in to two groups, the group I and group II. Microscopically between those groups could be distinguished by borders of the layers. In FCD there is alteration of neurotransmitter effect which is ?-amino butiric acid (GABA) in synaptic process. Its alteration causes seizures, epilepsy or other abnormalities which could be occurred in prenatal or perinatal period. Those seizures or epilepsy often drug resistant.
KARAKTERISTIK PASIEN TUBERKULOSIS TULANG BELAKANG DI RSUD DR. SOETOMO SURABAYA Sukamto, Amy Rosalie; Airlangga, Primadenny Ariesa; Yuliawati, Tri Hartini
Majalah Biomorfologi Vol 29, No 1 (2019): Majalah Biomorfologi
Publisher : Department of Anatomy and Histology, Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (280.077 KB) | DOI: 10.20473/mbiom.v29i1.2019.1-6

Abstract

Background: Spine tuberculosis or spondylitis TB is one of the most common found extrapulmonary form of Mycobacterium tuberculosis infection that can be rapidly transmitted. However, people?s alertness are still to be increased and this disease is still rarely investigated. Objective: To study the characteristics of spondylitis tuberculosis patients to enhance the understanding of the disease and improve alertness to its signs and symptoms. Material and method: This study was conducted by assessing patients? medical records based on particularly the epidemiology, signs and symptoms, radiology and laboratory tests. Collected data were assessed retrospectively and analyzed descriptively. Results: Of 35 patients, most come from early adult age group which is ranged from 26 to 35 years old (25.72%), and 57.14% of the patients were female. Sorted from the most to least common found signs and symptoms are back pain (85.71%), formation of abscess (74.29%), formation of gibbus (54.29%), fever (37.14%), and significant weight loss (34.29%). In radiologic evaluation, spine destruction were found on 82.86% of the patients. Erythrocyte sedimentation rate (ESR) was evaluated from 30 patients, 90% of which had increased ESR to >30 mm/hour. The leukocyte count was based from 35 patients, which result was 71.43% of them had normal count. Conclusions: Spondylitis TB is mostly found in adult females with back pain as the most common symptom. Most patients had spine destruction. Largely had elevated ESR while their leukocyte count mostly remains within normal range.
LESI MEDULA SPINALIS Maulina, Meutia; Kalanjati, Viskasari Pintoko
Majalah Biomorfologi Vol 26, No 1 (2013): Majalah Biomorfologi
Publisher : Department of Anatomy and Histology, Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (121.066 KB) | DOI: 10.20473/mbiom.v26i1.2013.1-5

Abstract

Spinal cord  lesion  is one of major causes  of neurological  disability  due to  trauma  and non  trauma. Thisdisability can cause damage and loss of function below the level of lesion and also has adversed effects onseveral body systems. Traumatic spinal cord lesion is the most widely reported incidence compared to nontraumatic spinal cord lesion. The most leading cause of traumatic spinal cord lesion is motor vehicle crash in children, whereas in old age, falls become the main cause. The mechanism of injury influences the type of spinal cord lesion and the degree of neurological deficit. Spinal cord lesions can be classified into completeand incomplete based on the presence or absence of a function that is maintained below the level of lesion.Complete spinal cord lesion shows absence of voluntary movement or sensation below the level of the lesionon both sides, whereas incomplete lesion shows the persistence of the variation of some functions below the level of  lesion. Knowledge on the anatomy of the  spinal  cord  plays an important role  in  the clinicaldiagnosis. The  level of  lesion  at the different  segments of  the spinal cord  determines different  signs  andsymptoms, caused by destruction of segmental tissue and disconnection of ascending and descending tracts above and below the level of lesion. The level of lesion is helpful in predicting deficits of body functions thatmay  occur, in  determining  the next  treatment  and in predicting the  prognosis of the disease. Incompletespinal cord lesion tends to have a better prognosis. Death usually occurs in lesion with multiple trauma. Theleading cause of death is complications due to neurological disability, i.e. pneumonia, pulmonary embolism,septicemia, and renal failure.
PERBEDAAN JUMLAH LIMFOSIT DAERAH PALS (PERIARTERIAL LYMPHOID SHEAT) ANTARA MENCIT SEHAT DAN MENCIT DIABETES Dewi, Arni Kusuma; Rahardjo, Iskantijah Budi; Gunawan, Ari
Majalah Biomorfologi Vol 27, No 1 (2014): Majalah Biomorfologi
Publisher : Department of Anatomy and Histology, Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (311.715 KB) | DOI: 10.20473/mbiom.v27i1.2014.5-8

Abstract

Diabetes mellitus complication that much happen and need attention is infection. Bacterial infection getting worse with the decrease of cellular immunity diabetic patient. Antibiotic treatment has not been optimaly yet without immunity intervention to the patient. This study is done to evaluate immunity state in diabetes with count lymphocyte in PALS spleen then compare with healthy ones. Thirty six mice BALB/c strain, sex male ware separated into 2 groups, the control group and the treatment group. The control groups were healty and had standart diet, while the treatment groups were diabetic group and had high fat diet to induct diabetes for ten weeks. After 10 weeks, both groups were induced with histamine intraperitoneally to show immune respons. Mice were sacrified for taken the spleen to make histology preparation with routine staining. Account of lymphocyte both groups compared with statistical tools by t test independent samples. Account of lymphocyte cell in the PALS area shown that the control had significant more than the treatment (p<0,0001). Smaller number of lymphocyte in diabetic is one of the proofs that there are decrease of immunity.
KONTRIBUSI INFLAMASI TERHADAP PATOGENESIS PENYAKIT PARKINSON Maulana, Reza; Kalanjati, Viskasari Pintoko
Majalah Biomorfologi Vol 25, No 2 (2012): Majalah Biomorfologi
Publisher : Department of Anatomy and Histology, Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (202.661 KB) | DOI: 10.20473/mbiom.v25i2.2012.27-32

Abstract

Parkinson?s disease is one of neurodegenerative diseases which is the second most common afterAlzheimer?s disease in the world. It is a chronic disease with selective loss of dopaminergic neurons withinthe substantia nigra (SN) pars compacta (pc) of the midbrain. The disease represents a complex interactionbetween the inherent vulnerability of the nigrostriatal dopaminergic system, a possible geneticpredisposition, and exposures to environmental toxins including inflammatory triggers. Until now, the exactcause of Parkinson?s disease remains uncertain, but recent studies suggest neuroinflammation andmicroglia activation play important roles in Parkinson?s disease pathogenesis. Evidence now suggest thatchronic neuroinflammation and systemic inflammation are consistently associated with the patophysiologyof Parkinson?s disease. Activated microglia and increased level of pro-inflammatory cytokine such as TumorNecrosis Factor (TNF)-?, interleukin (IL)-2, IL-6, RANTES, Reactive Oxygen Species (ROS) and NitricOxide (NO) have been reported from Parkinson?s disease patients and in animal models of Parkinson?sdisease. The blood brain barrier permeability dysfunction is also a contributing factor to the pathology ofthis disease. In this review, we discuss about neuronal cell pathology in Parkinson?s disease, its possiblerelationship with neuroinflammation and systemic inflammation, blood brain barrier disfunction and proinflammatory cytokine released during the disease?s progressivity. Lastly, we also review theepidemiological data suggest about the inflammation and the increased risk of Parkinson?s disease. Moreresearch are needed to undercover the role of inflammation in Parkinson?s disease. With a betterunderstanding about the relationship between inflammation and Parkinson?s disease cross-talk, the brightfuture with the possibility of specific immunomodulatory drugs play a role to limit a progressivity ofParkinson?s disease is no longer just a dream.
EVALUASI JARINGAN DALAM STUDI IN VIVO PEMBERIAN EKSTRAK PROPOLIS PADA MODEL LUKA INFEKSI Hendrata, Winona May; Sandhika, Willy; Widodo, Agung Dwi Wahyu
Majalah Biomorfologi Vol 29, No 2 (2019): Majalah Biomorfologi
Publisher : Department of Anatomy and Histology, Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (595.476 KB) | DOI: 10.20473/mbiom.v29i2.2019.32-39

Abstract

Background: Infection in wound could lead to various consequences including scarring and occurrence of sepsis. With increasing prevalence of resistant strain bacteria, option for treating infected wound need to be constantly expanded. Propolis, a product of honey bee, is a potential treatment which has been studied to have various effects including antibacterial, anti-inflammatory, and antioxidant. Objective: The study aims to assess the effect of propolis toward wound healing, by evaluating wound macroscopic and microscopic appearance. Material and method: Propolis extract were made using maceration technique using ethanol. Thirty Rattus norvegicus male rats were divided into six groups: three groups for treatment and three groups for control. Incision wound were made in the back and was infected with Methicillin ResistantStaphylococcus aureus (MRSA). Propolis was administered orally on daily basis. Wound excision for observation were done on day3, 5, and 7. The tissue were processed using haematoxylin-eosin (HE) staining for microscopic observation. The distance of normal tissue surrounding the wound were measured using image analysis program. Result: Macroscopic observation showed fewer visible wound in the propolis extract treated group. Measurement by microscopic observation on day 3 also demonstrated more narrow wound width in propolis extract treated group (405.75 ? 110.11 ?) compared to the control group (806.20? 644.41?). Conclusion: The result of this study suggests that propolis extract by oral administration promotes the healing of infected wound as shown within microscopic and microscopic observation.
GANGGUAN GINJAL AKUT AKIBAT RHABDOMIOLISIS Hasanatuludhhiyah, Nurina; Basori, Achmad; Suhartati, Suhartati
Majalah Biomorfologi Vol 28, No 2 (2015): Majalah Biomorfologi
Publisher : Department of Anatomy and Histology, Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (368.95 KB) | DOI: 10.20473/mbiom.v28i2.2015.26-31

Abstract

Acute kidney injury (AKI) is the most serious complication of rhabdomyolysis, a syndrome characterized by skeletal muscle destruction causing leakage of myoglobin and other intracellular protein as well as electrolytes into circulation. Due to its light molecular weight, myoglobin is readily filtered by the glomerus, and enters renal tubules, which may cause acute kidney injury with myoglobinuria. It is also characterized by significant increase of serum creatine kinase (CK) as well as electrolyte abnormalities. This review is intended to elucidate the mechanisms involved in pathogenesis of rhabdomyolysis induced AKI, which is related with its clinical as well as laboratory manifestations. This is used as a basis to determine correct diagnosis and management.The basic mechanisms in the pathogenesis of rhabdomyolysis induced AKI include: 1) renal vasoconstriction and ischemia induced by the release of several mediators which promote vasoconstriction including endothelin-1 and vasopressin which is triggered by activation of sympathetic system and rennin angiotensin aldosteron (RAA) system to compensate hypovolemia. Additionally TNF-?, thromboxane A2, and F2 Isoprostane are also generated in inflammatory response to muscle injury, endothelial dysfunction as well as oxidative injury, 2) formation of myoglobin cast, which is precipitation of myoglobin-Tamm Horsfal protein complex producing obstruction of distal tubules, 3) direct cytotoxic effect of myoglobin on proximal tubules through oxidative injury generated by Fenton Reaction and myoglobin redox cycling. It is concluded that rhabdomyolysis induced AKI is produced by renal ischemia, tubular obstruction and oxidative injury on tubular cells.
PENGARUH N-ACETYLCYSTEINE INTRAVENA TERHADAP KERUSAKAN TUBULUS GINJAL PADA TIKUS PUTIH (RATTUS NORVEGICUS) YANG DIINDUKSI GLISEROL Hasanatuludhhiyah, Nurina; Basori, Achmad
Majalah Biomorfologi Vol 27, No 2 (2014): Majalah Biomorfologi
Publisher : Department of Anatomy and Histology, Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (490.665 KB) | DOI: 10.20473/mbiom.v27i2.2014.33-40

Abstract

Oxidative injury produced via Fenton reaction and myoglobin redox cycle plays crucial role in the pathogenesis of myoglobinuric acute kidney injury (AKI). It may directly damage renal tubules as well as generate lipid peroxidation products with vasoconstrictor properties. N-acetylcysteine (NAC) is an antioxidant that has been proven for the protective effects in many experimental models of renal injury and also the improvement of renal microcirculation. The aim of this study was to scrutinize any possible protective effect of NAC in glycerol induced rat model by examining tubular necrosis and hyaline cast formation, and to explore whether the effect was dose-related or not. Thirty five male Wistar rats were divided into five groups: 1) saline control group, (2) glycerol (50%, 8ml/kg, i.m) plus saline i.v group, 3) glycerol plus NAC (100 mg/kg)-treated group, 4) glycerol plus NAC (200 mg/kg)-treated group, 5) glycerol plus NAC (400 mg/kg)-treated group. Rats were sacrificed at 24 h after glycerol injection, and renal tissues were harvested for making histopathologic slides. Glycerol administration significantly increased renal tubular necrosis and hyaline cast formation, however NAC administration prevented the tubular damage. There were significant differences of necrosis and hyaline cast formation scores between glycerol+NAC treated groups with glycerol alone treated group (p<0.05). However there was a significant correlation between NAC dose with tubular necrosis score (p<0.05), indicating that the dose increment produced less protection from tubular damage. N-acetylcysteine was found to attenuate renal tubular necrosis and hyaline cast formation in this glycerol induced rat model, and the least dose of NAC i.e 100 mg/kg was the recommanded dose.